In this study, we present a method for prediction of the drug-release profile based on the physical mechanisms that can intervene in drug release from a drug-carrier. The application presented here incorporates the effects of drug concentration and Reynolds number defining the circulating flow in the testing vein. The experimental data used relate to the release of diclofenac from samples of non-degradable polyurethane subjected to static and continuous flow. This case includes simultaneously three mechanisms: burst-release, diffusion and osmotic pressure, identified beforehand here as being able to contribute to the drug liberation. For this purpose, authors coded the Sequential Quadratic Programming Algorithm to solve the problem of non-linear optimization. The experimental data used to develop the mathematical model obtained from release studies carried out in water solution at 37 °C, for three concentrations of diclofenac and two water flow rates. We discuss the contribution of mechanisms and kinetics by considering two aforementioned parameters and, following that, we obtain the specific-model and compare the calculated results with the experimental results for the reserved cases. The results showed that drug percentage mostly affect the burst release, however flow rate has affected the osmotic release. In addition, release kinetics of all the mechanisms have increased by increasing the values of two considered parameters.

The influence of counter-rotation between the inducer and impeller, along with a newly introduced system for their independent rotation on the pump cavitation characteristics, has been studied experimentally. Remarkably, this pump allows users to select between co-rotation and counter-rotation modes, providing significant operational adaptability. The high-speed camera is used to analyze vaporization structures and closely monitor the stability of the head pressure delivered by the pump during the cavitation testing phase. For both co-rotation and counter-rotation modes, different types of cavitation within the inducer and between the inducer and the impeller at three varied flow rates have been studied using image analysis. The results reveal improved cavitation performance and comparable efficiency at consistent pressure–flowrate combinations, emphasizing the advantages of counter-rotation across the three tested flow rates. In counter-rotation mode, the tangential velocity of the flow at the output of the inducer is opposite to that of the co-rotation mode. Consequently, the tangential velocity of the flow entering the impeller is reduced, leading to enhanced flow stability and increased pump pressure. The findings from image analysis demonstrate that the structure of cavitation varies between co-rotation and counter-rotation modes. Reversing the rotation direction of the inducer not only improves the pump cavitation characteristics but also changes the vapor structure due to changes in the flow pattern.

This article introduces an innovative design for a centrifugal pump featuring an inducer that enables the independent rotation of both the inducer and the centrifugal impeller. Unlike conventional designs, this configuration allows for differential speeds and customizable rotation directions, including co-rotation and counter-rotation modes. These new capabilities offer numerous operational advantages. This study investigates the impact of the speed ratio between the inducer and the impeller on the pump’s performance in both the co-rotation and counter-rotation modes. The results demonstrate that the independent rotation of the inducer expands the pump’s operating range, while counter-rotation significantly enhances the generation of pressure and the pump’s efficiency compared to co-rotation. These findings pave the way for the development of pumps that offer benefits such as a reduced size, reduced vibration, minimized energy consumption, and improved cavitation performance.

This document deals with the design of a Permanent Magnet Synchronous Motor (PMSM) to peripherally drive a counter-rotating pump inducer. The motor/pump is associated using a rim-driven principle where the motor’s active parts are located at the periphery of the inducer blades. It proposes using a Halbach array of permanent magnets for the active rotor of the motor. This solution allows the generation of a Sinusoidal Electromotive Force (EMF). Therefore, a more stable electromagnetic torque is reached. An optimum geometry suitable for the inducer specifications while respecting operational constraints is determined. The obtained geometry is then simulated using the Finite Element Method. The results are satisfactory in terms of average torque and EMF waveform. Use of the Halbach array allows a significant improvement of the flux density in the air gap compared to a designed surface-mounted machine. The experimental validation will be performed once the prototype is realized in the Laboratory of Fluid Engineering and Energy systems (LISFE).

This article is devoted to the dynamic study of the brazed plate condenser (BPC). The proposed model is based on the bond graph theory. The proposed model is based on the bond graph theory because of its energetic approach and multi-physics character of the studied system. The model is discretized into five control volumes. The resolution of mass and energy equations is done by Runge-Kutta method embedded in 20sim software. Analyses of simulation results show that the model has a good ability to transcribe the time evolution of the temperature and pressure in both regimes, transitional and permanent. Also, the model is experimentally validated without any fitting of the set of thermal exchange coefficients.

The inducers increase the pressure available at the inlet of the impellers of centrifugal pumps. This technological solution may induce instabilities, such as prerotating flow at partial flow rates. The scientific literature offers studies on the cavitation in the inducers, as well as on the associated instabilities. However, studies describing devices that improve the behavior in these unstable regimes are rare. This is particularly true for fluids like aviation fuels or liquids with dissolved gases. In this work we expose, an experimental study for two axial inducers carried out at low flow rates in cavitating and noncavitating regimes in a closed-loop equipped with a transparent test pipe. The working liquid is water with and without dissolved CO2. We employ a camera and a high-speed camera to take the photographs of the dynamics of the cavitation structures. The experimental campaign provided results of head breakdown comparison. The added dissolved CO2 gas at a concentration of 300 mg L–1 does not change the overall inducers' performance in noncavitating regime. The paper presents also the impact of some of inducers' geometrical parameters on their cavitating performance. The authors observed prerotating flow instability, which they tried to decrease by incorporating a grooved ring into the inlet side of the inducers. It is found that prerotating structures are much less developed in the upstream when a grooved ring is employed.