Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial syndrome, the etiology and underlying mechanisms are not yet delineated. Moreover, research about nutritional interventions to prevent the development of sarcopenia is mainly focused on the amount and quality of protein intake. The impact of several nutrition strategies that consider timing of food intake, anti-inflammatory nutrients, metabolic control, and the role of mitochondrial function on the progression of sarcopenia is not fully understood. This narrative review summarizes the metabolic background of this phenomenon and proposes an integral nutritional approach (including dietary supplements such as creatine monohydrate) to target potential molecular pathways that may affect reduce or ameliorate the adverse effects of sarcopenia. Lastly, miRNAs, in particular those produced by skeletal muscle (MyomiR), might represent a valid tool to evaluate sarcopenia progression as a potential rapid and early biomarker for diagnosis and characterization.

Purpose: This study aimed to compare the post-activation performance enhancement (PAPE) induced by isometric and isotonic exercise on vertical jump performance. Methods: 18 healthy trained men (25.8±2.7 years; 78.4±8.2 kg; 175.7±6.1 cm; 25.4±1.8 BMI; 126.72±10.8 kg squat 1-RM) volunteered for this study. They randomly performed two different PAPE protocols: Isotonic squats (ISOTS), which consisted of 2 sets of 3 repetitions at 75% of one-maximum repetition (1-RM); and isometric squats (ISOMS), which consisted of 2 sets of 4 seconds of submaximal (75% of 1-RM) isometric contraction at 90°-knee flexion. Countermovement jump (CMJ) height was tested at baseline and 4 minutes after each conditioning set. Results: CMJ height significantly increased after set 1 in both PAPE protocols (ISOMS: p <0.001; ES = 0.34; ISOTS: p 0.05) were found between both isometric and isotonic exercise conditions. Conclusions: Despite both protocols showed similar PAPE effects on CMJ height after set 1, none of the protocols demonstrated greater efficacy in increasing subsequent performance in healthy trained men.

This study aimed to evaluate the relationship between injury risk, acute load (AL), acute chronic workload ratio (ACWR) and a new proposed ACWR. Design: a retrospective cohort study of the year 2018 was conducted on Argentine first-division soccer players. Participants: Data from 35 players (age = 26.7 ± 4.71 years; height = 176.28 ± 6.09 cm; mass = 74.2 ± 5.27 kg) were recorded; 12 players’ data were analyzed for 1 year, and 23 players’ data were analyzed for 6 months. Interventions: The mean difference of ACWR (MD = 0.22), high-density interval (HDI 95% = (0.07, 0.36)) and AL (MD = 449.23, HDI 95% = (146.41, 751.2)) between groups turned out to be statistically significant. The effect size between groups comparing ACWR and AL was identical (ES = 0.64). Results: The probability of suffering an injury conditioned by ACWR or random ACWR was similar for all estimated quantiles, and the differences between them were not statistically significant. Conclusions: The ACWR ratio, using internal load monitoring, is no better than a synthetic ACWR created from a random denominator to predict the probability of injury. ACWR should not be used in isolation to analyze the causality between load and injury.

Purpose: This study evaluated the concurrent training (CT) effect in combination with either progressive energy restriction (PER) or severe energy restriction (SER) on body composition and strength-related variables in resistance-trained women. Methods: Fourteen women (29.5 ± 3.8 years; 23.8 ± 2.8 kg·m⁻²) were randomly assigned to a PER (n = 7) or SER (n = 7) group. Participants performed an 8-week CT program. Pre- and post-intervention measures of fat mass (FM) and fat-free mass (FFM) were assessed by dual-energy X-ray absorptiometry and strength-related variables were assessed through 1-repetition maximum (in the squat and bench press) and countermovement jump. Results: Significant reductions in FM were observed in PER and SER (Δ = − 1.7 ± 0.4 kg; P = < 0.001; ES = − 0.39 and Δ = − 1.2 ± 0.6 kg; P = 0.002; ES = − 0.20, respectively). After correcting FFM for fat-free adipose tissue (FFAT), no significant differences for this variable were found either in PER (Δ = − 0.3 ± 0.1; P = 0.071; ES = − 0.06) or in SER (Δ = − 0.2 ± 0.1; P = 0.578; ES = − 0.04). There were no significant changes in the strength-related variables. No between-group differences were found in any of the variables. Conclusion: A PER has similar effects to a SER on body composition and strength in resistance-trained women performing a CT program. Given that PER is more flexible and thus may enhance dietary adherence, it might be a better alternative for FM reduction compared to SER.

The aim of this study was to investigate the effect of internal focus (IF) and external focus (EF) on lactate production and the perception of perceived exertion in the squat in strength trained-men. Methods: Thirteen men with experience in strength training (age =22.61 ± 1.19 years; height = 180 ± 6.55 cm; body mass = 79.38 ± 5.57 kg; BMI = 24.56 ± 2.11 kg·m-2; Squat = 129 ± 20 kg) performed two sessions, separated by one week, comprising 3 sets of 10 repetitions of the back squat with one minute of rest between sets. During the IF protocol participants were instructed to focus on tightening the quads during all repetitions, while participants in the EF were instructed to focus on lifting the barbell. Blood lactate samples were collected before and at immediately after each of the 3 sets, as well as 15 minutes after the last set. Additionally, the rating of perceived exertion (RPE) was evaluated using the OMNI-RES scale immediately after the completion of each session. Results: Significant increases were found in the IF protocol at the end of each of the 3 sets, with significant effect sizes (1ª set, P= .000, d= 2.66; 2ª set, P= .000; d= 3.14; 3ª set, P= .000, d= 3.50), as in the EF protocol (1ª set, P= .001, d= 2.24; 2ª set, P= .000, d= 3.35; 3ª set, P= .000; d= 3.67). However, there were no significant inter-group differences between pre and any set (1ª set, P=0.951, d=0.03; 2ª set, P=0.239, d=0.47; 3ª set, P=0.435, d=0.31, respectively). Additionally, the perceptions on the RPE scale were higher in the FI (P= 0.032; d = 0.47). Conclusions: Findings suggest that the application of IF may indirectly contribute to muscle hypertrophy in multi-joint lower limb exercises, due to the increase in RPE values and the existing correlation with lactate production. Keywords: Mind-muscle, muscle hypertrophy, internal focus, mind-muscle connection, resistance training

Cluster-set resistance training is focused on performance improvements of sports by increasing the repetition maximum, jump height, and efficiency in the sprint. In this commentary, we present relevant aspects to optimize the use of cluster training under the context of muscle hypertrophy. Therefore, we address intra-sets pauses, the number of repetitions per block, and strategies that benefit this methodology. During a cluster set resistance training program, not only the total number of repetitions could be higher, which means a superior total volume, but also a higher mechanical output might lead to potential benefits to muscle hypertrophy.