This work is devoted to the research of porous titanium alloy structures suitable for use in biomedical applications. Mechanical properties were examined on six series of samples with different structures and porosity via static compressive test to identify the type of structure suitable for elimination of the “stress shielding” effect. In addition, high porosity is desirable due to the overgrowth of bone tissue into the internal structure of the implant. The samples were made of titanium alloy Ti6Al4V by using selective laser melting (SLM) additive manufacturing. The series of samples differ from each other in pore size (200, 400, and 600 µm) and porous structure topology (cubic or trabecular). The actual weight of all samples, which plays an important role in identifying other characteristics, was determined. Compressive tests were focused on the detection of maximum stress. The highest porosity and thus the lowest weight were achieved in the samples with a trabecular structure and 600 µm pore size. All tested samples reached optimal values of maximum stress and tensile strength. The most appropriate mechanical properties were observed for samples with a 200 µm pore diameter and cubic structure.

Biopolymers have been the most frequently studied class of materials due to their biodegradability, renewability, and sustainability. The main aim of the presented study was to evaluate degradability of the polymer material blend which was immersed in different solutions. The present study included the production of three different mixtures of polylactic acid and polyhydroxybutyrate, each with a different content of triacetin, which was used as a plasticiser. Applying 3D printing technology, two types of cylindrical specimen were produced, i.e., a solid and a porous specimen, and subjected to in vitro natural degradation. The biodegradation process ran for 195 days in three different solutions (saline, phosphate-buffered saline (PBS), and Hank’s solution) in stable conditions of 37 °C and a pH of 7.4, while the specimens were kept in an orbital motion to simulate the flow of fluids. The goal was to identify the effects of a solution type, specimen shape and material composition on the biodegradation of the materials. The monitored parameters included changes in the solution quantity absorbed by the specimens; morphological changes in the specimen structure; and mechanical properties. They were measured by compressive testing using the Inspekt5 Table Blue testing device. The experiment revealed that specimen porosity affected the absorption of the solutions. The non-triacetin materials exhibited a higher mechanical resistance to compression than the materials containing a plasticiser. The final result of the experiment indicated that the plasticiser-free specimens exhibited higher values of solution absorption, no formation of block cracks or bubbles, and the pH values of the solutions in which these materials were immersed remained neutral for the entire experiment duration; furthermore, these materials did not reduce pH values down to the alkaline range, as was the case with the solutions with the plasticiser-containing materials. Generally, in applications where high mechanical resistance, earlier degradation, and more stable conditions are required, the use of non-plasticiser materials is recommended.

The purpose of this paper was writing down the process of preclinical testing which consisted from usage of bioinert polymer material enriched with bioactive ceramic elements. The testing was preceded by a study of the current state and method...

The aim of this study was to develop a methodology of preclinical animal testing in case studies for implants with PEEK material and its derivatives with possible use for other materials. In the theoretical part, the study deals with the analysis of the current situation in the area of preclinical animal testing, especially in the field of implantology. Based on this analysis, the test implant structures were prepared at the workplace, which were subsequently inserted into appropriate rabbit individuals by surgical intervention in case studies. These case studies serve to create a comprehensive test methodology for animal preclinical tests within a statistically relevant animal sample for the needs of subsequent clinical testing and certification of the biomaterial used. These studies confirmed that the proportion of ceramic admixture elements in PEEK promoted the growth of bone tissue.