Alireza Lajevardipour

Dr. Alireza Lajevardipour

Swinburne University of Technology, Melbourne, Victoria, Australia
orcid

Research Focus & Metrics

Academic Career Length

18Years (2009-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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31 October 2016 in Nature Communications
Verified
Journal Article
Open access
SNSarah R Needham
Sarah R Needham
SRSelene K. Roberts
Selene K. Roberts
AAAnton Arkhipov
Anton Arkhipov
VMVenkatesh P. Mysore
Venkatesh P. Mysore
CTChristopher J. Tynan
Christopher J. Tynan
MMMarisa Martin-Fernandez
Marisa Martin-Fernandez
Epidermal growth factor receptor (EGFR) signalling is activated by ligand-induced receptor dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures and functions of the oligomers are poorly understood. Here, we use fluorophore localization imaging with photobleaching to probe the structure of EGFR oligomers. We find that at physiological epidermal growth factor (EGF) concentrations, EGFR assembles into oligomers, as indicated by pairwise distances of receptor-bound fluorophore-conjugated EGF ligands. The pairwise ligand distances correspond well with the predictions of our structural model of the oligomers constructed from molecular dynamics simulations. The model suggests that oligomerization is mediated extracellularly by unoccupied ligand-binding sites and that oligomerization organizes kinase-active dimers in ways optimal for auto-phosphorylation in trans between neighbouring dimers. We argue that ligand-induced oligomerization is essential to the regulation of EGFR signalling.

18 October 2018 in Nature Communications
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Journal Article
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LZLaura Carolina Zanetti-Domingues
Laura Carolina Zanetti-Domingues
DKDimitris Korovesis
Dimitris Korovesis
SNSarah R Needham
Sarah R Needham
CTChristopher J. Tynan
Christopher J. Tynan
SSShiori Sagawa
Shiori Sagawa
MMMarisa Martin-Fernandez
Marisa Martin-Fernandez
Our current understanding of epidermal growth factor receptor (EGFR) autoinhibition is based on X-ray structural data of monomer and dimer receptor fragments and does not explain how mutations achieve ligand-independent phosphorylation. Using a repertoire of imaging technologies and simulations we reveal an extracellular head-to-head interaction through which ligand-free receptor polymer chains of various lengths assemble. The architecture of the head-to-head interaction prevents kinase-mediated dimerisation. The latter, afforded by mutation or intracellular treatments, splits the autoinhibited head-to-head polymers to form stalk-to-stalk flexible non-extended dimers structurally coupled across the plasma membrane to active asymmetric tyrosine kinase dimers, and extended dimers coupled to inactive symmetric kinase dimers. Contrary to the previously proposed main autoinhibitory function of the inactive symmetric kinase dimer, our data suggest that only dysregulated species bear populations of symmetric and asymmetric kinase dimers that coexist in equilibrium at the plasma membrane under the modulation of the C-terminal domain.

5 April 2012 in Journal of Physics: Condensed Matter
Verified
Journal Article
Closed access
ALAlireza Lajevardipour
Alireza Lajevardipour
MNM Neek-Amal
M Neek-Amal
FPF M Peeters
F M Peeters
Using the valence force field model of Perebeinos and Tersoff (2009 Phys. Rev. B 79 241409(R)), different energy modes of suspended graphene subjected to tensile or compressive strain are studied. By carrying out Monte Carlo simulations it is found that: (i) only for small strains (|ε|

30 September 2022 in Water
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Journal Article
Open access
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Reza PashaeiReza Pashaei
Reza Pashaei
RDReda Dzingelevičienė
Reda Dzingelevičienė
ABAida Bradauskaitė
Aida Bradauskaitė
ALAlireza Lajevardipour
Alireza Lajevardipour
Małgorzata Szultka-MłyńskaMałgorzata Szultka-Młyńska
Małgorzata Szultka-Młyńska
Bogusław BuszewskiBogusław Buszewski
Bogusław Buszewski
Pharmaceuticals, microplastics, and oil spills are the most hazardous contaminants in aquatic environments. The COVID-19 pandemic enhanced pharmaceutical and microplastic contamination in aquatic environments. The present study aimed to investigate the prevalence of pharmaceutical and microplastic pollution on a global scale. This study assessed the results of pharmaceutical contamination in 25 countries and microplastic pollution in 13 countries. The findings show that pharmaceutical residues were detected in surface water, groundwater, and wastewater influents and effluents. In total, 43 types of pharmaceutical products were detected in 25 countries. Caffeine, acetaminophen, ibuprofen, sulfamethoxazole, and carbamazepine were the most abundant. In total, 32 types of polymers were detected in 13 countries. In the case of microplastics, polypropylene, polyethylene, polystyrene, and polyethylene terephthalate were the more abundant polymers. Particles with a size of 1–2.5 mm and 2.5–5 mm accounted for half of the microplastics present in 13 countries. This study provides new evidence of the importance of emerging pollutants in aquatic environments before and during the COVID-19 pandemic.

30 January 2019 in Bioelectromagnetics
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Journal Article
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Zoltan VilagoshZoltan Vilagosh
Zoltan Vilagosh
ALAlireza Lajevardipour
Alireza Lajevardipour
AWAndrew Wood
Andrew Wood

28 September 2015 in Photonics Research
Verified
Journal Article
Open access
PDF file
CJChristiaan J. de Jong
Christiaan J. de Jong
ALAlireza Lajevardipour
Alireza Lajevardipour
MGMindaugas Gecevičius
Mindaugas Gecevičius
MBMartynas Beresna
Martynas Beresna
GGGediminas Gervinskas
Gediminas Gervinskas
Saulius JuodkazisSaulius Juodkazis
Saulius Juodkazis
A novel fluorescence lifetime imaging microscopy (FLIM) working with deep UV 240–280 nm wavelength excitations has been developed. UV-FLIM is used for measurement of defect-related fluorescence and its changes upon annealing from femtosecond laser-induced modifications in fused silica. This FLIM technique can be used with microfluidic and biosamples to characterize temporal characteristics of fluorescence upon UV excitation, a capability easily added to a standard microscope-based FLIM. UV-FLIM was tested to show annealing of the defects induced by silica structuring with ultrashort laser pulses. Frequency-domain fluorescence measurements were converted into the time domain to extract long fluorescence lifetimes from defects in silica.