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Propolis, a resin produced by honeybees, has long been used as a dietary supplement and folk remedy, and more recent preclinical investigations have demonstrated a large spectrum of potential therapeutic bioactivities, including antioxidant, antibacterial, anti-inflammatory, neuroprotective, immunomodulatory, anticancer, and antiviral properties. As an antiviral agent, propolis and various constituents have shown promising preclinical efficacy against adenoviruses, influenza viruses, respiratory tract viruses, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), human immunodeficiency virus (HIV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 300 chemical components have been identified in propolis, including terpenes, flavonoids, and phenolic acids, with the specific constituent profile varying widely according to geographic origin and regional flora. Propolis and its constituents have demonstrated potential efficacy against SARS-CoV-2 by modulating multiple pathogenic and antiviral pathways. Molecular docking studies have demonstrated high binding affinities of propolis derivatives to multiple SARS-CoV-2 proteins, including 3C-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp), the receptor-binding domain (RBD) of the spike protein (S-protein), and helicase (NSP13), as well as to the viral target angiotensin-converting enzyme 2 (ACE2). Among these compounds, retusapurpurin A has shown high affinity to 3CLpro (ΔG = −9.4 kcal/mol), RdRp (−7.5), RBD (−7.2), NSP13 (−9.4), and ACE2 (−10.4) and potent inhibition of viral entry by forming hydrogen bonds with amino acid residues within viral and human target proteins. In addition, propolis-derived baccharin demonstrated even higher binding affinity towards PLpro (−8.2 kcal/mol). Measures of drug-likeness parameters, including metabolism, distribution, absorption, excretion, and toxicity (ADMET) characteristics, also support the potential of propolis as an effective agent to combat COVID-19.
Nermeen Yosri; Aida A. Abd El-Wahed; Reem Ghonaim; Omar M. Khattab; Aya Sabry; Mahmoud A. A. Ibrahim; Mahmoud F. Moustafa; Zhiming Guo; Xiaobo Zou; Ahmed F. M. Algethami; Saad H. D. Masry; Mohamed F. AlAjmi; Hanan S. Afifi; Shaden A. M. Khalifa; Hesham R. El-Seedi. Anti-Viral and Immunomodulatory Properties of Propolis: Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2. Foods 2021, 10, 1776 .
AMA StyleNermeen Yosri, Aida A. Abd El-Wahed, Reem Ghonaim, Omar M. Khattab, Aya Sabry, Mahmoud A. A. Ibrahim, Mahmoud F. Moustafa, Zhiming Guo, Xiaobo Zou, Ahmed F. M. Algethami, Saad H. D. Masry, Mohamed F. AlAjmi, Hanan S. Afifi, Shaden A. M. Khalifa, Hesham R. El-Seedi. Anti-Viral and Immunomodulatory Properties of Propolis: Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2. Foods. 2021; 10 (8):1776.
Chicago/Turabian StyleNermeen Yosri; Aida A. Abd El-Wahed; Reem Ghonaim; Omar M. Khattab; Aya Sabry; Mahmoud A. A. Ibrahim; Mahmoud F. Moustafa; Zhiming Guo; Xiaobo Zou; Ahmed F. M. Algethami; Saad H. D. Masry; Mohamed F. AlAjmi; Hanan S. Afifi; Shaden A. M. Khalifa; Hesham R. El-Seedi. 2021. "Anti-Viral and Immunomodulatory Properties of Propolis: Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2." Foods 10, no. 8: 1776.
Bee pollen is a combination of plant pollen and honeybee secretions and nectar. The Bible and ancient Egyptian texts are documented proof of its use in public health. It is considered a gold mine of nutrition due to its active components that have significant health and medicinal properties. Bee pollen contains bioactive compounds including proteins, amino acids, lipids, carbohydrates, minerals, vitamins, and polyphenols. The vital components of bee pollen enhance different bodily functions and offer protection against many diseases. It is generally marketed as a functional food with affordable and inexpensive prices with promising future industrial potentials. This review highlights the dietary properties of bee pollen and its influence on human health, and its applications in the food industry.
Shaden Khalifa; Mohamed Elashal; Nermeen Yosri; Ming Du; Syed Musharraf; Lutfun Nahar; Satyajit Sarker; Zhiming Guo; Wei Cao; Xiaobo Zou; Aida Abd El-Wahed; Jianbo Xiao; Hany Omar; Mohamed-Elamir Hegazy; Hesham El-Seedi. Bee Pollen: Current Status and Therapeutic Potential. Nutrients 2021, 13, 1876 .
AMA StyleShaden Khalifa, Mohamed Elashal, Nermeen Yosri, Ming Du, Syed Musharraf, Lutfun Nahar, Satyajit Sarker, Zhiming Guo, Wei Cao, Xiaobo Zou, Aida Abd El-Wahed, Jianbo Xiao, Hany Omar, Mohamed-Elamir Hegazy, Hesham El-Seedi. Bee Pollen: Current Status and Therapeutic Potential. Nutrients. 2021; 13 (6):1876.
