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Nowadays, there is increasing evidence that the intake of essential fatty acids (FAs) and oleic acid has high nutritional importance. However, the vulnerability of these FAs to oxidation deserves special attention. FA oxidation may be avoided or delayed by intercalation of its anionic form in inorganic matrices as layered double hydroxides (LDH). Thus, the aim of the study was to evaluate the protective effects of MgAl LDH towards oleate (O), linoleate (L) and α-linolenate (Ln) degradation. The incorporation and the loading of different FAs in anionic form in LDH was determined by X-ray diffraction and thermogravimetric analysis (TGA), respectively. In order to study the selectivity of LDH towards the FA, the inorganic solid was equilibrated with a mixture of O, L and Ln (1:1:1). TGA and gas chromatography showed that Ln was preferentially intercalated. Free FA (FFA) and intercalated FA (IFA) were heated at 40 °C in the dark and then analyzed weekly for a maximum of 42 days. Their oxidative stability was evaluated by monitoring the primary and secondary oxidative compounds. The volatile compounds were determined by solid-phase microextraction, coupled with gas chromatography–mass spectrometry. Peroxide values were higher in FFA samples than in IFA samples, such as hexanal and trans,trans-2,4-heptadienal % contents. The results showed the potential of LDH intercalation for FA preservation from oxidative modification.
Francesca Blasi; Claudia Chiesi; Roberto Spogli; Lina Cossignani; Morena Nocchetti. Oxidative Stability of Long-Chain Fatty Acids with Different Unsaturation Degrees into Layered Double Hydroxides. Applied Sciences 2021, 11, 7035 .
AMA StyleFrancesca Blasi, Claudia Chiesi, Roberto Spogli, Lina Cossignani, Morena Nocchetti. Oxidative Stability of Long-Chain Fatty Acids with Different Unsaturation Degrees into Layered Double Hydroxides. Applied Sciences. 2021; 11 (15):7035.
Chicago/Turabian StyleFrancesca Blasi; Claudia Chiesi; Roberto Spogli; Lina Cossignani; Morena Nocchetti. 2021. "Oxidative Stability of Long-Chain Fatty Acids with Different Unsaturation Degrees into Layered Double Hydroxides." Applied Sciences 11, no. 15: 7035.
Dry (D.E.) and liquid (L.E.) extracts were prepared from flaxseeds and their application in health field was evaluated. The chemical analysis showed that D.E. is rich in the lignan secoisolariciresinol diglucoside and L.E. in unsaturated triglycerides containing linolenic acid. Mainly, D.E. showed reducing (15.73 μmol Fe2+/g) and radical scavenging capacities (5.25 mg TE/g) and ability to down-regulate the expression of the pro-inflammatory cytokines NO (IC50 = 0.136 ± 0.009 mg/mL) and IL-6 (IC50 = 0.308 ± 0.103 mg/mL), suggesting its use in wound treatment. D.E. and L.E. were active against S. pyogenes and D.E. also against S. aureus. The two extracts were combined in a novel O/W emulgel in which the water phase was viscosized using a low molecular weight and highly deacetylated chitosan (1% wt./v). The presence of this polymer in the emulgel decreased the MIC values of the extracts. In fact, MIC shifted from 0.59 mg/mL to 0.052 mg/mL for D.E. and from 0.22 mg/mL to 0.036 mg/mL for L.E., concentrations safe both for keratinocytes and macrophages. Moreover, the emulgel demonstrated to inhibit S. aureus, P. aeruginosa, S. pyogenes, E. coli, and K. pneumoniae growth (inhibition halos 24–36 mm), strains often responsible for diabetic foot ulcer infection.
Cinzia Pagano; Claudio Baiocchi; Tommaso Beccari; Francesca Blasi; Lina Cossignani; Maria Ceccarini; Ciriana Orabona; Elena Orecchini; Enrico Di Raimo; Sara Primavilla; Laura Salvini; Alessandro Michele; Luana Perioli; Maurizio Ricci. Emulgel Loaded with Flaxseed Extracts as New Therapeutic Approach in Wound Treatment. Pharmaceutics 2021, 13, 1107 .
AMA StyleCinzia Pagano, Claudio Baiocchi, Tommaso Beccari, Francesca Blasi, Lina Cossignani, Maria Ceccarini, Ciriana Orabona, Elena Orecchini, Enrico Di Raimo, Sara Primavilla, Laura Salvini, Alessandro Michele, Luana Perioli, Maurizio Ricci. Emulgel Loaded with Flaxseed Extracts as New Therapeutic Approach in Wound Treatment. Pharmaceutics. 2021; 13 (8):1107.
Chicago/Turabian StyleCinzia Pagano; Claudio Baiocchi; Tommaso Beccari; Francesca Blasi; Lina Cossignani; Maria Ceccarini; Ciriana Orabona; Elena Orecchini; Enrico Di Raimo; Sara Primavilla; Laura Salvini; Alessandro Michele; Luana Perioli; Maurizio Ricci. 2021. "Emulgel Loaded with Flaxseed Extracts as New Therapeutic Approach in Wound Treatment." Pharmaceutics 13, no. 8: 1107.
