The main target of this article is to analyze the role of activation energy and thermal radiation effects on the bioconvective peristaltic transport of Sutterby nanofluid in a two-dimensional flexible porous channel with heat and mass transfer. Also, the consequences of Hall current, heat source, and complaint wall properties along with an inclined magnetic field are taken into consideration. The proposed system of governing equations is simplified by using lubrication approximation and solved numerically using MATLAB's bvp5c solver. Further, numerical observations are analyzed to figure out the consequence of different physical parameters on the flow characteristics. According to the observations, it is identified that the Sutterby nanofluid velocity declines with the climb in the damping force parameter, while it enhances with the upsurge in the Darcy number. The Sutterby fluid temperature profile strengthens when the influence of the heat generation and Brinkman number increase, while it depicts the reverse effect with the elevation in the fluid parameter and radiation parameter. The temperature ratio and activation energy parameters were found to have a significant impact on the fluid concentration. The volume of the trapped fluid bolus is an enhancing function of the channel's non-uniformity parameter. Moreover, current work reveals its applicability to recognize the hemodynamic flow analysis and other biofluid movements in the human body and industrial sectors.