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Hu Sheng
State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China

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Journal article
Published: 11 May 2021 in Nature Communications
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COVID-19 pandemic caused by SARS-CoV-2 constitutes a global public health crisis with enormous economic consequences. Monoclonal antibodies against SARS-CoV-2 can provide an important treatment option to fight COVID-19, especially for the most vulnerable populations. In this work, potent antibodies binding to SARS-CoV-2 Spike protein were identified from COVID-19 convalescent patients. Among them, P4A1 interacts directly with and covers majority of the Receptor Binding Motif of the Spike Receptor-Binding Domain, shown by high-resolution complex structure analysis. We further demonstrate the binding and neutralizing activities of P4A1 against wild type and mutant Spike proteins or pseudoviruses. P4A1 was subsequently engineered to reduce the potential risk for Antibody-Dependent Enhancement of infection and to extend its half-life. The engineered antibody exhibits an optimized pharmacokinetic and safety profile, and it results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection. These data suggest its potential against SARS-CoV-2 related diseases.

ACS Style

Yu Guo; Lisu Huang; Guangshun Zhang; Yanfeng Yao; He Zhou; Shu Shen; Bingqing Shen; Bo Li; Xin Li; Qian Zhang; Mingjie Chen; Da Chen; Jia Wu; Dan Fu; Xinxin Zeng; Mingfang Feng; ChunJiang Pi; Yuan Wang; Xingdong Zhou; Minmin Lu; Yarong Li; Yaohui Fang; Yun-Yueh Lu; Xue Hu; Shanshan Wang; Wanju Zhang; Ge Gao; Francisco Adrian; Qisheng Wang; Feng Yu; Yun Peng; Alexander G. Gabibov; Juan Min; Yuhui Wang; Heyu Huang; Alexey Stepanov; Wei Zhang; Yan Cai; Junwei Liu; Zhiming Yuan; Chen Zhang; Zhiyong Lou; Fei Deng; Hongkai Zhang; Chao Shan; Liang Schweizer; Kun Sun; Zihe Rao. A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nature Communications 2021, 12, 1 -11.

AMA Style

Yu Guo, Lisu Huang, Guangshun Zhang, Yanfeng Yao, He Zhou, Shu Shen, Bingqing Shen, Bo Li, Xin Li, Qian Zhang, Mingjie Chen, Da Chen, Jia Wu, Dan Fu, Xinxin Zeng, Mingfang Feng, ChunJiang Pi, Yuan Wang, Xingdong Zhou, Minmin Lu, Yarong Li, Yaohui Fang, Yun-Yueh Lu, Xue Hu, Shanshan Wang, Wanju Zhang, Ge Gao, Francisco Adrian, Qisheng Wang, Feng Yu, Yun Peng, Alexander G. Gabibov, Juan Min, Yuhui Wang, Heyu Huang, Alexey Stepanov, Wei Zhang, Yan Cai, Junwei Liu, Zhiming Yuan, Chen Zhang, Zhiyong Lou, Fei Deng, Hongkai Zhang, Chao Shan, Liang Schweizer, Kun Sun, Zihe Rao. A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nature Communications. 2021; 12 (1):1-11.

Chicago/Turabian Style

Yu Guo; Lisu Huang; Guangshun Zhang; Yanfeng Yao; He Zhou; Shu Shen; Bingqing Shen; Bo Li; Xin Li; Qian Zhang; Mingjie Chen; Da Chen; Jia Wu; Dan Fu; Xinxin Zeng; Mingfang Feng; ChunJiang Pi; Yuan Wang; Xingdong Zhou; Minmin Lu; Yarong Li; Yaohui Fang; Yun-Yueh Lu; Xue Hu; Shanshan Wang; Wanju Zhang; Ge Gao; Francisco Adrian; Qisheng Wang; Feng Yu; Yun Peng; Alexander G. Gabibov; Juan Min; Yuhui Wang; Heyu Huang; Alexey Stepanov; Wei Zhang; Yan Cai; Junwei Liu; Zhiming Yuan; Chen Zhang; Zhiyong Lou; Fei Deng; Hongkai Zhang; Chao Shan; Liang Schweizer; Kun Sun; Zihe Rao. 2021. "A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes." Nature Communications 12, no. 1: 1-11.

Brief research report article
Published: 24 March 2021 in Frontiers in Cellular and Infection Microbiology
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Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne viral disease of global concerns due to the increasing incidence and lack of effective treatments. The causative agent, CCHF virus (CCHFV), has been characterized for years; however, its tropism in cell lines of different host and tissue origins remains unclear. This study characterized the susceptibility of 16 human and 6 animal cell lines to CCHFV. Increased viral load and viral nucleoprotein expression, and productive CCHFV replication were detected in human vascular (HUVEC), renal (SW-13 and HEK-293), hepatic (Huh7), and cerebral (U-87 MG) cell lines, which were considered CCHFV-highly permissive cell lines. Renal cell lines derived from monkey and dog could also support CCHFV replication. This study evaluated the susceptibility of different cell lines to CCHFV and identified CCHFV-permissive cell lines. Our findings raise concerns regarding the use of cell lines in ex vivo studies of CCHFV and may have important implications for further fundamental research, which would promote understanding of CCHFV pathogenesis and transmission, as well as benefit designing strategies for disease prevention and control.

