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Yuko Kurosawa is a senior lecturer at Tokyo Medical University. She has received a postdoctoral award at the Cincinnati Translational Neuroscience Symposium 2007 and Best Poster Award of the International Creatine-2015 Conference. Her research expertise is creatine metabolism in brain and skeletal muscles.
This study examined the relationship between plasma amino acid (AA) concentrations, including branched-chain AAs, and brown adipose tissue density (BAT-d). One hundred and seventy-three subjects (69 men, 104 women) aged 22–68 years were recruited during the winter season. AAs were comprehensively quantified using liquid chromatography-time-of-flight-mass spectrometry. The total hemoglobin concentration in the supraclavicular region ([total-Hb]sup), an indicator of BAT-d, was assessed using near-infrared time-resolved spectroscopy. Anthropometric parameters, including age, percentage of body fat, and visceral fat, were evaluated. Factors associated with higher (≥74 µM) or lower (<74 µM) [total-Hb]sup were investigated by multiple logistic regression models that included AA concentrations alone (model 1) or AA concentrations and anthropometric parameters (model 2) as independent variables. When adjusted for the false discovery rate, [total-Hb]sup was positively correlated with glycine and asparagine levels in men and with the serine level in both men and women and was negatively correlated with the branched-chain AA concentration in men. Models 1 and 2 correlated with higher or lower BAT-d for men (r = 0.73, p = 0.015) and women (r = 0.58, p = 0.079) and for men (r = 0.82, p = 0.0070) and women (r = 0.70, p = 0.020), respectively. A combination of anthropometric parameters and plasma AA concentrations could be a reliable biomarker for higher and lower BAT-d.
Miyuki Kuroiwa; Sayuri Hamaoka-Fuse; Masahiro Sugimoto; Yuko Kurosawa; Yasuko Aita; Atsumi Tomita; Mikiko Anjo; Riki Tanaka; Tasuki Endo; Ryotaro Kime; Takafumi Hamaoka. Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans. Journal of Clinical Medicine 2021, 10, 2339 .
AMA StyleMiyuki Kuroiwa, Sayuri Hamaoka-Fuse, Masahiro Sugimoto, Yuko Kurosawa, Yasuko Aita, Atsumi Tomita, Mikiko Anjo, Riki Tanaka, Tasuki Endo, Ryotaro Kime, Takafumi Hamaoka. Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans. Journal of Clinical Medicine. 2021; 10 (11):2339.
Chicago/Turabian StyleMiyuki Kuroiwa; Sayuri Hamaoka-Fuse; Masahiro Sugimoto; Yuko Kurosawa; Yasuko Aita; Atsumi Tomita; Mikiko Anjo; Riki Tanaka; Tasuki Endo; Ryotaro Kime; Takafumi Hamaoka. 2021. "Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans." Journal of Clinical Medicine 10, no. 11: 2339.
Capsinoids are some of the most promising ingredients to increase energy expenditure (EE) due to brown adipose tissue (BAT) activation. However, there is limited information regarding the effect of prolonged capsinoid ingestion (CI) on BAT activity and resting EE (REE) in healthy, middle-aged, normal to overweight subjects (Subhealthy) with distinct BAT characteristics. We examined the changes in BAT density (BAT-d), using near-infrared time-resolved spectroscopy, and REE/kg induced by daily CI. Forty Subhealthy [age, 43.8 (mean) years; BMI, 25.4 kg/m2] received either capsinoid (9 mg/day) or a placebo daily for 6 weeks in a double-blind design. Total hemoglobin concentration in the supraclavicular region ([total-Hb]sup), an indicator of BAT-d, and REE/kg were measured. The changes in post-intervention [total-Hb]sup were greater in the capsinoid group (CA-G) than in the placebo group (PL-G) [5.8 µM (+12.4%) versus 1.0 µM (+2.1%); P = 0.017]. There was a significant relationship between BAT-d and REE/kg; however, post-supplementation REE/kg was not significantly different between the two groups (P = 0.228). In the overweight subgroup, changes in REE/kg were greater in the CA-G than in the PL-G [0.6 cal/kg/min (+4.3%) versus −0.3 cal/kg/min (−2.1%); P = 0.021]. CI enhanced [total-Hb]sup, a reflection of BAT-d, showing a good correlation with REE in Subhealthy.
