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Francesco Lauria
National Institute for Infectious Diseases, “Lazzaro Spallanzani”–IRCCS, Via Portuense, 292, 00149 Rome, Italy

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Journal article
Published: 06 July 2021 in Viruses
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Complex systems are inherently multilevel and multiscale systems. The infectious disease system is considered a complex system resulting from the interaction between three sub-systems (host, pathogen, and environment) organized into a hierarchical structure, ranging from the cellular to the macro-ecosystem level, with multiscales. Therefore, to describe infectious disease phenomena that change through time and space and at different scales, we built a model framework where infectious disease must be considered the set of biological responses of human hosts to pathogens, with biological pathways shared with other pathologies in an ecological interaction context. In this paper, we aimed to design a framework for building a disease model for COVID-19 based on current literature evidence. The model was set up by identifying the molecular pathophysiology related to the COVID-19 phenotypes, collecting the mechanistic knowledge scattered across scientific literature and bioinformatic databases, and integrating it using a logical/conceptual model systems biology. The model framework building process began from the results of a domain-based literature review regarding a multiomics approach to COVID-19. This evidence allowed us to define a framework of COVID-19 conceptual model and to report all concepts in a multilevel and multiscale structure. The same interdisciplinary working groups that carried out the scoping review were involved. The conclusive result is a conceptual method to design multiscale models of infectious diseases. The methodology, applied in this paper, is a set of partially ordered research and development activities that result in a COVID-19 multiscale model.

ACS Style

Francesco Messina; Chiara Montaldo; Isabella Abbate; Manuela Antonioli; Veronica Bordoni; Giulia Matusali; Alessandra Sacchi; Emanuela Giombini; Gian Fimia; Mauro Piacentini; Maria Capobianchi; Francesco Lauria; Giuseppe Ippolito; on behalf of COVID-19 Scoping Review Working Group. Rationale and Criteria for a COVID-19 Model Framework. Viruses 2021, 13, 1309 .

AMA Style

Francesco Messina, Chiara Montaldo, Isabella Abbate, Manuela Antonioli, Veronica Bordoni, Giulia Matusali, Alessandra Sacchi, Emanuela Giombini, Gian Fimia, Mauro Piacentini, Maria Capobianchi, Francesco Lauria, Giuseppe Ippolito, on behalf of COVID-19 Scoping Review Working Group. Rationale and Criteria for a COVID-19 Model Framework. Viruses. 2021; 13 (7):1309.

Chicago/Turabian Style

Francesco Messina; Chiara Montaldo; Isabella Abbate; Manuela Antonioli; Veronica Bordoni; Giulia Matusali; Alessandra Sacchi; Emanuela Giombini; Gian Fimia; Mauro Piacentini; Maria Capobianchi; Francesco Lauria; Giuseppe Ippolito; on behalf of COVID-19 Scoping Review Working Group. 2021. "Rationale and Criteria for a COVID-19 Model Framework." Viruses 13, no. 7: 1309.

Editorial
Published: 02 November 2020 in International Journal of Infectious Diseases
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Giuseppe Ippolito; Francesco Nicola Lauria; Franco Locatelli; Nicola Magrini; Chiara Montaldo; Raffaella Sadun; Markus Maeurer; Gino Strada; Francesco Vairo; Salvatore Curiale; Antoine Lafont; Antonino di Caro; Maria Rosaria Capobianchi; Rainer Meilicke; Eskild Petersen; Alimuddin Zumla; Michel Pletschette. Lessons from the COVID-19 Pandemic—Unique Opportunities for Unifying, Revamping and Reshaping Epidemic Preparedness of Europe’s Public Health Systems. International Journal of Infectious Diseases 2020, 101, 361 -366.

AMA Style

Giuseppe Ippolito, Francesco Nicola Lauria, Franco Locatelli, Nicola Magrini, Chiara Montaldo, Raffaella Sadun, Markus Maeurer, Gino Strada, Francesco Vairo, Salvatore Curiale, Antoine Lafont, Antonino di Caro, Maria Rosaria Capobianchi, Rainer Meilicke, Eskild Petersen, Alimuddin Zumla, Michel Pletschette. Lessons from the COVID-19 Pandemic—Unique Opportunities for Unifying, Revamping and Reshaping Epidemic Preparedness of Europe’s Public Health Systems. International Journal of Infectious Diseases. 2020; 101 ():361-366.

