Magnetic resonance imaging (MRI) is corrupted by Rician noise, which is image dependent and computed from both real and imaginary images. Rician noise makes image-based quantitative measurement difficult. The non-local means (NLM) filter has been proven to be effective against additive noise. Considering the characteristics of both Rician noise and the NLM filter, this study proposes a frame for a pre-smoothing NLM (PSNLM) filter combined with image transformation. In the PSNLM frame, noisy MRI is first transformed into an image in which noise can be treated as additive noise. Second, the transformed MRI is pre-smoothed via a traditional denoising method. Third, the NLM filter is applied to the transformed MRI, with weights that are computed from the pre-smoothed image. Finally, inverse transformation is performed on the denoised MRI to obtain the denoising results. To test the performance of the proposed method, both simulated and real patient data are used, and various pre-smoothing (Gaussian, median, and anisotropic filters) and image transformation [squared magnitude of the MRI, and forward and inverse variance-stabilizing trans-formations (VST)] methods are used to reduce noise. The performance of the proposed method is evaluated through visual inspection and quantitative comparison of the peak signal-to-noise ratio of the simulated data. The real data include Alzheimer’s disease patients and normal controls. For the real patient data, the performance of the proposed method is evaluated by detecting atrophy regions in the hippocampus and the parahippocampal gyrus. The comparison of the experimental results demonstrates that using a Gaussian pre-smoothing filter and VST produce the best results for the peak signal-to-noise ratio (PSNR) and atrophy detection.

Precise automatic vertebra segmentation in computed tomography (CT) images is important for the quantitative analysis of vertebrae-related diseases but remains a challenging task due to high variation in spinal anatomy among patients. In this paper, we propose a deep learning approach for automatic CT vertebra segmentation named patch-based deep belief networks (PaDBNs). Our proposed PaDBN model automatically selects the features from image patches and then measures the differences between classes and investigates performance. The region of interest (ROI) is obtained from CT images. Unsupervised feature reduction contrastive divergence algorithm is applied for weight initialization, and the weights are optimized by layers in a supervised fine-tuning procedure. The discriminative learning features obtained from the steps above are used as input of a classifier to obtain the likelihood of the vertebrae. Experimental results demonstrate that the proposed PaDBN model can considerably reduce computational cost and produce an excellent performance in vertebra segmentation in terms of accuracy compared with state-of-the-art methods.

Automatic liver tumor segmentation plays a key role in radiation therapy of hepatocellular carcinoma. In this paper, we propose a novel densely connected U-Net model with criss-cross attention (CC-DenseUNet) to segment liver tumors in computed tomography (CT) images. The dense interconnections in CC-DenseUNet ensure the maximum information flow between encoder layers when extracting intra-slice features of liver tumors. Moreover, the criss-cross attention is used in CC-DenseUNet to efficiently capture only the necessary and meaningful non-local contextual information of CT images containing liver tumors. We evaluated the proposed CC-DenseUNet on the LiTS dataset and the 3DIRCADb dataset. Experimental results show that the proposed method reaches the state-of-the-art performance for liver tumor segmentation. We further experimentally demonstrate the robustness of the proposed method on a clinical dataset comprising 20 CT volumes.