ACS Style

Shiyu Dai; Qiaoli Wu; Xiaoli Wu; Cheng Peng; Jia Liu; Shuang Tang; Tao Zhang; Fei Deng; Shu Shen. Differential Cell Line Susceptibility to Crimean-Congo Hemorrhagic Fever Virus. Frontiers in Cellular and Infection Microbiology 2021, 11, 1 .

AMA Style

Shiyu Dai, Qiaoli Wu, Xiaoli Wu, Cheng Peng, Jia Liu, Shuang Tang, Tao Zhang, Fei Deng, Shu Shen. Differential Cell Line Susceptibility to Crimean-Congo Hemorrhagic Fever Virus. Frontiers in Cellular and Infection Microbiology. 2021; 11 ():1.

Chicago/Turabian Style

Shiyu Dai; Qiaoli Wu; Xiaoli Wu; Cheng Peng; Jia Liu; Shuang Tang; Tao Zhang; Fei Deng; Shu Shen. 2021. "Differential Cell Line Susceptibility to Crimean-Congo Hemorrhagic Fever Virus." Frontiers in Cellular and Infection Microbiology 11, no. : 1.

Journal article
Published: 22 March 2021 in Nature Communications
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Long-term antibody responses and neutralizing activities in response to SARS-CoV-2 infection are not yet clear. Here we quantify immunoglobulin M (IgM) and G (IgG) antibodies recognizing the SARS-CoV-2 receptor-binding domain (RBD) of the spike (S) or the nucleocapsid (N) protein, and neutralizing antibodies during a period of 6 months from COVID-19 disease onset in 349 symptomatic COVID-19 patients who were among the first be infected world-wide. The positivity rate and magnitude of IgM-S and IgG-N responses increase rapidly. High levels of IgM-S/N and IgG-S/N at 2-3 weeks after disease onset are associated with virus control and IgG-S titers correlate closely with the capacity to neutralize SARS-CoV-2. Although specific IgM-S/N become undetectable 12 weeks after disease onset in most patients, IgG-S/N titers have an intermediate contraction phase, but stabilize at relatively high levels over the 6 month observation period. At late time points, the positivity rates for binding and neutralizing SARS-CoV-2-specific antibodies are still >70%. These data indicate sustained humoral immunity in recovered patients who had symptomatic COVID-19, suggesting prolonged immunity.

ACS Style

Jun Wu; Boyun Liang; Cunrong Chen; Hua Wang; Yaohui Fang; Shu Shen; Xiaoli Yang; Baoju Wang; Liangkai Chen; Qi Chen; Yang Wu; Jia Liu; Xuecheng Yang; Wei Li; Bin Zhu; Wenqing Zhou; Sumeng Li; Sihong Lu; Di Liu; Huadong Li; Adalbert Krawczyk; Mengji Lu; Dongliang Yang; Fei Deng; Ulf Dittmer; Mirko Trilling; Xin Zheng. SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19. Nature Communications 2021, 12, 1 -9.

AMA Style

Jun Wu, Boyun Liang, Cunrong Chen, Hua Wang, Yaohui Fang, Shu Shen, Xiaoli Yang, Baoju Wang, Liangkai Chen, Qi Chen, Yang Wu, Jia Liu, Xuecheng Yang, Wei Li, Bin Zhu, Wenqing Zhou, Sumeng Li, Sihong Lu, Di Liu, Huadong Li, Adalbert Krawczyk, Mengji Lu, Dongliang Yang, Fei Deng, Ulf Dittmer, Mirko Trilling, Xin Zheng. SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19. Nature Communications. 2021; 12 (1):1-9.

Chicago/Turabian Style

Jun Wu; Boyun Liang; Cunrong Chen; Hua Wang; Yaohui Fang; Shu Shen; Xiaoli Yang; Baoju Wang; Liangkai Chen; Qi Chen; Yang Wu; Jia Liu; Xuecheng Yang; Wei Li; Bin Zhu; Wenqing Zhou; Sumeng Li; Sihong Lu; Di Liu; Huadong Li; Adalbert Krawczyk; Mengji Lu; Dongliang Yang; Fei Deng; Ulf Dittmer; Mirko Trilling; Xin Zheng. 2021. "SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19." Nature Communications 12, no. 1: 1-9.