Sayuri Fuse; Tasuki Endo; Riki Tanaka; Miyuki Kuroiwa; Akira Ando; Ayami Kume; Akiko Yamamoto; Kanna Kuribayashi; Shinji Somekawa; Masamichi Takeshita; Masaki Hashimoto; Ryotaro Kime; Yuko Kurosawa; Takafumi Hamaoka. Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients 2020, 12, 2676 .
AMA StyleSayuri Fuse, Tasuki Endo, Riki Tanaka, Miyuki Kuroiwa, Akira Ando, Ayami Kume, Akiko Yamamoto, Kanna Kuribayashi, Shinji Somekawa, Masamichi Takeshita, Masaki Hashimoto, Ryotaro Kime, Yuko Kurosawa, Takafumi Hamaoka. Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2020; 12 (9):2676.
Chicago/Turabian StyleSayuri Fuse; Tasuki Endo; Riki Tanaka; Miyuki Kuroiwa; Akira Ando; Ayami Kume; Akiko Yamamoto; Kanna Kuribayashi; Shinji Somekawa; Masamichi Takeshita; Masaki Hashimoto; Ryotaro Kime; Yuko Kurosawa; Takafumi Hamaoka. 2020. "Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study." Nutrients 12, no. 9: 2676.
Brown adipose tissue (BAT) plays a role in adaptive thermogenesis in response to cold environments and dietary intake via sympathetic nervous system (SNS) activation. It is unclear whether physical activity increases BAT density (BAT-d). Two-hundred ninety-eight participants (age: 41.2 ± 12.1 (mean ± standard deviation), height: 163.6 ± 8.3 cm, weight: 60.2 ± 11.0 kg, body mass index (BMI): 22.4 ± 3.0 kg/m2, body fat percentage: 25.4 ± 7.5%) without smoking habits were categorized based on their physical activity levels (a group performing physical activities including walking and moderate physical activity (WM) and a group performing WM + vigorous-intensity physical activities (VWM)). We measured the total hemoglobin concentration ([Total-Hb]) in the supraclavicular region, an index of BAT-d, and anthropometric parameters. [Total-Hb] was significantly higher in VWM than WM for all participant groups presumably owing to SNS activation during vigorous-intensity physical activities, and unrelated to the amount of total physical activity levels. Furthermore, multiple regression analysis revealed that BAT-d was related to visceral fat area and VWM in men and related to body fat percentage in women. We conclude that vigorous-intensity physical activities are associated with high BAT-d in humans, especially in men.
Riki Tanaka; Sayuri Fuse; Miyuki Kuroiwa; Shiho Amagasa; Tasuki Endo; Akira Ando; Ryotaro Kime; Yuko Kurosawa; Takafumi Hamaoka. Vigorous-Intensity Physical Activities Are Associated with High Brown Adipose Tissue Density in Humans. International Journal of Environmental Research and Public Health 2020, 17, 2796 .
AMA StyleRiki Tanaka, Sayuri Fuse, Miyuki Kuroiwa, Shiho Amagasa, Tasuki Endo, Akira Ando, Ryotaro Kime, Yuko Kurosawa, Takafumi Hamaoka. Vigorous-Intensity Physical Activities Are Associated with High Brown Adipose Tissue Density in Humans. International Journal of Environmental Research and Public Health. 2020; 17 (8):2796.
Chicago/Turabian StyleRiki Tanaka; Sayuri Fuse; Miyuki Kuroiwa; Shiho Amagasa; Tasuki Endo; Akira Ando; Ryotaro Kime; Yuko Kurosawa; Takafumi Hamaoka. 2020. "Vigorous-Intensity Physical Activities Are Associated with High Brown Adipose Tissue Density in Humans." International Journal of Environmental Research and Public Health 17, no. 8: 2796.
High whole-body and visceral adiposity are risk factors that can cause metabolic diseases. We hypothesized that the total hemoglobin concentration (total-Hb) in abdominal subcutaneous adipose tissue (SATab), an indicator of white adipose tissue (WAT) vascularity, correlates negatively with risk factors for developing metabolic diseases, such as whole-body and visceral adiposity. We tested the optical characteristics of abdominal tissue in 140 participants (45 men and 95 women) who were apparently healthy individuals with a median age of 39 years. They also had a median body fat percentage of 25.4%, a visceral fat area of 50.4 cm2, and a SATab thickness of 1.05 cm. These tests were conducted using near-infrared time-resolved spectroscopy (NIRTRS) with a 2-cm optode separation. To distinguish the segments of SATab (SegSAT) and the mixture of muscle and SATab (SegSAT+Mus), the threshold was analyzed using the slopes of (total-Hb) against the thickness of SATab using the least-squares mean method. According to the results from the logistic regression analysis, the percentage of body fat and visceral fat area remained significant predictors of the (total-Hb) (p = 0.005 and p = 0.043, respectively) in the data for SegSAT (no influence from the SATab thickness). We conclude that simple, rapid, and noninvasive NIRTRS-determined (total-Hb) in WAT could be a useful parameter for evaluating risk factors for metabolic diseases.
