Candida albicans is a common overgrowth in people wearing dentures. Long-term use of antifungal chemicals carries a risk of toxic side effects. This study focused on the edible Piper betle extract because of its safety. The broth dilution method was applied for antifungal determination of the ethyl acetate fractionated extract (fEA) and fEA-loaded polymeric micelles (PMF). The PMF was prepared by thin-film hydration using poloxamer 407 as a polymer base. The results found that the weight ratio of fEA to polymer is the main factor to obtain PMF system as a clear solution, nanoparticle sizes, narrow size distribution, negative zeta potential, and high entrapment efficiency. The activity of PMF against C. albicans is significantly higher than fEA alone, with a minimum fungicidal concentration of 1.5 mg/mL. PMF from 1:3 ratio of fEA to polymer is used to develop a denture-soaking solution contained 1.5 mg fEA/mL (PMFS). A clinical study on dentures of 15 volunteers demonstrated an 86.1 ± 9.2% reduction of C. albicans after soaking the dentures in PMFS daily for 14 days. Interestingly, PMFS did not change the hardness and roughness of the denture base resins. The developed PMFS may serve as a potential natural denture-soaking solution against candidiasis in denture wearers.

Introduction. The removable partial denture (RPD) components, especially the retentive arm, play a major role in the loading characteristic on supporting structures. Objective. To evaluate and compare the effect of different clasp designs on the stress distribution pattern, maximum von Mises stress, and average hydrostatic pressure on abutment teeth, as well as edentulous ridges, mini dental implants (MDIs), and peri‐implant bone between the conventional removable partial denture (CRPD) and mini dental implant‐assisted distal extension removable partial denture (IARPD) using a three‐dimensional finite element analysis (3D FEA). Materials and Methods. 3D FEA models of mandibular arches, with and without bilateral MDI at the second molar areas, and Kennedy class I RPD frameworks, with RPA, RPI, Akers, and no clasp component, were generated. A total of 200 N vertical load was bilaterally applied on both sides of distal extension areas, and the stress was analyzed by 3D FEA. Results. The stress concentration of IARPD with RPI clasp design was located more lingually on abutment teeth, MDI, and peri‐implant bone, while the other designs were observed distally on the supporting structures. The maximum von Mises stress on the abutment root surface was decreased when the RPDs were assisted with MDIs. The CRPD and IARPD with the Akers clasp design showed the highest von Mises stress followed by the designs with RPA and RPI clasp, respectively. The average hydrostatic pressure in each group was in approximation. Conclusion. The placement of MDIs on distal extension ridges helps to reduce the stress concentration on denture supporting structures. The maximum von Mises stress is affected by the different designs of clasp components. The CRPD and the IARPD with RPI clasp provide the least stress on supporting structures.

The development of scaffolds that simultaneously provide porous architectures and osteogenic properties is the major challenge in tissue engineering. Herein, a scaffold with high porosity and well interconnected networks, namely poly(lactic acid)/poly(butylene adipate-co-terephthalate) (PLA/PBAT), was fabricated using the gas foaming/ammonium bicarbonate particulate leaching technique. Mussel-inspired polydopamine (PDA)-assisted biomineralization generated by two-step simple soaking in dopamine solution and 10× SBF-like solution was performed to improve the material’s osteogenicity. Highly porous scaffolds available in less organized opened cell structures with diameters ranging from 10 µm to 100 µm and 200 µm to 500 µm were successfully prepared. The well interconnected porous architectures were observed through the whole thickness of the scaffold. The even deposition of the organic–inorganic bioactive mineralized layer composed of PDA and nano-scale hydroxyapatite (HA) crystals on the scaffold surface was evidenced by scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDX), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The developed scaffold exhibited high total porosity (84.17 ± 1.29%), a lower surface contact angle (θ = 45.7 ± 5.9°), lower material degradation rate (7.63 ± 2.56%), and a high level of material biocompatibility. The MTT assay and Alizarin Red S staining (ARS) confirmed its osteogenic enhancement property toward human osteoblast-like cells (MG-63). These results clarified that the developed porous PLA/PBAT scaffold with PDA-assisted biomineralization exhibited good potential for application as a biomaterial for bone tissue regeneration and hard tissue engineering.