Preprint content
Published: 14 November 2020
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The Coronavirus Disease of 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens global public health and economy. Therapeutic options such as monoclonal antibodies (mAbs) against SARS-CoV-2 are in urgent need. We have identified potent monoclonal antibodies binding to SARS-CoV-2 Spike protein from COVID-19 convalescent patients and one of these antibodies, P4A1, interacts directly and covers the majority of the Receptor Binding Motif (RBM) of Spike receptor-binding domain (RBD), shown by high-resolution complex structure analysis. We further demonstrated P4A1 binding and neutralizing activities against wild type and mutant spike proteins. P4A1 was subsequently engineered to reduce the potential risk for antibody-dependent enhancement (ADE) of infection and to extend its half-life. The engineered mAb exhibits optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection.

ACS Style

Yu Guo; Lisu Huang; Guangshun Zhang; Yanfeng Yao; He Zhou; Shu Shen; Bingqing Shen; Bo Li; Xin Li; Mingjie Chen; Da Chen; Jia Wu; Dan Fu; Xinxin Zeng; Mingfang Feng; ChunJiang Pi; Yuan Wang; Xingdong Zhou; Minmin Lu; Yaohui Fang; Yun-Yueh Lu; Xue Hu; Shanshan Wang; Wanju Zhang; Qian Zhang; Ge Gao; Francisco Adrian; Qisheng Wang; Feng Yu; Yun Peng; Alexander Gabibov; Juan Min; Yuhui Wang; Heyu Huang; Alexey Stepanov; Wei Zhang; Yan Cai; Junwei Liu; Zhi-Ming Yuan; Chen Zhang; Zhiyong Lou; Fei Deng; Hongkai Zhang; Chao Shan; Liang Schweizer; Kun Sun; Zihe Rao. A SARS-CoV-2 neutralizing antibody with exceptional spike binding coverage and optimized therapeutic potentials. 2020, 1 .

AMA Style

Yu Guo, Lisu Huang, Guangshun Zhang, Yanfeng Yao, He Zhou, Shu Shen, Bingqing Shen, Bo Li, Xin Li, Mingjie Chen, Da Chen, Jia Wu, Dan Fu, Xinxin Zeng, Mingfang Feng, ChunJiang Pi, Yuan Wang, Xingdong Zhou, Minmin Lu, Yaohui Fang, Yun-Yueh Lu, Xue Hu, Shanshan Wang, Wanju Zhang, Qian Zhang, Ge Gao, Francisco Adrian, Qisheng Wang, Feng Yu, Yun Peng, Alexander Gabibov, Juan Min, Yuhui Wang, Heyu Huang, Alexey Stepanov, Wei Zhang, Yan Cai, Junwei Liu, Zhi-Ming Yuan, Chen Zhang, Zhiyong Lou, Fei Deng, Hongkai Zhang, Chao Shan, Liang Schweizer, Kun Sun, Zihe Rao. A SARS-CoV-2 neutralizing antibody with exceptional spike binding coverage and optimized therapeutic potentials. . 2020; ():1.

Chicago/Turabian Style

Yu Guo; Lisu Huang; Guangshun Zhang; Yanfeng Yao; He Zhou; Shu Shen; Bingqing Shen; Bo Li; Xin Li; Mingjie Chen; Da Chen; Jia Wu; Dan Fu; Xinxin Zeng; Mingfang Feng; ChunJiang Pi; Yuan Wang; Xingdong Zhou; Minmin Lu; Yaohui Fang; Yun-Yueh Lu; Xue Hu; Shanshan Wang; Wanju Zhang; Qian Zhang; Ge Gao; Francisco Adrian; Qisheng Wang; Feng Yu; Yun Peng; Alexander Gabibov; Juan Min; Yuhui Wang; Heyu Huang; Alexey Stepanov; Wei Zhang; Yan Cai; Junwei Liu; Zhi-Ming Yuan; Chen Zhang; Zhiyong Lou; Fei Deng; Hongkai Zhang; Chao Shan; Liang Schweizer; Kun Sun; Zihe Rao. 2020. "A SARS-CoV-2 neutralizing antibody with exceptional spike binding coverage and optimized therapeutic potentials." , no. : 1.

Research articles
Published: 22 September 2020 in Virologica Sinica
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ACS Style

Xiaoli Wu; Mingyue Li; Yanfang Zhang; Boyun Liang; Junming Shi; Yaohui Fang; Zhengyuan Su; Mengmeng Li; Wenjing Zhang; Ling Xu; Jun Wang; Qiaoli Wu; Shuang Tang; Hualin Wang; Tao Zhang; Cheng Peng; Xin Zheng; Fei Deng; Shu Shen. Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes. Virologica Sinica 2020, 36, 300 -310.

