During the preparation of high dilutions, repeated external vibration (shaking) is used. We hypothesized that it was the vibration treatment, and not the negligible content of the initial substance, that underlies the activity of highly diluted preparations. In order to test this, the vibration was separated from the dilution process. After vibrating two tubes together on a vortex mixer (one containing water and the other the initial substance) the electrical conductivity and radio frequency radiation intensity of water differed from the unvibrated control, and the ability to exert a modifying effect on the target solution appeared, as assessed using ELISA and terahertz spectroscopy, appeared. Thus, the properties of the neutral carrier (water) changed after non-contact exposure to the initial substance. We have named this process ‘crossing’ and its products ‘aqueous iterations of the initial substance’. Several aqueous iterations with different physical properties were obtained, some of which have a modifying effect and others cause various chemical (catalytic) and biological (antiviral) effects similar to those of the initial substance. This indicates that during crossing, substances enter into post-vibration supramolecular interactions. At the nanoscale level, aqueous iterations and the initial substance are structurally symmetrical, which allows us to assume that the preservation of the symmetry of substances subjected to vibration treatment is the basis of the post-vibration interaction phenomenon.

The coupled dynamics of low-lying modes and various giant resonances are studied with the help of the Wigner function moments method on the basis of time-dependent Hartree-Fock equations in the harmonic oscillator model including spin-orbit potential plus quadrupole-quadrupole and spin-spin residual interactions. New low-lying spin-dependent modes are analyzed. Special attention is paid to the spin scissors mode.

[[abstract]]Motivated by arguments of the nuclear core-layer model formulated in [S.I. Bastrukov, J.A. Maruhn, Z. Phys. A 335 (1990) 139], the macroscopic excitation mechanism of the electric pygmy dipole resonance (PDR) is considered as owing its origin to perturbation-induced effective decomposition of a nucleus into two spherical domains–undisturbed inner region treated as a static core and dynamical layer undergoing elastic shear vibrations. The elastic restoring force is central to the excitation mechanism under consideration and has the same physical meaning as in macroscopic model of nuclear giant resonances involving distortions of the Fermi-sphere providing unified description of isoscalar giant electric and magnetic resonances of multipole degree ℓ2 in terms of two fundamental vibrational modes in an elastic sphere, to wit, as spheroidal (electric) and torsional (magnetic) modes of shear elastic oscillations of the nodeless field of material displacements excited in the entire nucleus volume. In the present Letter focus is placed on the emergence of dipole overtone in the frequency spectrum of spheroidal elastic vibrations as Goldstone soft mode. To emphasis this feature of dipole resonant excitation imprinted in the core-layer model we regain spectral equation for the frequency of spheroidal elastic vibrations trapped in the finite-depth layer, derived in the above paper, but using canonical equation of an elastic continuous medium. The obtained analytic equations for the frequency of dipole vibrational state in question and its excitation strength lead to the following estimates for the PDR energy centroid EPDR(E1)=[31±1]A−1/3 MeV and the total excitation probability BPDR(E1)=[1.85±0.05]10−3Z2A−2/3e2 fm2 throughout the nuclear chart exhibiting fundamental character of this soft dipole mode of nuclear resonant response.[[fileno]]2010507010002[[department]]天文

A new class of biologics is obtained using the technologically processed of antibodies (TPA), which are used as the initial substance, and their dilution at each stage is accompanied by a controlled external vibrational (mechanical) treatment. This article focuses on the development and validation of a novel technique that can be applied for assessing the identity of TPA-based drugs. It has previously been found that after such treatment, the resulting solution either acquired new properties that were not present in the initial substance or a quantitative change in properties compared to the initial substance was observed. The use of mechanical treatment during the manufacture of the TPA-based drugs can cause the formation of new bonds between the solvent and antibody molecules. These changes manifest themselves in altered adsorption at the surface of the test solutions, which results in the formation of a near-surface film. One of the indicators of such events is the change in the surface temperature of the solution, which can be analyzed using high-resolution thermography. Unlike other methods, the high-resolution thermography allows the near-surface layer of a heterogeneous aqueous solution to be clearly visualized and quantified. A number of experiments were performed: seven replicates of sample preparations were tested; the influence of factors “day” or “operator” was investigated during 12 days of testing by two operators. The method also allowed us to distinguish between technologically processed antibodies and samples containing technologically processed buffer. The thermographic analysis has proven to be a simple, specific, and reproducible technique that can be used to analyze the identity of TPA-based drugs, regardless of the dosage form tested.

For many years, our research group has been studying a phenomenon initially discovered in biological models: a solution of a substance subjected to vibration treatment exerts a modifying effect on an intact sample of the same substance, altering its physicochemical and biological properties. This effect also occurs without direct contact, when the vibration-treated and intact substances are kept in separate vials. Since the emergence of this modifying effect requires minimal energy input, we suggest that it is mediated by pre-existing supramolecular mechanisms. During vibration, the molecules deviate from a specific axis of symmetry (a local stationary state), which likely activates an evolutionarily developed supramolecular control over the molecular spatial structure. While testing this hypothesis, we observed that the modifying effect can be detected at a significant distance. This finding indicates that the phenomenon cannot be explained solely by the direct electromagnetic radiation of the vibrating molecules. Instead, the vibration treatment remotely alters the electromagnetic environment of the intact substance, thereby inducing the modifying effect. While non-trivial quantum effects might underlie this process, we favor the assumption that other fundamental interactions influence the electromagnetic field.