Red Delicious apple pomace was produced at laboratory scale with a domestic blender and different non-conventional extraction techniques were performed to isolate phenolic compounds, such as ultrasound-assisted extraction (UAE), ultraturrax extraction (UTE), accelerated solvent extraction (ASE) and pulsed electric field (PEF) extraction pre-treatment. Total phenolic content (TPC) was determined by Folin–Ciocalteu assay. Phloridzin, the main phenolic compound in apples, was determined by chromatographic analysis Q-TOF-LC/MS. The results obtained with these techniques were compared in order to identify the most efficient method to recover polyphenols. The highest value of TPC (1062.92 ± 59.80 µg GAE/g fresh apple pomace) was obtained when UAE was performed with EtOH:H2O (50:50, v/v), while ASE with EtOH:H2O (30:70, v/v) at 40 °C and 50% of flush was the most efficient technique in the recovery of phloridzin. The concentration of the main phenolic compounds ranged from 385.84 to 650.56 µg/g fresh apple pomace. The obtained results confirm that apple pomace represents an interesti-ng by-product, due to the presence of phenolic compounds. In particular, phloridzin could be considered a biomarker to determine the quality of numerous apple products. Therefore, this research could be a good starting point to develop a value-added product such as a functional food or nutraceutical.
Luna Pollini; Lina Cossignani; Cristina Juan; Jordi Mañes. Extraction of Phenolic Compounds from Fresh Apple Pomace by Different Non-Conventional Techniques. Molecules 2021, 26, 4272 .
AMA StyleLuna Pollini, Lina Cossignani, Cristina Juan, Jordi Mañes. Extraction of Phenolic Compounds from Fresh Apple Pomace by Different Non-Conventional Techniques. Molecules. 2021; 26 (14):4272.
Chicago/Turabian StyleLuna Pollini; Lina Cossignani; Cristina Juan; Jordi Mañes. 2021. "Extraction of Phenolic Compounds from Fresh Apple Pomace by Different Non-Conventional Techniques." Molecules 26, no. 14: 4272.
Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further.
Gokhan Zengin; Mohamad Mahomoodally; Abdurrahman Aktumsek; József Jekő; Zoltán Cziáky; Maria Rodrigues; Luisa Custodio; Rıdvan Polat; Ugur Cakilcioglu; Adnan Ayna; Monica Gallo; Domenico Montesano; Carene Picot-Allain. Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey. Plants 2021, 10, 1176 .
AMA StyleGokhan Zengin, Mohamad Mahomoodally, Abdurrahman Aktumsek, József Jekő, Zoltán Cziáky, Maria Rodrigues, Luisa Custodio, Rıdvan Polat, Ugur Cakilcioglu, Adnan Ayna, Monica Gallo, Domenico Montesano, Carene Picot-Allain. Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey. Plants. 2021; 10 (6):1176.
Chicago/Turabian StyleGokhan Zengin; Mohamad Mahomoodally; Abdurrahman Aktumsek; József Jekő; Zoltán Cziáky; Maria Rodrigues; Luisa Custodio; Rıdvan Polat; Ugur Cakilcioglu; Adnan Ayna; Monica Gallo; Domenico Montesano; Carene Picot-Allain. 2021. "Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey." Plants 10, no. 6: 1176.
The faunatic world represents an untapped potential reservoir for both food and medicine. A plethora of uses that humans have exploited since time immemorial to counter sufferings and deficiency diseases. This study aims to systematically review the scientific literature for the last 10 years and highlight the therapeutic uses of marine animal and animal products used globally. A total of 159 marine animals were documented comprising of 305 traditional uses. Marine animals of the Actinopterygii class were the most used against ailments. From the study, it was observed that a single aquatic animal could be used for treating and/or managing multiple ailments and at the same an ailment could be addressed by several marine animals and animal-derived products. The latter were mostly consumed cooked and the mode of administration varies depending on their origin. Although a panoply of traditional uses of marine animal and animal products exists, a dearth of validated pharmacological studies was observed to support the functional and medical uses of such products. This calls out researchers to address this gap as the exploration of marine faunatic resources, which could provide sustainable solution to many current health and wellness challenges. Graphical abstract
Mohamad Fawzi Mahomoodally; Dilmar Aniisah Sanaa; Gokhan Zengin; Monica Gallo; Domenico Montesano. Traditional Therapeutic Uses of Marine Animal Parts and Derived Products as Functional Foods – A Systematic Review. Food Reviews International 2021, 1 -31.
AMA StyleMohamad Fawzi Mahomoodally, Dilmar Aniisah Sanaa, Gokhan Zengin, Monica Gallo, Domenico Montesano. Traditional Therapeutic Uses of Marine Animal Parts and Derived Products as Functional Foods – A Systematic Review. Food Reviews International. 2021; ():1-31.
Chicago/Turabian StyleMohamad Fawzi Mahomoodally; Dilmar Aniisah Sanaa; Gokhan Zengin; Monica Gallo; Domenico Montesano. 2021. "Traditional Therapeutic Uses of Marine Animal Parts and Derived Products as Functional Foods – A Systematic Review." Food Reviews International , no. : 1-31.
Cydonia oblonga Mill., normally known as the quince fruit, has been widely used in agro-food industries mainly to produce jams and jellies. However, other parts of the plants are still underutilized and not completely assessed for their nutraceutical profile. Therefore, in this work, the polyphenolic profile of C. oblonga was investigated using an untargeted metabolomics approach based on high-resolution mass spectrometry. Several compounds were identified in the different parts of the plants, including flavonoids (i.e., anthocyanins, flavones, flavan-3-ols, and flavonols), phenolic acids (both hydroxycinnamics and hydroxybenzoics), low-molecular-weight phenolics (tyrosol equivalents), lignans, and stilbenes. Overall, C. oblonga leaves showed the highest in vitro antioxidant potential, as revealed by 2,2-difenil-1-picrylhydrazyl (DPPH), 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), and cupric ion reducing antioxidant capacity (CUPRAC) assays, being 189.5, 285.6, 158.9, and 348.8 mg Trolox Equivalent/g, respectively. The enzymes acetyl- and butyryl-cholinesterases were both inhibited by the different plant parts of C. oblonga, with stems showing the higher inhibitory potential. Interestingly, the fruit extracts were the only parts inhibiting the α-glucosidase, with a value of 1.36 mmol acarbose equivalents (ACAE)/g. On the other hand, strong tyrosinase inhibition was found for stems and leaves, being 72.11 and 68.32 mg Kojic acid Equivalent/g, respectively. Finally, a high number of significant (0.05 < p< 0.01) correlations were outlined between phenolics (mainly anthocyanins, flava-3-ols, and tyrosol equivalents) and the different biological assays. Taken together, our findings suggest a potential exploitation of C. oblonga leaves and stems for the food, pharmaceutical, and cosmetic industries.
