Electronic cigarettes (e-cigarettes) are considered relatively safe, thus tobacco and nicotine delivery products have become popular in the last few years. However, the safety of long-term use of these products on oral health is still questionable. E-cigarettes may have potential risks to oral health that can be demonstrated as cellular damage, genetic instability, and mucosal lesions. This review aims to observe the role of e-cigarettes as a risk factor for oral cancer development. This systematic review was conducted following the PRISMA guidelines to provide reliable data on the role of electronic cigarettes as a risk factor for oral cancer development. The research was performed on Pubmed and Scopus by three reviewers from the Oral Pathology Department (Sapienza University of Rome) in May 2024. The search terms included: "e-cigarette", "oral cancer", and "risk factor" where 32 articles from PubMed and 75 from Scopus were collected. A total of 12 studies met the eligibility criteria: 6 clinical studies and 6 in vitro. All the included studies were subjected to quality assessment and data extraction processes. The risk of bias assessment of in vitro studies revealed low or unknown risk. None of the studies had any industrial sponsoring and almost all the papers (90%) had the same methods, 64% measured the cell vitality. The qualitative analysis was done for all the included clinical studies using the RoB assessment tool (MINORS). The range of the total RoB score in the comparative studies was between 12 and 23. The clinical studies involved a total of 413 participants were also included. Most studies did not specify the age and gender of participants and patients were divided into three main groups based on specific criteria: non-smokers, smokers, and e-cigarette users. These studies highlighted cases of mucosal lesions and genetic instability associated with e-cigarette use. However, the limited long-term data and conflicting results emphasize the need for a larger number of studies, such as randomized controlled trials and cohort studies, to acquire more data about the safety and risks associated with e-cigarettes. Key words:E-cigarettes, squamous cell carcinoma, oral oncology, smoking.

Il ruolo chiave dei canini mascellari nella stabilità funzionale dell’apparato stomatognatico, nell’estetica facciale e nei movimenti funzionali della mandibola ne rende cruciale la loro preservazione. Tra le varie opzioni di trattamento, l’autotrapianto si è distinto per gli alti tassi di successo terapeutico e di sopravvivenza a lungo termine. In questo case report un canino superiore … Continued

Il seguente report tratta il caso di una paziente donna, di razza caucasica di 56 anni, che si presenta alla prima visita in buono stato di salute generale, non fumatrice, non fa uso di alcolici e non riferisce terapia farmacologica in atto. Si reca all’osservazione degli autori a causa della presenza di una neoformazione distale … Continued

Background and Clinical Significance: Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) of the oral cavity is a chronic, rapidly developing mucosal lesion with an unclear pathogenesis, manifesting as a solitary ulcer. Given the malignant clinical appearance of the lesions, it is crucial to ensure the accuracy of the diagnosis to avoid unnecessary invasive surgical interventions. Case Presentation: We present a case involving a 69-year-old female affected by a wide, painful ulcer on the left margin of the tongue. An incisional biopsy was performed, and histopathological examination confirmed the diagnosis, revealing a neutrophilic inflammatory infiltrate with components of eosinophils and lymphocytes. Considering the condition’s reactive and inflammatory nature, we planned a corticosteroid treatment with intralesional injections of triamcinolone acetonide. This therapy delivers the active principle directly to the tissues beneath the ulcerative lesion. In three treatment sessions, we achieved the complete regression of the lesion’s signs and symptoms. During a one-year follow-up period, no recurrences were reported. Conclusions: The scarcity of documented cases and the ambiguity of definitions in the scientific literature highlight the importance of clinical reports, which refine scientific knowledge about this condition. At the same time, we record an effective and non-invasive treatment that could facilitate healthcare professionals in managing these types of oral pathologies.

Background: This proof-of-concept clinical study evaluated the feasibility, applicability, tolerability, and preliminary response of a customised 3D-printed, thermoformed intraoral device for gingival topical treatment. Immune-mediated conditions, including oral lichen planus, mucous membrane pemphigoid, and pemphigus vulgaris often cause desquamative gingivitis. Topical corticosteroids are often ineffective in the oral environment, and frequent reapplication may increase systemic absorption. Methods: Two adults with immune-mediated gingival disease—oral lichen planus and mucous membrane pemphigoid—were unresponsive to topical corticosteroids. Following intraoral scanning, digital design, 3D printing, and thermoforming, each received a custom device with reservoirs over the lesions. They applied the corticosteroid gel and wore the device for 30 minutes, three times daily, in four cycles of five treatment days and two rest days. Results: Both cases completed the digital workflow successfully, with high compliance and no device-related mucosal irritation or pressure lesions. Mean pain scores fell from 8.5 at T0 to 4 at T1 (day 20) and 1.5 at T2 (day 40). Erythema and erosive areas decreased markedly, while symptoms nearly resolved. Conclusions: Device-mediated clobetasol was feasible, well tolerated, and effective in two topical treatment–resistant patients, but is currently limited to keratinized, dentition-supported sites (gingiva and palate). Randomized controlled trials must confirm efficacy versus conventional application.

Early identification of oral potentially malignant disorders (OPMD) remains a major clinical challenge. Point-of-care (PoC) salivary testing may provide a rapid, non-invasive adjunctive approach to support clinical decision-making. This case–control study included 42 participants: 21 patients with clinically and histologically confirmed OPMD and 21 healthy controls. Salivary p16 and EGFR were assessed using a point-of-care device, and their measurements were integrated with predefined clinical variables by the OraFusion software to generate a device-generated risk classification of low, moderate, or high risk. Among patients with OPMD, 57.14% were classified as high risk, 4.76% as moderate risk, and 38.10% as low risk, whereas 95.24% of controls were classified as low risk and 4.76% as moderate risk. Considering moderate and high device-generated risk classifications as positive test results, the assay achieved a sensitivity of 61.90% (95% CI, 38.44–81.89%) and a specificity of 95.24% (95% CI, 76.18–99.88%). These findings suggest that PoC salivary testing may provide valuable adjunctive information through a device-generated risk classification. However, its moderate sensitivity and the small, single-centre sample preclude its use as a substitute for histopathological diagnosis. Larger prospective, multicentre studies are needed to validate its clinical utility.