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Nabeelah Bibi Sadeer
Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit 80837, Mauritius

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Journal article
Published: 16 July 2021 in International Journal of Molecular Sciences
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This study focused on the biological evaluation and chemical characterization of Geranium pyrenaicum Burm. f. Different solvent extracts (hexane, ethyl acetate, methanol, and water extracts) were prepared. The phytochemical profile, antioxidant, and enzyme inhibitory activity were investigated. Cytotoxicity was assessed using VERO, FaDu, HeLa and RKO cells. The antiviral activity was carried out against HSV-1 (Herpes simplex virus 1) propagated in VERO cell line. The aqueous extract, possessing high phenolic content (170.50 mg gallic acid equivalent/g extract), showed the highest reducing capacity (613.27 and 364.10 mg Trolox equivalent/g extract, for cupric reducing antioxidant capacity and ferric reducing antioxidant power, respectively), radical scavenging potential (469.82 mg Trolox equivalent/g extract, against 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)), metal chelating ability (52.39 mg ethylenediaminetetraacetic acid equivalent/g extract) and total antioxidant capacity (3.15 mmol Trolox equivalent/g extract). Liquid chromatography-electrospray ionization-quadrupole time-of-flight-mass spectrometry (LC-ESI-QTOF-MS/MS) alloved to tentatively identify a total of 56 compounds in the extracts, including ellagitannins, gallic acid and galloyl derivatives amongst others. The ethyl acetate extracts substantially depressed cholinesterase enzymes (4.49 and 12.26 mg galantamine equivalent/g extract against AChE and BChE, respectively) and α-amylase enzyme (1.04 mmol acarbose equivalent/g extract). On the other hand, the methanolic extract inhibited tyrosinase (121.42 mg kojic acid equivalent/g extract) and α-glucosidase (2.39 mmol acarbose equivalent/g extract) activities. The highest selectivity towards all cancer cell lines (SI 4.5–10.8) was observed with aqueous extract with the FaDu cells being the most sensitive (CC50 40.22 µg/mL). It can be concluded that the presence of certain bioactive antiviral molecules may be related to the high anti HSV-1 activity of the methanolic extract. This work has generated vital scientific data on this medicinal plant, which is a prospective candidate for the creation of innovative phyto-pharmaceuticals.

ACS Style

Łukasz Świątek; Elwira Sieniawska; Kouadio Sinan; Magdalena Maciejewska-Turska; Anastazja Boguszewska; Małgorzata Polz-Dacewicz; Ismail Senkardes; Gokalp Guler; Nabeelah Bibi Sadeer; Mohamad Mahomoodally; Gokhan Zengin. LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure. International Journal of Molecular Sciences 2021, 22, 7621 .

AMA Style

Łukasz Świątek, Elwira Sieniawska, Kouadio Sinan, Magdalena Maciejewska-Turska, Anastazja Boguszewska, Małgorzata Polz-Dacewicz, Ismail Senkardes, Gokalp Guler, Nabeelah Bibi Sadeer, Mohamad Mahomoodally, Gokhan Zengin. LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure. International Journal of Molecular Sciences. 2021; 22 (14):7621.

Chicago/Turabian Style

Łukasz Świątek; Elwira Sieniawska; Kouadio Sinan; Magdalena Maciejewska-Turska; Anastazja Boguszewska; Małgorzata Polz-Dacewicz; Ismail Senkardes; Gokalp Guler; Nabeelah Bibi Sadeer; Mohamad Mahomoodally; Gokhan Zengin. 2021. "LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure." International Journal of Molecular Sciences 22, no. 14: 7621.

Journal article
Published: 26 November 2020 in Journal of Pharmaceutical and Biomedical Analysis
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Mitracarpus hirtus (L.) DC. (Family: Rubiaceae) is a tropical annual herb commonly found in America and Mexico. In the present study, the methanol, ethyl acetate, dichloromethane and aqueous extracts of the plant were tested for total phenolic (TPC) and flavonoid content (TFC) and antioxidant activities were evaluated using a battery of assays including 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity, total antioxidant capacity (TAC) (phosphomolybdenum) and metal chelating. Enzyme inhibitory effects were investigated using acetylcholinesterase (AChE), tyrosinase, α-amylase and α-glucosidase as target enzymes. The phytochemical profile was obtained using liquid chromatography-diode array detection-electrospray ionization-mass spectrometry (LC-DAD-ESI-MSn), liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (LC-APCI-MSn) and nuclear magnetic resonance (NMR) experiments. Results showed that the dichloromethane and ethyl acetate extracts yielded the highest TPC (29.10 ± 0.07 mg gallic acid equivalent/g) and TFC (38.14 ± 0.91 mg rutin equivalent/g), respectively. Aqueous extract showed weak activity against tested enzymes but demonstrated the strongest ABTS scavenging activity (59.39 ± 1.19 mg trolox equivalent/g) and Fe3+ reducer (59.42 ± 0.59 mg trolox equivalent/g). Phytochemical analysis revealed the presence of phenolics, pyrrolizidine alkaloids and triterpene acid. This is the first report gathering scientific data on antioxidant, enzyme inhibitory activities and phytochemical composition of M. hirtus and the obtained results can be used as starting point for further investigation on this traditional medicinal herb.

ACS Style

Ouattara Katinan Etienne; Stefano Dall’Acqua; Kouadio Ibrahime Sinan; Irene Ferrarese; Stefania Sut; Nabeelah Bibi Sadeer; Mohamad Fawzi Mahomoodally; Gunes Ak; Gokhan Zengin. Chemical characterization, antioxidant and enzyme inhibitory effects of Mitracarpus hirtus extracts. Journal of Pharmaceutical and Biomedical Analysis 2020, 194, 113799 .

