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Dr. Nahim Salgado Medrano
Facultad de Ciencias Biológicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
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Academic Career Length
7Years (2020-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
NMNahim Salgado Medrano
Nahim Salgado MedranoCMCésar Millán-Pacheco
César Millán-Pacheco
Veronica RodriguezCLCorona Lucia
Corona LuciaFMFrancois Mesnard
Francois MesnardATAlexandre Toshirrico Cardoso Taketa
Alexandre Toshirrico Cardoso Taketa +3
The antioxidant action of terngymnoside C (1) and hydroxytyrosol-1-glucoside (2), isolated for the first time from the flower buds of Ternstroemia lineata, as well as katsumadin (3), obtained from the seedless fruits, was evaluated using ABTS•+ and H2O2–Saccharomyces cerevisiae models. In silico docking analysis of 1, 2, and 3 determined their affinity forces to the aquaporin monomers of the modeled S. cerevisiae protein 3 (AQP3) and human protein 7 (AQP7) channels that regulate the H2O2 cell transport. The ABTS•+ antiradical capacity of these compounds showed IC50 values of 22.00 μM (1), 47.64 μM (2), and 73.93 μM (3). The S. cerevisiae antioxidant assay showed that at 25 µM (1) and 50 µM (2 and 3), the cells were protected from H2O2-oxidative stress. These compounds, together with quercetin and vitamin C, were explored through the modeled S. cerevisiae AQP3 and human AQP7 by molecular docking analysis. To explain these results, an antioxidant mechanism for the isolated compounds was proposed through blocking H2O2 passage mediated by aquaporin transport. On the other hand, 1, 2, and 3 were not cytotoxic in a panel of three cancer cell lines.
10 December 2020 in Journal of Medicinal Herbs and Ethnomedicine
Journal Article
JAJosué Nicanor Díaz Avilés
Josué Nicanor Díaz AvilésJMJosé Luis Alanís Méndez
José Luis Alanís MéndezNMNahim Salgado Medrano
Nahim Salgado MedranoATAlexandre Toshirrico Cardoso Taketa
Alexandre Toshirrico Cardoso TaketaIFIvette Alicia Chamorro Florescano
Ivette Alicia Chamorro FlorescanoODOswaldo Javier Enciso Díaz
Oswaldo Javier Enciso Díaz
Phytochemical composition, antioxidant, and toxic effects of two orchid (Prosthechea cochleata and Prosthechea livida) were examined in their different hexane and dichloromethane/methanol extracts of leaves, pseudobulbs, rhizome and roots. Phytochemical screening reveals the presence of alkaloids, coumarins, flavonoids, saponins, steroids and terpenes except for anthracene derivatives in P. livida and tannins in both species. Results showed exhibited significant toxicity against brine shrimp with an LC50 values ranged from 3 to 54 µg/ml in 24 h. Finally, the results of the antioxidant test in yeast (Saccharomyces cerevisiae) showed that CH2Cl2:MeOH extract of P. cochleata root extract presented the most efficient protective antioxidant percentage (%PA), with 20 µg/mL, displaying a cell viability of 68.58%. In P. livida case, rhizome extract presented the most efficient %PA, with 1000 µg/mL, with a cell viability of 65.82%. The results evidenced the toxicity of Prosthechea cochleata and Prosthechea livida and reveals potential antioxidative of extracts.
Journal Article
ADAlexis Uriel Soto Díaz
Alexis Uriel Soto DíazMVMaria Luisa Villarreal
Maria Luisa VillarrealNMNahim Salgado Medrano
Nahim Salgado MedranoMSMarcelo Victorio-De Los Santos
Marcelo Victorio-De Los SantosESEdda Sciutto
Edda SciuttoATAlexandre Toshirrico Cardoso Taketa
Alexandre Toshirrico Cardoso Taketa +2
Metabolomic profiling of the leaves, floral buds, flowers, and fruits of Ternstroemia lineata was conducted across the dry and rainy seasons in Mexico. The presence of katsumadin was determined and its antibacterial activity was evaluated. Multivariate data analysis was performed using proton nuclear magnetic resonance (1H NMR) and Principal Component Analysis (PCA). Katsumadin was identified by 1H NMR and, quantified by HPLC, and its antibacterial activity was assessed using a microdilution assay. The results revealed conserved 1H NMR signals among leaf, flower buds, flowers and fruits, as well as signals that were either organ-specific or time-dependent. The spatial and temporal distribution of katsumadin was monitored over a nine-month period. During the dry season, katsumadin reached 1.5 mg/g DW in the leaves, whereas it was not detected during the rainy season. Higher katsumadin contents were observed in floral buds, fruits, and flowers (6.09 ± 0.10, 3.0 ± 0.79, and 3.4 ± 0.42 mg/g DW, respectively). In addition, katsumadin was evaluated against Salmonella Typhi and Pseudomonas aeruginosa, exhibiting a minimum inhibitory concentration and bactericidal effect at 0.5 mg/mL.
About Me
As can be seen from his CV, Doctor of Natural Sciences Nahim Salgado Medrano has multidisciplinary training to carry out quality research in the field of natural medicinal products. Its preparation includes biotechnological, phytochemical aspects and analysis of the biological properties of natural products. As a result of this work, several articles have been published to date in indexed journals and participated in various forums, including some international ones. Throughout his career, he has also carried out various teaching activities at the undergraduate and postgraduate levels, along with constant training of human resources with whom he participates in numerous conferences and forums in the area in a prominent manner. From these observations, Dr. Salgado positions himself as a future member of the National System of Researchers (NSR), who also meets a desirable profile. In his performance for more than 4 years as a Research Professor within the Faculty of Biological Sciences of the Autonomous University of the State of Morelos (UAEM), he has created the research line “Sustainable Bioactive Natural Products”, in accordance with the current Development Plan from the Faculty of Biological Sciences, which has had a favorable impact on the study plan of this academic unit, when accompanied by numerous supervised theses at the undergraduate and postgraduate level.