AMA Style

Xiaoli Wu, Mingyue Li, Yanfang Zhang, Boyun Liang, Junming Shi, Yaohui Fang, Zhengyuan Su, Mengmeng Li, Wenjing Zhang, Ling Xu, Jun Wang, Qiaoli Wu, Shuang Tang, Hualin Wang, Tao Zhang, Cheng Peng, Xin Zheng, Fei Deng, Shu Shen. Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes. Virologica Sinica. 2020; 36 (2):300-310.

Chicago/Turabian Style

Xiaoli Wu; Mingyue Li; Yanfang Zhang; Boyun Liang; Junming Shi; Yaohui Fang; Zhengyuan Su; Mengmeng Li; Wenjing Zhang; Ling Xu; Jun Wang; Qiaoli Wu; Shuang Tang; Hualin Wang; Tao Zhang; Cheng Peng; Xin Zheng; Fei Deng; Shu Shen. 2020. "Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes." Virologica Sinica 36, no. 2: 300-310.

Other
Published: 24 July 2020
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Long-term antibody responses and neutralizing activities following SARS-CoV-2 infections have not yet been elucidated. We quantified immunoglobulin M (IgM) and G (IgG) antibodies recognizing the SARS-CoV-2 receptor-binding domain (RBD) of the spike (S) or the nucleocapsid (N) protein, and neutralizing antibodies during a period of six months following COVID-19 disease onset in 349 symptomatic COVID-19 patients, which were among the first world-wide being infected. The positivity rate and magnitude of IgM-S and IgG-N responses increased rapidly. High levels of IgM-S/N and IgG-S/N at 2-3 weeks after disease onset were associated with virus control and IgG-S titers correlated closely with the capacity to neutralize SARS-CoV-2. While specific IgM-S/N became undetectable 12 weeks after disease onset in most patients, IgG-S/N titers showed an intermediate contraction phase, but stabilized at relatively high levels over the six months observation period. At late time points the positivity rates for binding and neutralizing SARS-CoV-2-specific antibodies was still over 70%. Taken together, our data indicate sustained humoral immunity in recovered patients who suffer from symptomatic COVID-19, suggesting prolonged immunity.

ACS Style

Jun Wu; Boyun Liang; Cunrong Chen; Hua Wang; Yaohui Fang; Shu Shen; Xiaoli Yang; Baoju Wang; Liangkai Chen; Qi Chen; Yang Wu; Jia Liu; Xuecheng Yang; Wei Li; Bin Zhu; Wenqing Zhou; Shumeng Li; Sihong Lu; Di Liu; Huadong Li; Adalbert Krawczyk; Mengji Lu; Dongliang Yang; Fei Deng; Ulf Dittmer; Mirko Trilling; Xin Zheng. SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19. 2020, 1 .

AMA Style

Jun Wu, Boyun Liang, Cunrong Chen, Hua Wang, Yaohui Fang, Shu Shen, Xiaoli Yang, Baoju Wang, Liangkai Chen, Qi Chen, Yang Wu, Jia Liu, Xuecheng Yang, Wei Li, Bin Zhu, Wenqing Zhou, Shumeng Li, Sihong Lu, Di Liu, Huadong Li, Adalbert Krawczyk, Mengji Lu, Dongliang Yang, Fei Deng, Ulf Dittmer, Mirko Trilling, Xin Zheng. SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19. . 2020; ():1.

Chicago/Turabian Style

Jun Wu; Boyun Liang; Cunrong Chen; Hua Wang; Yaohui Fang; Shu Shen; Xiaoli Yang; Baoju Wang; Liangkai Chen; Qi Chen; Yang Wu; Jia Liu; Xuecheng Yang; Wei Li; Bin Zhu; Wenqing Zhou; Shumeng Li; Sihong Lu; Di Liu; Huadong Li; Adalbert Krawczyk; Mengji Lu; Dongliang Yang; Fei Deng; Ulf Dittmer; Mirko Trilling; Xin Zheng. 2020. "SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19." , no. : 1.

Letter
Published: 21 July 2020 in Virologica Sinica
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ACS Style

Jun Wang; Xiaoping Liu; Qiong Zhu; Qiaoli Wu; Shuang Tang; Lei Zhang; Zhaojun Fan; Zhihong Hu; Hualin Wang; Fei Deng; Shu Shen. Identification, Isolation, and Characterization of an Ectromelia Virus New Strain from an Experimental Mouse. Virologica Sinica 2020, 36, 155 -158.

AMA Style

Jun Wang, Xiaoping Liu, Qiong Zhu, Qiaoli Wu, Shuang Tang, Lei Zhang, Zhaojun Fan, Zhihong Hu, Hualin Wang, Fei Deng, Shu Shen. Identification, Isolation, and Characterization of an Ectromelia Virus New Strain from an Experimental Mouse. Virologica Sinica. 2020; 36 (1):155-158.

