The characteristics of a person's health status are often guided by how they live, grow, learn, their genetics, as well as their access to health care. Yet, all too often, studies examining the relationship between social determinants of health (behavioral, sociocultural, and physical environmental factors), the role of demographics, and health outcomes poorly represent these relationships, leading to misinterpretations, limited study reproducibility, and datasets with limited representativeness and secondary research use capacity. This is a profound hurdle in what questions can or cannot be rigorously studied about COVID‐19. In practice, gene–environment interactions studies have paved the way for including these factors into research. Similarly, our understanding of social determinants of health continues to expand with diverse data collection modalities as health systems, patients, and community health engagement aim to fill the knowledge gaps toward promoting health and wellness. Here, a conceptual framework is proposed, adapted from the population health framework, socioecological model, and causal modeling in gene–environment interaction studies to integrate the core constructs from each domain with practical considerations needed for multidisciplinary science.

As society moves towards a preventative approach to healthcare, there is growing interest in scientific research involving technology that can monitor and prevent adverse health outcomes. The primary objective of this paper is to develop an Internet of Things (IoT) wearable system based on Fried’s phenotype that is capable of detecting frailty. To determine user requirements, the system’s architecture was designed based on the findings of a questionnaire administered to individuals confirmed to be frail. A functional prototype was successfully developed and tested under real-world conditions. This paper introduces the methodology that was used to analyze the data collected from the prototype. It proposes an interdisciplinary approach to interpret wearable sensor data, providing a comprehensive overview through both visual representations and computational analyses facilitated by machine learning models. The findings of these analyses offer insights into the ways in which different types of activities can be classified and quantified as part of an overall physical activity level, which is recognized as an important indicator of frailty. The results provide the foundations for a new generation of affordable and non-intrusive systems able to detect and assess early signs of frailty.

Sharing research code in an open access version-controlled repository offers significant benefits for both science as a whole and for individual researchers. In this article, we focus on this practice, which is fully aligned with the NIH’s Gold Standard Science (GSS) program as well as FAIR (findable, accessible, interoperable, reusable) and TRUST (transparency, responsibility, user focus, sustainability, technology) principles. Gold Standard Science supports open science by emphasizing transparency, reproducibility, and the use of best practices that enable others to verify and extend research. Pairing a research article’s cited data snapshot with a versioned, environment-specific code release, deposited in a companion code repository, ensures that, upon submission to a medical journal, readers and reviewers can directly verify results. An executable and updatable companion code repository complements, rather than replaces, established research data repositories. When code underlying medical research results is made openly available, then other scientists can inspect, run, and validate analyses. These activities enhance reproducibility, which is a core aim of GSS. Shared code also facilitates collaborative innovation by allowing researchers to extend the utility of the code to new datasets and applications. For researchers, code sharing can increase visibility, credibility, and citation impact. Demonstrating transparency through shared executable and updatable code builds trust with journal readers, peer reviewers, funders, and peers. Shared code in an open access repository signals adherence to high standards of scientific integrity and attracts opportunities for collaboration. A researcher who shares code receives recognition as a leader in reproducible, trustworthy research consistent with NIH’s GSS principles.

The general condition of urban watercourses is inextricably linked to ecological balance and public health (physical and mental well-being). Given the vulnerability of these systems to climate change and human pollution, this work aims to demonstrate the effective use of environmental indicators to: a) rapidly assess soil and water conditions near urban streams and b) highlight the importance of geoinformatics and earth observation supported by ground-based techniques. There is a great need for new technology and methods for spatial and temporal monitoring and further quantification of environmental quality in urban streams and the land surrounding them to sensitize policymakers and the public to the environmental degradation of these exceptional habitats and to further protect people’s mental health.

The scope of this work is to describe the overall process of assessing the compliance of the main Digital Objects produced in the OneAquaHealth project with the FAIR principles (Findability, Accessibility, Interoperability, and Reusability) via a custom FAIR Data Maturity Model. The model was designed and developed according to the project features, and in according with the One Digital Health Framework. Its goal is also to provide a tool characterized by a solid educational ground, so as to set the foundation of a timely FAIRification process for the next project steps.