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Zuh-Kyung Seong
Natural Medicine Research Center, KRIBB, 30 Yeongudanji-ro, Ochang-eup, Cheongju-si, Chungbuk 28116, Korea

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Journal article
Published: 28 May 2020 in Plants
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Flavonoids, including maackiain (Maac) from Sophora flavescens Aiton roots, have many pharmacological properties, such as antitumor, antimicrobial, and antifungal activities. This research aimed to develop an in vitro plant and callus culture system for S. flavescens for the purpose of generating an alternative production system for enhancing Maac production, as Maac is usually present in very small amounts in S. flavescens’ roots. We arranged the optimal conditions of different tissues of S. flavescens and supplemented the medium with various plant growth regulators (PGRs). The highest induction and proliferation rates of callus was shown in combination treatments of all concentrations of thidiazuron (TDZ) and picloram. In addition, calli induced with leaf explants cultured on 2.0 mg/L picloram and 0.5 mg/L 6-benzyladenine (BA) in Murashige and Skoog (MS) medium had the highest accumulation of the active metabolite Maac. In vitro shoots were regenerated on medium containing combinations of TDZ and α-Naphthalene acetic acid (NAA). A reliable protocol for the mass production of secondary metabolites using a callus culture of S. flavescens was successfully established.

ACS Style

Ji-Sun Park; Zuh-Kyung Seong; Mi-Sun Kim; Jang-Ho Ha; Ki-Beom Moon; Hyo-Jun Lee; Hyeong-Kyu Lee; Jae-Heung Jeon; Sang Un Park; Hyun-Soon Kim. Production of Flavonoids in Callus Cultures of Sophora flavescens Aiton. Plants 2020, 9, 688 .

AMA Style

Ji-Sun Park, Zuh-Kyung Seong, Mi-Sun Kim, Jang-Ho Ha, Ki-Beom Moon, Hyo-Jun Lee, Hyeong-Kyu Lee, Jae-Heung Jeon, Sang Un Park, Hyun-Soon Kim. Production of Flavonoids in Callus Cultures of Sophora flavescens Aiton. Plants. 2020; 9 (6):688.

Chicago/Turabian Style

Ji-Sun Park; Zuh-Kyung Seong; Mi-Sun Kim; Jang-Ho Ha; Ki-Beom Moon; Hyo-Jun Lee; Hyeong-Kyu Lee; Jae-Heung Jeon; Sang Un Park; Hyun-Soon Kim. 2020. "Production of Flavonoids in Callus Cultures of Sophora flavescens Aiton." Plants 9, no. 6: 688.

Journal article
Published: 28 September 2016 in Molecules
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Melanin plays an important role in protecting the skin against ultraviolet light and is responsible for skin color. However, overproduction of melanin is related to several skin disorders, such as age spots, freckles, café au lait spots, Becker’s nevus and other hyperpigmentation syndromes. The aim of this study was to identify the effects of kaempferol-7-O-β-d-glucuronide (K7G) and tilianin, isolated from Cryptotaenia japonica, on melanogenesis and their mechanisms of action in murine B16 melanoma cells. The α-melanocyte-stimulating hormone (α-MSH)-induced melanin production was significantly inhibited by K7G and tilianin in a dose-dependent manner. The effects of these compounds on the signaling pathway of melanogenesis were examined. K7G and tilianin downregulated the expression of microphthalmia-associated transcription factor (MITF) and melanocyte-specific enzymes, i.e., tyrosinase and TRP1. These compounds also inhibited the phosphorylation of cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB) in a dose-dependent manner. In addition, these compounds increased the phosphorylation of extracellular signal-regulated kinase (ERK) but decreased the phosphorylation of c-Jun N-terminal kinase (JNK) in B16 cells. Based on the above results, the anti-melanogenic effects of these compounds are caused by suppression of the MAPK signaling pathway through the down-regulation of α-MSH-induced CREB accumulation. This finding suggests that K7G and tilianin may be good candidates for further research to develop therapeutic agents for hyperpigmentation diseases.

ACS Style

Zuh-Kyung Seong; Sung-Yoon Lee; Amrit Poudel; Sei-Ryang Oh; Hyeong-Kyu Lee. Constituents of Cryptotaenia japonica Inhibit Melanogenesis via CREB- and MAPK-Associated Signaling Pathways in Murine B16 Melanoma Cells. Molecules 2016, 21, 1296 .

AMA Style

Zuh-Kyung Seong, Sung-Yoon Lee, Amrit Poudel, Sei-Ryang Oh, Hyeong-Kyu Lee. Constituents of Cryptotaenia japonica Inhibit Melanogenesis via CREB- and MAPK-Associated Signaling Pathways in Murine B16 Melanoma Cells. Molecules. 2016; 21 (10):1296.

Chicago/Turabian Style

Zuh-Kyung Seong; Sung-Yoon Lee; Amrit Poudel; Sei-Ryang Oh; Hyeong-Kyu Lee. 2016. "Constituents of Cryptotaenia japonica Inhibit Melanogenesis via CREB- and MAPK-Associated Signaling Pathways in Murine B16 Melanoma Cells." Molecules 21, no. 10: 1296.