Chicago/Turabian Style

Giuseppe Ippolito; Francesco Nicola Lauria; Franco Locatelli; Nicola Magrini; Chiara Montaldo; Raffaella Sadun; Markus Maeurer; Gino Strada; Francesco Vairo; Salvatore Curiale; Antoine Lafont; Antonino di Caro; Maria Rosaria Capobianchi; Rainer Meilicke; Eskild Petersen; Alimuddin Zumla; Michel Pletschette. 2020. "Lessons from the COVID-19 Pandemic—Unique Opportunities for Unifying, Revamping and Reshaping Epidemic Preparedness of Europe’s Public Health Systems." International Journal of Infectious Diseases 101, no. : 361-366.

Preprint content
Published: 07 May 2020
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Background Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2 infection are under evaluation. A better understanding of the pathophysiology associated with COVID-19 is crucial to improve treatment modalities and to develop effective prevention strategies. Transcriptomic and proteomic data on the host response against SARS-CoV-2 still have anecdotic character; currently available data from other coronavirus infections are therefore a key source of information. Methods We investigated selected molecular aspects of three human coronavirus (HCoV) infections, namely SARS-CoV, MERS-CoV and HCoV-229E, through a network based-approach. A functional analysis of HCoV-host interactome was carried out in order to provide a theoretic host-pathogen interaction model for HCoV infections and in order to translate the results in prediction for SARS-CoV-2 pathogenesis. The 3D model of S-glycoprotein of SARS-CoV-2 was compared to the structure of the corresponding SARS-CoV, HCoV-229E and MERS-CoV S-glycoprotein. SARS-CoV, MERS-CoV, HCoV-229E and the host interactome were inferred through published protein-protein interactions (PPI) as well as gene co-expression, triggered by HCoV S-glycoprotein in host cells. Results Although the amino acid sequences of the S-glycoprotein were found to be different between the various HCoV, the structures showed high similarity, but the best 3D structural overlap shared by SARS-CoV and SARS-CoV-2, consistent with the shared ACE2 predicted receptor. The host interactome, linked to the S-glycoprotein of SARS-CoV and MERS-CoV, mainly highlighted innate immunity pathway components, such as Toll Like receptors, cytokines and chemokines. Conclusions In this paper, we developed a network-based model with the aim to define molecular aspects of pathogenic phenotypes in HCoV infections. The resulting pattern may facilitate the process of structure-guided pharmaceutical and diagnostic research with the prospect to identify potential new biological targets.

ACS Style

Francesco Messina; Emanuela Giombini; Chiara Agrati; Francesco Vairo; Tommaso Ascoli Bartoli; Samir Al Moghazi; Mauro Piancentini; Franco Locatelli; Gary Kobinger; Markus Maeurer; Alimuddin Zumla; Maria R. Capobianchi; Francesco Nicola Lauria; Giuseppe Ippolito. COVID-19: Viral-host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection. 2020, 1 .

AMA Style

Francesco Messina, Emanuela Giombini, Chiara Agrati, Francesco Vairo, Tommaso Ascoli Bartoli, Samir Al Moghazi, Mauro Piancentini, Franco Locatelli, Gary Kobinger, Markus Maeurer, Alimuddin Zumla, Maria R. Capobianchi, Francesco Nicola Lauria, Giuseppe Ippolito. COVID-19: Viral-host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection. . 2020; ():1.

Chicago/Turabian Style

Francesco Messina; Emanuela Giombini; Chiara Agrati; Francesco Vairo; Tommaso Ascoli Bartoli; Samir Al Moghazi; Mauro Piancentini; Franco Locatelli; Gary Kobinger; Markus Maeurer; Alimuddin Zumla; Maria R. Capobianchi; Francesco Nicola Lauria; Giuseppe Ippolito. 2020. "COVID-19: Viral-host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection." , no. : 1.

Review
Published: 01 March 2019 in International Journal of Infectious Diseases
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To make an informed viewpoint on the usefulness of Tuberculin Skin test (TST) compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of Latent TB Infection (LTBI) in different geographical settings. We reviewed the current literature on TST compared to IGRA, including national implementation of WHO LTBI recommendations and retrospective data over the past 7 years at the National Institute for Infectious Diseases "L. Spallanzani" as indirect indicator of usage of both tests under actual programmatic conditions. Current national guidelines vary considerably, reflecting the uncertainty and rapidly evolving evidence about the potential use of these tests. Data from Institute "L. Spallanzani" showed IGRA concordance in TST positive subjects only in 54.74% of subjects, while there was strong concordance between two tests in TST negative subjects (93.78%). Neither IGRAs nor TST can distinguish active TB from LTBI. TST will continue to be clinically useful in low and high TB endemic areas until more accurate and predictive tests will become available. Clinical judgment remains fundamental in choosing between IGRA/TST tests and interpreting their results.