Leilei Zhang; Gabriele Rocchetti; Gökhan Zengin; Gunes Ak; Fatema Saber; Domenico Montesano; Luigi Lucini. The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential. Foods 2021, 10, 1230 .
AMA StyleLeilei Zhang, Gabriele Rocchetti, Gökhan Zengin, Gunes Ak, Fatema Saber, Domenico Montesano, Luigi Lucini. The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential. Foods. 2021; 10 (6):1230.
Chicago/Turabian StyleLeilei Zhang; Gabriele Rocchetti; Gökhan Zengin; Gunes Ak; Fatema Saber; Domenico Montesano; Luigi Lucini. 2021. "The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential." Foods 10, no. 6: 1230.
Oyster mushroom (Pleurotus ostreatus) has gained in the last years increasing attention due to its richness in bioactive metabolites with health properties, making this variety an attractive candidate for promising developments in nutraceutical and cosmeceutical fields. According to the conditions planned by the experimental design approach, the ultrasound-assisted extraction of the phenol fraction from P. ostreatus was performed by evaluating the influence of critical variables (solvent, solvent/solid ratio, time, temperature) on total phenol content and antioxidant activity. The results of the optimization showed that a more performing extraction can be obtained with the highest values of solvent/solid ratio and water % in ethanol. The optimal extraction conditions were applied to four P. ostreatus samples, differing for geographical origin and growth substrate. The hydroalcoholic extracts were characterized in terms of total phenol content, and in vitro antioxidant and antimicrobial activities and interesting correlations were found among them. The obtained results highlighted significant differences for the antioxidant and antimicrobial activities for P. ostreatus samples grown on different substrates and geographical areas. The investigation on biological activity of edible mushroom extracts has a high relevance since it has a positive impact on the nutritional and health properties.
Federica Ianni; Francesca Blasi; Paola Angelini; Simonetta Simone; Giancarlo Angeles Flores; Lina Cossignani; Roberto Venanzoni. Extraction Optimization by Experimental Design of Bioactives from Pleurotus ostreatus and Evaluation of Antioxidant and Antimicrobial Activities. Processes 2021, 9, 743 .
AMA StyleFederica Ianni, Francesca Blasi, Paola Angelini, Simonetta Simone, Giancarlo Angeles Flores, Lina Cossignani, Roberto Venanzoni. Extraction Optimization by Experimental Design of Bioactives from Pleurotus ostreatus and Evaluation of Antioxidant and Antimicrobial Activities. Processes. 2021; 9 (5):743.
Chicago/Turabian StyleFederica Ianni; Francesca Blasi; Paola Angelini; Simonetta Simone; Giancarlo Angeles Flores; Lina Cossignani; Roberto Venanzoni. 2021. "Extraction Optimization by Experimental Design of Bioactives from Pleurotus ostreatus and Evaluation of Antioxidant and Antimicrobial Activities." Processes 9, no. 5: 743.
Hemp seed oil (HSO) has received considerable attention for its health properties, especially due to unsaturated fatty acid (UFA) content. In this work, the triacylglycerol (TAG) fraction of Italian and Extra-European HSO was characterized by applying an enzymatic approach, based on the use of pancreatic lipase and sn-1,2-diacylglycerol kinase. This procedure allows determination of the intrapositional FA% composition of TAG. The results of the stereospecific analysis are useful for deepening knowledge on HSO nutritional aspects. The high percentage of UFA (88.3–89.9%), in particular essential FA (74.4–85.9%), of HSO samples in sn-2 position is important for long-term health effects, but also to enhance the use of this oil as a functional ingredient in food, cosmetic and nutraceutical fields. Furthermore, the results of total and intrapositional FA % compositions, subjected to principal component analysis, were able to differentiate HSO Italian samples from Extra-European ones. Based on the obtained results, it can be stated that the stereospecific analysis represents a potent analytical tool providing the fingerprint of TAG fraction, useful to highlight possible chemical descriptors for HSO authenticity and traceability purposes.
Carmela Tringaniello; Lina Cossignani; Francesca Blasi. Characterization of the Triacylglycerol Fraction of Italian and Extra-European Hemp Seed Oil. Foods 2021, 10, 916 .
AMA StyleCarmela Tringaniello, Lina Cossignani, Francesca Blasi. Characterization of the Triacylglycerol Fraction of Italian and Extra-European Hemp Seed Oil. Foods. 2021; 10 (5):916.
Chicago/Turabian StyleCarmela Tringaniello; Lina Cossignani; Francesca Blasi. 2021. "Characterization of the Triacylglycerol Fraction of Italian and Extra-European Hemp Seed Oil." Foods 10, no. 5: 916.
