Acute cardiac contusion induced by trauma is known with its high mortality and morbidity. The role of oxidative stress and inflammation in its pathophysiology has led to the investigation of antioxidant and anti-inflammatory substances in non-surgical treatment. In this study, the effects of rutin which has these two features on acute cardiac contusion were investigated. Thirty male albino Wistar rats were divided into three equal groups as healthy (HG), contusion (CG), and rutin + contusion (rutin + CG). A heart contusion was created dropping 200 g weight from 1-m height onto anterior thorax of CG (n=10) and Rutin + CG (n=10) group animals by anesthetizing with intraperitoneal administration of 60 mg/kg ketamine and xylazine inhalation at appropriate intervals. Thirty minutes after contusion was applied, rutin at the dose of 50 mg/kg was administered orally to the stomach by gavage to the rutin + CG group animals. The rutin was used once a day for 2 days. Rats were killed at the end of 48 h. Heart tissues were removed and examined biochemically and histopathologically. Troponin I (TP I) and creatine kinase-MB (CK-MB) were measured in blood samples taken from the tail veins just before the rats were killed. TP I, CK-MB, malondialdehyde, total oxidant status, and nuclear factor-kappa B levels increased in the CG when compared to the HG, and Rutin application prevented this increase, total glutathione (eGSH) and total antioxidant status levels decreased, and rutin application prevented this decrease. Histopathological findings also supported these findings. Rutin had a protective effect on heart tissue.

Objectıves: T4 non-small-cell lung cancer comprises a biologically and anatomically heterogeneous group. The 9th edition of the Tumour-Node-Metastasis staging system introduced refined T4 definitions and subdivided N2 disease into single- and multi-station involvement. This study aimed to assess long-term survival and prognostic factors in surgically treated T4 non-small-cell lung cancer patients, focusing on T4 subgroups and nodal status. Methods: We retrospectively analysed patients who underwent resection for pathologically confirmed T4 non-small cell lung cancer between 2006 and 2024. Patients were categorized based on T4 criteria: tumour diameter >7 cm, adjacent structure invasion, or multiple T4 features. Survival outcomes were assessed using Kaplan-Meier, Aalen-Johansen and Cox regression analyses. Results: A total of 191 patients were analysed. The 5-year overall survival rate was 34.1%, varying across subgroups: 38.7% (size), 29.9% (invasion), and 6.1% (multiple criteria) (P < .001). Adjuvant chemotherapy was associated with improved overall survival (hazard ratio [HR]: 0.511; P = .001), while N2 disease (HR: 1.750; P = .012) and multiple T4 features (HR: 2.590; P < .001) predicted worse outcomes. Similar patterns were observed in recurrence-free survival. N2 involvement was particularly adverse in the invasion group. Conclusıons: T4 aetiology and nodal status significantly impact survival following surgery. These findings support the prognostic utility of the 9th Tumour-Node-Metastasis edition and underscore the value of tailored surgical strategies.

This study aimed to investigate the most appropriate treatment options for patients with non-epithelioid malignant pleural mesothelioma. We retrospectively analyzed patients with non-epithelioid malignant pleural mesothelioma who received treatment at our center. Forty-two patients were included in this study. Hyperthermic intrathoracic chemotherapy (HITHOT) was performed in 20 (47.6 %) patients. There were 20 (47.6 %) patients in the macroscopic complete resection (MCR) group and 22 (52.4 %) patients in the non-MCR group. The median overall survival (mOS) of patients in the MCR group was 16 (95 % CI,7.2-24.8) months, and the mOS of patients in the non-MCR group was 6 (95 % CI,2.9-9.1) months (p = 0.001). The mOS of patients who underwent HITHOT was 12 (95%CI,5.4-18.6) months, and the mOS of non-HITHOT patents was 6 (95%CI,2.6-9.4) months (p = 0.007). The mOS of patients who did and did not undergo the HITHOT in the MCR group was 21 and 15 months, respectively (p = 0.161). The mOS of biphasic subtype patients was 11 (95%CI,6.8-15.2) months and sarcomatoid subtype patients was 6 (95%CI,3.1-8.9) months (p = 0.179). In the OS analysis, performing MCR (p = 0.003), applying HITHOT (p = 0.012), TNM stage (p = 0.006), and receiving adjuvant chemotherapy (p = 0.001) were found to be significant factors. In the multivariate analysis for OS, the HITHOT application was found to be a significant parameter (p = 0.035). The mOS of patients who achieved MCR in non-epithelioid malignant pleural mesothelioma was better than that of patients who did not achieve MCR. However, the OS of patients who underwent the HITHOT was better than that of patients who did not.

Background: This study aims to investigate the possible protective effects of rutin, also called vitamin P1, against pulmonary contusion induced by blunt chest trauma in a rat model. Methods: Thirty male albino Wistar rats were separated into three equal groups as healthy group, trauma group, and trauma+rutin group. After anesthesia provided by intraperitoneal administration of 60 mg/kg ketamine and xylazine by inhalation at appropriate intervals, 200 g weight was dropped from 1 m height to the anterior chest wall of the animals in the trauma group (n=10) and trauma+rutin group (n=10) and pulmonary contusion was created. Thirty min after the trauma, 50 mg/kg of rutin was administered into the stomach of trauma+rutin group animals orally with gavage. The rats received rutin once daily for two days and were sacrificed 48 h later. Their lung tissues were removed and examined biochemically and histopathologically. Results: Nuclear factor-kappa B, cyclooxygenase-2, and malondialdehyde levels increased in the trauma group compared to the healthy group, and rutin administration prevented this increase. Total glutathione levels decreased in the trauma group, and rutin administration also prevented this decrease. The histopathological findings were compatible with the biochemical findings. Conclusion: Our study results suggest that rutin has a protective effect on contused lung tissue in rats.