Chicago/Turabian Style

Jun Wang; Xiaoping Liu; Qiong Zhu; Qiaoli Wu; Shuang Tang; Lei Zhang; Zhaojun Fan; Zhihong Hu; Hualin Wang; Fei Deng; Shu Shen. 2020. "Identification, Isolation, and Characterization of an Ectromelia Virus New Strain from an Experimental Mouse." Virologica Sinica 36, no. 1: 155-158.

Journal article
Published: 01 July 2020 in Emerging Infectious Diseases
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ACS Style

Ali Zohaib; Jingyuan Zhang; Muhammad Saqib; Muhammad Ammar Athar; Muhammad Hammad Hussain; Jing Chen; Awais-Ur-Rahman Sial; M. Haleem Tayyab; Murrafa Batool; Saeed Khan; Yun Luo; Cecilia Waruhiu; Zeeshan Taj; Zulfiqar Hayder; Riaz Ahmed; Abu Bakr Siddique; Xinglou Yang; Muhammad Asif Qureshi; Ikram Uddin Ujjan; Amanullah Lail; Iahtasham Khan; Tao Zhang; Fei Deng; Zhengli Shi; Shu Shen; Sajjad- Ur- Rahman. Serologic Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and Related Viruses in Pakistan. Emerging Infectious Diseases 2020, 26, 1513 -1516.

AMA Style

Ali Zohaib, Jingyuan Zhang, Muhammad Saqib, Muhammad Ammar Athar, Muhammad Hammad Hussain, Jing Chen, Awais-Ur-Rahman Sial, M. Haleem Tayyab, Murrafa Batool, Saeed Khan, Yun Luo, Cecilia Waruhiu, Zeeshan Taj, Zulfiqar Hayder, Riaz Ahmed, Abu Bakr Siddique, Xinglou Yang, Muhammad Asif Qureshi, Ikram Uddin Ujjan, Amanullah Lail, Iahtasham Khan, Tao Zhang, Fei Deng, Zhengli Shi, Shu Shen, Sajjad- Ur- Rahman. Serologic Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and Related Viruses in Pakistan. Emerging Infectious Diseases. 2020; 26 (7):1513-1516.

Chicago/Turabian Style

Ali Zohaib; Jingyuan Zhang; Muhammad Saqib; Muhammad Ammar Athar; Muhammad Hammad Hussain; Jing Chen; Awais-Ur-Rahman Sial; M. Haleem Tayyab; Murrafa Batool; Saeed Khan; Yun Luo; Cecilia Waruhiu; Zeeshan Taj; Zulfiqar Hayder; Riaz Ahmed; Abu Bakr Siddique; Xinglou Yang; Muhammad Asif Qureshi; Ikram Uddin Ujjan; Amanullah Lail; Iahtasham Khan; Tao Zhang; Fei Deng; Zhengli Shi; Shu Shen; Sajjad- Ur- Rahman. 2020. "Serologic Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and Related Viruses in Pakistan." Emerging Infectious Diseases 26, no. 7: 1513-1516.

Journal article
Published: 15 November 2019 in Computers, Environment and Urban Systems
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Many studies are in an effort to explore urban spatial structure, and urban functional regions have become the subject of increasing attention among planners, engineers and public officials. Attempts have been made to identify urban functional regions using high spatial resolution (HSR) remote sensing images and extensive geo-data. However, the research scale and throughput have also been limited by the accessibility of HSR remote sensing data. Recently, big geo-data are becoming increasingly popular for urban studies since research is still accessible and objective with regard to the use of these data. This study aims to build a novel framework to provide an alternative solution for sensing urban spatial structure and discovering urban functional regions based on emerging geo-data – points of interest (POIs) data and an embedding learning method in the natural language processing (NLP) field. We started by constructing the intraurban functional corpus using a center-context pairs-based approach. A word embeddings representation model for training that corpus was used to extract multiprototype vectors in the second step, and the last step aggregated the functional parcels based on an introduced spatial clustering method, hierarchical density-based spatial clustering of applications with noise (HDBSCAN). The clustering results suggested that our proposed framework used in this study is capable of discovering the utilization of urban space with a reasonable level of accuracy. The limitation and potential improvement of the proposed framework are also discussed.

ACS Style

Sheng Hu; Hu Sheng; Liang Wu; Li Yin; Yongyang Xu; Haifu Cui. A framework for extracting urban functional regions based on multiprototype word embeddings using points-of-interest data. Computers, Environment and Urban Systems 2019, 80, 101442 .

AMA Style

Sheng Hu, Hu Sheng, Liang Wu, Li Yin, Yongyang Xu, Haifu Cui. A framework for extracting urban functional regions based on multiprototype word embeddings using points-of-interest data. Computers, Environment and Urban Systems. 2019; 80 ():101442.