To date, the leading causes of mortality and morbidity worldwide include viral infections, such as Ebola, influenza virus, acquired immunodeficiency syndrome (AIDS), severe acute respiratory syndrome (SARS) and recently COVID-19 disease, caused by the SARS-CoV-2 virus. Currently, we can count on a narrow range of antiviral drugs, especially older generation ones like ribavirin and interferon which are effective against viruses in vitro but can often be ineffective in patients. In addition to these, we have antiviral agents for the treatment of herpes virus, influenza virus, HIV and hepatitis virus. Recently, drugs used in the past especially against ebolavirus, such as remdesivir and favipiravir, have been considered for the treatment of COVID-19 disease. However, even if these drugs represent important tools against viral diseases, they are certainly not sufficient to defend us from the multitude of viruses present in the environment. This represents a huge problem, especially considering the unprecedented global threat due to the advancement of COVID-19, which represents a potential risk to the health and life of millions of people. The demand, therefore, for new and effective antiviral drugs is very high. This review focuses on three fundamental points: (1) presents the main threats to human health, reviewing the most widespread viral diseases in the world, thus describing the scenario caused by the disease in question each time and evaluating the specific therapeutic remedies currently available. (2) It comprehensively describes main phytochemical classes, in particular from plant foods, with proven antiviral activities, the viruses potentially treated with the described phytochemicals. (3) Consideration of the various applications of drug delivery systems in order to improve the bioavailability of these compounds or extracts. A PRISMA flow diagram was used for the inclusion of the works. Taking into consideration the recent dramatic events caused by COVID-19 pandemic, the cry of alarm that denounces critical need for new antiviral drugs is extremely strong. For these reasons, a continuous systematic exploration of plant foods and their phytochemicals is necessary for the development of new antiviral agents capable of saving lives and improving their well-being.
Tapan Behl; Gabriele Rocchetti; Swati Chadha; Gokhan Zengin; Simona Bungau; Arun Kumar; Vineet Mehta; Sahab Uddin; Gaurav Khullar; Dhruv Setia; Sandeep Arora; Kouadio Sinan; Gunes Ak; Predrag Putnik; Monica Gallo; Domenico Montesano. Phytochemicals from Plant Foods as Potential Source of Antiviral Agents: An Overview. Pharmaceuticals 2021, 14, 381 .
AMA StyleTapan Behl, Gabriele Rocchetti, Swati Chadha, Gokhan Zengin, Simona Bungau, Arun Kumar, Vineet Mehta, Sahab Uddin, Gaurav Khullar, Dhruv Setia, Sandeep Arora, Kouadio Sinan, Gunes Ak, Predrag Putnik, Monica Gallo, Domenico Montesano. Phytochemicals from Plant Foods as Potential Source of Antiviral Agents: An Overview. Pharmaceuticals. 2021; 14 (4):381.
Chicago/Turabian StyleTapan Behl; Gabriele Rocchetti; Swati Chadha; Gokhan Zengin; Simona Bungau; Arun Kumar; Vineet Mehta; Sahab Uddin; Gaurav Khullar; Dhruv Setia; Sandeep Arora; Kouadio Sinan; Gunes Ak; Predrag Putnik; Monica Gallo; Domenico Montesano. 2021. "Phytochemicals from Plant Foods as Potential Source of Antiviral Agents: An Overview." Pharmaceuticals 14, no. 4: 381.
Nowadays, much interest is devoted to the extraction of plant materials, considering also their waste and by-products, to obtain antioxidant-rich products. The effect of household microwave-assisted extraction (MAE) on the phenolic content and antioxidant activity of Lycium barbarum leaf extracts was investigated. An experimental design approach was adopted considering solid/liquid ratio (1, 3, and 5 g of leaves in 150 mL water), irradiation time (1, 3, and 5 min), and microwave power (300, 400, and 500 W) as independent variables. These three factors and their interactions were studied to evaluate the effect of MAE conditions on the responses of total phenolic content, antioxidant activity, and chlorogenic acid content. The results showed that the analytical parameters were positively influenced by the solid/liquid ratio and time. On the contrary, microwave power was inversely correlated with the investigated responses. This research revealed that microwave extraction conditions should be carefully monitored to obtain bioactive-rich aqueous extracts with high antioxidant activity. A comparison with household traditional methods showed an unexpected lower phenolic content and antioxidant activity for MAE extract in respect to the decoction and infusion. In fact, it was found that L. barbarum leaf infusion had the best functional properties, regarding the investigated characteristics. The outcome of this study has implications for raising awareness that household preparation conditions strongly affect the health properties of herbal extracts.
Luna Pollini; Federica Ianni; Giuseppa Verducci; Francesca Blasi; Lina Cossignani. Is the Household Microwave Recommended to Obtain Antioxidant-Rich Extracts from Lycium barbarum Leaves? Processes 2021, 9, 656 .
AMA StyleLuna Pollini, Federica Ianni, Giuseppa Verducci, Francesca Blasi, Lina Cossignani. Is the Household Microwave Recommended to Obtain Antioxidant-Rich Extracts from Lycium barbarum Leaves? Processes. 2021; 9 (4):656.
Chicago/Turabian StyleLuna Pollini; Federica Ianni; Giuseppa Verducci; Francesca Blasi; Lina Cossignani. 2021. "Is the Household Microwave Recommended to Obtain Antioxidant-Rich Extracts from Lycium barbarum Leaves?" Processes 9, no. 4: 656.