Polyetheretherketone (PEEK) has become an alternative material for orthopaedics and dental implants. However, bio-inertness is an important limitation in this material. In the present study, a hydroxyapatite (HA)–titanium nitride (TiN) coating was fabricated via pulsed DC magnetron sputtering and treated with hydrothermal treatment to improve the bioactive property of PEEK. The dissolution behavior of the coating was studied in simulated body fluid solution (SBF) at 1, 3, 5, 7, 14, 21, 28, and 56 days. The coating surface was analyzed before and after the immersion process by X-ray photoelectron spectroscopy (XPS), atomic force microscope (AFM), and scanning electron microscope (SEM). The calcium and phosphorus concentration alteration in SBF was quantified by an inductively coupled plasma-optical emission spectrometer (ICP-OES). Coating dissolution and the precipitation of calcium phosphate complex from SBF were observed as occurring suddenly and continuously throughout the immersion times. These processes resulted in an alteration in both physical and chemical coating properties. After 56 days, the coating remained on PEEK surfaces and the Ca/P ratio was 1.16. These results indicate that HA-TiN coating via pulsed DC magnetron sputtering followed by hydrothermal treatment improved the bioactivity of materials and provided a potential benefit to orthopedics and dental applications.

Background. Adequate ventilation is imperative for controlling respiratory transmission, particularly in the context of the COVID-19 pandemic. The commercial portable air cleaners have emerged as practical solutions to reduce contaminated aerosols in dental treatment rooms. This study employs computational fluid dynamics (CFD) to assess their impact on airflow dynamics. Methods. Dental treatment room models were constructed using SolidWorks software, encompassing two distinct air conditioner grille orientations (straightening and 45-degree downward directions) and five different positions for the portable air cleaner (two located at the rear left/right of the dental unit and three at the foot end of the dental unitcenter, left, and right corners). The study examined alterations in airflow direction and residual aerosol concentrations using ANSYS Fluent software. Results. The incorporation of portable air cleaners in dental treatment rooms significantly reduced aerosol levels across all model configurations. Notably, the placement of the portable air cleaner emerged as a critical factor influencing airflow patterns. In models with straightening and 45-degree downward air conditioner grille orientations, optimal positioning was near the operating field and at the foot end of the dental chair, respectively. Conclusion. This investigation highlights the pivotal role of strategic portable air cleaner placement in dental treatment rooms for effective aerosol removal. Placing the air cleaner near the operating field or at the foot end of the dental chair not only improved airflow patterns but also enhanced aerosol removal efficiency, ultimately promoting superior air quality within dental treatment environments.

This study investigates the fluoride release, rechargeability and degradation behaviors of newly developed anticariogenic poly(lactic acid) (PLA) composites. The PLA composite with various concentrations (0%, 5%, 10%, 15% and 20% by weight) of glass ionomer cement (GIC) and sodium fluoride (NaF) were prepared using solvent casting method. The fluoride release, fluoride rechargeability and degradation behavior were evaluated. All experimental groups demonstrated fluoride-releasing ability. The highest level of fluoride ions released was found in PLA composite with sodium fluoride (PLA/NaF). Following the 28-day period, both groups showed a gradual reduction in fluoride ion released, ranging between 0.03 ± 0.01 and 0.53 ± 0.06 ppm, although remaining within the effective range for tooth remineralization. However, the rechargeability was only observed in PLA composite with GIC (PLA/GIC). Following an eight-week in vitro degradation test, all PLA/NaF groups displayed a significantly higher percentage of weight change and water absorption compared to the PLA/GIC and the control group. In SEM analysis, the formation of surface porosities was clearly noticed in all PLA/NaF. All specimens retained their structural integrity throughout the study. In conclusion, the newly developed PLA/GIC displays promising possibilities as an anticariogenic material. Furthermore, the rechargeability of these ions are repeatable, ensuring their long-term utility.