This study aims to remove arsenic from an aqueous medium by adsorption on a nanocomposite material obtained by the sol–gel method starting from matrices of silica, iron oxide and NaF (SiO₂/Fe(acac)₃/NaF). Initially, the study focused on the synthesis and characterization of the material by physico–chemical methods such as: X-ray diffraction, FT-IR spectroscopy, Raman spectroscopy, atomic force microscopy, and magnetization. Textural properties were obtained using nitrogen adsorption/desorption measurements. The zero load point, pHpZc, was also determined by the method of bringing the studied system into equilibrium. In addition, this study also provides a comprehensive discussion of the mechanism of arsenic adsorption by conducting kinetic, thermodynamic and equilibrium studies. Studies have been performed to determine the effects of adsorbent dose, pH and initial concentration of arsenic solution, material/arsenic contact time and temperature on adsorption capacity and material efficiency. Three theoretical adsorption isotherms were used, namely Langmuir, Freundlich and Sips, to describe the experimental results. The Sips isotherm was found to best describe the experimental data obtained, the maximum adsorption capacity being ~575 µg As(III)/g. The adsorption process was best described by pseudo-second order kinetics. Studies have been performed at different pH values to establish not only the optimal pH at which the adsorption capacity is maximum, but also which is the predominantly adsorbed species. The effect of pH and desorption studies have shown that ion exchange and the physiosorption mechanism are implicated in the adsorption process. From a thermodynamic point of view, parameters such as ΔG°, ΔH° and ΔS° were evaluated to establish the mechanism of the adsorption process. Desorption studies have been performed to determine the efficiency of the material and it has been shown that the material can be used successfully to treat a real-world example of deep water with a high arsenic content.

Copper nanoparticles (CuNPs) have attracted attention due to their low cost and high specific surface area. In this work, a simple and inexpensive two-step synthesis method was proposed to prepare highly stable and well-dispersed spherical CuNPs in solution with a particle size of approximately 37 nm. Synthesis of CuNPs was carried on in the presence of complexing agent trisodium citrate (TSC), while for the chemical reduction step, sodium borohydride (NaBH₄) was used. Taking into account the potential of this type of nanoparticles, their synthesis and characterization represent a current and relevant topic in the field. The ability to control the size, shape and properties of CuNPs by adjusting the synthesis parameters (pH, precursor:stabilizer:reductant ratio, homogenization time, temperature) offers extraordinary flexibility in the development of these materials. The combination of characterization techniques such as SEM, EDX, UV–Vis, Raman, FT-IR and AFM provides a thorough understanding of the structure and properties of CuNPs, allowing the modulation of the properties of the obtained nanoparticles in the desired direction. Based on the studies, the copper reduction mechanism was proposed. For the theoretical verification of the size of the experimentally obtained spherical CuNPs, Mie theory was applied. A stability study of the synthesized CuNPs in optimal conditions was performed using UV–Vis analysis at specific time intervals (1, 3, 30 and 60 days), the sample being kept in the dark, inside a drawer at 25 °C. The CuNPs obtained after setting the optimal synthesis parameters (Cu(II):TSC:${\mathrm{B}\mathrm{H}}_4^{+}$ = 1:1:0.2, pH = 5, homogenization time 60 min and temperature 25 °C) were then tested to highlight their antibacterial effect on some reference bacterial strains. The obtained CuNPs demonstrated very good antimicrobial efficacy compared to traditional antimicrobials, for both Gram-negative and Gram-positive bacteria. This may reduce the development of antimicrobial resistance, an urgent medical issue. After evaluating the cytotoxic effects of CuNPs on the SKBR3 cancer cell line, a significant decrease in cell proliferation was observed at the 0.5 mg/mL concentration, with a reduction of 89% after 60 h of cultivation. Higher concentrations of CuNPs induced a more rapid cytotoxic effect, leading to an accelerated decline in cell viability.

Medical and pharmaceutical research has shown that liposomes are very efficient in transporting drugs to targets. In this study, we prepared six liposome formulas, three in which we entrapped caffeic acid (CA), and three with only phospholipids and without CA. Determination of entrapment efficiency (EE) showed that regardless of the phospholipids used, the percentage of CA entrapment was up to 76%. The characterization of the liposomes was performed using Dynamic Light Scattering (DLS), Atomic Force Microscopy (AFM), zeta potential and polydispersity and showed that about 75–99% of the liposomes had dimensions between 40 ± 0.55–500 ± 1.45 nm. The size and zeta potential of liposomes were influenced by the type of phospholipid used to obtain them. CA release from liposomes was performed using a six-cell Franz diffusion system, and it was observed that the release of entrapped CA occurs gradually, the highest amount occurring in the first eight hours (over 80%), after which the release is much reduced. Additionally, the time stability of the obtained liposomes was analysed using univariate and multivariate statistical analysis. Therefore, liposomes offer great potential in CA entrapment.