In fish processing, a great amount of side streams, including skin, bones, heads and viscera, is wasted or downgraded as feed on a daily basis. These side streams are rich sources of bioactive nitrogenous compounds and protein, which can be converted into peptides through enzymatic hydrolysis as well as bacterial fermentation. Peptides are short or long chains of amino acids differing in structure and molecular weight. They can be considered as biologically active as they can contribute to physiological functions in organisms with applications in the food and pharmaceutical industries. In the food industry, such bioactive peptides can be used as preservatives or antioxidants to prevent food spoilage. Furthermore, peptides contain several functional qualities that can be exploited as tools in modifying food ingredient solubility, water-holding and fat-binding capacity and gel formation. In the pharmaceutical industry, peptides can be used as antioxidants, but also as antihypertensive, anticoagulant and immunomodulatory compounds, amongst other functions. On the basis of their properties, peptides can thus be used in the development of functional foods and nutraceuticals. This review focuses on the bioactive peptides derived from seafood side streams and discusses their technological properties, biological activities and applications.
Ilknur Ucak; Maliha Afreen; Domenico Montesano; Celia Carrillo; Igor Tomasevic; Jesus Simal-Gandara; Francisco Barba. Functional and Bioactive Properties of Peptides Derived from Marine Side Streams. Marine Drugs 2021, 19, 71 .
AMA StyleIlknur Ucak, Maliha Afreen, Domenico Montesano, Celia Carrillo, Igor Tomasevic, Jesus Simal-Gandara, Francisco Barba. Functional and Bioactive Properties of Peptides Derived from Marine Side Streams. Marine Drugs. 2021; 19 (2):71.
Chicago/Turabian StyleIlknur Ucak; Maliha Afreen; Domenico Montesano; Celia Carrillo; Igor Tomasevic; Jesus Simal-Gandara; Francisco Barba. 2021. "Functional and Bioactive Properties of Peptides Derived from Marine Side Streams." Marine Drugs 19, no. 2: 71.
In this study, the effects of gelatin films enriched with 2% of citrus (orange ([OSE] and lemon [LSE]) seed extracts (CSE) on the quality of sea bass (Dicentrarchus labrax) fillets during refrigerated storage (4 ± 1°C) for 15 days were determined. The results showed that lipid oxidation delayed in OSE and LSE groups compared with control and gelatin‐film (without extract)‐coated groups. According to microbial results, the addition of CSE enhanced the antimicrobial activity of gelatin films and, therefore, delayed the microbial growth. The incorporation of CSE with gelatin films showed a positive effect on the sensorial parameters of fillets. The shelf life of fillets was found as 6 days for the control, 9 days for GF group, and 12 days for both OSE and LSE groups. In conclusion, the supplementation of CSE raised the effectiveness of the gelatin films and can be recommended to maintain the quality of sea bass fillets. Practical applications Seafoods are highly perishable products and maintaining the quality of seafoods is a very important issue. As excessive citrus wastes are produced in the food industry, possible ways of their utilization are need to be searched. Citrus seed extract (CSE) was evaluated as natural antioxidant and antimicrobial agent in prolonging the shelf life of sea bass fillets in this study. The results revealed that CSE contributed to maintain the oxidative, microbiological, and sensory quality of sea bass fillets during storage. Thus, considering the consumers concerns about the synthetic ingredients, CSE can be suggested as a natural antioxidant and antimicrobial source in foods. Additionally, finding of this research could help to evaluate food wastes and the industrial usage of these products as a natural preservative.
Ilknur Ucak; Ahlam K. M. Abuibaid; Turki M. S. Aldawoud; Charis M. Galanakis; Domenico Montesano. Antioxidant and antimicrobial effects of gelatin films incorporated with citrus seed extract on the shelf life of sea bass ( Dicentrarchus labrax ) fillets. Journal of Food Processing and Preservation 2021, 45, e15304 .
AMA StyleIlknur Ucak, Ahlam K. M. Abuibaid, Turki M. S. Aldawoud, Charis M. Galanakis, Domenico Montesano. Antioxidant and antimicrobial effects of gelatin films incorporated with citrus seed extract on the shelf life of sea bass ( Dicentrarchus labrax ) fillets. Journal of Food Processing and Preservation. 2021; 45 (4):e15304.
Chicago/Turabian StyleIlknur Ucak; Ahlam K. M. Abuibaid; Turki M. S. Aldawoud; Charis M. Galanakis; Domenico Montesano. 2021. "Antioxidant and antimicrobial effects of gelatin films incorporated with citrus seed extract on the shelf life of sea bass ( Dicentrarchus labrax ) fillets." Journal of Food Processing and Preservation 45, no. 4: e15304.
Among various food sources, milk proteins remain the major vector for functional peptides endowed with several biological activities. Particularly, the proteolytic activity of lactic acid bacteria during milk fermentation has been one of the most followed strategies to produce bioactive peptides. In the present study, the exploration of the activity of several starter cultures, at different fermentation times, was firstly investigated by reversed phase-high performance liquid chromatography. Among the tested strains, Lactobacillus helveticus showed a higher proteolytic activity and it was submitted to further investigations by changing the fermentation substrate (skim milk, brain heart infusion, peptone water) as well as the extraction strategy (trichloroacetic acid vs. glass beads). The chromatographic analyses and the in vitro antioxidant and antihypertensive assays highlighted considerable differences for L. helveticus hydrolysates from different substrates, while a negligible impact by the two extraction protocols emerged. Furthermore, nano-high pressure liquid chromatography coupled with a high resolution mass spectrometry analyzer allowed the preliminary discrimination of fractions from fermented skim milk, likely responsible for the found activity. The obtained results suggest the possibility of varying the fermentation parameters in order to maximize the functional effects of the bioactive peptides.
