Diabetes exacerbates the progression of atherosclerosis and is associated with increased risk of developing acute coronary syndrome (ACS). Approximatively 25-30% of patients admitted for ACS have diabetes. ACS occurs earlier in diabetics and is associated with increased mortality and a higher risk of recurrent ischemic events. An increased proinflammatory and prothrombotic state is involved in the poorer outcomes of diabetic patients. In the past decade advancement in both percutaneous coronary intervention (PCI) and coronary artery by-pass graft (CABG) techniques and more potent antiplatelet drugs like prasugrel and ticagrelor improved outcomes of diabetic patients with ACS, but this population still experiences worse outcomes compared to non-diabetic patients. While in ST elevation myocardial infarction urgent PCI is the method of choice for revascularization, in patients with non-ST elevation ACS an early invasive approach is suggested by the guidelines, but in the setting of multivessel (MV) or complex coronary artery disease (CAD) the revascularization strategy is less clear. This review describes the accumulating evidence regarding factors involved in promoting increased incidence and poor prognosis of ACS in patients with diabetes, the evolution over time of prognosis and outcomes, revascularization strategies and antithrombotic therapy studied until now.

Background and Objectives: Osteoarthritis, the most common degenerative joint disease, causes pain, decreased mobility, and functional disability, having a significant impact on patients’ quality of life. This study aimed to evaluate the impact of hip osteoarthritis (HOA) and knee osteoarthritis (KOA) on physical functioning and quality of life, and to explore how these outcomes vary according to sex, disease stage, and common comorbidities. Materials and Methods: A cross-sectional study was conducted between 1 October and 30 December 2024, at the Medical Rehabilitation Department of Avram Iancu Clinical Hospital in Oradea, Romania. A total of 133 adult patients diagnosed with HOA or KOA, based on clinical and radiographic criteria, were included. Functional status was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), while quality of life was evaluated using the World Health Organization quality of life questionnaire-BREF version (WHOQOL-BREF). The main outcomes were the total scores of these instruments, analyzed in relation to demographic and clinical variables. Results: Based on the clinical staging criteria applied in the study, 23 patients (17.3%) were classified as being in the early stage, 98 (73.7%) in the progressive stage, and 12 (9.0%) in the advanced or end stage of the disease. The mean WOMAC total score was 52.0 ± 7.9 (scale: 0–96), indicating moderate to severe functional impairment. The mean WHOQOL-BREF score was 67.9 ± 13.1 (scale: 0–100), reflecting a moderately reduced quality of life. A moderate, statistically significant inverse correlation was observed between WOMAC and WHOQOL-BREF scores (Spearman’s rho = −0.565, p < 0.001). Patients with knee osteoarthritis reported significantly lower quality of life compared to those without this condition (66.48 ± 12.73 vs. 71.76 ± 13.31, p = 0.006). No statistically significant differences were found in functional, or quality-of-life scores based on sex. Conclusions: Knee osteoarthritis, particularly when combined with hip involvement, is associated with a substantial decline in quality of life and functional capacity. The severity and location of joint involvement appear to be the primary determinants of disability in this patient population, while systemic comorbidities have a less pronounced influence in the rehabilitation setting.

The assessment of an individual’s development by investigating the skeletal maturity is of much use in various medical fields. Skeletal maturity can be estimated by evaluating the morphology of the cervical vertebrae. The aim of this study was to conduct comparisons of the chronological age in different bone development stages. The retrospective study was conducted based on lateral cephalometric radiographs belonging to patients with ages between 6 and 15.9 years, from Romania. For the assessment of skeletal maturity, the Cervical Vertebral Maturation (CVM) method was used. In total, 356 radiographs were selected, but after applying the exclusion criteria, 252 radiographs remained in the study (178 girls and 74 boys). Different mean chronological age values were obtained for the general sample, as well as for the two genders. The chronological age started to be significantly different at the CS4 stage. Patients with CS4, CS5, and CS6 stages had a significantly higher chronological age compared to patients with CS1, CS2, and CS3 stages. It was noted that patients with CS1 and CS2 stages were more frequently boys, while patients with the CS5 stage were more frequently girls.