ACS Style

Gina Gualano; Paola Mencarini; Francesco Nicola Lauria; Fabrizio Palmieri; Sayoki Mfinanga; Peter Mwaba; Jeremiah Chakaya; Professor Sir Alimuddin Zumla; Giuseppe Ippolito. Tuberculin skin test – Outdated or still useful for Latent TB infection screening? International Journal of Infectious Diseases 2019, 80, S20 -S22.

AMA Style

Gina Gualano, Paola Mencarini, Francesco Nicola Lauria, Fabrizio Palmieri, Sayoki Mfinanga, Peter Mwaba, Jeremiah Chakaya, Professor Sir Alimuddin Zumla, Giuseppe Ippolito. Tuberculin skin test – Outdated or still useful for Latent TB infection screening? International Journal of Infectious Diseases. 2019; 80 ():S20-S22.

Chicago/Turabian Style

Gina Gualano; Paola Mencarini; Francesco Nicola Lauria; Fabrizio Palmieri; Sayoki Mfinanga; Peter Mwaba; Jeremiah Chakaya; Professor Sir Alimuddin Zumla; Giuseppe Ippolito. 2019. "Tuberculin skin test – Outdated or still useful for Latent TB infection screening?" International Journal of Infectious Diseases 80, no. : S20-S22.

Journal article
Published: 01 October 2016 in The new microbiologica
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Daniele Macciocchi; Simone Lanini; Francesco Vairo; Alimuddin Zumla; Luiz Tadeu Moraes Figueiredo; Francesco Nicola Lauria; Gino Strada; Philippe Brouqui; Vincenzo Puro; Sanjeev Krishna; Peter Kremsner; Paola Scognamiglio; Carsten Köhler; Emanuele Nicastri; Antonino Di Caro; Rodolfo Maria Cieri; John P A Ioannidis; Gary Kobinger; Marcelo Nascimento Burattini; Giuseppe Ippolito. Short-term economic impact of the Zika virus outbreak. The new microbiologica 2016, 39, 287 -289.

AMA Style

Daniele Macciocchi, Simone Lanini, Francesco Vairo, Alimuddin Zumla, Luiz Tadeu Moraes Figueiredo, Francesco Nicola Lauria, Gino Strada, Philippe Brouqui, Vincenzo Puro, Sanjeev Krishna, Peter Kremsner, Paola Scognamiglio, Carsten Köhler, Emanuele Nicastri, Antonino Di Caro, Rodolfo Maria Cieri, John P A Ioannidis, Gary Kobinger, Marcelo Nascimento Burattini, Giuseppe Ippolito. Short-term economic impact of the Zika virus outbreak. The new microbiologica. 2016; 39 (4):287-289.

Chicago/Turabian Style

Daniele Macciocchi; Simone Lanini; Francesco Vairo; Alimuddin Zumla; Luiz Tadeu Moraes Figueiredo; Francesco Nicola Lauria; Gino Strada; Philippe Brouqui; Vincenzo Puro; Sanjeev Krishna; Peter Kremsner; Paola Scognamiglio; Carsten Köhler; Emanuele Nicastri; Antonino Di Caro; Rodolfo Maria Cieri; John P A Ioannidis; Gary Kobinger; Marcelo Nascimento Burattini; Giuseppe Ippolito. 2016. "Short-term economic impact of the Zika virus outbreak." The new microbiologica 39, no. 4: 287-289.