Federica Ianni; Alessandra Anna Altomare; Beniamino T. Cenci-Goga; Francesca Blasi; Luca Grispoldi; Luca Regazzoni; Lina Cossignani. Chromatographic Characterization and In Vitro Bioactivity Evaluation of Lactobacillus helveticus Hydrolysates upon Fermentation of Different Substrates. Applied Sciences 2021, 11, 811 .
AMA StyleFederica Ianni, Alessandra Anna Altomare, Beniamino T. Cenci-Goga, Francesca Blasi, Luca Grispoldi, Luca Regazzoni, Lina Cossignani. Chromatographic Characterization and In Vitro Bioactivity Evaluation of Lactobacillus helveticus Hydrolysates upon Fermentation of Different Substrates. Applied Sciences. 2021; 11 (2):811.
Chicago/Turabian StyleFederica Ianni; Alessandra Anna Altomare; Beniamino T. Cenci-Goga; Francesca Blasi; Luca Grispoldi; Luca Regazzoni; Lina Cossignani. 2021. "Chromatographic Characterization and In Vitro Bioactivity Evaluation of Lactobacillus helveticus Hydrolysates upon Fermentation of Different Substrates." Applied Sciences 11, no. 2: 811.
Geophytes are gaining interest as sources of natural ingredients in nutraceutical and pharmaceutical area. In this sense, six bulbous plant species from Turkey are investigated, namely Hyacinthella campanulata K.Perss. & Wendelbo, Muscari neglectum Guss. ex Ten., Tulipa humilis herb., Iris stenophylla Hausskn. ex Baker, Galanthus elwesii Hook. f. and Crocus danfordiae Maw. with the aim to highlight their chemical compositions and biological properties. Polyphenolic profiles of the different plant parts (flower, bulb and leaf) of the six genotypes were evaluated using colorimetric methods as well LC–MS/MS. The antioxidant properties and enzymes inhibitory potential (α-amylase, α-glucosidase, tyrosinase and cholinesterases) of the extracts were determined. Overall, highest total phenolic content and total flavonoid content were observed in the leaf extracts of the studied species, except for M. neglectum (flower extract) and T. humilis (flower extract). LC–MS/MS analysis revealed the abundance of some phenolic compounds including quinic acid, hesperidin and chlorogenic acid in selective extracts. The extracts showed significant antioxidant potentials, with leaf extract of the I. stenophylla being more potent, which is linked to its high phenolic contents. All the extracts displayed notable anti-acetylcholinesterase (1.77 – 2.53 mg GALAE/g) and tyrosinase (54.9–67.20 mg KAE/g). Selective extracts have showed activity against butyrylcholinesterase, with bulb extract of M. neglectum (2.99 mg GALAE/g), I. stenophylla (2.53 mg GALAE/g) and G. elwesii (2.52 mg GALAE/g) showing highest activity. Modest activity was observed against α-amylase and α-glucosidase. The experimental data gathered herein is the first report on the phytochemical and biological attributes of these bulbous plant species which project them as potential sources of biologically active compounds for phytomedicines and nutraceuticals development.
Mohamad Fawzi Mahomoodally; Gokhan Zengin; Kouadio Ibrahime Sinan; Evren Yıldıztugay; Devina Lobine; Rayene Ouelbani; Souheir Bensari; Gunes Ak; Mustafa Abdullah Yılmaz; Monica Gallo; Domenico Montesano. A comprehensive evaluation of the chemical profiles and biological properties of six geophytes from Turkey: Sources of bioactive compounds for novel nutraceuticals. Food Research International 2020, 140, 110068 .
AMA StyleMohamad Fawzi Mahomoodally, Gokhan Zengin, Kouadio Ibrahime Sinan, Evren Yıldıztugay, Devina Lobine, Rayene Ouelbani, Souheir Bensari, Gunes Ak, Mustafa Abdullah Yılmaz, Monica Gallo, Domenico Montesano. A comprehensive evaluation of the chemical profiles and biological properties of six geophytes from Turkey: Sources of bioactive compounds for novel nutraceuticals. Food Research International. 2020; 140 ():110068.
Chicago/Turabian StyleMohamad Fawzi Mahomoodally; Gokhan Zengin; Kouadio Ibrahime Sinan; Evren Yıldıztugay; Devina Lobine; Rayene Ouelbani; Souheir Bensari; Gunes Ak; Mustafa Abdullah Yılmaz; Monica Gallo; Domenico Montesano. 2020. "A comprehensive evaluation of the chemical profiles and biological properties of six geophytes from Turkey: Sources of bioactive compounds for novel nutraceuticals." Food Research International 140, no. : 110068.
Nowadays, bioactive compounds from vegetable food and waste are of great interest for their inhibitory potential against digestive enzymes. In the present study, the inhibitory activity of methanolic extract from Lycium barbarum leaves on porcine pancreas α-amylase has been studied. The α-amylase inhibitory activity of the constituent phenolic acids was also investigated. The leaves were extracted by ultrasound-assisted method, one of the most efficient techniques for bioactive extraction from plant materials, and then the phenolic acids were identified by Accurate-Mass Quadrupole Time-of-Flight (Q-TOF) Liquid Chromatography/Mass Spectrometry (LC/MS). Chlorogenic and salicylic acids were the most abundant phenolic acids in L. barbarum leaf extract. The inhibitory effect against α-amylase, determined for individual compounds by in vitro assay, was higher for chlorogenic, salicylic, and caffeic acids. L. barbarum leaf extract showed an appreciable α-amylase inhibitory effect in a concentration-dependent manner. Docking studies of the considered phenolic acids into the active site of α-amylase suggested a conserved binding mode that is mainly stabilized through H-bonds and π-π stacking interactions.
