(1) Objective: To review the criteria proposed by Cerero-Lapiedra et al. and to retrospectively identify the under-diagnosed disease in patients diagnosed with proliferative verrucous leukoplakia. (2) Materials and methods: In this study, we included patients who were diagnosed with leukoplakia (histological label consistent with the clinical diagnosis, n = 95), and cases with a final diagnosis within the spectrum of proliferative verrucous leukoplakia (n = 110) as defined by Batsakis et al. We applied the criteria proposed by Cerero-Lepiedra et al. to screen for the possible cases of proliferative verrucous leukoplakia. (3) Results: Although many of our patients satisfied specific isolated criteria, only 11 cases satisfied specific combinations of the guidelines to satisfy a diagnosis of proliferative verrucous leukoplakia. However, due to the lack of follow-up data, the disease is not confirmed in these 11 cases. (4) Conclusion: A limited number of cases of proliferative verrucous leukoplakia were diagnosed using the criteria given by Cerero-Lapiedra et al. The true natural history of the disease could not be studied due to the lack of follow-up data. (5) Clinical relevance: Proliferative verrucous leukoplakia presenting as hyperkeratosis or mild epithelial dysplasia are often not followed up, and they subsequently transform into carcinoma. Thus, clinicians must be vigilant whenever they encounter leukoplakia, especially with multifocal presentations. In such cases, the follow-up data are the key to understanding the true nature of the disease entity.

Debonding and detachment of artificial teeth from the denture base is frequently encountered in prosthodontic practice. This study aims to assess the effect of modifications in the ridge-lap surface of denture teeth with various combinations of mechanical and chemical surface treatments with hydrofluoric acid on bond strength with the acrylic denture base resin and to identify the failure modes (adhesive, cohesive, or mixed). Seventy acrylic resin teeth samples were randomly divided into seven groups (n = 10): a control group (unmodified) and six treatment groups, in which various combinations of mechanical and chemical surface treatments were performed. Then, these teeth were attached to a heat-cured denture base resin block at 45° angulation. The acrylized test samples were thermocycled, and the compressive bond strength was evaluated using a universal mechanical testing machine. The results suggest that roughening with diamond burs yields the highest bond strength, whereas etching/grooving and air abrasion result in the lowest bond strength. Acid etching complemented air abrasion to improve bond strength, while negative effects were noted with acid etching in other groups. Furthermore, roughening at the neck portion of the acrylic teeth can be used by the manufacturing companies as a standard to provide higher bond strength while maintaining the esthetics of the anterior teeth.

A well-made provisional fixed prosthesis must present as a preview of the future prosthesis and may also augment the health of the abutments and periodontium. Provisional restorations have been prepared chairside with polymethyl methacrylate (PMMA) since time immemorial. CAD/CAM additive and subtractive technologies have revolutionized the fabrication of interim restorations in dental clinics. The current literature lacks substantial data about retention of provisional crowns manufactured using Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) additive and subtractive techniques with various temporary cements. This in vitro study aims to assess and compare the retention of temporary/provisional anterior crowns based on the combined effect of different digital manufacturing techniques, preparation tapers, and the temporary cements used for cementation. Two maxillary right central incisor typodont teeth were prepared to receive all-ceramic crowns, one with a 10-degree taper and the other with a 20-degree taper. Forty 3D-printed working models with the 10° taper and forty working models with the 20° taper were prepared to receive the temporary crowns. Forty temporary crowns were 3D-printed and forty crowns were milled (20 from each taper group). Kerr Temp-Bond NE conventional cement and Kerr Temp-Bond clear cement were used for cementation in the two groups. The number of samples per test group was 10. All samples were thermocycled and subjected to a universal testing machine to measure the pull-off force until retention loss (N) under tension with a crosshead speed of 5 mm/min. The pull-off force was highest for group 8, i.e., 3D-printed crowns with a 20° taper and cemented with Kerr Temp-Bond clear cement, followed by groups 6, 7, 4, 5, 3, and 2. Group 1, i.e., milled crowns with 10° taper cemented with Kerr Temp-Bond NE conventional cement, exhibited the lowest pull-off retentive force. The clinical selection of long-term provisional crowns fabricated using 3D-printing technology, prepared with 10° or 20° tapers, and cemented with clear cement, is the most favorable in terms of the retention of provisional crowns. 3D-printed provisional crowns can be used as an alternative to conventional and CAD/CAM-milled crowns for long-term provisionalization.

Background/Objectives: Clinically node-negative (cN0) neck management in cT1–T2 oral cavity squamous cell carcinoma continues to be a subject of controversy. The eighth edition AJCC has incorporated depth of invasion (DOI) as a significant factor in staging and consideration for possible neck dissection. Establishment of accurate DOI thresholds and their clinical relevance is crucial to maximize oncological outcomes with reduced unnecessary morbidity. Methods: A comprehensive analysis of clinical research assessing elective neck dissection (END) techniques in oral cavity cancers classified by DOI in cT1–T2N0 patients was carried out. The included studies reported occult nodal metastasis rates, overall survival, disease-specific survival, disease-free survival, and regional control. Results: With hazard ratios favoring END for overall survival (HR 0.64; 95% CI 0.45–0.92) and disease-free survival (HR 0.45; 95% CI 0.34–0.59), elective neck dissection provided advantages in both survival and regional control. In a national registry, DOI ≥ 5 mm independently raised the risk of nodal failure (HR 2.099; 95% CI 1.346–3.271), while END enhanced neck control in comparison to observation (HR 1.749; 95% CI 1.141–2.680). With ROC-derived cut-offs like 4.59 mm producing positive predictive values for nodal metastasis up to 41.7%, diagnostic thresholds clustered around 4 mm. Conclusions: Under DOI guidance, elective neck dissection consistently showed oncologic benefit, with practical thresholds convergent around 4 mm for sites in the mixed oral cavity and 3 mm for high-risk subsites. The synthesized results confirmed that DOI is the primary determinant of END when combined with histopathologic and subsite-specific risk factors.

Background: OSMF is an oral precancerous condition with a high potential for malignant transformation. The main etiologic factor linked to OSMF is gutkha and tobacco chewing. Management of OSMF includes various therapies and drugs where the use of antioxidants has proven to be efficacious. Aim: The present study was conducted to compare and assess the efficacy of Lycopene antioxidant alone to its combination with intralesional injection of Hyaluronidase for managing the subjects with OSMF.Material and Method: The study included 54 subjects having stage 2 OSMF and were divided into 2 groups where the group I subjects were given lycopene daily in a dose of 8mg in two equal doses, whereas, group II subjects were given lycopene daily in a dose of 8mg combined with intralesional hyaluronidase injection of 1500 IU twice in a week for 3 months. VAS and inter-incisal mouth opening were assessed at baseline and 90th day after treatment completion.Results: At baseline, interincisal opening in Group I was 25.18±3.03mm and was 24.56±3.92mm in Group II. This difference was statistically non-significant with p=0.5184. On the 90th day, the last day of the study, interincisal opening in Group I was 29.34±3.19mm, whereas, in Group II was 32.39±3.24mm.