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Prader–Willi syndrome (PWS) is a rare disease determined by the loss of the paternal copy of the 15q11-q13 region, and it is characterized by hypotonia, hyperphagia, obesity, short stature, hypogonadism, craniofacial dysmorphisms, and cognitive and behavioral disturbances. The aims of this retrospective study were to analyze interictal EEG findings in a group of PWS patients and to correlate them with genetic, clinical, and neuroimaging data. The demographic, clinical, genetic, EEG, and neuroimaging data of seventy-four patients were collected. Associations among the presence of paroxysmal EEG abnormalities, genotype, and clinical and neuroimaging features were investigated. Four patients (5.4%) presented drug-sensitive epilepsy. Interictal paroxysmal EEG abnormalities—focal or multifocal—were present in 25.7% of the cases, and the normalization of the EEG occurred in about 25% of the cases. In 63.2% of the cases, the paroxysmal abnormalities were bilaterally localized over the middle–posterior regions. Brain magnetic resonance imaging (MRI) was performed on 39 patients (abnormal in 59%). No relevant associations were found between paroxysmal EEG abnormalities and all of the other variables considered. Interictal paroxysmal EEG abnormalities—in particular, with a bilateral middle–posterior localization—could represent an important neurological feature of PWS that is not associated with genotype, cognitive or behavioral endophenotypes, MRI anomalies, or prognosis.
Maurizio Elia; Irene Rutigliano; Michele Sacco; Simona Madeo; Malgorzata Wasniewska; Alessandra Li Pomi; Giuliana Trifirò; Paolo Di Bella; Silvana De Lucia; Luigi Vetri; Lorenzo Iughetti; Maurizio Delvecchio. EEG Patterns in Patients with Prader–Willi Syndrome. Brain Sciences 2021, 11, 1045 .
AMA StyleMaurizio Elia, Irene Rutigliano, Michele Sacco, Simona Madeo, Malgorzata Wasniewska, Alessandra Li Pomi, Giuliana Trifirò, Paolo Di Bella, Silvana De Lucia, Luigi Vetri, Lorenzo Iughetti, Maurizio Delvecchio. EEG Patterns in Patients with Prader–Willi Syndrome. Brain Sciences. 2021; 11 (8):1045.
Chicago/Turabian StyleMaurizio Elia; Irene Rutigliano; Michele Sacco; Simona Madeo; Malgorzata Wasniewska; Alessandra Li Pomi; Giuliana Trifirò; Paolo Di Bella; Silvana De Lucia; Luigi Vetri; Lorenzo Iughetti; Maurizio Delvecchio. 2021. "EEG Patterns in Patients with Prader–Willi Syndrome." Brain Sciences 11, no. 8: 1045.
The prevalence of primary hypertension in pediatric patients is increasing, especially as a result of the increased prevalence of obesity in children. New diagnostic guidelines for blood pressure were published by the American Academy of Pediatrics (AAP) in 2017 to better define classes of hypertension in children. The aim of our study is to evaluate the impact of new guidelines on diagnosis of hypertension in pediatrics and their capacity to identify the presence of cardiovascular and metabolic risk. Methods: Retrospective clinical and laboratory data from 489 overweight and obese children and adolescents were reviewed. Children were classified according to the 2004 and 2017 AAP guidelines for systolic and diastolic blood pressure. Lipid profile and glucose metabolism data were recorded; triglyceride/HDL ratio (TG/HDL) was calculated as an index of endothelial dysfunction. Hepatic steatosis was detected using the ultrasonographic steatosis score. Results: Children with elevated blood pressure increased from 12.5% with the 2004 AAP to 23.1% with the 2017 AAP criteria (p< 0.001). There was a statistically significant increase in children with high blood pressure in all age groups according to the new cut-off values. Notably, the diagnosis of hypertension according to 2017 AAP criteria had a greater positive association with Hepatic Steatosis (rho 0.2, p< 0.001) and TG/HDL ratio (rho 0.125, p = 0.025). Conclusions: The 2017 AAP tables offer the opportunity to better identify overweight and obese children at risk for organ damage, allowing an earlier and more impactful prevention strategy to be designed.
Irene Rutigliano; Gianpaolo De Filippo; Luigi Pastore; Giovanni Messina; Carlo Agostoni; Angelo Campanozzi. Obesity-Related Hypertension in Pediatrics, the Impact of American Academy of Pediatrics Guidelines. Nutrients 2021, 13, 2586 .