Chicago/Turabian StyleShaden Khalifa; Mohamed Elashal; Nermeen Yosri; Ming Du; Syed Musharraf; Lutfun Nahar; Satyajit Sarker; Zhiming Guo; Wei Cao; Xiaobo Zou; Aida Abd El-Wahed; Jianbo Xiao; Hany Omar; Mohamed-Elamir Hegazy; Hesham El-Seedi. 2021. "Bee Pollen: Current Status and Therapeutic Potential." Nutrients 13, no. 6: 1876.
Bee venom (BV) is a rich source of secondary metabolites from honeybees (Apis mellifera L.). It contains a variety of bioactive ingredients including peptides, proteins, enzymes, and volatile metabolites. The compounds contribute to the venom’s observed biological functions as per its anti-inflammatory and anticancer effects. The antimicrobial action of BV has been shown in vitro and in vivo experiments against bacteria, viruses, and fungi. The synergistic therapeutic interactions of BV with antibiotics has been reported. The synergistic effect contributes to a decrease in the loading and maintenance dosage, a decrease in the side effects of chemotherapy, and a decrease in drug resistance. To our knowledge, there have been no reviews on the impact of BV and its antimicrobial constituents thus far. The purpose of this review is to address the antimicrobial properties of BV and its compounds.
Hesham El-Seedi; Aida Abd El-Wahed; Nermeen Yosri; Syed Ghulam Musharraf; Lei Chen; Moustafa Moustafa; Xiaobo Zou; Saleh Al-Mousawi; Zhiming Guo; Alfi Khatib; Shaden Khalifa. Antimicrobial Properties of Apis mellifera’s Bee Venom. Toxins 2020, 12, 451 .
AMA StyleHesham El-Seedi, Aida Abd El-Wahed, Nermeen Yosri, Syed Ghulam Musharraf, Lei Chen, Moustafa Moustafa, Xiaobo Zou, Saleh Al-Mousawi, Zhiming Guo, Alfi Khatib, Shaden Khalifa. Antimicrobial Properties of Apis mellifera’s Bee Venom. Toxins. 2020; 12 (7):451.
Chicago/Turabian StyleHesham El-Seedi; Aida Abd El-Wahed; Nermeen Yosri; Syed Ghulam Musharraf; Lei Chen; Moustafa Moustafa; Xiaobo Zou; Saleh Al-Mousawi; Zhiming Guo; Alfi Khatib; Shaden Khalifa. 2020. "Antimicrobial Properties of Apis mellifera’s Bee Venom." Toxins 12, no. 7: 451.
Over the past thousand years, Islamic physicians have collected cultural, philosophical, sociological and historical backgrounds for understanding diseases and medications. The Prophet Mohammed (Peace Be Upon Him (PBUH) said: "There is no disease that Allah has created, except that Allah also has created its cure." Therefore, Islamic scholars are encouraged to explore and use both traditional and modern forms of medicine. (1) To identify some of the medicinal plants mentioned in the Holy Qur'ân and Ahadith textbooks of the period 700-1500 AD; (2) to compare them with presently used traditional medicines; (3) to evaluate their value based on modern research; and (4) to investigate the contributions of Islamic scholars to the development of the scientific branches, particularly medicine. A literature search was performed relating to 12 medicinal plants mentioned in the Holy Qur'ân and Ahadith using textbooks, Al-Azhar scholars, published articles, the plant list website (http://www.theplantlist.org/), the medicinal plant names services website (http://mpns.kew.org/mpns-portal/) and web databases (PubMed, Science Direct, and Google Scholar). The Islamic Golden Age was a step towards modern medicine, with unique insights and multi-disciplinary aspects. Traditional Islamic Medicine has had a significant impact on the development of various medical, scientific and educational activities. Innumerable Muslim and non-Muslim physicians have built on the strong foundation of Traditional Islamic Medicine by translating the described natural remedies and effects. The influences of different ancient cultures on the traditional uses of natural products were also documented in Islamic Scriptures in the last part of the second millennium. The divine teachings of Islam combine natural and practical healing and incorporate inherited science and technology. In this review, we discuss Traditional Islamic Medicine with reference to both medical recommendations mentioned in the Holy Qur'ân and Prophetic Traditional Medicine (al-Tibb al-Nabawi). Although the molecular mechanisms and functions of some of the listed medicinal plants and their derivatives have been intensively studied, some traditional remedies have yet to be translated into clinical applications.
Hesham R. El-Seedi; Shaden A.M. Khalifa; Nermeen Yosri; Alfi Khatib; Lei Chen; Aamer Saeed; Thomas Efferth; Rob Verpoorte. Plants mentioned in the Islamic Scriptures (Holy Qur'ân and Ahadith): Traditional uses and medicinal importance in contemporary times. Journal of Ethnopharmacology 2019, 243, 112007 .