This study aimed to evaluate the comparative biological effects of Polygonum aviculare L. herba (PAH) extract and quercetin-entrapped liposomes on doxorubicin (Doxo)-induced toxicity in HUVECs. HUVECs were treated with two formulations of liposomes loaded with PAH extract (L5 and L6) and two formulations of liposomes loaded with quercetin (L3 prepared with phosphatidylcholine and L4 prepared with phosphatidylserine). The results obtained with atomic force microscopy, zeta potential and entrapment liposome efficiency confirmed the interactions of the liposomes with PAH or free quercetin and a controlled release of flavonoids entrapped in all the liposomes. Doxo decreased the cell viability and induced oxidative stress, inflammation, DNA lesions and apoptosis in parallel with the activation of Nrf2 and NF-kB. Free quercetin, L3 and L4 inhibited the oxidative stress and inflammation and reduced apoptosis, particularly L3. Additionally, these compounds diminished the Nrf2 and NF-kB expressions and DNA lesions, principally L4. PAH extract, L5 and L6 exerted antioxidant and anti-inflammatory activities, reduced γH2AX formation and inhibited extrinsic apoptosis and transcription factors activation but to a lesser extent. The loading of quercetin in liposomes increased the cell viability and exerted better endothelial protection compared to free quercetin, especially L3. The liposomes with PAH extract had moderate efficiency, mainly due to the antioxidant and anti-inflammatory effects and the inhibition of extrinsic apoptosis.

The coating of orthopedic and dental implants with hydroxyapatite (HA) is recognized as a method to increase their integration ability. A new metal coating method, comprising simultaneous precipitation and electrodeposition, is presented. Two studies are described: the first is related to the influence of time/temperature increase on the morpho-structural characteristics of the deposited layer on the Ti substrate, while the second study presents the characteristics of the layers deposited on different metal substrates. For comparison, specimens were obtained using the classical electrochemical deposition under the same experimental conditions. The addition of Ca to the electrolyte creates more compact and more uniform coatings, while the addition of P creates more porous layers. Only a very small quantity of crystalline HA deposited on the C55, Cu, and Ni substrates when the classic electrodeposition method was employed, while using the new approach has clearly led to a larger crystalline HA amount electrodeposited on the same types of metals. With some exceptions, the advantages of using the new method are: better crystallinity, more uniform and continuous surface, higher roughness, and potentially higher anti-corrosion capabilities.

Adsorption recovery of precious metals on a variety of solid substrates has steadily gained increased attention in recent years. Special attention was paid to the studies on the characterization of the adsorptive properties of materials with a high affinity for gold depending on the nature of the pendant groups present in the structure of the material. The aim of the present work was to synthesize and characterize a new material by using the sol-gel synthesis method (designated as BCb/CB). In this case, synthesis involved the following precursors: bismuth carbonate (III), carbon black, and IGEPAL surfactant (octylphenoxypolyethoxyethanol). Immobilization of the heterojunction as bismuth oxide over a flexible support such as carbon black (CB) can prevent their elution in solution and make it versatile for its use in a system. In this work, a new adsorbent material based on bismuth carbonate supported over carbon black (BCb/CB) was developed and used further for gold recovery from aqueous solutions. The required material was characterized physically/chemically by scanning electron microscopy (SEM); energy dispersive X-ray spectrometry (EDX); X-ray diffraction (XRD); thermal analysis (DTG/DTA); atomic force microscopy (AFM). The Brunauer–Emmett–Teller (BET) method was used to determine the specific surface area indicating a value of approximately 40 m²/g, higher than the surface of CB precursor (36 m²/g). The adsorptive properties and the adsorption mechanism of the materials were highlighted in order to recover Au(III). For this, static adsorption studies were carried out. The parameters that influence the adsorption process were studied, namely: the pH, the contact time, the temperature, and the initial concentration of the gold ions in the used solution. In order to establish the mechanism of the adsorption process, kinetic, thermodynamic, and equilibrium studies were carried out. Experimental data proved that the gold recovery can be conducted with maximum performance at pH 3, at room temperature. Thermodynamic studies proved that the gold adsorption on BCb/CB material is a spontaneous and endothermal process. The results indicate a total adsorption capacity of 13.1 mg Au(III)/g material. By using this material in real solutions, a recovery efficiency of 90.5% was obtained, concomitant with a higher selectivity (around 95%).