Case report
Published: 16 October 2015 in BMC Infectious Diseases
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In the current Ebola epidemic in Western Africa, many healthcare workers have become infected. Some of these have been medically evacuated to hospitals in Europe and the USA. These clinical experiences provide unique insights into the course of Ebola virus disease under optimized condition within high level isolation units. A 50-year-old Caucasian male physician contracted Ebola virus diseases in Sierra Leone and was medically evacuated to Italy. Few days after the admission the course of the illness was characterized by severe gastro-intestinal symptoms followed by respiratory failure, accompanied by pulmonary infiltration and high Ebola viral load in the bronchial aspirate and Plasmodium vivax co-infection. The patient received experimental antiviral therapy with favipiravir, convalescent plasma and ZMAb. Ebola viral load started to steadily decrease in the blood after ZMAb administration and became undetectable by day 19 after admission, while it persisted longer in urine samples. No temporal association was observed between viral load decay in plasma and administration of favipiravir. The patient completely recovered and was discharged 39 days after admission. This is the first case of Ebola-related interstitial pneumonia documented by molecular testing of lung fluid specimens. This reports underlines the pivotal role of fluid replacement and advanced life support with mechanical ventilation in the management of patients with Ebola virus diseases respiratory failure. Beside our finding indicates a close temporal association between administration of cZMAb and Ebola virus clearance from blood.

ACS Style

Nicola Petrosillo; Inmi Ebov Team; Emanuele Nicastri; Simone Lanini; Maria Rosaria Capobianchi; Antonino Di Caro; Mario Antonini; Vincenzo Puro; Francesco Nicola Lauria; Nakono Shindo; Nicola Magrini; Gary P. Kobinger; Giuseppe Ippolito. Ebola virus disease complicated with viral interstitial pneumonia: a case report. BMC Infectious Diseases 2015, 15, 1 -9.

AMA Style

Nicola Petrosillo, Inmi Ebov Team, Emanuele Nicastri, Simone Lanini, Maria Rosaria Capobianchi, Antonino Di Caro, Mario Antonini, Vincenzo Puro, Francesco Nicola Lauria, Nakono Shindo, Nicola Magrini, Gary P. Kobinger, Giuseppe Ippolito. Ebola virus disease complicated with viral interstitial pneumonia: a case report. BMC Infectious Diseases. 2015; 15 (1):1-9.

Chicago/Turabian Style

Nicola Petrosillo; Inmi Ebov Team; Emanuele Nicastri; Simone Lanini; Maria Rosaria Capobianchi; Antonino Di Caro; Mario Antonini; Vincenzo Puro; Francesco Nicola Lauria; Nakono Shindo; Nicola Magrini; Gary P. Kobinger; Giuseppe Ippolito. 2015. "Ebola virus disease complicated with viral interstitial pneumonia: a case report." BMC Infectious Diseases 15, no. 1: 1-9.

Journal article
Published: 22 September 2013 in BMC Public Health
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In Italy the proportion of cases of tuberculosis in persons originating from high-prevalence countries has been increasing in the last decade. We designed a study to assess adherence to and yield of a tuberculosis screening programme based on symptom screening conducted at primary care centres for regular and irregular immigrants and refugees/asylum seekers.

ACS Style

Monica Sañé Schepisi; Gina Gualano; Claudia Fellus; Nazario Bevilacqua; Marco Vecchi; Pierluca Piselli; Giuliana Battagin; Giulia Silvestrini; Andrea Attanasio; Alberto Vela; Giorgia Rocca; Alessandro Rinaldi; Pietro Benedetti; Salvatore Geraci; Francesco Nicola Lauria; Enrico Girardi. Tuberculosis case finding based on symptom screening among immigrants, refugees and asylum seekers in Rome. BMC Public Health 2013, 13, 872 -872.

AMA Style

Monica Sañé Schepisi, Gina Gualano, Claudia Fellus, Nazario Bevilacqua, Marco Vecchi, Pierluca Piselli, Giuliana Battagin, Giulia Silvestrini, Andrea Attanasio, Alberto Vela, Giorgia Rocca, Alessandro Rinaldi, Pietro Benedetti, Salvatore Geraci, Francesco Nicola Lauria, Enrico Girardi. Tuberculosis case finding based on symptom screening among immigrants, refugees and asylum seekers in Rome. BMC Public Health. 2013; 13 (1):872-872.

Chicago/Turabian Style

Monica Sañé Schepisi; Gina Gualano; Claudia Fellus; Nazario Bevilacqua; Marco Vecchi; Pierluca Piselli; Giuliana Battagin; Giulia Silvestrini; Andrea Attanasio; Alberto Vela; Giorgia Rocca; Alessandro Rinaldi; Pietro Benedetti; Salvatore Geraci; Francesco Nicola Lauria; Enrico Girardi. 2013. "Tuberculosis case finding based on symptom screening among immigrants, refugees and asylum seekers in Rome." BMC Public Health 13, no. 1: 872-872.