AMA StyleIrene Rutigliano, Gianpaolo De Filippo, Luigi Pastore, Giovanni Messina, Carlo Agostoni, Angelo Campanozzi. Obesity-Related Hypertension in Pediatrics, the Impact of American Academy of Pediatrics Guidelines. Nutrients. 2021; 13 (8):2586.
Chicago/Turabian StyleIrene Rutigliano; Gianpaolo De Filippo; Luigi Pastore; Giovanni Messina; Carlo Agostoni; Angelo Campanozzi. 2021. "Obesity-Related Hypertension in Pediatrics, the Impact of American Academy of Pediatrics Guidelines." Nutrients 13, no. 8: 2586.
With the current obesity epidemic and the decline of fitness among school-aged children, the importance of obesity interventions to promote physical activity and healthy habits has become indisputable. The purpose of this study was to assess the efficacy of a school-based multicomponent intervention in increasing physical activity (PA) levels, actual physical abilities, and perceived physical abilities in clinical and nonclinical samples of overweight/obese boys and girls aged 10–12 years. The clinical intervention group (n = 35) participated in a 7-month after-school program in addition to curricular physical education lessons, while the nonclinical control group (n = 29) received usual curricular lessons. Measures included levels of PA and fitness and individual’s perceptions of physical ability. After treatment, the intervention group showed improved PA levels, perceived physical ability, and throwing and jumping task performances compared to the control group. Results indicate that a multicomponent program can improve levels of PA, fitness, and perceived competence of overweight participants. Findings highlight the importance of a comprehensive healthy lifestyle program that includes physical, psychosocial, and behavioral factors and suggest practical implications for educators, trainers, and teachers in identifying best practices targeting childhood obesity.
Milena Morano; Claudio Robazza; Laura Bortoli; Irene Rutigliano; Montse C. Ruiz; Angelo Campanozzi. Physical Activity and Physical Competence in Overweight and Obese Children: An Intervention Study. International Journal of Environmental Research and Public Health 2020, 17, 6370 .
AMA StyleMilena Morano, Claudio Robazza, Laura Bortoli, Irene Rutigliano, Montse C. Ruiz, Angelo Campanozzi. Physical Activity and Physical Competence in Overweight and Obese Children: An Intervention Study. International Journal of Environmental Research and Public Health. 2020; 17 (17):6370.
Chicago/Turabian StyleMilena Morano; Claudio Robazza; Laura Bortoli; Irene Rutigliano; Montse C. Ruiz; Angelo Campanozzi. 2020. "Physical Activity and Physical Competence in Overweight and Obese Children: An Intervention Study." International Journal of Environmental Research and Public Health 17, no. 17: 6370.
The obesity epidemic and the decline of fitness among children highlights the need for suitable interventions designed to promote Physical Activity (PA) and healthy habits. The purpose of our pilot study was to assess the feasibility of a school-based program among overweight and obese children, by examining changes in their body composition, PA, physical fitness, and some psychosocial determinants of active behavior. An additional objective was to investigate the reciprocal relationship over time between PA and body image. Self-reported PA and health-related fitness tests were administered to 18 overweight and obese children (11.3 ± 0.4 years), before and after a 6-month intervention including nutritional education, skill-learning, playful physical activities, and exercise training. Participants were assessed on body composition, perceived physical ability, body image, and pleasant and unpleasant psychobiosocial states towards PA. After treatment, children showed decreased body mass index, body fat percentage, arm and waist circumferences, and skinfold thickness. Actual and perceived physical abilities, body image, and PA also improved over six months. Cross-lagged correlations suggest body image to be an antecedent to being physically active. Results showed that the multi-component school program may have sustainable benefits in reducing adiposity indicators and improving exercise adherence, physical fitness, and psychological well-being.
Milena Morano; Claudio Robazza; Irene Rutigliano; Laura Bortoli; Montse C. Ruiz; Angelo Campanozzi. Changes in Physical Activity, Motor Performance, and Psychosocial Determinants of Active Behavior in Children: A Pilot School-Based Obesity Program. Sustainability 2020, 12, 1128 .
AMA StyleMilena Morano, Claudio Robazza, Irene Rutigliano, Laura Bortoli, Montse C. Ruiz, Angelo Campanozzi. Changes in Physical Activity, Motor Performance, and Psychosocial Determinants of Active Behavior in Children: A Pilot School-Based Obesity Program. Sustainability. 2020; 12 (3):1128.
