Background: Women’s menstrual cycle is an important component of their overall health. Physiological cycles and associated symptoms can be monitored continuously and used as indicators in various fields. Menstrual apps are accessible and can be used to promote overall female health. However, no study has evaluated these apps’ functionality from both consumers’ and health care providers’ perspectives. As such, the evidence indicating whether the menstrual apps available on the market provide user satisfaction is insufficient. Objective: This study was performed to investigate the key content and quality of menstrual apps from the perspectives of health care providers and consumers. We also analyzed the correlations between health care provider and consumer evaluation scores. On the basis of this analysis, we offer technical and policy recommendations that could increase the usability and convenience of future app. Methods: We searched the Google Play Store and iOS App Store using the keywords “period” and “menstrual cycle” in English and Korean and identified relevant apps. An app that met the following inclusion criteria was selected as a research app: nonduplicate; with >10,000 reviews; last updated ≤180 days ago; relevant to this topic; written in Korean or English; available free of charge; and currently operational. App quality was evaluated by 6 consumers and 4 health care providers using Mobile Application Rating Scale (MARS) and user version of the Mobile Application Rating Scale (uMARS). We then analyzed the correlations among MARS scores, uMARS scores, star ratings, and the number of reviews. Results: Of the 34 apps, 31 (91%) apps could be used to predict the menstrual cycle, and 2 (6%) apps provided information pertinent to health screening. All apps that scored highly in the MARS evaluation offer a symptom logging function and provide the user with personalized notifications. The “Bom Calendar” app had the highest MARS (4.51) and uMARS (4.23) scores. The MARS (2.22) and uMARS (4.15) scores for the “Menstrual calendar—ovulation & pregnancy calendar” app were different. In addition, there was no relationship between MARS and uMARS scores (r=0.32; P=.06). Conclusions: We compared consumer and health care provider ratings for menstrual apps. Continuous monitoring of app quality from consumer and health care provider perspectives is necessary to guide their development and update content.

Background: This study aimed to investigate the effect of the time from diagnosis to breast cancer surgery on breast cancer patients’ prognosis. Methods: Of the 1900 patients diagnosed with invasive (stage 1–3) breast cancer who underwent surgery in KUH between 2012 and 2019, 279 patients were enrolled in this study. All patients, including those who received neoadjuvant chemotherapy, were classified as Model 1 subjects, and those who received immediate surgical treatment were classified as Model 2 subjects. We conducted a Cox regression analysis to identify prognostic factors of breast cancer associated with the time from diagnosis to surgery. Results: The univariate results indicated a sharp drop in both groups’ survival rates when the time to surgery was delayed for more than 8 weeks (Model 1 p = 0.000; Model 2 p = 0.001). In the multivariate analysis, the hazard ratio (HR) of Model 1increased (HR = 6.84, 95% CI 1.06–44.25) in response to a delay in surgery of more than 8 weeks. Smoking and the American Joint Committee on Cancer (AJCC) staging system had a negative effect on breast cancer prognosis, while hormone therapy had a positive effect. Conclusion: For all patients, a delay in breast cancer surgery of more than 8 weeks was inversely associated with survival.

Background: Electronic health record (EHR) data are anticipated to inform the development of health policy systems across countries and furnish valuable insights for the advancement of health and medical technology. As the current paradigm of clinical research is shifting toward data centricity, the utilization of health care data is increasingly emphasized. Objective: We aimed to review the literature on clinical data quality management and define a process for ensuring the quality management of clinical data, especially in the secondary utilization of data. Methods: A systematic review of PubMed articles from 2010 to October 2023 was conducted. A total of 82,346 articles were retrieved and screened based on the inclusion and exclusion criteria, narrowing the number of articles to 851 after title and abstract review. Articles focusing on clinical data quality management life cycles, assessment methods, and tools were selected. Results: We reviewed 105 papers describing the clinical data quality management process. This process is based on a 4-stage life cycle: planning, construction, operation, and utilization. The most frequently used dimensions were completeness, plausibility, concordance, security, currency, and interoperability. Conclusions: Given the importance of the secondary use of EHR data, standardized quality control methods and automation are necessary. This study proposes a process to standardize data quality management and develop a data quality assessment system.