Miyuki Kuroiwa; Sayuri Fuse; Shiho Amagasa; Ryotaro Kime; Tasuki Endo; Yuko Kurosawa; Takafumi Hamaoka. Relationship of Total Hemoglobin in Subcutaneous Adipose Tissue with Whole-Body and Visceral Adiposity in Humans. Applied Sciences 2019, 9, 2442 .
AMA StyleMiyuki Kuroiwa, Sayuri Fuse, Shiho Amagasa, Ryotaro Kime, Tasuki Endo, Yuko Kurosawa, Takafumi Hamaoka. Relationship of Total Hemoglobin in Subcutaneous Adipose Tissue with Whole-Body and Visceral Adiposity in Humans. Applied Sciences. 2019; 9 (12):2442.
Chicago/Turabian StyleMiyuki Kuroiwa; Sayuri Fuse; Shiho Amagasa; Ryotaro Kime; Tasuki Endo; Yuko Kurosawa; Takafumi Hamaoka. 2019. "Relationship of Total Hemoglobin in Subcutaneous Adipose Tissue with Whole-Body and Visceral Adiposity in Humans." Applied Sciences 9, no. 12: 2442.
Brown adipose tissue (BAT) may potentially be used in strategies for preventing lifestyle-related diseases. We examine evidence that near-infrared time-resolved spectroscopy (NIRTRS) is capable of estimating human BAT density (BAT-d). The parameters examined in this study are total hemoglobin [total-Hb]sup, oxygenated Hb [oxy-Hb]sup, deoxygenated Hb [deoxy-Hb]sup, Hb O2 saturation (StO2sup), and the reduced scattering coefficient in the supraclavicular region (μs'sup), where BAT deposits can be located; corresponding parameters in the control deltoid region are obtained as controls. Among the NIRTRS parameters, [total-Hb]sup and [oxy-Hb]sup show region-specific increases in winter, compared to summer. Further, [total-Hb]sup and [oxy-Hb]sup are correlated with cold-induced thermogenesis in the supraclavicular region. We conclude that NIRTRS-determined [total-Hb]sup and [oxy-Hb]sup are useful parameters for evaluating BAT-d in a simple, rapid, non-invasive manner.
Shinsuke Nirengi; Sayuri Fuse; Shiho Amagasa; Toshiyuki Homma; Ryotaro Kime; Miyuki Kuroiwa; Tasuki Endo; Naoki Sakane; Mami Matsushita; Masayuki Saito; Yuko Kurosawa; Takafumi Hamaoka. Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans. International Journal of Molecular Sciences 2019, 20, 2214 .
AMA StyleShinsuke Nirengi, Sayuri Fuse, Shiho Amagasa, Toshiyuki Homma, Ryotaro Kime, Miyuki Kuroiwa, Tasuki Endo, Naoki Sakane, Mami Matsushita, Masayuki Saito, Yuko Kurosawa, Takafumi Hamaoka. Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans. International Journal of Molecular Sciences. 2019; 20 (9):2214.
Chicago/Turabian StyleShinsuke Nirengi; Sayuri Fuse; Shiho Amagasa; Toshiyuki Homma; Ryotaro Kime; Miyuki Kuroiwa; Tasuki Endo; Naoki Sakane; Mami Matsushita; Masayuki Saito; Yuko Kurosawa; Takafumi Hamaoka. 2019. "Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans." International Journal of Molecular Sciences 20, no. 9: 2214.