Comparative study
Published: 16 September 2011 in BMC Infectious Diseases
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Computer Tomography (CT) is considered the gold standard for assessing the morphological changes of lung parenchyma. Although novel CT techniques have substantially decreased the radiation dose, radiation exposure is still high. Magnetic Resonance Imaging (MRI) has been established as a radiation- free alternative to CT for several lung diseases, but its role in infectious diseases still needs to be explored further. Therefore, the purpose of our study was to compare MRI with high resolution CT (HRCT) for assessing pulmonary tuberculosis.

ACS Style

Elisa Busi Rizzi; Vincenzo Schinina'; Massimo Cristofaro; Delia Goletti; Fabrizio Palmieri; Nazario Bevilacqua; Francesco N Lauria; Enrico Girardi; Corrado Bibbolino. Detection of Pulmonary tuberculosis: comparing MR imaging with HRCT. BMC Infectious Diseases 2011, 11, 243 -243.

AMA Style

Elisa Busi Rizzi, Vincenzo Schinina', Massimo Cristofaro, Delia Goletti, Fabrizio Palmieri, Nazario Bevilacqua, Francesco N Lauria, Enrico Girardi, Corrado Bibbolino. Detection of Pulmonary tuberculosis: comparing MR imaging with HRCT. BMC Infectious Diseases. 2011; 11 (1):243-243.

Chicago/Turabian Style

Elisa Busi Rizzi; Vincenzo Schinina'; Massimo Cristofaro; Delia Goletti; Fabrizio Palmieri; Nazario Bevilacqua; Francesco N Lauria; Enrico Girardi; Corrado Bibbolino. 2011. "Detection of Pulmonary tuberculosis: comparing MR imaging with HRCT." BMC Infectious Diseases 11, no. 1: 243-243.

Journal article
Published: 23 May 2011 in BMC Infectious Diseases
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The first influenza pandemic of the 21th century was ignited by a new strain of influenza A virus (A/H1N1pdm). Specific patient groups, including those with comorbidities, pregnant women, young children, older and immunocompromised patients, are at increased risk for serious influenza-related disease. This study was aimed at investigating the influence of clinical presentation, antiviral treatment and possible drug resistance-associated mutations, on the extent and duration of viral shedding in patients infected with A/H1N1pdm. An observational study was performed, based on retrospective review of clinical and laboratory records of patients who were hospitalized for A/H1N1pdm infection at the National Institute for Infectious Diseases "L. Spallanzani", Rome, Italy, between April 24 and December 31, 2009. Among 119 hospitalized patients, 39 were selected for a post hoc analysis, based on the availability of serial nasopharyngeal swabs samples and related information. Eleven out of the 39 study patients (28.2%) presented with pneumonia; 29 (74.4%) received antiviral treatment. Patients with pneumonia were significantly older than patients without pneumonia. The mean values of viral RNA concentration were not significantly increased in patients with pneumonia, but a significant increase in the duration of viral shedding was observed as compared to patients without pneumonia. In patients receiving antivirals, the viral RNA concentration was significantly reduced in comparison to untreated patients at days 4-5 after symptom onset, while the overall duration of viral shedding was only marginally affected. A significant correlation between duration of viral shedding and time elapsed between symptom onset and therapy start was observed, with a significant reduction of days of viral shedding when therapy was initiated within 2 days of symptoms appearance. No known drug resistance mutations were detected in patients with prolonged viral shedding. Our results show that severe respiratory illness is associated with delayed virus clearance in patients with A/H1N1pdm infection. Antivirals caused an early reduction of viral load, but only marginally affected the overall duration of shedding. Prolonged shedding was not associated with the emergence of strains carrying known drug-resistance mutations.

ACS Style

Silvia Meschi; Marina Selleri; Eleonora Lalle; Licia Bordi; Maria B Valli; Federica Ferraro; Giuseppe Ippolito; Nicola Petrosillo; Francesco N Lauria; Maria Rosaria Capobianchi. Duration of viral shedding in hospitalized patients infected with pandemic H1N1. BMC Infectious Diseases 2011, 11, 140 -140.

AMA Style

Silvia Meschi, Marina Selleri, Eleonora Lalle, Licia Bordi, Maria B Valli, Federica Ferraro, Giuseppe Ippolito, Nicola Petrosillo, Francesco N Lauria, Maria Rosaria Capobianchi. Duration of viral shedding in hospitalized patients infected with pandemic H1N1. BMC Infectious Diseases. 2011; 11 (1):140-140.

