We apply terahertz time-domain spectroscopy for the quantitative non-invasive assessment of the water content in biological samples, such as Carpinus caroliniana tree leaves and pork muscles. The developed experimental terahertz time-domain spectroscopy system operates both in transmission and reflection modes. The Landau-Looyenga-Lifshitz-based model is used for the calculation of the water concentration within the samples. The results of the water concentration measurements are compared with the results of the gravimetric measurements. The obtained results show that the water content in biological samples can be measured non-invasively, with a high accuracy, utilizing terahertz waves in transmission and reflection modes.
In recent times, terahertz (THz) technologies have been actively applied in many biomedical research work, including gastric cancer diagnosis. In order to provide an effective removal of tumor during surgery, it is necessary to clearly distinguish it from different membranes of the stomach. In this work, we reported an investigation of various normal and cancer fresh gastric tissues using terahertz time-domain spectroscopy in the reflection mode. Refractive index and absorption coefficient of moderately differentiated and poorly differentiated gastric adenocarcinomas, as well as both serosa and mucosa were obtained in the frequency range from 0.2 to 1 THz. All cancer tissues were distinguishable from normal ones. The influence of the morphology of the investigated tissues on the obtained optical properties is discussed. The obtained results demonstrated a potential of THz time-domain spectroscopy to discriminate a tumor from normal serous and mucous gastric membranes. Thus, this method might be applied to gastric cancer diagnosis.
A room-temperature terahertz (THz) detector based on a thermoelectric frequency selective surface (FSS) has been numerically simulated, designed, fabricated, and tested. The FSS has been fabricated from a 150 nm thin Bi88Sb12 thermoelectric film with the engraved periodic Greek crosses. The detector prototype has been tested under the 0.14 THz radiation exposure and showed a voltage response due to the photo-thermoelectric effect up to 0.13–0.18 mV, and voltage responsivity equal to 14–20 mV/W. The detector based on the FSS has shown voltage responsivity up to three times higher in comparison with the detector based on the continuous film. Thermal imaging has shown a temperature increase in the FSS up to 1.5 K under the THz exposure. The obtained results demonstrate prospects for utilization of the Bi88Sb12 FSS detector as a low cost, compact, high-speed, highly sensitive room-temperature THz detector.
We report results of galvanomagnetic and terahertz time-domain spectroscopy measurements on thin films of Bi Sb on polyimide and mica substrates with various antimony concentrations (x from 0 to 15 %) and film thickness (70, 150 nm). The resistivity, Hall coefficient and magnetoresistivity of the films were measured experimentally in the magnetic field of 0.65 T at room temperature. Mobility and concentration of electrons and holes in the film plane were calculated using the transport coefficients. The terahertz time-domain spectroscopy is used to measure the complex conductivity and permittivity of Bi Sb thin films on the dielectric substrates in the frequency range from 0.2 to 1 THz. The plasma frequency, relaxation time, DC conductivity and effective carrier mass were extracted from these data and evaluated as functions of the Sb concentration for different film thickness and substrate. We observed that the film magnetoresistivity decreases with increasing the Sb concentration and for most of the films the Hall coefficient is negative and depends on the external factors insignificantly. We show that the mobility of charge carriers weakly depends on Sb concentration, which confirms the assertion about the scattering of carriers on themselves and not on defects in the structure. It was revealed that film static and dynamic resistivity (conductivity) as well as dielectric permittivity depend on Sb content and the film thickness. The results may be used for development of various thermoelectric, electronic and optical devices, such as THz detectors or components which can control the properties of THz radiation.
Terahertz (THz) technology has been applied in many scientific areas, such as explosive detection, quality control, and medical diagnostics.1–9 Compared with other medical diagnosis methods, THz technology has many advantages. THz radiation does not cause ionization in biotissues because it has very low photon energy.2–6 Since THz radiation is very sensitive to water and the hydration state of the object, which leads to good contrast between the normal and diseased tissues, THz has great promise in medical applications, especially for cancer diagnosis and tumor resection.4,5,8–10