Luna Pollini; Alessandra Riccio; Cristina Juan; Carmela Tringaniello; Federica Ianni; Francesca Blasi; Jordi Mañes; Antonio Macchiarulo; Lina Cossignani. Phenolic Acids from Lycium barbarum leaves: In Vitro and In Silico Studies of the Inhibitory Activity Against Porcine Pancreatic α-Amylase. Processes 2020, 8, 1388 .
AMA StyleLuna Pollini, Alessandra Riccio, Cristina Juan, Carmela Tringaniello, Federica Ianni, Francesca Blasi, Jordi Mañes, Antonio Macchiarulo, Lina Cossignani. Phenolic Acids from Lycium barbarum leaves: In Vitro and In Silico Studies of the Inhibitory Activity Against Porcine Pancreatic α-Amylase. Processes. 2020; 8 (11):1388.
Chicago/Turabian StyleLuna Pollini; Alessandra Riccio; Cristina Juan; Carmela Tringaniello; Federica Ianni; Francesca Blasi; Jordi Mañes; Antonio Macchiarulo; Lina Cossignani. 2020. "Phenolic Acids from Lycium barbarum leaves: In Vitro and In Silico Studies of the Inhibitory Activity Against Porcine Pancreatic α-Amylase." Processes 8, no. 11: 1388.
Alberto Berardi; Beniamino Cenci-Goga; Luca Grispoldi; Lina Cossignani; Diego Romano Perinelli. Analysis of Commercial Hand Sanitisers amid CoViD-19: Are We Getting the Products that We Need? 2020, 21, 1 .
AMA StyleAlberto Berardi, Beniamino Cenci-Goga, Luca Grispoldi, Lina Cossignani, Diego Romano Perinelli. Analysis of Commercial Hand Sanitisers amid CoViD-19: Are We Getting the Products that We Need? . 2020; 21 (7):1.
Chicago/Turabian StyleAlberto Berardi; Beniamino Cenci-Goga; Luca Grispoldi; Lina Cossignani; Diego Romano Perinelli. 2020. "Analysis of Commercial Hand Sanitisers amid CoViD-19: Are We Getting the Products that We Need?" 21, no. 7: 1.
Several studies demonstrated the wide pharmacological properties of extracts and essential oils (EOs) prepared from Euphorbia species. In the present study, the chemical composition and biological activities of EOs from three different Euphorbia species were evaluated using in vitro methods. A total of 29, 33 and 42 constituents were identified in the EOs of E hirta, E convolvuloides and E heterophylla, respectively. The EOs exhibited in vitro radical scavenging potential in the ABTS assay (2.89‐21.50 mg/g). Additionally, an inhibitory effect on acetylcholinesterase (4.23‐5.12 mg/g) was detected. Besides, remarkable tyrosinase inhibition was reported by the EOs (95.24‐113.74 mg/g). Molecular docking was also performed to elucidate the binding interactions between selected EO components and enzymes. Phytol and geranyl‐(E)‐acetone had a good binding with tyrosinase in the molecular docking. This study highlighted the promising pharmacological profiles of these EOs as natural sources of antioxidants as well as cholinesterase and tyrosinase inhibitors that could be further explored in the management of human ailments in food and pharmaceutical industries.
Kouadio Ibrahime Sinan; Ouattara Katinan Etienne; Azzurra Stefanucci; Adriano Mollica; Mohamad Fawzi Mahomoodally; Sharmeen Jugreet; Gabriele Rocchetti; Luigi Lucini; Abdurrahman Aktumsek; Domenico Montesano; Gunes Ak; Gokhan Zengin. Chemodiversity and biological activity of essential oils from three species from the Euphorbia genus. Flavour and Fragrance Journal 2020, 36, 148 -158.
AMA StyleKouadio Ibrahime Sinan, Ouattara Katinan Etienne, Azzurra Stefanucci, Adriano Mollica, Mohamad Fawzi Mahomoodally, Sharmeen Jugreet, Gabriele Rocchetti, Luigi Lucini, Abdurrahman Aktumsek, Domenico Montesano, Gunes Ak, Gokhan Zengin. Chemodiversity and biological activity of essential oils from three species from the Euphorbia genus. Flavour and Fragrance Journal. 2020; 36 (1):148-158.
Chicago/Turabian StyleKouadio Ibrahime Sinan; Ouattara Katinan Etienne; Azzurra Stefanucci; Adriano Mollica; Mohamad Fawzi Mahomoodally; Sharmeen Jugreet; Gabriele Rocchetti; Luigi Lucini; Abdurrahman Aktumsek; Domenico Montesano; Gunes Ak; Gokhan Zengin. 2020. "Chemodiversity and biological activity of essential oils from three species from the Euphorbia genus." Flavour and Fragrance Journal 36, no. 1: 148-158.
Calendula officinalis L., (marigold), well known for its medicinal properties, has been extensively studied for its therapeutic properties. Nonetheless, as far as the literature could establish, no study has attempted to comparatively assess the biological (antioxidant and enzyme inhibitory potential) of the flowers, leaves, and roots of C. officinalis extracted using conventional (maceration and Soxhlet extraction (SE)) and non-conventional extraction (homogenizer (HAE) and ultrasound (UAE) assisted extraction) techniques. The detailed phytochemical profile of each extract along with the concentration of specific bioactive compounds has also been established. Total phenolic content was highest for the flower extracts while flavonoid content was highest in the leaf extracts. Phytochemical profiling showed that the extraction method influenced the phytochemical composition of the extract. Nicotiflorin was identified in the flower extracts only while amentoflavone occurred only in the roots, inferring that the occurrence of bioactive compounds varies within a plant. The flower extracts showed highest antioxidant potential while the roots extracts were potent inhibitors of cholinesterase and tyrosinase. This study provides valuable data on the influence of extraction techniques on the recovery of bioactive compounds from plants. In an endeavor to scale-up extraction from plant considering the more efficient extraction method is of paramount importance. Moreover, the study highlighted the necessity to thoroughly examine the biological activities of various parts of a plant obtained via different extraction protocols.