The recent increase in the tendency of people to marry late or to opt out of marriage entirely is among the key contributors to Korea’s low fertility rate. One possible cause of this tendency may be a change in how marriage is valued among Korea’s youth. The marriage intentions of young adults can be classified into “positive”, “negative”, and “neutral”. Over time, positive marriage intentions have declined across all age groups (2010: 61% → 2020: 39%; ages 25–29), with no significant change in negative marriage intentions. In contrast, neutral marriage intentions have increased significantly (2010: 36% → 2020: 53%; ages 25–29). This phenomenon may be attributable to the increase in the number of young adults who prioritize survival over thinking about the future. However, neutral marriage values can be changed into positive values at any time. A holistic overview of Korean society is necessary to determine how the values of young adults might be influenced to align with a traditional life process.

The Nottingham histologic grade is crucial for assessing severity and predicting prognosis in breast cancer, a prevalent cancer worldwide. Traditional grading systems rely on subjective expert judgment and require extensive pathological expertise, are time-consuming, and often lead to inter-observer variability. To address these limitations, we develop an AI-based model to predict Nottingham grade from whole-slide images of hematoxylin and eosin (H&E)-stained breast cancer tissue using a pathology foundation model. From TCGA database, we trained and evaluated using 521 H&E breast cancer slide images with available Nottingham scores through internal split validation, and further validated its clinical utility using an additional set of 597 cases without Nottingham scores. The model leveraged deep features extracted from a pathology foundation model (UNI) and incorporated 14 distinct multiple instance learning (MIL) algorithms. The best-performing model achieved an F1 score of 0.731 and a multiclass average AUC of 0.835. The top 300 genes correlated with model predictions were significantly enriched in pathways related to cell division and chromosome segregation, supporting the model’s biological relevance. The predicted grades demonstrated statistically significant association with 5-year overall survival (p < 0.05). Our AI-based automated Nottingham grading system provides an efficient and reproducible tool for breast cancer assessment, offering potential for standardization of histologic grade in clinical practice.

Background: Data quality is the degree to which data are fit for their intended purpose and is described using quality dimensions. The increased use of medical data in clinical research and medical artificial intelligence development has rendered data quality assessment essential. Despite existing data quality definitions, frameworks, and tools, data quality assessment in real-world settings faces multiple challenges. This stems from a lack of understanding of how to assess real-world data quality and interpret the results. Therefore, practical approaches to data quality assessment are needed that are appropriate for diverse data environments, intended uses, quality dimensions, and requirements. Objective: This study proposes a practical approach for assessing the completeness of electronic health records (EHRs) for medical research. This approach integrates structural completeness, rule-based assessment, and descriptive analyses of completeness and data diversity to clarify how data quality can be measured and meaningfully interpreted in practice. Methods: The completeness of a large-scale EHR dataset from Gachon University Gil Medical Center was evaluated covering January 2005 to December 2023. Completeness was assessed using a three-part approach comprising (1) structural completeness assessment, (2) rule-based assessment, and (3) descriptive analyses of completeness and data diversity. Assessments were conducted using clinical data quality assessment tools. This practical approach was used to assess EHR completeness for medical research from 1,798,153 patient records. Results: In the structural assessment, 12.8% (5/39) of the data tables were unavailable, indicating limited capturing of clinician free-text data. The rule-based assessment identified substantial missingness in vocabulary fields (38/124, 30.6%) and missing or special characteristic values in relation to observations (3,643,581/15,313,287, 23.8%), measurements (25,583,622/642,623,715, 4%), care sites (28/1715, 1.6%), and deaths (117/34,330, 0.3%). Descriptive analyses demonstrated a balanced gender distribution (886,489/1,798,153, 49.3% male and 911,664/1,798,153, 50.7% female) and a predominantly Korean racial distribution (1,739,628/1,798,153, 96.7%). Collectively, these findings illustrate the completeness quality of a multiperspective completeness assessment for medical research. Conclusions: This study demonstrates how data quality dimensions can be measured in practice through a real-world completeness assessment. This practical approach enables evaluation of EHR completeness and provides insights into data quality. Its findings have implications for researchers conducting data quality assessments and applying quality dimensions in medical research.