There is an incontestable need for improved treatment modality for glioblastoma due to its extraordinary resistance to traditional chemoradiation therapy. Boron neutron capture therapy (BNCT) may play a role in the future. We designed and synthesized a ¹⁰B-boronated derivative of temozolomide, TMZB. BNCT was carried out with a total neutron radiation fluence of 2.4 ± 0.3 × 10¹¹ n/cm². The effects of TMZB in BNCT were measured with a clonogenic cell survival assay in vitro and PET/CT imaging in vivo. Then, ¹⁰B-boronated phenylalanine (BPA) was tested in parallel with TMZB for comparison. The IC50 of TMZB for the cytotoxicity of clonogenic cells in HS683 was 0.208 mM, which is comparable to the IC50 of temozolomide at 0.213 mM. In BNCT treatment, 0.243 mM TMZB caused 91.2% ± 6.4% of clonogenic cell death, while 0.239 mM BPA eliminated 63.7% ± 6.3% of clonogenic cells. TMZB had a tumor-to-normal brain ratio of 2.9 ± 1.1 and a tumor-to-blood ratio of 3.8 ± 0.2 in a mouse glioblastoma model. BNCT with TMZB in this model caused 58.2% tumor shrinkage at 31 days after neutron irradiation, while the number for BPA was 35.2%. Therefore, by combining the effects of chemotherapy from temozolomide and radiotherapy with heavy charged particles from BNCT, TMZB-based BNCT exhibited promising potential for therapeutic applications in glioblastoma treatment.

The present article analyzes the dissipation characteristics of the direct contact condensation (DCC) phenomenon that occurs when steam is injected into a water tank at a subsonic speed using a new modeling approach for the entropy generation over the calculation domain. The developed entropy assessment model is based on the local equilibrium hypothesis of non-equilibrium thermodynamics. The fluid flow and heat transfer processes are investigated numerically. To describe the condensation and evaporation process at the vapor-liquid interface, a phase change model originated from the kinetic theory of gas is implemented with the mixture model for multiphase flow in the computational fluid dynamics (CFD) code ANSYS-FLUENT. The CFD predictions agree well with the published works, which indicates the phase change model combined with the mixture model is a promising way to simulate the DCC phenomenon. In addition, three clear stages as initial stage, developing stage and oscillatory stage are discriminated from both the thermal-hydraulic results and the entropy generation information. During different stages, different proportion of the entropy generation rate owing to heat transfer, viscous direct dissipation, turbulent dissipation and inner phase change in total entropy generation rate is estimated, which is favorable to deeper understanding the irreversibility of DCC phenomenon, designing and optimizing the equipment involved in the process.

Hydrogen bubble phenomenon is one of the key issues to be solved in the development of a long-life target system for boron neutron capture therapy (BNCT). In this study, we assessed the kinetic behaviors of H impurities in the nano-composite target from the atomic level. Firstly, two kinds of Li/Ta nanolayer models were constructed, based on the calculated lattice parameters and surface energies. The H solution energy, diffusion mechanism, and hydrogen bubbles formation in the Li/Ta nanostructured bilayer were studied, through theoretical modeling and simulation. Our results show that the Li/Ta interfaces are effective sinks of H atoms because the H solution energies in the interface are lower. Meanwhile, due to the relatively low diffusion barriers, the large-scale H transport through the interface is possible. In addition, although it is more likely to form hydrogen bubbles in the Ta layer, compared with the Li layer, the anti-blistering ability of Ta is more impressive compared with most of other candidate materials. Therefore, the Ta layer is able to act as the hydrogen absorber in the Li/Ta bilayer, and relieve the hydrogen damage of the Li layer in the large-scale proton radiations.

Due to the existence of a Dean vortex in a U-tube, the flow and heat transfer process of supercritical methane is complex, and its thermophysical property are greatly influenced by different factors. Based on computational fluid dynamics theory, the numerical simulation of the turbulent flow and heat transfer characteristics of supercritical methane in a U-tube with an inner diameter of 10 mm and a radius of curvature of 27 mm carried out by using the finite volume method. On the basis of verifying the reliability of the model, the influences of inlet mass flux (G), heat flux on the tube wall boundary (q), pressure on the outlet (P), and gravity acceleration factors (g) on heat transfer characteristics were analyzed. The calculation results show that the sensitivity of the effects of G, q, P, and g on the heat transfer coefficient is, from large to small, in the order of P, G, g, and q. Compared with a horizontal straight tube, a U-tube can significantly improve heat transfer in the elbow part, but the presence of the elbow reduces heat transfer in the subsequent straight pipe section. The research in this paper has significance as a reference for the construction of the LNG gasification process.

In order to provide a theoretical basis for the thermal design of the neutron production target, flow and heat transfer characteristics are studied by using numerical simulations and experiments. A rectangular mini-channel experimental model consistent with the geometric shape of the heat dissipation structure of neutron production target was established, in which the aspect ratio and gap thickness of the test channel were 53.8:1 and 1.3 mm, respectively. The experimental results indicate that the critical Re of the mini-channel is between 3500 and 4000, and when Re reaches 21,000, Nu can reach 160. The simulation results are in good agreement with the experimental data, and the numerical simulation method can be used for the variable structure optimization design of the target in the later stage. The relationship between the flow pressure drop of the target mini-channel and the aspect ratio and Re is obtained by numerical simulation. The maximum deviation between the correlation and the experimental value is 6%.