In many countries, accessibility of healthcare remains a major challenge, especially in remote rural and urban areas. This research is relevant because of the push towards the application of technology in the healthcare sector to improve healthcare accessibility worldwide. The objectives of this study are to evaluate the role of e-Health in improving healthcare accessibility, explore the impact of digital transformation in improving the quality and coverage of healthcare services, and to draw conclusions about the implications of e-Health implementation and digital transformation in the context of improving healthcare accessibility. This research method uses a literature analysis approach to collect and analyze data from various sources of information related to e-Health and digital transformation in health services. The results of this study show that the implementation of e-Health and digital transformation has brought significant impact in improving the accessibility of health services, especially through the utilization of telemedicine, electronic medical records, and health applications. This has enabled easier access for individuals to obtain medical consultations and health information, especially for those living in remote areas. The conclusion of this study shows that e-Health and digital transformation have great potential in improving healthcare accessibility. By continuing to develop and integrate technology in the health sector, we can achieve the greater goal of providing more equitable and affordable healthcare to the global community. These steps can help reduce disparities in access to healthcare and improve people's overall quality of life.

Telemedicine telah menjadi alternatif penting dalam memberikan pelayanan kesehatan, terutama selama pandemi COVID-19. Telemedicine adalah praktik pemberian layanan kesehatan jarak jauh menggunakan teknologi komunikasi seperti telepon, video conference, atau platform online. Namun, masih terdapat tantangan dalam mengimplementasikan teknologi ini secara efektif. Penelitian ini bertujuan untuk mengidentifikasi tantangan utama yang dihadapi dalam mengimplementasikan telemedicine, serta untuk mengevaluasi peluang dan manfaat yang mungkin terwujud dalam memanfaatkan teknologi ini dalam pelayanan kesehatan. Metode penelitian ini menggunakan pendekatan kualitatif. Data juga dikumpulkan melalui studi pustaka untuk memperoleh pemahaman yang komprehensif tentang implementasi telemedicine. Hasil penelitian menunjukkan bahwa tantangan utama dalam implementasi telemedicine meliputi masalah keamanan data, keterbatasan akses teknologi, perubahan dalam praktik klinis, dan regulasi. Namun, terdapat peluang besar dalam meningkatkan akses pelayanan kesehatan, meningkatkan efisiensi, dan memperluas jangkauan pelayanan. Implementasi telemedicine menawarkan potensi besar dalam meningkatkan pelayanan kesehatan, namun tantangan yang ada perlu diatasi dengan strategi yang tepat. Regulasi yang jelas, infrastruktur teknologi yang memadai, serta keterlibatan stakeholder kunci akan menjadi kunci dalam mengoptimalkan manfaat telemedicine dalam pelayanan kesehatan. Dengan telemedicine, diagnosis, konsultasi medis, pengobatan, serta monitoring kondisi medis dapat dilakukan secara efisien dan cepat tanpa memerlukan pertemuan langsung. Teknologi ini sangat membantu dalam mengatasi kendala geografis atau waktu serta meningkatkan aksesibilitas layanan kesehatan bagi individu yang sulit untuk mengunjungi praktisi medis secara langsung.

Almost all current antipyretic drugs irreversibly inhibit COX-2 with high selectivity; hence , they are toxic to liver cells, glomeruli, brain cortex, and heart muscle. Meanwhile, natural COX-2 inhibitors have been widely reported to have relatively few side effects. T he leaves of Cep-cepan (Castanopsis costata) are often used to treat fever, but no studies have confirmed this effect. This study aims to determine the antioxidant effects in the DPPH model, the antipyretic activity of EEC C in pe

Estrogen receptor alpha (ERα) plays a vital role in the development and progression of breast cancer by regulating the expression of genes associated with cell proliferation in breast tissue. ERα inhibition is a key strategy in the prevention and treatment of breast cancer. Previous research modified chalcone compounds into pyrazoline benzenesulfonamide derivatives (Modifina) which show activity as an ERα inhibitor. This study aimed to design novel pyrazoline benzenesulfonamide derivatives (PBDs) as ERα antagonists using in silico approaches. Structure-based and ligand-based drug design approaches were used to create drug target molecules. A total of forty-five target molecules were initially designed and screened for drug likeness (Lipinski’s rule of five), cytotoxicity, pharmacokinetics and toxicity using a web-based prediction tools. Promising candidates were subjected to molecular docking using AutoDock 4.2.6 to evaluate their binding interaction with ERα, followed by molecular dynamics simulations using AMBER20 to assess complex stability. A pharmacophore model was also generated using LigandScout 4.4.3 Advanced. The molecular docking results identified PBD-17 and PBD-20 as the most promising compounds, with binding free energies (ΔG) of −11.21 kcal/mol and −11.15 kcal/mol, respectively. Both formed hydrogen bonds with key ERα residues ARG394, GLU353, and LEU387. MM-PBSA further supported these findings, with binding energies of −58.23 kJ/mol for PDB-17 and −139.46 kJ/mol for PDB-20, compared to −145.31 kJ/mol, for the reference compound, 4-OHT. Although slightly less favorable than 4-OHT, PBD-20 demonstrated a more stable interaction with ERα than PBD-17. Furthermore, pharmacophore screening showed that both PBD-17 and PBD-20 aligned well with the generated model, each achieving a match score of 45.20. These findings suggest that PBD-17 and PBD-20 are promising lead compounds for the development of a potent ERα inhibitor in breast cancer therapy.