Chicago/Turabian Style

Sheng Hu; Hu Sheng; Liang Wu; Li Yin; Yongyang Xu; Haifu Cui. 2019. "A framework for extracting urban functional regions based on multiprototype word embeddings using points-of-interest data." Computers, Environment and Urban Systems 80, no. : 101442.

Case reports
Published: 01 January 2019 in Emerging Microbes & Infections
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The Xinjiang Uygur Autonomous Region locating in Northwest of China was not considered the epidemic area of severe fever with thrombocytopenia syndrome (SFTS). Here we report the first laboratory-confirmed SFTS case that a female patient had tick bite in Xinjiang and illness onset after returning to Hainan Province. Laboratory tests identified SFTS virus (SFTSV) infection, and the virus was isolated from the patient's serum sample. Furthermore, SFTSV prevalence among tick groups was identified, and IgM response to SFTSV from febrile patients was identified. The findings suggested that there have been risks of SFTSV infection due to exposure to ticks in Xinjiang.

ACS Style

Liying Zhu; Feifei Yin; Abulimiti Moming; Jingyuan Zhang; Bo Wang; Lijuan Gao; Jianwen Ruan; Qiaoli Wu; Na Wu; Hualin Wang; Fei Deng; Gang Lu; Shu Shen. First case of laboratory-confirmed severe fever with thrombocytopenia syndrome disease revealed the risk of SFTSV infection in Xinjiang, China. Emerging Microbes & Infections 2019, 8, 1122 -1125.

AMA Style

Liying Zhu, Feifei Yin, Abulimiti Moming, Jingyuan Zhang, Bo Wang, Lijuan Gao, Jianwen Ruan, Qiaoli Wu, Na Wu, Hualin Wang, Fei Deng, Gang Lu, Shu Shen. First case of laboratory-confirmed severe fever with thrombocytopenia syndrome disease revealed the risk of SFTSV infection in Xinjiang, China. Emerging Microbes & Infections. 2019; 8 (1):1122-1125.

Chicago/Turabian Style

Liying Zhu; Feifei Yin; Abulimiti Moming; Jingyuan Zhang; Bo Wang; Lijuan Gao; Jianwen Ruan; Qiaoli Wu; Na Wu; Hualin Wang; Fei Deng; Gang Lu; Shu Shen. 2019. "First case of laboratory-confirmed severe fever with thrombocytopenia syndrome disease revealed the risk of SFTSV infection in Xinjiang, China." Emerging Microbes & Infections 8, no. 1: 1122-1125.

Review
Published: 01 February 2018 in Virologica Sinica
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Ticks are important vectors for the transmission of pathogens including viruses. The viruses carried by ticks also known as tick-borne viruses (TBVs), contain a large group of viruses with diverse genetic properties and are concluded in two orders, nine families, and at least 12 genera. Some members of the TBVs are notorious agents causing severe diseases with high mortality rates in humans and livestock, while some others may pose risks to public health that are still unclear to us. Herein, we review the current knowledge of TBVs with emphases on the history of virus isolation and identification, tick vectors, and potential pathogenicity to humans and animals, including assigned species as well as the recently discovered and unassigned species. All these will promote our understanding of the diversity of TBVs, and will facilitate the further investigation of TBVs in association with both ticks and vertebrate hosts.

ACS Style

Junming Shi; Zhihong Hu; Fei Deng; Shu Shen. Tick-Borne Viruses. Virologica Sinica 2018, 33, 21 -43.

AMA Style

Junming Shi, Zhihong Hu, Fei Deng, Shu Shen. Tick-Borne Viruses. Virologica Sinica. 2018; 33 (1):21-43.

Chicago/Turabian Style

Junming Shi; Zhihong Hu; Fei Deng; Shu Shen. 2018. "Tick-Borne Viruses." Virologica Sinica 33, no. 1: 21-43.

Research article
Published: 11 December 2017 in Virologica Sinica
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Chikungunya virus (CHIKV) is a mosquito-borne virus that causes epidemics widely in the world especially in the tropical and subtropical regions. Phylogenetic analysis has found that the CHIKV lineages were associated with the spatial and temporal distributions, which were related to the virus adaption to the major mosquito species and their distributions. In this study, we reported the complete genome sequences of eight CHIKV isolates from the outbreak in Pakistan last year. Then we reviewed the evolutionary history using extensive phylogenetic analysis, analyzed lineage-specific substitutions in viral proteins, and characterized the spreading pathway of CHIKV strains including the Pakistani strains. The results showed that the Pakistani stains belonged to the ECSA.IOL sub-lineage and derived from India. The genetic properties of the Pakistani strains including the adaptive substitution to vectors were further characterized, and the potential risks from the occurrence of CHIKV infection in Pakistan were discussed. These results provided better understanding of CHIKV evolution and transmission in the world and revealed the possible origination of the CHIKV outbreak and epidemic in Pakistan, which would promote the disease prevention and control in the identified countries and territories with the history of CHIKV infections as well as new regions with potential risk of CHIKV outbreaks.

