Prostate-specific membrane antigen (PSMA) is a biomarker for prostate cancer (PCa), and a specific and reliable detection technique of PSMA is urgently required for PCa early diagnosis. A Love wave sensor has been widely studied for real-time sensing and highly sensitive applications, but the sensing unit needs special handling for selective detection purpose. In this study, we prepared a versatile Love wave sensor functionalized with molecularly-imprinted polymers (MIP), PSMA as the template molecule. To enhance the specific template bindings of MIP in pure aqueous solutions, facile reversible addition/fragmentation chain transfer (RAFT) precipitation polymerization (RAFTPP) was used to produce surface hydrophilic polymer brushes on MIP. The presence of hydrophilic polymer brushes on MIP improved its surface hydrophilicity and significantly reduced their hydrophobic interactions with template molecules in pure aqueous media. In detection process, the acoustic delay-line is confederative to a microfluidic chip and inserted in an oscillation loop. The real-time resonance frequency of the MIP-based Love wave sensor to different concentrations of PSMA was investigated. The limit of detection (LOD) for this Love SAW sensor was 0.013 ng mL−1, which demonstrates that this sensor has outstanding performance in terms of the level of detection.
22 February 2019 in Journal of Materials Chemistry A
The use of phase change materials (PCMs) to manage thermal energy is a promising and popular strategy. Many of the current thermal energy storage (TES) materials have almost no additional functions other than the TES function. Making TES materials electrically respond to temperature change and phase change processes in real time will enable people to manage thermal energy more efficiently. The present work demonstrated a novel TES composite with dual functions of energy storage and temperature sensing. The temperature change of the composite and the energy storage process can be reflected in real time by electrical signals. The TES composite with high thermal conductivity (98.1–126.4 W m−1 K−1) and high thermal effusivity (11.9–13.5 kJ m−2 K−1 s−1/2) could be prepared by simply increasing the load of PCMs. Finally, a modified parallel model was proposed to guide the further performance improvement of the TES composite.
The La2O3-doped basaltic glass simulated high-level waste form (HLW) was prepared by the solid-state melt method. The simulated waste La2O3 maximum loading and the doping effect on structure, thermal stability, leaching behavior, density, and hardness of basaltic glasses were studied. XRD and SEM results show that the simulated waste loading of La2O3 in basaltic glass can be up to ~46 wt.%, and apatite (CaLa4(SiO4)3O) precipitates when the content of La2O3 reaches 56 wt.%. Raman results indicate that the addition of La2O3 breaks the Si–O–Si bond of large-membered and four-membered, but the number of A13+ involved in the formation of the network increase. Low content of La2O3 can help to repair the glass network, but it destroys the network as above 26 wt.%. DSC results show the thermal stability of simulated waste forms first increases and then decreases with the increase of La2O3 content. With the increase of La2O3 content, the density of the simulated waste form increases, and the hardness decreases. The leaching chemical stability of samples was evaluated by the ASTM Product Consistency Test (PCT) Method, which show that all the samples have good chemical stability. The leaching rates of La and Fe are three orders of magnitude lower than those of the other elements. Among them, L36 has the best comprehensive leaching performance.