Chicago/Turabian StyleMilena Morano; Claudio Robazza; Irene Rutigliano; Laura Bortoli; Montse C. Ruiz; Angelo Campanozzi. 2020. "Changes in Physical Activity, Motor Performance, and Psychosocial Determinants of Active Behavior in Children: A Pilot School-Based Obesity Program." Sustainability 12, no. 3: 1128.
BackgroundIodine is an essential micronutrient for intellectual development in children. Information on iodine intakes based on 24-h urinary iodine excretion (UIE) is scant, because iodine status is only assessed by the measurement of urinary iodine concentration (UIC) in spot urine samples.ObjectivesThe aim of our study was to evaluate the iodine intake of school-age children and adolescents, using UIE measurement in 24-h urine collections.MethodsThe study population included 1270 healthy subjects (677 boys, 593 girls) aged 6–18 y (mean age ± SD: 10.3 ± 2.9) from 10 Italian regions. Daily iodine intake was estimated as UIE/0.92, based on the notion that $\sim$92% of the dietary iodine intake is absorbed. The adequacy of intakes was assessed according to the Dietary Reference Values for iodine of the European Food Safety Authority (EFSA). Body mass index (BMI) and UIC were also measured for each subject.ResultsBased on the scientific opinion of EFSA, 600 of 1270 subjects (47.2%) had a lower than adequate iodine intake, with a higher prevalence among girls (54.6%) compared with boys (40.2%) (P < 0.001). Although UIE and 24-h urinary volumes increased with age (P < 0.001), a progressive decrease in the percentage of subjects with iodine excretion ConclusionsA sizable proportion of our population, especially girls, appeared to be at risk of iodine inadequacy. The simple measurement of UIC could lead to underestimation of the occurrence of iodine deficiency in younger children, because of the age-related smaller urine volumes producing spuriously higher iodine concentrations.
Angelo Campanozzi; Irene Rutigliano; Paolo Emidio Macchia; Gianpaolo De Filippo; Antonio Barbato; Roberto Iacone; Ornella Russo; Giuseppina D'Angelo; Monica Frigeri; Licia Pensabene; Basilio Malamisura; Gaetano Cecere; Maria Micillo; Ruggiero Francavilla; Anna Tetro; Giuliano Lombardi; Lisa Tonelli; Giuseppe Castellucci; Luigi Ferraro; Rita Di Biase; Antonella Lezo; Silvia Salvatore; Silvia Paoletti; Alfonso Siani; Daniela Galeone; Pietro Formisano; Pasquale Strazzullo. Iodine deficiency among Italian children and adolescents assessed through 24-hour urinary iodine excretion. The American Journal of Clinical Nutrition 2019, 109, 1080 -1087.
AMA StyleAngelo Campanozzi, Irene Rutigliano, Paolo Emidio Macchia, Gianpaolo De Filippo, Antonio Barbato, Roberto Iacone, Ornella Russo, Giuseppina D'Angelo, Monica Frigeri, Licia Pensabene, Basilio Malamisura, Gaetano Cecere, Maria Micillo, Ruggiero Francavilla, Anna Tetro, Giuliano Lombardi, Lisa Tonelli, Giuseppe Castellucci, Luigi Ferraro, Rita Di Biase, Antonella Lezo, Silvia Salvatore, Silvia Paoletti, Alfonso Siani, Daniela Galeone, Pietro Formisano, Pasquale Strazzullo. Iodine deficiency among Italian children and adolescents assessed through 24-hour urinary iodine excretion. The American Journal of Clinical Nutrition. 2019; 109 (4):1080-1087.
Chicago/Turabian StyleAngelo Campanozzi; Irene Rutigliano; Paolo Emidio Macchia; Gianpaolo De Filippo; Antonio Barbato; Roberto Iacone; Ornella Russo; Giuseppina D'Angelo; Monica Frigeri; Licia Pensabene; Basilio Malamisura; Gaetano Cecere; Maria Micillo; Ruggiero Francavilla; Anna Tetro; Giuliano Lombardi; Lisa Tonelli; Giuseppe Castellucci; Luigi Ferraro; Rita Di Biase; Antonella Lezo; Silvia Salvatore; Silvia Paoletti; Alfonso Siani; Daniela Galeone; Pietro Formisano; Pasquale Strazzullo. 2019. "Iodine deficiency among Italian children and adolescents assessed through 24-hour urinary iodine excretion." The American Journal of Clinical Nutrition 109, no. 4: 1080-1087.