This study quantitatively analyzed the effects of 3 h of constant sitting on skeletal muscle oxygenation in the lower extremities, using near-infrared time-resolved spectroscopy (NIRTRS). The effects of compression stockings were also evaluated. Eleven healthy men (age, 30.0 ± 6.7 years) maintained their knee joints at 90° flexion during 3 h of constant sitting and wore a compression stocking on either the right or left leg. The side the stocking was worn was chosen randomly. Subsequently, leg circumference and extracellular water were measured. After 3 h of sitting, both factors increased significantly in uncompressed limbs. Furthermore, intracellular water and muscle oxygenation had significantly decreased. In contrast, extracellular water had not increased in the limbs wearing compression stockings. Furthermore, the increased circumference of compressed limbs was significantly smaller than that of uncompressed limbs. Decreases in oxygenated hemoglobin and total hemoglobin were significantly smaller in compressed limbs than in uncompressed limbs (oxy-Hb; p = 0.021, total-Hb; p = 0.013). Three hours of sitting resulted in decreased intracellular water and increased extracellular water in the lower extremities, leading to reduced blood volume and oxygenation levels in skeletal muscle. Compression stockings successfully suppressed these negative effects.
Misato Kinoshita; Yuko Kurosawa; Sayuri Fuse; Riki Tanaka; Nobuko Tano; Ryota Kobayashi; Ryotaro Kime; Takafumi Hamaoka. Compression Stockings Suppressed Reduced Muscle Blood Volume and Oxygenation Levels Induced by Persistent Sitting. Applied Sciences 2019, 9, 1800 .
AMA StyleMisato Kinoshita, Yuko Kurosawa, Sayuri Fuse, Riki Tanaka, Nobuko Tano, Ryota Kobayashi, Ryotaro Kime, Takafumi Hamaoka. Compression Stockings Suppressed Reduced Muscle Blood Volume and Oxygenation Levels Induced by Persistent Sitting. Applied Sciences. 2019; 9 (9):1800.
Chicago/Turabian StyleMisato Kinoshita; Yuko Kurosawa; Sayuri Fuse; Riki Tanaka; Nobuko Tano; Ryota Kobayashi; Ryotaro Kime; Takafumi Hamaoka. 2019. "Compression Stockings Suppressed Reduced Muscle Blood Volume and Oxygenation Levels Induced by Persistent Sitting." Applied Sciences 9, no. 9: 1800.
Brown adipose tissue (BAT) contributes to the regulation of non-shivering thermogenesis and adiposity. Increasing BAT has recently attracted much attention as a countermeasure to obesity. Animal studies have shown that prolonged catechin treatment increases uncoupling protein 1, a thermogenic protein in BAT. On the other hand, supportable evidence in human is lacking. Thus, the purpose of this study was to examine whether BAT increases after catechin ingestion in humans. Twenty-two healthy young women were given either a catechin-rich (540 mg/day; catechin) or placebo beverage every day for 12 weeks in a double-blind design. BAT density was measured using near-infrared time-resolved spectroscopy (NIRTRS), visceral fat area were measured using magnetic resonance imaging, extramyocellular lipids (EMCL) using proton magnetic resonance spectroscopy, and body fat mass using dual-energy X-ray absorptiometry scans. BAT density was significantly increased (18.8 %), and EMCL was decreased (17.4 %) after the 12-week ingestion. There was a significant negative correlation between the changes in BAT density and those in EMCL (r = −0.66, P < 0.05). There were no notable changes in other parameters. In conclusion, prolonged ingestion of a catechin-rich beverage increases the BAT density in parallel with a decrease in EMCL.
Shinsuke Nirengi; Shiho Amagasa; Toshiyuki Homma; Takeshi Yoneshiro; Saori Matsumiya; Yuko Kurosawa; Naoki Sakane; Kumiko Ebi; Masayuki Saito; Takafumi Hamaoka. Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women. SpringerPlus 2016, 5, 1 -9.
AMA StyleShinsuke Nirengi, Shiho Amagasa, Toshiyuki Homma, Takeshi Yoneshiro, Saori Matsumiya, Yuko Kurosawa, Naoki Sakane, Kumiko Ebi, Masayuki Saito, Takafumi Hamaoka. Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women. SpringerPlus. 2016; 5 (1):1-9.
Chicago/Turabian StyleShinsuke Nirengi; Shiho Amagasa; Toshiyuki Homma; Takeshi Yoneshiro; Saori Matsumiya; Yuko Kurosawa; Naoki Sakane; Kumiko Ebi; Masayuki Saito; Takafumi Hamaoka. 2016. "Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women." SpringerPlus 5, no. 1: 1-9.