ACS Style

Junming Shi; Zhengyuan Su; Zhaojun Fan; Jun Wang; Siqing Liu; Bo Zhang; Hongping Wei; Shoukat Jehan; Nadia Jamil; Shu Shen; Fei Deng. Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016. Virologica Sinica 2017, 32, 520 -532.

AMA Style

Junming Shi, Zhengyuan Su, Zhaojun Fan, Jun Wang, Siqing Liu, Bo Zhang, Hongping Wei, Shoukat Jehan, Nadia Jamil, Shu Shen, Fei Deng. Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016. Virologica Sinica. 2017; 32 (6):520-532.

Chicago/Turabian Style

Junming Shi; Zhengyuan Su; Zhaojun Fan; Jun Wang; Siqing Liu; Bo Zhang; Hongping Wei; Shoukat Jehan; Nadia Jamil; Shu Shen; Fei Deng. 2017. "Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016." Virologica Sinica 32, no. 6: 520-532.

Journal article
Published: 19 November 2017 in ISPRS International Journal of Geo-Information
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Much of the taxi route-planning literature has focused on driver strategies for finding passengers and determining the hot spot pick-up locations using historical global positioning system (GPS) trajectories of taxis based on driver experience, distance from the passenger drop-off location to the next passenger pick-up location and the waiting times at recommended locations for the next passenger. The present work, however, considers the average taxi travel speed mined from historical taxi GPS trajectory data and the allocation of cruising routes to more than one taxi driver in a small-scale region to neighboring pick-up locations. A spatio-temporal trajectory model with load balancing allocations is presented to not only explore pick-up/drop-off information but also provide taxi drivers with cruising routes to the recommended pick-up locations. In simulation experiments, our study shows that taxi drivers using cruising routes recommended by our spatio-temporal trajectory model can significantly reduce the average waiting time and travel less distance to quickly find their next passengers, and the load balancing strategy significantly alleviates road loads. These objective measures can help us better understand spatio-temporal traffic patterns and guide taxi navigation.

ACS Style

Liang Wu; Sheng Hu; Li Yin; Yazhou Wang; Zhanlong Chen; Mingqiang Guo; Hao Chen; Zhong Xie. Optimizing Cruising Routes for Taxi Drivers Using a Spatio-Temporal Trajectory Model. ISPRS International Journal of Geo-Information 2017, 6, 373 .

AMA Style

Liang Wu, Sheng Hu, Li Yin, Yazhou Wang, Zhanlong Chen, Mingqiang Guo, Hao Chen, Zhong Xie. Optimizing Cruising Routes for Taxi Drivers Using a Spatio-Temporal Trajectory Model. ISPRS International Journal of Geo-Information. 2017; 6 (11):373.

Chicago/Turabian Style

Liang Wu; Sheng Hu; Li Yin; Yazhou Wang; Zhanlong Chen; Mingqiang Guo; Hao Chen; Zhong Xie. 2017. "Optimizing Cruising Routes for Taxi Drivers Using a Spatio-Temporal Trajectory Model." ISPRS International Journal of Geo-Information 6, no. 11: 373.

Journal article
Published: 02 August 2017 in The American Journal of Tropical Medicine and Hygiene
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Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus that was identified to be the etiological pathogen of the emerging infectious disease, severe fever with thrombocytopenia syndrome (SFTS). SFTSV could be transmitted through tick bite. Transmission of SFTSV among humans has also been reported mainly through direct blood contact. In July 2014, a cluster of six suspected SFTS cases occurred in Shandong Province, China. In this cluster, both symptomatic and asymptomatic persons were included. By analyzing the clinical data and results of laboratory tests, and conducting the epidemiological interviews with the cases and their families, risk factors responsible for the transmission were evaluated. The findings suggested that SFTSV transmission among humans may cause asymptomatic infection via personal contact without blood exposure.

ACS Style

Deyu Huang; Junming Shi; Hui Wang; Shu Shen; Hanyun Liu; Shuang Tang; Bo Wang; Fei Deng; Zhan Su; Yueping Jiang; Ting Wang; Xiaoping Liu; Zhihong Hu. A Cluster of Symptomatic and Asymptomatic Infections of Severe Fever with Thrombocytopenia Syndrome Caused by Person-to-Person Transmission. The American Journal of Tropical Medicine and Hygiene 2017, 97, 396 -402.

AMA Style

Deyu Huang, Junming Shi, Hui Wang, Shu Shen, Hanyun Liu, Shuang Tang, Bo Wang, Fei Deng, Zhan Su, Yueping Jiang, Ting Wang, Xiaoping Liu, Zhihong Hu. A Cluster of Symptomatic and Asymptomatic Infections of Severe Fever with Thrombocytopenia Syndrome Caused by Person-to-Person Transmission. The American Journal of Tropical Medicine and Hygiene. 2017; 97 (2):396-402.