Journal article
Published: 26 April 2016 in Archives of Pharmacal Research
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Three new phenylacylphenol derivatives, stewartianol (1), deoxystewartianol-4′-O-arabinoglucoside (2), and stewartianol-3-O-glucoside (3), along with nine known compounds, methylesculin (4), fraxoside (5), fraxetin (6), scopletin (7), (+)-dihydromyricetin (8), (+)-taxifolin-7-O-β-d-glucose (9), (+)-taxifolin (10), (+)-dihydrokaempferol-7-O-β-d-glucose (11), and 3-acetyl-ursolic acid (12), were isolated from the twigs of Stewartia pseudocamellia; commonly used as folk medicine in Korea. The structures of the isolated compounds were identified using spectroscopic analysis, including 1D, 2D NMR, MS and compared with published data. The compounds were tested for their anti-melanogenic activity in cultured murine B16 melanoma cells. Stewartianol (1) and stewartianol-3-O-glucoside (3) showed an inhibitory effect significantly on melanogenesis in a concentration-dependent manner.

ACS Style

Zuh-Kyung Seong; Hui-Seong Kim; Yu-Mi Won; Jae-Lim Kim; Hyuk-Hwan Song; Doo-Young Kim; Sei-Ryang Oh; Hyun-Woo Cho; Jung-Hee Cho; Hyeong-Kyu Lee. Phenylacylphenol derivatives with anti-melanogenic activity from Stewartia pseudocamellia. Archives of Pharmacal Research 2016, 39, 636 -645.

AMA Style

Zuh-Kyung Seong, Hui-Seong Kim, Yu-Mi Won, Jae-Lim Kim, Hyuk-Hwan Song, Doo-Young Kim, Sei-Ryang Oh, Hyun-Woo Cho, Jung-Hee Cho, Hyeong-Kyu Lee. Phenylacylphenol derivatives with anti-melanogenic activity from Stewartia pseudocamellia. Archives of Pharmacal Research. 2016; 39 (5):636-645.

Chicago/Turabian Style

Zuh-Kyung Seong; Hui-Seong Kim; Yu-Mi Won; Jae-Lim Kim; Hyuk-Hwan Song; Doo-Young Kim; Sei-Ryang Oh; Hyun-Woo Cho; Jung-Hee Cho; Hyeong-Kyu Lee. 2016. "Phenylacylphenol derivatives with anti-melanogenic activity from Stewartia pseudocamellia." Archives of Pharmacal Research 39, no. 5: 636-645.

Journal article
Published: 29 January 2015 in Archives of Pharmacal Research
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Three new triterpene glycosides (Lonicerosides K, L and M) and 11 known compounds were isolated from the aerial parts of Weigela subsessilis. Among the known isolated compounds, loniceroside A, sweroside, kaempferol-3-O-glucopyranoside 6″-(3-hydroxy-3-methylglutarate), kaempferol-3-O-acetylglucoside and grandifloroside were reported for the first time in a Weigela genus plant. Their chemical structures were identified using extensive spectroscopic analysis including two-dimensional (2D)-NMR experiments, HR-ESI-QTOF-MS and comparison with reported data. Among these compounds, lonicerosides A and L had potent melanogenesis stimulatory activity in murine B16F0 melanoma cells. The structural relationship of active compounds was discussed.

ACS Style

Yu-Mi Won; Zuh-Kyung Seong; Jae-Lim Kim; Hui-Seong Kim; Hyuk-Hwan Song; Doo-Young Kim; Jung-Hee Kim; Sei-Ryang Oh; Hyun-Woo Cho; Jung-Hee Cho; Hyeong-Kyu Lee. Triterpene glycosides with stimulatory activity on melanogenesis from the aerial parts of Weigela subsessilis. Archives of Pharmacal Research 2015, 38, 1541 -1551.

AMA Style

Yu-Mi Won, Zuh-Kyung Seong, Jae-Lim Kim, Hui-Seong Kim, Hyuk-Hwan Song, Doo-Young Kim, Jung-Hee Kim, Sei-Ryang Oh, Hyun-Woo Cho, Jung-Hee Cho, Hyeong-Kyu Lee. Triterpene glycosides with stimulatory activity on melanogenesis from the aerial parts of Weigela subsessilis. Archives of Pharmacal Research. 2015; 38 (8):1541-1551.

Chicago/Turabian Style

Yu-Mi Won; Zuh-Kyung Seong; Jae-Lim Kim; Hui-Seong Kim; Hyuk-Hwan Song; Doo-Young Kim; Jung-Hee Kim; Sei-Ryang Oh; Hyun-Woo Cho; Jung-Hee Cho; Hyeong-Kyu Lee. 2015. "Triterpene glycosides with stimulatory activity on melanogenesis from the aerial parts of Weigela subsessilis." Archives of Pharmacal Research 38, no. 8: 1541-1551.