Full-duplex (FD) enables high spectrum efficiency and dynamic spectrum accessing, although its application is restricted by significant self-interference. In this work, we present an integrated, single antenna, wideband FD self-interference suppression front-end solution, targeting for short-range wireless communication. Based on the characteristic of bi-directional signal transparency of N-phase passive mixer, a mixer-first active electrical balance self-interference suppression architecture is proposed. As no costly and space-consuming out-of-chip circulator is needed, compared with traditional single antenna suppression solutions, it is attractive for cost and area saving In addition, to alleviate the multi-path effect, a two-tap baseband self-interference suppression is adopted, which also helps broaden the self-interference suppression bandwidth. The fabricated FD front-end chip, employing 180nm CMOS process, has a noise figure (NF) of 8.6dB, and at the maximum TX power, the NF is degrade by 4.9dB. Test results show the achieved self-interference suppression depth is up to 52dB over 30MHz, with a much smaller antenna interface and chip size which is 0.75 mm $^{2}$ , compared with other dual and signal antenna solutions. The wireless communication function of the propose FD front-end has been verified and the operation carrier frequency range is 0.4-1.2GHz.

At present, studies on macrophage proteins mainly focus on biological stimuli, with less attention paid to the responses of macrophage proteins to physical stimuli, such as electric fields. Here, we exploited the electric field-sensitive hub proteins of macrophages. RAW 264.7 macrophages were treated with a direct current electric field (dcEF) (200 mV/mm) for four hours, followed by RNA-Seq analysis. Differentially expressed genes (DEGs) were obtained, followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) and protein–protein interaction (PPI) analysis. Eight qPCR-verified DEGs were selected. Subsequently, three-dimensional protein models of DEGs were modeled by Modeller and Rosetta, followed by molecular dynamics simulation for 200 ns with GROMACS. Finally, dcEFs (10, 50, and 500 mV/mm) were used to simulate the molecular dynamics of DEG proteins for 200 ns, followed by trajectory analysis. The dcEF has no obvious effect on RAW 264.7 morphology. A total of 689 DEGs were obtained, and enrichment analysis showed that the steroid biosynthesis pathway was most affected by the dcEF. Moreover, the three-dimensional protein structures of hub proteins were constructed, and trajectory analysis suggested that the dcEF caused an increase in the atomic motion of the protein in a dcEF-intensity-dependent manner. Overall, we provide new clues and a basis for investigating the hub proteins of macrophages in response to electric field stimulation.

Recently, nanosecond pulsed electric field (nsPEF) has been considered as a new tool for tumor therapy, but its molecular mechanism of function remains to be fully elucidated. Here, we explored the cellular processes of Jurkat cells exposed to nanosecond pulsed electric field. Differentially expressed genes (DEGs) were acquired from the GEO2R, followed by analysis with a series of bioinformatics tools. Subsequently, 3D protein models of hub genes were modeled by Modeller 9.21 and Rosetta 3.9. Then, a 100 ns molecular dynamics simulation for each hub protein was performed with GROMACS 2018.2. Finally, three kinds of nsPEF voltages (0.01, 0.05, and 0.5 mV/mm) were used to simulate the molecular dynamics of hub proteins for 100 ns. A total of 1769 DEGs and eight hub genes were obtained. Molecular dynamic analysis, including root mean square deviation (RMSD), root mean square fluctuation (RMSF), and the Rg, demonstrated that the 3D structure of hub proteins was built, and the structural characteristics of hub proteins under different nsPEFs were acquired. In conclusion, we explored the effect of nsPEF on Jurkat cell signaling pathway from the perspective of molecular informatics, which will be helpful in understanding the complex effects of nsPEF on acute T-cell leukemia Jurkat cells.

In compact power electronic devices, magnetic-ring-free current sensors are increasingly preferred due to their compact size and lightweight nature. However, in high-precision small current measurements, the geomagnetic field can introduce substantial errors. To address this issue, a sensor chip using a bridge structure composed of four highly sensitive tunnel magnetoresistance (TMR) elements was employed, and a novel magnetic-ring-free current sensor was designed that eliminates geomagnetic field interference, thereby achieving precise small current measurements. This sensor operates in a zero-magnetic-flux state for the geomagnetic field, where the geomagnetic signal is fed back through a feedback coil, effectively canceling the geomagnetic field with the magnetic field generated in the feedback coil. This design enables the current sensor to achieve high-precision measurements. Experimental results showed that the current sensor achieved a sensitivity of 3.808 V/A and a measurement accuracy of ±1.854% within a sensing range of ±1.8 A. These findings offer a novel design strategy for future current sensors.

Facing the problems of ohmic loss and short propagation length, the application of plasmonic waveguides is limited. Here, a triangle hybrid plasmonic waveguide is introduced, where a cylinder silicon waveguide is separated from the triangle prism silver waveguide by a nanoscale silica gap. The process of constant optimization of waveguide structure is completed and simulation results indicate that the propagation length could reach a length of 510 μm, and the normalized mode area could reach 0.03 along with a high figure of merit 3150. This implies that longer propagation length could be simultaneously achieved along with relatively ultra-deep subwavelength mode confinement due to the hybridization between metallic plasmon polarization mode and silicon waveguide mode, compared with previous study. By an analysis of fabrication errors, it is confirmed that this waveguide is fairly stable over a wide error range. Additionally, the excellent performance of this is further proved by the comparison with other hybrid plasmonic waveguides. Our work is significant to manipulate light waves at sub-wavelength dimensions and enlarge the application fields, such as light detection and photoelectric sensors, which also benefit the improvement of the integration of optical devices.