Chicago/Turabian Style

Deyu Huang; Junming Shi; Hui Wang; Shu Shen; Hanyun Liu; Shuang Tang; Bo Wang; Fei Deng; Zhan Su; Yueping Jiang; Ting Wang; Xiaoping Liu; Zhihong Hu. 2017. "A Cluster of Symptomatic and Asymptomatic Infections of Severe Fever with Thrombocytopenia Syndrome Caused by Person-to-Person Transmission." The American Journal of Tropical Medicine and Hygiene 97, no. 2: 396-402.

Journal article
Published: 01 January 2017 in Infection, Genetics and Evolution
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Severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) has been identified as the etiological agent causing severe fever with thrombocytopenia syndrome (SFTS). SFTSV was reported in recent years as a newly emerging tick-borne virus in China, Japan and South Korea and is a novel member of the genus Phlebovirus, family Bunyaviridae, which is suspected to be transmitted by the tick Haemaphysalis longicornis. The genetic diversity and evolutionary relationships between geographically distributed SFTSV strains are currently unclear. In this study we used extensive bioinformatics analyses to provide deep insight into the mechanisms of evolution and relationships among SFTSV strains. The genetic diversity of SFTSV was characterized and found to be generated through recombination and reassortment events. Further, potential correlations between the geographic distribution and migration pathways of SFTSV were subject to in-depth analysis. The potential of birds migration related to SFTSV migration were also discussed. The results of this study will facilitate better understanding of the mechanisms of evolution of SFTSV, which will be important in developing public-health interventions and strategies for SFTS disease control and prevention in endemic areas.

ACS Style

Junming Shi; Sheng Hu; Xiaoping Liu; Juan Yang; Dan Liu; Liang Wu; Hualin Wang; Zhihong Hu; Fei Deng; Shu Shen. Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus. Infection, Genetics and Evolution 2017, 47, 109 -117.

AMA Style

Junming Shi, Sheng Hu, Xiaoping Liu, Juan Yang, Dan Liu, Liang Wu, Hualin Wang, Zhihong Hu, Fei Deng, Shu Shen. Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus. Infection, Genetics and Evolution. 2017; 47 ():109-117.

Chicago/Turabian Style

Junming Shi; Sheng Hu; Xiaoping Liu; Juan Yang; Dan Liu; Liang Wu; Hualin Wang; Zhihong Hu; Fei Deng; Shu Shen. 2017. "Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus." Infection, Genetics and Evolution 47, no. : 109-117.

Journal article
Published: 11 November 2016 in International Journal of Environmental Research and Public Health
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Severe fever with thrombocytopenia syndrome (SFTS) is caused by severe fever with thrombocytopenia syndrome virus (SFTSV), which has had a serious impact on public health in parts of Asia. There is no specific antiviral drug or vaccine for SFTSV and, therefore, it is important to determine the factors that influence the occurrence of SFTSV infections. This study aimed to explore the spatial associations between SFTSV infections and several potential determinants, and to predict the high-risk areas in mainland China. The analysis was carried out at the level of provinces in mainland China. The potential explanatory variables that were investigated consisted of meteorological factors (average temperature, average monthly precipitation and average relative humidity), the average proportion of rural population and the average proportion of primary industries over three years (2010–2012). We constructed a geographically weighted logistic regression (GWLR) model in order to explore the associations between the selected variables and confirmed cases of SFTSV. The study showed that: (1) meteorological factors have a strong influence on the SFTSV cover; (2) a GWLR model is suitable for exploring SFTSV cover in mainland China; (3) our findings can be used for predicting high-risk areas and highlighting when meteorological factors pose a risk in order to aid in the implementation of public health strategies.

ACS Style

Liang Wu; Fei Deng; Zhong Xie; Sheng Hu; Hu Sheng; Junming Shi; Dan Liu. Spatial Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in China Using a Geographically Weighted Logistic Regression Model. International Journal of Environmental Research and Public Health 2016, 13, 1125 .

AMA Style

Liang Wu, Fei Deng, Zhong Xie, Sheng Hu, Hu Sheng, Junming Shi, Dan Liu. Spatial Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in China Using a Geographically Weighted Logistic Regression Model. International Journal of Environmental Research and Public Health. 2016; 13 (11):1125.

Chicago/Turabian Style

Liang Wu; Fei Deng; Zhong Xie; Sheng Hu; Hu Sheng; Junming Shi; Dan Liu. 2016. "Spatial Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in China Using a Geographically Weighted Logistic Regression Model." International Journal of Environmental Research and Public Health 13, no. 11: 1125.