Polyetheretherketone (PEEK), a high-strength, aesthetic, and non-allergic thermoplastic polymer, recently became a candidate for replacing metallic components in dental prosthesis. However, as PEEK is flexible, the need for retention presents a key challenge in terms of its clinical application. In this study, clasps prepared using PEEK were optimized and evaluated to provide the mechanical properties required by dentures. Seventy-two three-dimensional rod-shape models, based on four thickness/width ratios, three base widths, and six taper ratios were created. These models were analyzed using finite-element methods to determine which modified clasp arm shape provided the most appropriate mechanical properties. Three shape-optimized PEEK specimens and one standard-shape Co-Cr alloy specimen were then fabricated. Constant-displacement fatigue testing was performed to calculate load values and deformations after ten years of clinical use. Shape optimization indicated a maximum stress concentration that was consistently located at the base of the specimen, a correlation between mean load values and thickness that was greater than that with the width, and a correlation between taper ratio and mean load values. Fatigue testing showed that although PEEK exhibited significantly lower average load values than the Co-Cr alloy, these were sufficient for clinical use. All specimens exhibited significant deformation during the first period of cycling; however, there was no significant difference in the deformation between the two materials after fatigue testing. PEEK exerts fewer stresses on abutments compared to standard-alloy clasps, provides adequate retention, and satisfy aesthetic demands, indicating that PEEK presents a promising alternative to conventional metal clasps.

The purpose of this research is to compare the cytotoxicity of polyetheretherketone (PEEK) and polyetherketoneketone (PEKK) with conventional dental implant–abutment materials, namely titanium alloy (Ti-6Al-4V) and yttria-stabilized tetragonal zirconia polycrystal (Y-TZP), to evaluate the cell metabolic activity, cytotoxicity, and inflammation potential of human oral fibroblasts (HOF) on these materials. Disk-shaped specimens were designed and prepared via a dental computer-aided manufacturing technology system. Surface topography, roughness, and free energy were investigated by atomic force microscope and contact angle analyzer; cell metabolic activity and cytotoxicity by MTT assay; and morphological changes by scanning electron microscopy (SEM). The effect of pro-inflammatory gene expression was evaluated by RT-qPCR. The obtained data were analyzed with one-way analysis of variance and post-hoc Tukey’s honest significant difference tests. PEEK and PEKK exhibited higher submicron surface roughness (0.04 μm) and hydrophobicity (>80°) than the control. Although the cell activity of PEEK was lower than that of Ti-6Al-4V and Y-TZP for the first 24 h (p < 0.05), after 48 h there was no difference (p > 0.05). According to the cell cytotoxicity and the pro-inflammatory cytokine gene expression assays, there was no difference between the materials (p > 0.05). SEM observations indicated that HOF adhered poorly to PEKK but properly to Ti-6Al-4V, Y-TZP, and PEEK. PEEK and PEKK show comparable epithelial biological responses to Ti-6Al-4V and Y-TZP as implant–abutment materials. Between the two polymeric materials, the PEEK surface, where the HOF showed better cell metabolic activity and cytotoxicity, was a more promising implant–abutment material.

Poly-ether-ether-ketone (PEEK) is an aesthetically pleasing natural material with good biocompatibility and shock absorption characteristics. The application of PEEK as a dental implant or abutment is expected to reduce the risk of failure and enhance aesthetics. Given that approximately one in 15 patients have allergic reactions to antibiotics, photodynamic therapy (PDT) has been gaining attention as an alternative treatment. Herein, the applicability of PEEK dental implants or abutments was investigated using material analyses, biofilm formation assay, and cell viability tests. The possible use of PDT for peri-implant mucositis was evaluated with the biofilm removal assay. The obtained data were analyzed based on the multivariate analysis of variance, paired t-tests, and the Pearson correlation coefficient (α = 0.05). The results revealed that PEEK was significantly less conducive to the formation of biofilms with S. mutans and A. actinomycetemcomitan (p < 0.001) but exhibited comparable MG-63 (human osteoblast-like) osteoblast cell viability (p > 0.05) to the other materials. PDT had similar antimicrobial efficacy and yielded similar biofilm removal effects to antibiotics. Altogether, these findings suggest that PEEK has attractive features and can serve as an alternative material for dental implants or abutments. In cases where peri-implant mucositis occurs, PDT can be used as an accessible therapeutic approach.