Chicago/Turabian Style

Silvia Meschi; Marina Selleri; Eleonora Lalle; Licia Bordi; Maria B Valli; Federica Ferraro; Giuseppe Ippolito; Nicola Petrosillo; Francesco N Lauria; Maria Rosaria Capobianchi. 2011. "Duration of viral shedding in hospitalized patients infected with pandemic H1N1." BMC Infectious Diseases 11, no. 1: 140-140.

Journal article
Published: 01 April 2011 in Journal of Medical Case Reports
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The influenza virus infection may be severe in non-immune people. Common complications of influenza virus include upper and lower respiratory tract infections, otitis media, myocarditis, acute respiratory distress syndrome and multi-organ failure. There have been cases of vasculitis following influenza vaccination, and rash and acute purpura may occur in certain viral infections. To the best of our knowledge, there are no reports concerning cases of systemic vasculitis associated with pandemic 2009 (H1N1) infection.

ACS Style

Rocco Urso; Nazario Bevilacqua; Marco Gentile; Daniele Biagioli; Francesco Nicola Lauria. Pandemic 2009 H1N1 virus infection associated with purpuric skin lesions: a case report. Journal of Medical Case Reports 2011, 5, 132 -132.

AMA Style

Rocco Urso, Nazario Bevilacqua, Marco Gentile, Daniele Biagioli, Francesco Nicola Lauria. Pandemic 2009 H1N1 virus infection associated with purpuric skin lesions: a case report. Journal of Medical Case Reports. 2011; 5 (1):132-132.

Chicago/Turabian Style

Rocco Urso; Nazario Bevilacqua; Marco Gentile; Daniele Biagioli; Francesco Nicola Lauria. 2011. "Pandemic 2009 H1N1 virus infection associated with purpuric skin lesions: a case report." Journal of Medical Case Reports 5, no. 1: 132-132.

Comparative study
Published: 22 November 2010 in BMC Infectious Diseases
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Blood cytokines and chemokines have been proposed as biomarkers for tuberculosis (TB). Recently, some immune mediators found in the urine of patients with renal dysfunctions have also been suggested as potential biomarkers. Finding biomarkers for TB in urine would present several advantages over blood in terms of collection and safety. The objective of this study was to investigate the presence of cytokines and chemokines in the urine of patients with pulmonary TB at the time of diagnosis. In a subgroup, the evaluation was also performed during TB treatment and at therapy completion. Patients with lung diseases other than TB, and healthy subjects were also enrolled.

ACS Style

Angela Cannas; Ludovica Calvo; Teresa Chiacchio; Gilda Cuzzi; Valentina Vanini; Francesco N Lauria; Luigia Pucci; Enrico Girardi; Delia Goletti. IP-10 detection in urine is associated with lung diseases. BMC Infectious Diseases 2010, 10, 333 -333.

AMA Style

Angela Cannas, Ludovica Calvo, Teresa Chiacchio, Gilda Cuzzi, Valentina Vanini, Francesco N Lauria, Luigia Pucci, Enrico Girardi, Delia Goletti. IP-10 detection in urine is associated with lung diseases. BMC Infectious Diseases. 2010; 10 (1):333-333.

Chicago/Turabian Style

Angela Cannas; Ludovica Calvo; Teresa Chiacchio; Gilda Cuzzi; Valentina Vanini; Francesco N Lauria; Luigia Pucci; Enrico Girardi; Delia Goletti. 2010. "IP-10 detection in urine is associated with lung diseases." BMC Infectious Diseases 10, no. 1: 333-333.

Journal article
Published: 01 September 2010 in Journal of Infectious Diseases
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Background. Pandemic A/H1N1v influenza is characterized by a mild clinical course. However, a small subset of patients develops a rapidly progressive course caused by primary viral pneumonia or secondary bacterial infections that, in many cases, lead to death due to respiratory failure. The aim of the present study was to analyze the involvement of the immune response in the clinical presentation of H1N1v influenza. Methods. The differentiation and functional capability of T cells from H1N1v-infected patients presenting with either mild disease (n = 22) or severe or fatal disease (n = 6) were compared. Moreover, plasma cytokines and chemokines were quantified Results. T cells from H1N1v-infected patients presenting with a severe clinical course resulted in impaired effector cell differentiation and failed to respond to mitogenic stimulation. T cell anergy was strictly associated with a severe acute phase of infection, but T cells could be restored in patients able to recover. Of interest, massive expression of CD95 marker was found on anergic T cells, suggesting an apoptosis-related mechanism. Finally, lower plasma levels of interferon-a and monocyte chemoattractant protein-1 were found in patients with a worse clinical course of influenza, suggesting impaired production of these cytokines. Conclusions. Our results show a strict association between host immune competence and the severity of the clinical course of H1N1v infection. By monitoring host functional response, patients with an enhanced risk of developing influenza-associated severe complications could be identified in a timely manner.

