In recent years, deep-learning models gained attention for electroencephalography (EEG) classification tasks due to their excellent performance and ability to extract complex features from raw data. In particular, convolutional neural networks (CNN) showed adequate results in brain-computer interfaces (BCI) based on different control signals, including event-related potentials (ERP). In this study, we propose a novel CNN, called EEG-Inception, that improves the accuracy and calibration time of assistive ERP-based BCIs. To the best of our knowledge, EEG-Inception is the first model to integrate Inception modules for ERP detection, which combined efficiently with other structures in a light architecture, improved the performance of our approach. The model was validated in a population of 73 subjects, of which 31 present motor disabilities. Results show that EEG-Inception outperforms 5 previous approaches, yielding significant improvements for command decoding accuracy up to 16.0%, 10.7%, 7.2%, 5.7% and 5.1% in comparison to rLDA, xDAWN + Riemannian geometry, CNN-BLSTM, DeepConvNet and EEGNet, respectively. Moreover, EEG-Inception requires very few calibration trials to achieve state-of-the-art performances taking advantage of a novel training strategy that combines cross-subject transfer learning and fine-tuning to increase the feasibility of this approach for practical use in assistive applications.

Objective. Code-modulated visual evoked potentials (c-VEP) have been consolidated in recent years as robust control signals capable of providing non-invasive brain–computer interfaces (BCIs) for reliable, high-speed communication. Their usefulness for communication and control purposes has been reflected in an exponential increase of related articles in the last decade. The aim of this review is to provide a comprehensive overview of the literature to gain understanding of the existing research on c-VEP-based BCIs, since its inception (1984) until today (2021), as well as to identify promising future research lines. Approach. The literature review was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis guidelines. After assessing the eligibility of journal manuscripts, conferences, book chapters and non-indexed documents, a total of 70 studies were included. A comprehensive analysis of the main characteristics and design choices of c-VEP-based BCIs was discussed, including stimulation paradigms, signal processing, modeling responses, applications, etc. Main results. The literature review showed that state-of-the-art c-VEP-based BCIs are able to provide an accurate control of the system with a large number of commands, high selection speeds and even without calibration. In general, a lack of validation in real setups was observed, especially regarding the validation with disabled populations. Future work should be focused toward developing self-paced c-VEP-based portable BCIs applied in real-world environments that could exploit the unique benefits of c-VEP paradigms. Some aspects such as asynchrony, unsupervised training, or code optimization still require further research and development. Significance. Despite the growing popularity of c-VEP-based BCIs, to the best of our knowledge, this is the first literature review on the topic. In addition to providing a joint discussion of the advances in the field, some future lines of research are suggested to contribute to the development of reliable plug-and-play c-VEP-based BCIs.

In this study, we present a new Deep Learning (DL) architecture for Motor Imagery (MI) based Brain Computer Interfaces (BCIs) called EEGSym . Our implementation aims to improve previous state-of-the-art performances on MI classification by overcoming inter-subject variability and reducing BCI inefficiency, which has been estimated to affect 10-50% of the population. This convolutional neural network includes the use of inception modules, residual connections and a design that introduces the symmetry of the brain through the mid-sagittal plane into the network architecture. It is complemented with a data augmentation technique that improves the generalization of the model and with the use of transfer learning across different datasets. We compare EEGSym ’s performance on inter-subject MI classification with ShallowConvNet, DeepConvNet, EEGNet and EEG-Inception. This comparison is performed on 5 publicly available datasets that include left or right hand motor imagery of 280 subjects. This population is the largest that has been evaluated in similar studies to date. EEGSym significantly outperforms the baseline models reaching accuracies of 88.6±9.0 on Physionet, 83.3±9.3 on OpenBMI, 85.1±9.5 on Kaya2018, 87.4±8.0 on Meng2019 and 90.2±6.5 on Stieger2021. At the same time, it allows 95.7% of the tested population (268 out of 280 users) to reach BCI control (≥70% accuracy). Furthermore, these results are achieved using only 16 electrodes of the more than 60 available on some datasets. Our implementation of EEGSym , which includes new advances for EEG processing with DL, outperforms previous state-of-the-art approaches on inter-subject MI classification.

This paper presents an electroencephalographic (EEG) P300-based brain-computer interface (BCI) Internet browser. The system uses the “odd-ball” row-col paradigm for generating the P300 evoked potentials on the scalp of the user, which are immediately processed and translated into web browser commands. There were previous approaches for controlling a BCI web browser. However, to the best of our knowledge, none of them was focused on an assistive context, failing to test their applications with a suitable number of end users. In addition, all of them were synchronous applications, where it was necessary to introduce a “read-mode” command in order to avoid a continuous command selection. Thus, the aim of this study is twofold: 1) to test our web browser with a population of multiple sclerosis (MS) patients in order to assess the usefulness of our proposal to meet their daily communication needs; and 2) to overcome the aforementioned limitation by adding a threshold that discerns between control and non-control states, allowing the user to calmly read the web page without undesirable selections. The browser was tested with sixteen MS patients and five healthy volunteers. Both quantitative and qualitative metrics were obtained. MS participants reached an average accuracy of 84.14%, whereas 95.75% was achieved by control subjects. Results show that MS patients can successfully control the BCI web browser, improving their personal autonomy.

Neurotechnologies have great potential to transform our society in ways that are yet to be uncovered. The rate of development in this field has increased significantly in recent years, but there are still barriers that need to be overcome before bringing neurotechnologies to the general public. One of these barriers is the difficulty of performing experiments that require complex software, such as brain-computer interfaces (BCI) or cognitive neuroscience experiments. Current platforms have limitations in terms of functionality and flexibility to meet the needs of researchers, who often need to implement new experimentation settings. This work was aimed to propose a novel software ecosystem, called MEDUSA©, to overcome these limitations. We followed strict development practices to optimize MEDUSA© for research in BCI and cognitive neuroscience, making special emphasis in the modularity, flexibility and scalability of our solution. Moreover, it was implemented in Python, an open-source programming language that reduces the development cost by taking advantage from its high-level syntax and large number of community packages. MEDUSA© provides a complete suite of signal processing functions, including several deep learning architectures or connectivity analysis, and ready-to-use BCI and neuroscience experiments, making it one of the most complete solutions nowadays. We also put special effort in providing tools to facilitate the development of custom experiments, which can be easily shared with the community through an app market available in our website to promote reproducibility. MEDUSA© is a novel software ecosystem for modern BCI and neurotechnology experimentation that provides state-of-the-art tools and encourages the participation of the community to make a difference for the progress of these fields. Visit the official website at https://www.medusabci.com/ to know more about this project.