In this study, graphene is used as a photothermal material, which is added to the SiO₂ superhydrophobic solution treated with fluorine silane, and then sprayed on the copper plate surface to prepare a new type of photothermal superhydrophobic surface with contact angles up to 160.5° and 159.8°. Under the conditions of natural convection, the effects of photothermal superhydrophobic surfaces on droplet condensation, freezing, and frost growth are investigated in different environments. The results show that the photothermal superhydrophobic surface can not only delay the freezing of surface droplets, prolong the freezing time of droplets, and reduce the thickness of the frost layer, but also allow for the rapid removal of droplets under near-infrared (NIR) irradiation. If the droplet is irradiated by an infrared laser emitter while the cooling system is still turned on, the internal temperature of the droplet will always be higher than the crystallization temperature under the illumination intensity of 2 W/cm², and the droplets will not freeze. With the extension of irradiation time, the droplet will evaporate, and the volume of the droplet will decrease. On the basis of summarizing and evaluating the study on the anti-icing performance of superhydrophobic surfaces and the properties of photothermal materials, a new research direction regarding the anti-icing of fan blade surfaces was established. This kind of surface combines the photothermal capabilities of light absorption materials with the micro- and nanostructure of the superhydrophobic surface to improve the anti-icing capability of wind turbine blade surfaces in difficult conditions.

Neonatal necrotizing enterocolitis (NEC) is one of the most prevalent and severe intestinal emergencies in newborns. The inflammatory activation of macrophages is associated with the intestinal injury of NEC. The neuroimmune regulation mediated by α7 nicotinic acetylcholine receptor (α7nAChR) plays an important role in regulating macrophage activation and inflammation progression, but in NEC remains unclear. This study aims to explore the effect of macrophage α7nAChR on NEC. Mice NEC model were conducted with high-osmolarity formula feeding, hypoxia, and cold stimulation. The α7nAChR agonist PNU-282987 and mTOR inhibitor rapamycin were treated by intraperitoneal injections in mice. The expression and distribution of macrophages, α7nAChR, and phospho-mammalian target of rapamycin (p-mTOR) in the intestines of NEC patients and mice was assessed using immunohistochemistry, immunofluorescence, and flow cytometry. The expression of NLRP3, activated caspase-1 and IL-1β in mice intestines was detected by flow cytometry, western blot or ELISA. In vitro, the mouse RAW264.7 macrophage cell line was also cultured followed by various treatments. Expression of p-mTOR, NLRP3, activated caspase-1, and IL-1β in macrophages was determined. Macrophages accumulated in the intestines and the expression of α7nAChR in the mucosal and submucosal layers of the intestines was increased in both the NEC patients and mice. The p-mTOR and CD68 were increased and co-localized in intestines of NEC patients. In vitro, α7nAChR agonist PNU-282987 significantly reduced the increase of NLRP3, activated caspase-1, and IL-1β in macrophages. PNU-282987 also significantly reduced the increase of p-mTOR. The effect was blocked by AMPK inhibitor compound C. The expression of NLRP3, activated caspase-1, and IL-1β was inhibited after mTOR inhibitor rapamycin treatment. In NEC model mice, PNU-282987 reduced the expression of p-mTOR, NLRP3, activated caspase-1, and IL-1β in the intestine. Meanwhile, rapamycin significantly attenuated NLRP3 activation and the release of IL-1β. Moreover, the proportion of intestinal macrophages and intestinal injury decreased after PNU-282987 treatment. Macrophage α7nAChR activation mitigates NLRP3 inflammasome activation by modulating mTOR phosphorylation, and subsequently alleviates intestinal inflammation and injury in NEC.

The aerodynamic performance of wind turbine airfoils is crucial for the efficiency and reliability of wind energy systems, with leading-edge roughness significantly impacting blade performance. This study conducts numerical simulations on the DU 00-W-401 airfoil to investigate the effects of leading-edge roughness. Results reveal that the rough airfoil exhibits a distinctive “N”-shaped lift coefficient curve. The formation mechanism of this nonlinear lift curve is primarily attributed to the development of the trailing-edge separation vortex and variations in the adverse pressure gradient from the maximum thickness position to the trailing-edge confluence. The impact of different roughness heights is further investigated. It is discovered that when the roughness height is higher than 0.3 mm, the boundary layer can be considered fully turbulent, and the lift curve shows the “N” shape stably. When the roughness height is between 0.07 mm and 0.1 mm, a transitional state can be observed, with several saltation points in the lift curve. The main characteristics of different flow regimes based on different lift curve segments are summarized. This research enhances the understanding of the effects of leading-edge roughness on the aerodynamic performance of a thick wind turbine airfoil, and the simulation method for considering the effect of leading-edge roughness is practical to be applied on large-scale wind turbine blade to estimate the aerodynamic performance under rough leading-edge conditions, thereby supporting advancements in wind turbine technology and promoting the broader adoption of renewable energy.