ACS Style

Chiara Agrati; Cristiana Gioia; Eleonora Lalle; Eleonora Cimini; Concetta Castilletti; Orlando Armignacco; Francesco Nicola Lauria; Federica Ferraro; Mario Antonini; Giuseppe Ippolito; Maria Rosaria Capobianchi; Federico Martini. Association of Profoundly Impaired Immune Competence in H1N1v‐Infected Patients with a Severe or Fatal Clinical Course. Journal of Infectious Diseases 2010, 202, 681 -689.

AMA Style

Chiara Agrati, Cristiana Gioia, Eleonora Lalle, Eleonora Cimini, Concetta Castilletti, Orlando Armignacco, Francesco Nicola Lauria, Federica Ferraro, Mario Antonini, Giuseppe Ippolito, Maria Rosaria Capobianchi, Federico Martini. Association of Profoundly Impaired Immune Competence in H1N1v‐Infected Patients with a Severe or Fatal Clinical Course. Journal of Infectious Diseases. 2010; 202 (5):681-689.

Chicago/Turabian Style

Chiara Agrati; Cristiana Gioia; Eleonora Lalle; Eleonora Cimini; Concetta Castilletti; Orlando Armignacco; Francesco Nicola Lauria; Federica Ferraro; Mario Antonini; Giuseppe Ippolito; Maria Rosaria Capobianchi; Federico Martini. 2010. "Association of Profoundly Impaired Immune Competence in H1N1v‐Infected Patients with a Severe or Fatal Clinical Course." Journal of Infectious Diseases 202, no. 5: 681-689.

Journal article
Published: 01 October 2009 in The new microbiologica
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Silvia Pittalis; Francesco Maria Fusco; Simone Lanini; Carla Nisii; Vincenzo Puro; Francesco Nicola Lauria; Giuseppe Ippolito. Case definition for Ebola and Marburg haemorrhagic fevers: a complex challenge for epidemiologists and clinicians. The new microbiologica 2009, 32, 1 .

AMA Style

Silvia Pittalis, Francesco Maria Fusco, Simone Lanini, Carla Nisii, Vincenzo Puro, Francesco Nicola Lauria, Giuseppe Ippolito. Case definition for Ebola and Marburg haemorrhagic fevers: a complex challenge for epidemiologists and clinicians. The new microbiologica. 2009; 32 (4):1.

Chicago/Turabian Style

Silvia Pittalis; Francesco Maria Fusco; Simone Lanini; Carla Nisii; Vincenzo Puro; Francesco Nicola Lauria; Giuseppe Ippolito. 2009. "Case definition for Ebola and Marburg haemorrhagic fevers: a complex challenge for epidemiologists and clinicians." The new microbiologica 32, no. 4: 1.

English abstract
Published: 01 September 2007 in Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive
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Franceso Maria Fusco; Silvia Pittalis; Vincenzo Puro; Francesco Nicola Lauria; Giuseppe Ippolito. [Pandemic influenza: impact on health care facilities in Lazio, Italy, and the role of hospitals in pandemic management]. Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 2007, 15, 1 .

AMA Style

Franceso Maria Fusco, Silvia Pittalis, Vincenzo Puro, Francesco Nicola Lauria, Giuseppe Ippolito. [Pandemic influenza: impact on health care facilities in Lazio, Italy, and the role of hospitals in pandemic management]. Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive. 2007; 15 (3):1.

Chicago/Turabian Style

Franceso Maria Fusco; Silvia Pittalis; Vincenzo Puro; Francesco Nicola Lauria; Giuseppe Ippolito. 2007. "[Pandemic influenza: impact on health care facilities in Lazio, Italy, and the role of hospitals in pandemic management]." Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 15, no. 3: 1.