In this work, we aim to address several strategies to improve transdermal drug delivery, such as iontophoresis, sonophoresis, electroporation and micron. We also propose a review of some transdermal patches and their applications in medicine. TDDs (transdermal patches with delayed active substances) are multilayered pharmaceutical preparations that may contain one or more active substances, of which, systemic absorption is achieved through intact skin. The paper also presents new approaches to the controlled release of drugs: niosomes, microemulsions, transfersomes, ethosomes, but also hybrid approaches nanoemulsions and microns. The novelty of this review lies in the presentation of strategies to improve the transdermal administration of drugs, combined with their applications in medicine, in light of pharmaceutical technological developments.

In this study, we focused on innovative approaches to improve drug administration in oral pathology, especially by transmucosal and transdermal pathways. These improvements refer to the type of microneedles used (proposing needles in the saw), to the use of certain enhancers such as essential oils (which, besides the amplifier action, also have intrinsic actions on oral health), to associations of active substances with synergistic action, as well as the use of copolymeric membranes, cemented directly on the tooth. We also propose a review of the principles of release at the level of the oral mucosa and of the main release systems used in oral pathology. Controlled failure systems applicable in oral pathology include the following: fast dissolving films, mucoadhesive tablets, hydrogels, intraoral mucoadhesive films, composite wafers, and smart drugs. The novelty elements brought by this paper refer to the possibilities of optimizing the localized drug delivery system in osteoarthritis of the temporomandibular joint, neuropathic pain, oral cancer, periodontitis, and pericoronitis, as well as in maintaining oral health. We would like to mention the possibility of incorporating natural products into the controlled failure systems used in oral pathology, paying special attention to essential oils.

Skin conditions are numerous and often have a major impact on patients’ quality of life, and effective and safe treatment is very important. The conventional drugs used for skin diseases are usually corticosteroids and antimicrobial products that can induce various side effects, especially with long-term use, which is why researchers are studying alternatives, especially biologically active natural products. Three products caught our attention: bee venom (BV), due to reported experimental results showing anti-inflammatory, antibacterial, antiviral, antioxidant, antimycotic, and anticancer effects, Ficus carica (FC) due to its demonstrated antioxidant, antibacterial, and anti-inflammatory action, and finally Geranium essential oil (GEO), with proven antifungal, antibacterial, anti-inflammatory, and antioxidant effects. Following a review of the literature, we produced this paper, which presents a review of the potential therapeutic applications of the three products in combating various skin conditions and for skin care, because BV, FC, and GEO have common pharmacological actions (anti-inflammatory, antibacterial, and antioxidant). We also focused on studying the safety of the topical use of BV, FC, and GEO, and new approaches to this. This paper presents the use of these natural therapeutic agents to treat patients with conditions such as vitiligo, melasma, and melanoma, as well as their use in treating dermatological conditions in patients with diabetes.

(1) Background: Currently, more and more studies reveal the fact that the use of ozonated oil in dentistry brings visible benefits. The aim of this study was to evaluate the efficacy of ozonated olive oil by evaluating daily index changes (2) Methods: The available products were used in this study: ozonized olive oil (Ozon Relive) and organic cold-pressed extra virgin olive oil. At the start of the study, all mouthwashes are placed in the same type of containers and labeled with numbers from 1 to 20. The recommended dose is one teaspoon of oil, about 6 mL per day. (3) Results: Ozonated oil (Group 1) and olive oil (Group 2) groups showed statistically significant differences to oral indices (p < 0.001 in both). (4) Conclusions: The results suggested that ozonized olive oil can be fully included among the products able to assist in controlling the causative factors of gingivitis while reducing its clinical manifestations.

At the end of any orthodontic treatment, retention is a necessary phase. Unfortunately, the current retention devices and the lack of proper oral hygiene on the part of patients lead to the accumulation of dental plaque, periodontal inflammation, and gingival retraction. Our retrospective study included 116 adult patients wearing various types of orthodontic retainers. To quantitatively determine the accumulation of dental plaque, we used the Quigley–Hein plaque index modified by Turesky and the Navy plaque index modified by Rustogi. Another studied parameter was related to the gingival recession associated with retention devices. We had investigated the correctness of patients’ dental hygiene, their preferences for auxiliary means of oral hygiene, the consistency with which they wear the mobile retainers, and respect the orthodontist’s instructions; we also investigated the inconveniences and the accidents that may occur during the retention period. Statistical analysis showed that plaque accumulation is significantly lower in the case of mobile retainer than fixed retainer wearers; the exception was the Hawley plate, where the interdental plaque was more than in all the other studied retainers. Periodontal recessions were more frequent in the case of fixed retainer wearing. Flossing was the most commonly used auxiliary mean for oral hygiene. The compliance of women in wearing vacuum-formed retainers was better than that of men. Patients with a class III history had more plaque accumulation, and class II/1 had the most problems related to detachment/damage of fixed retainers. Mobile retainers proved better results for oral hygiene, but fixed retainers cannot be waved.

The purpose of this in vitro study was to analyze and identify a methodology for the improvement of the shear bond strength of orthodontic brackets bonded with two orthodontic adhesive systems considered to be widely used, Transbond Plus Color Change with Transbond Plus Self-Etching Primer and Fuji Ortho LC with orthophosphoric acid under various enamel conditions: dry, moistened with water and moistened with saliva. The sample size included a group of 120 freshly extracted premolars distributed into six study groups, each one of 20 teeth. A universal testing machine was used to detach the brackets. We determined and compared the strength of the two studied adhesive systems used in different enamel surface conditions. The mean shear bond strength values in groups 1 (TPCC, TSEP, dry), 2 (TPCC, TSEP, water), 3 (TPCC, TSEP, saliva), 4 (Fuji Ortho LC, etched, dry enamel), 5 (Fuji Ortho LC, etched enamel, water) and 6 (Fuji Ortho LC, etched enamel, saliva) were 15.86, 12.31, 13.04, 15.27, 14.14 and 13.11 MPa, respectively. ANOVA test and Student’s t-test showed significant differences between groups. While clinically acceptable shear bond strengths were obtained for all six studied groups, a particular outcome that to the authors’ knowledge has not been documented elsewhere has been obtained: in case of water contamination, it is preferable to use Fuji Ortho LC instead of Transbond Plus.