Arrhythmia is a life-threatening cardiac condition characterized by irregular heart rhythm. Early and accurate detection is crucial for effective treatment. However, single-lead electrocardiogram (ECG) methods have limited sensitivity and specificity. This study propose an improved ensemble learning approach for arrhythmia detection using multi-lead ECG data. Proposed method, based on a boosting algorithm, namely Fine Tuned Boosting (FTBO) model detects multiple arrhythmia classes. For the feature extraction, introduce a new technique that utilizes a sliding window with a window size of 5 R-peaks. This study compared it with other models, including bagging and stacking, and assessed the impact of parameter tuning. Rigorous experiments on the MIT-BIH arrhythmia database focused on Premature Ventricular Contraction (PVC), Atrial Premature Contraction (PAC), and Atrial Fibrillation (AF) have been performed. The results showed that the proposed method achieved high sensitivity, specificity, and accuracy for all three classes of arrhythmia. It accurately detected Atrial Fibrillation (AF) with 100% sensitivity and specificity. For Premature Ventricular Contraction (PVC) detection, it achieved 99% sensitivity and specificity in both leads. Similarly, for Atrial Premature Contraction (PAC) detection, proposed method achieved almost 96% sensitivity and specificity in both leads. The proposed method shows great potential for early arrhythmia detection using multi-lead ECG data.

The clinical investigation explored that early recognition and intervention are crucial for preventing clinical deterioration in patients in Intensive Care units (ICUs). Deterioration of patients is predictable and can be preventable if early risk factors are recognized and developed in the clinical setting. Timely detection of deterioration in ICU patients may also lead to better health management. In this paper, a new model was proposed based on Long Short-Term Memory-Recurrent Neural Network (LSTM-RNN) to predict deterioration of ICU patients. An optimisation model based on a modified genetic algorithm (GA) has also been proposed in this study to optimize the observation window, prediction window, and the number of neurons in hidden layers to increase accuracy, AUROC, and minimize test loss. The experimental results demonstrate that the prediction model proposed in this study acquired a significantly better classification performance compared with many other studies that used deep learning models in their works. Our proposed model was evaluated for two tasks: mortality and sudden transfer of patients to ICU. Our results show that the proposed model could predict deterioration before one hour of onset and outperforms other models. In this study, the proposed predictive model is implemented using the state-of-the-art graphical processing unit (GPU) virtual machine provided by Google Colaboratory. Moreover, the study uses a novel time-series approach, which is minute-by-minute. This novel approach enables the proposed model to obtain highly accurate results (i.e., an AUROC of 0.933 and an accuracy of 0.921). This study utilizes the individual and combined effectiveness of different types of variables (i.e., vital signs, laboratory measurements, GCS, and demographic data). In this study, data was extracted from MIMIC-III database. The ad-hoc frameworks proposed by previous studies can be improved by the novel and reliable prediction framework proposed in this research, which will result in predictions of more accurate performance. The proposed predictive model could reduce the required observation window (i.e., a reduction of 83%) for the prediction task while improving the performance. In fact, the proposed significant small size of observation window could obtain higher results which outperformed all previous works that utilize different sizes of observation window (i.e., 48 hours and 24 hours). Moreover, this research demonstrates the ability of the proposed predictive model to achieve accurate results (>80%) on ‘raw’ data in an experimental work. This shows that the rule-based pre-processing of clinical features is unnecessary for deep learning predictive models.

Background: Atrial fibrillation (AFIB) is one of the most common types of arrhythmia, which leads to heart failure and stroke to public. As AFIB has the high potential to cause permanent disability in patients, its early detection is extremely important. There are different types of AFIB classification algorithm that have been proposed by researchers in recent years. Methods: This paper reviews the features of AFIB in terms of ECG morphological features and heart rate variability (HRV) analysis on different methods. The existing classification method, particularly focusing on Artificial Intelligence technique, is also comprehensively described. Other than that, the existing implementation technology of arrhythmia detection platforms such as smart phone and System-on-Chip-based embedded device are also elaborated in terms of their design trade-offs. Conclusion: Current existing AFIB detection algorithm cannot compromise for high accuracy and low complexity. Due to the limitation of embedded system, design trade off should be considered to strike the balance between the performance of algorithm and the limitation.

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopment psychiatric disorder which causes inattention, hyperactivity, or impulsivity, that directly leads to the learning disability in children. The conventional ADHD diagnosis method such as behavioural rating scare required long term behavior observation and subjective interpretation which leads to misleading result. Over the past decades, in biomedical engineering perspective there has been exponential growth in the literature such as Electroencephalograph (EEG), Magnetic Resonance Imaging (MRI) and electrodermal responding to identify accurate and objective measurements in the diagnosis ADHD. Nevertheless, there is still a lack of methodological standardisation among all these approaches. The purpose of this study is to investigate ADHD in children aged from 7 to 14 years old at primary schools in Malaysia with Electro Interstitial Scan (EIS) technology. There are total of 182 children data have been collected, which consist of 58 ADHD children and 124 healthy children. All subjects will undergo EIS measurement and the SPSS statistical analysis was conducted on the primary parameters and secondary parameters to determine the significance level of each channel in differentiating ADHD and non-ADHD children. The statistical analysis result shows that the EIS system reflects significant difference between control group and study group in both primary parameters (EIS channels 1, 2, 3, 4, 9, 10, 15, 16, 17 and 18) and secondary parameters (brain and neurotransmitter related parameters) (p<0.05). This study concludes that the EIS system has a good potential in providing a new measurable marker to complement the conventional diagnosis of ADHD as decision support system.