The incidence of the no-reflow (NR) phenomenon varies depending on the diagnostic criteria used. If just the angiographic criteria are considered (i.e., a degree of thrombolysis in myocardial infarction ≤2), it will be found that the incidence of NR is quite low; on the other hand, when the myocardial NR is taken into account (i.e., a decrease in the quality of myocardial reperfusion expressed by the degree of myocardial blush), the real incidence is higher. Thus, the early establishment of a diagnosis of NR and the administration of specific treatment can lead to its reversibility. Otherwise, regardless of the follow-up period, patients with NR have a poor prognosis. In the present work, we offer a comprehensive perspective on diagnostic tools for NR detection, for improving the global management of patients with arterial microvasculature damage, which is a topic of major interest in the cardiology field, due to its complexity and its link with severe clinical outcomes.

Background/Objectives: Musculoskeletal symptoms, such as neck pain, back pain, and eye strain, are prevalent in modern work environments, particularly among individuals engaged in prolonged sitting and repetitive tasks. This study aimed to explore the prevalence of these symptoms and the impact of ergonomic tool usage, break frequency, posture awareness, and proactive measures on symptom intensity and daily functioning. Methods: This cross-sectional pilot study used a self-developed questionnaire to assess the prevalence and intensity of musculoskeletal symptoms among participants aged 6–18 years. The survey collected data on ergonomic tool usage, break frequency, posture awareness, and proactive measures (such as taking breaks and seeking professional help). Symptom intensity was assessed across common musculoskeletal issues. Internal consistency was assessed using Cronbach’s Alpha. Statistical analyses, including descriptive statistics, Chi-squared tests, ANOVA, and Spearman’s correlation, were used to identify significant correlations and associations between variables. Results: A significant proportion of participants reported moderate to severe symptoms, including neck pain, back pain, and eye strain. Participants who used ergonomic tools reported significantly lower symptom intensity (<0.001). A positive correlation was found between fewer breaks and higher symptom intensity (r = 0.908, p < 0.001). Those with higher posture awareness reported lower symptom intensity (p < 0.001). Proactive measures, including regular breaks and ergonomic interventions, were perceived as effective strategies for managing symptoms. Increased symptom intensity was associated with reduced ability to perform daily activities (p < 0.001). Conclusions: The study highlights the significant role of ergonomic tools, posture awareness, and regular breaks in mitigating musculoskeletal symptoms. Proactive measures, including structured interventions, can effectively reduce symptom intensity and improve daily functioning. These findings suggest that workplace health strategies focusing on ergonomics and posture education are crucial for reducing the impact of musculoskeletal discomfort on employee well-being and productivity.

Background/Objectives: Ischemic heart disease (IHD) is a major cause of morbidity and mortality worldwide, and it is frequently associated with depression, which can negatively impact both clinical outcomes and quality of life. The relationship between IHD and depression is complex, with gender differences influencing the severity of depression and willingness to seek psychological support. This study aims to evaluate the prevalence and severity of depression in IHD patients using the Depression Assessment in Ischemic Heart Disease Questionnaire (DA-IHDQ) and to explore gender differences in depression severity and help-seeking behavior. Methods: This cross-sectional study involved 103 patients diagnosed with IHD (62 males, 41 females), with data collected from two general practice clinics in Arad, Romania, between November 2023 and November 2024. Participants completed the DA-IHDQ, a self-developed questionnaire designed to screen for depression in IHD patients. The questionnaire categorizes depression severity into four grades: minimal to no depression, mild depression, moderate depression, and severe depression. The study also assessed participants’ interest in receiving psychological support. Descriptive and inferential statistical analyses were performed, and the psychometric properties of DA-IHDQ, including its reliability (Cronbach’s α = 0.957) and diagnostic accuracy (sensitivity = 90.0%, specificity = 98.8%), were evaluated. Results: Mild depression was the most common grade in both male and female IHD patients, while severe depression was the least prevalent. Males had a higher overall frequency of depression, with more cases of mild depression, whereas females had a higher proportion of moderate and severe depression. Additionally, males demonstrated significantly lower interest in psychological or psychiatric help, while females showed greater willingness to seek mental health support. The DA-IHDQ exhibited strong internal consistency and high diagnostic accuracy in identifying depressive symptoms in IHD patients. The DA-IHDQ exhibited strong internal consistency and high diagnostic accuracy in identifying depressive symptoms in IHD patients. Conclusions: The findings highlight the high prevalence of depression in IHD patients and the gender disparities in mental health engagement, emphasizing the need for targeted psychological interventions. The DA-IHDQ demonstrated strong psychometric properties and could serve as an effective screening tool for depression in IHD care. The DA-IHDQ demonstrated strong psychometric properties and could serve as an effective screening tool for depression in IHD care. Future research should explore the barriers to help-seeking among male IHD patients and develop gender-sensitive strategies to improve access to mental health services.