Ponatinib may be effective in chronic myeloid leukemia (CML) patients after failure of first/second line therapies. Although its efficacy for minimum plasma concentrations (C_min) is >21.3 ng/mL (equal to 40 nM), ponatinib may cause adverse events (AE) that require dose optimization. The present study was aimed at investigating any possible correlations among ponatinib dose, plasma concentration, molecular response (MR), and tolerability in a real-world setting. Clinical and laboratory records (including MR and drug plasma concentrations) of 32 CML patients treated with ponatinib were harvested and analyzed. Twenty-seven patients (71%) had ponatinib C_min values > 21.3 ng/mL, but C_min values > 10.7 ng/mL (considered efficacious in BCR-Abl unmutated patients) were achieved by 80% of the patients receiving ≥30 mg/day and 45% of the subjects treated with 15 mg/day. No significant correlations were identified among clinical efficacy, tolerability, daily dose, and plasma concentration. Notably, patients who underwent dose tapering for tolerability or safety reasons did not experience treatment failure. In a real-world setting, adjustment of ponatinib daily doses lower than those registered may maintain therapeutic efficacy while reducing the risk of vascular events and improving tolerability. Further studies are warranted to confirm the present results in a larger cohort of patients.

The essential oil (EO) industry generates large volumes of solid distillation residues that are commonly discarded as waste, despite their potential as a source of nutrients and bioactive compounds. This study evaluated the chemical quality and the volatile profile of four types of exhausted biomasses (EBs) obtained after steam distillation of EOs from bay laurel (Laurus nobilis), lavender (Lavandula angustifolia), lavandin (L. angustifolia × L. latifolia) and two industrial hemp specimens (Carifit1p, a breeding line, and Codimono, a cultivar), with a view to their potential valorisation in animal feeding. The nutritional composition of the distillation residues was determined according to AOAC methods, while the headspace volatile fraction was characterised by HS-SPME–GC/MS. The EBs were generally characterised by a high fibre content, with the highest crude fibre and NDF values in whole lavender and lavandin plants, whereas the industrial hemp line Carifit1p showed the highest crude protein (17.1% DM) and ash contents. The volatile profiles of the residues differed markedly from those typical of the corresponding fresh EOs: the bay laurel residue was dominated by monoterpene hydrocarbons (74.5%) with strongly depleted 1,8-cineole (1.9%), while lavender and lavandin retained high levels of β-caryophyllene (35.8% and 32.4%, respectively). Industrial hemp residues were enriched in oxygenated sesquiterpenes, with caryophyllene oxide reaching 21.2% in Carifit1p and exceeding β-caryophyllene. Overall, the results indicate that EO exhausted biomasses retain a species-specific profile of fibre, residual nutrients and less volatile, less water-soluble terpenoids, supporting their potential reuse as feed ingredients and contributing to a more sustainable, near-zero-waste distillation supply chain.

Background/Objectives: 3,4-Methylenedioxy-alpha-pyrrolidinohexanophenone (MDPHP) is a pyrrolidinophenone synthetic cathinone whose post-mortem interpretation is particularly difficult when advanced decomposition prevents blood-based toxicology. This case report examined instrument-derived semiquantitative MDPHP values in solid tissues and necrophagous larvae and assessed the complementary evidential value of larval matrices. Methods: Post-mortem computed tomography, complete autopsy, histology, and liquid chromatography–high-resolution mass spectrometry (LC-HRMS) were performed in an adult decedent found in advanced decomposition. Brain, liver, kidney, and four separately collected larval groups were analyzed using a procedure previously validated in blood but not validated in tissues or larvae. Results: No fatal traumatic lesion was identified. Pulmonary edema and myocardial fibrofatty replacement were documented. Instrument-derived semiquantitative MDPHP values were 0.45 ng/mg in brain, 0.75 ng/mg in liver, and 2.44 ng/mg in kidney; the four larval groups yielded <0.06, 0.43, 1.58, and 0.22 ng/mg, respectively. These values are exploratory and semiquantitative because matrix-specific validation data are unavailable. The Larvae III extract also showed signals tentatively assigned to M3.1, M5.2, and M9.1. Conclusions: Necrophagous larvae preserved evidence of MDPHP exposure and phase-I metabolite signals. The findings do not establish validated quantitative concentrations, a lethal threshold, or a tissue-to-larva relationship. In the integrated medicolegal context, MDPHP intoxication remained a plausible contributor, but causal interpretation was limited by the single-case design, decomposition, underlying myocardial pathology, absence of conventional matrices, and lack of tissue- and larva-specific method validation.