Gunes Ak; Gokhan Zengin; Kouadio Ibrahime Sinan; Mohamad Fawzi Mahomoodally; Marie Carene Nancy Picot-Allain; Oguz Cakır; Souheir Bensari; Mustafa Abdullah Yılmaz; Monica Gallo; Domenico Montesano. A Comparative Bio-Evaluation and Chemical Profiles of Calendula officinalis L. Extracts Prepared via Different Extraction Techniques. Applied Sciences 2020, 10, 5920 .
AMA StyleGunes Ak, Gokhan Zengin, Kouadio Ibrahime Sinan, Mohamad Fawzi Mahomoodally, Marie Carene Nancy Picot-Allain, Oguz Cakır, Souheir Bensari, Mustafa Abdullah Yılmaz, Monica Gallo, Domenico Montesano. A Comparative Bio-Evaluation and Chemical Profiles of Calendula officinalis L. Extracts Prepared via Different Extraction Techniques. Applied Sciences. 2020; 10 (17):5920.
Chicago/Turabian StyleGunes Ak; Gokhan Zengin; Kouadio Ibrahime Sinan; Mohamad Fawzi Mahomoodally; Marie Carene Nancy Picot-Allain; Oguz Cakır; Souheir Bensari; Mustafa Abdullah Yılmaz; Monica Gallo; Domenico Montesano. 2020. "A Comparative Bio-Evaluation and Chemical Profiles of Calendula officinalis L. Extracts Prepared via Different Extraction Techniques." Applied Sciences 10, no. 17: 5920.
Many plant materials, such as fruits and vegetables as well as herbs and spices, represent valuable sources of antioxidants. In recent years, wastes from agriculture and food industrial processes have been shown to be interesting sources for bioactive compound recovery, strongly contributing to the circular economy. Nowadays, because of their possible adverse effects on human health, there is a tendency to replace synthetic antioxidants with natural compounds. This review attempts to critically summarize the current evidence on plant bioactives, extracted from food or waste, added to unsaturated vegetable oils, in order to obtain high added-value products and to ameliorate their oxidative stability and shelf life. The goal of this review is to demonstrate the current status of the research on edible oils added with natural plant bioactives, highlighting new approaches in the field of health-promoting foods.
Francesca Blasi; Lina Cossignani. An Overview of Natural Extracts with Antioxidant Activity for the Improvement of the Oxidative Stability and Shelf Life of Edible Oils. Processes 2020, 8, 956 .
AMA StyleFrancesca Blasi, Lina Cossignani. An Overview of Natural Extracts with Antioxidant Activity for the Improvement of the Oxidative Stability and Shelf Life of Edible Oils. Processes. 2020; 8 (8):956.
Chicago/Turabian StyleFrancesca Blasi; Lina Cossignani. 2020. "An Overview of Natural Extracts with Antioxidant Activity for the Improvement of the Oxidative Stability and Shelf Life of Edible Oils." Processes 8, no. 8: 956.
Currently, there is a growing interest in screening and quantifying antioxidants from biological samples in the quest for natural and effective antioxidants to combat free radical-related pathological complications. Antioxidant assays play a crucial role in high-throughput and cost-effective assessment of antioxidant capacities of natural products such as medicinal plants and food samples. However, several investigators have expressed concerns about the reliability of existing in vitro assays. Such concerns arise mainly from the poor correlation between in vitro and in vivo results. In addition, in vitro assays have the problem of reproducibility. To date, antioxidant capacities are measured using a panel of assays whereby each assay has its own advantages and limitations. This unparalleled review hotly disputes on in vitro antioxidant assays and elaborates on the chemistry behind each assay with the aim to point out respective principles/concepts. The following critical questions are also addressed: (1) What make antioxidant assays coloured? (2) What is the reason for working at a particular wavelength? (3) What are the advantages and limitations of each assay? and (4) Why is a particular colour observed in antioxidant–oxidant chemical reactions? Furthermore, this review details the chemical mechanism of reactions that occur in each assay together with a colour ribbon to illustrate changes in colour. The review ends with a critical conclusion on existing assays and suggests constructive improvements on how to develop an adequate and universal antioxidant assay.
Nabeelah Bibi Sadeer; Domenico Montesano; Stefania Albrizio; Gokhan Zengin; Mohamad Fawzi Mahomoodally. The Versatility of Antioxidant Assays in Food Science and Safety—Chemistry, Applications, Strengths, and Limitations. Antioxidants 2020, 9, 709 .
AMA StyleNabeelah Bibi Sadeer, Domenico Montesano, Stefania Albrizio, Gokhan Zengin, Mohamad Fawzi Mahomoodally. The Versatility of Antioxidant Assays in Food Science and Safety—Chemistry, Applications, Strengths, and Limitations. Antioxidants. 2020; 9 (8):709.
Chicago/Turabian StyleNabeelah Bibi Sadeer; Domenico Montesano; Stefania Albrizio; Gokhan Zengin; Mohamad Fawzi Mahomoodally. 2020. "The Versatility of Antioxidant Assays in Food Science and Safety—Chemistry, Applications, Strengths, and Limitations." Antioxidants 9, no. 8: 709.