Rooftop photovoltaic (RPV) is often understood as a niche contribution to climate change mitigation. However, the global potential of RPVs to mitigate global warming is unknown. Here we map the global rooftop area at 1-km resolution, quantifying 286,393 km² of rooftops worldwide through geospatial data mining and artificial intelligence techniques. Using nine advanced Earth system models from the coupled model intercomparison project phase 6, we reveal that RPVs could substantially contribute to reducing global temperatures by 0.05–0.13 °C before 2050. Region-specific analysis underscores the variability in RPV potential and the necessity of tailored approaches to optimize RPV deployment, considering local solar resources, existing infrastructure and grid carbon intensity. Our findings reveal that leveraging RPV systems offers a viable and impactful strategy for reducing carbon footprints and combating climate change globally, while advocating targeted interventions to enhance the benefits of RPVs, particularly in areas with high solar radiation or rapid urbanization.