AMA StyleHesham R. El-Seedi, Shaden A.M. Khalifa, Nermeen Yosri, Alfi Khatib, Lei Chen, Aamer Saeed, Thomas Efferth, Rob Verpoorte. Plants mentioned in the Islamic Scriptures (Holy Qur'ân and Ahadith): Traditional uses and medicinal importance in contemporary times. Journal of Ethnopharmacology. 2019; 243 ():112007.
Chicago/Turabian StyleHesham R. El-Seedi; Shaden A.M. Khalifa; Nermeen Yosri; Alfi Khatib; Lei Chen; Aamer Saeed; Thomas Efferth; Rob Verpoorte. 2019. "Plants mentioned in the Islamic Scriptures (Holy Qur'ân and Ahadith): Traditional uses and medicinal importance in contemporary times." Journal of Ethnopharmacology 243, no. : 112007.
Rehan El-Shabasy; Nermeen Yosri; Hesham El-Seedi; Kamel Shoueir; Maged El-Kemary. A green synthetic approach using chili plant supported Ag/Ag [email protected] heterostructure with enhanced photocatalytic properties under solar irradiation. Optik 2019, 192, 1 .
AMA StyleRehan El-Shabasy, Nermeen Yosri, Hesham El-Seedi, Kamel Shoueir, Maged El-Kemary. A green synthetic approach using chili plant supported Ag/Ag [email protected] heterostructure with enhanced photocatalytic properties under solar irradiation. Optik. 2019; 192 ():1.
Chicago/Turabian StyleRehan El-Shabasy; Nermeen Yosri; Hesham El-Seedi; Kamel Shoueir; Maged El-Kemary. 2019. "A green synthetic approach using chili plant supported Ag/Ag [email protected] heterostructure with enhanced photocatalytic properties under solar irradiation." Optik 192, no. : 1.
Shaden A.M. Khalifa; Mohamed A. Farag; Nermeen Yosri; Jamal S.M. Sabir; Aamer Saeed; Saleh Al-Mousawi; Wafaa Taha; Syed Ghulam Musharraf; Seema Patel; Hesham El-Seedi. Truffles: From Islamic culture to chemistry, pharmacology, and food trends in recent times. Trends in Food Science & Technology 2019, 91, 193 -218.
AMA StyleShaden A.M. Khalifa, Mohamed A. Farag, Nermeen Yosri, Jamal S.M. Sabir, Aamer Saeed, Saleh Al-Mousawi, Wafaa Taha, Syed Ghulam Musharraf, Seema Patel, Hesham El-Seedi. Truffles: From Islamic culture to chemistry, pharmacology, and food trends in recent times. Trends in Food Science & Technology. 2019; 91 ():193-218.
Chicago/Turabian StyleShaden A.M. Khalifa; Mohamed A. Farag; Nermeen Yosri; Jamal S.M. Sabir; Aamer Saeed; Saleh Al-Mousawi; Wafaa Taha; Syed Ghulam Musharraf; Seema Patel; Hesham El-Seedi. 2019. "Truffles: From Islamic culture to chemistry, pharmacology, and food trends in recent times." Trends in Food Science & Technology 91, no. : 193-218.
Background/Aim: Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers. Methods: The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model. Results: A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, 1H-NMR and 13C-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 µg/mL, respectively. Conclusion: Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet.
Maram Hussein Zahra; Tarek A.R. Salem; Bishoy El-Aarag; Nermeen Yosri; Samah El-Ghlban; Kholoud Zaki; Amel H. Marei; Aida Abd El-Wahed; Aamer Saeed; Alfi Khatib; Mohamed F. Alajmi; Abdulrahman M. Shathili; Jianbo Xiao; Shaden A. M. Khalifa; Hesham R. El-Seedi. Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities. Molecules 2019, 24, 2495 .
AMA StyleMaram Hussein Zahra, Tarek A.R. Salem, Bishoy El-Aarag, Nermeen Yosri, Samah El-Ghlban, Kholoud Zaki, Amel H. Marei, Aida Abd El-Wahed, Aamer Saeed, Alfi Khatib, Mohamed F. Alajmi, Abdulrahman M. Shathili, Jianbo Xiao, Shaden A. M. Khalifa, Hesham R. El-Seedi. Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities. Molecules. 2019; 24 (13):2495.
Chicago/Turabian StyleMaram Hussein Zahra; Tarek A.R. Salem; Bishoy El-Aarag; Nermeen Yosri; Samah El-Ghlban; Kholoud Zaki; Amel H. Marei; Aida Abd El-Wahed; Aamer Saeed; Alfi Khatib; Mohamed F. Alajmi; Abdulrahman M. Shathili; Jianbo Xiao; Shaden A. M. Khalifa; Hesham R. El-Seedi. 2019. "Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities." Molecules 24, no. 13: 2495.