AMA Style

Ouattara Katinan Etienne, Stefano Dall’Acqua, Kouadio Ibrahime Sinan, Irene Ferrarese, Stefania Sut, Nabeelah Bibi Sadeer, Mohamad Fawzi Mahomoodally, Gunes Ak, Gokhan Zengin. Chemical characterization, antioxidant and enzyme inhibitory effects of Mitracarpus hirtus extracts. Journal of Pharmaceutical and Biomedical Analysis. 2020; 194 ():113799.

Chicago/Turabian Style

Ouattara Katinan Etienne; Stefano Dall’Acqua; Kouadio Ibrahime Sinan; Irene Ferrarese; Stefania Sut; Nabeelah Bibi Sadeer; Mohamad Fawzi Mahomoodally; Gunes Ak; Gokhan Zengin. 2020. "Chemical characterization, antioxidant and enzyme inhibitory effects of Mitracarpus hirtus extracts." Journal of Pharmaceutical and Biomedical Analysis 194, no. : 113799.

Journal article
Published: 25 November 2020 in Molecules
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Breynia retusa (Dennst.) Alston (also known as Cup Saucer plant) is a food plant with wide applications in traditional medicine, particularly in Ayurveda. Extracts obtained with four solvents (dichloromethane, methanol, ethyl acetate and water), from three plant parts, (fruit, leaf and bark) were obtained. Extracts were tested for total phenolic, flavonoid content and antioxidant activities using a battery of assays including 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), total antioxidant capacity (TAC) (phosphomolybdenum) and metal chelating. Enzyme inhibitory effects were investigated using acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, α-amylase and α-glucosidase as target enzymes. Results showed that the methanolic bark extract exhibited significant radical scavenging activity (DPPH: 202.09 ± 0.15; ABTS: 490.12 ± 0.18 mg Trolox equivalent (TE)/g), reducing potential (FRAP: 325.86 ± 4.36: CUPRAC: 661.82 ± 0.40 mg TE/g) and possessed the highest TAC (3.33 ± 0.13 mmol TE/g). The methanolic extracts were subjected to LC-DAD-MSn and NMR analysis. A two-column LC method was developed to separate constituents, allowing to identify and quantify forty-four and fifteen constituents in bark and fruits, respectively. Main compound in bark was epicatechin-3-O-sulphate and isolation of compound was performed to confirm its identity. Bark extract contained catechins, procyanidins, gallic acid derivatives and the sulfur containing spiroketal named breynins. Aerial parts mostly contained flavonoid glycosides. Considering the bioassays, the methanolic bark extract resulted a potent tyrosinase (152.79 ± 0.27 mg kojic acid equivalent/g), α-amylase (0.99 ± 0.01 mmol acarbose equivalent ACAE/g) and α-glucosidase (2.16 ± 0.01 mmol ACAE/g) inhibitor. In conclusion, methanol is able to extract the efficiently the phytoconstituents of B. retusa and the bark is the most valuable source of compounds.

ACS Style

Stefano Dall’Acqua; Kouadio Ibrahime Sinan; Irene Ferrarese; Stefania Sut; Kouadio Bene; Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Monika Waksmundzka-Hajnos; Gokhan Zengin. Chromatographic Separation of Breynia retusa (Dennst.) Alston Bark, Fruit and Leaf Constituents from Bioactive Extracts. Molecules 2020, 25, 5537 .

AMA Style

Stefano Dall’Acqua, Kouadio Ibrahime Sinan, Irene Ferrarese, Stefania Sut, Kouadio Bene, Mohamad Fawzi Mahomoodally, Nabeelah Bibi Sadeer, Monika Waksmundzka-Hajnos, Gokhan Zengin. Chromatographic Separation of Breynia retusa (Dennst.) Alston Bark, Fruit and Leaf Constituents from Bioactive Extracts. Molecules. 2020; 25 (23):5537.

Chicago/Turabian Style

Stefano Dall’Acqua; Kouadio Ibrahime Sinan; Irene Ferrarese; Stefania Sut; Kouadio Bene; Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Monika Waksmundzka-Hajnos; Gokhan Zengin. 2020. "Chromatographic Separation of Breynia retusa (Dennst.) Alston Bark, Fruit and Leaf Constituents from Bioactive Extracts." Molecules 25, no. 23: 5537.

Journal article
Published: 02 November 2020 in Current Medicinal Chemistry
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Background: Diabetes Mellitus (DM) is a severe endocrine metabolic disease coupled with various long-term complications. A plethora of targets have been identified, however with possible adverse effects. Therefore, researchers are in the perpetual quest for safe and more effective therapeutics. Natural products, particularly derived from plants have proven to exert anti-diabetic effects via diverse mechanisms. Methods: An overview of DM pathogenesis and its associated micro- and macro-vascular complications is presented. Possible underlying mechanisms of herbal remedies in DM management are provided highlighting some key therapeutic targets. The review also appraises the recent progress of herbal products in treating DM through regulating inflammation and gut microbiota. Finally, currently available pharmacological treatments are discussed. Results: The results show that numerous plants have proved to be promising sources of insulin secreting agents, αglucosidase and α-amylase inhibitors. Among the non- conventional targets, inhibition of key enzymes such as lipase, cholinesterases and angiotensin converting enzyme have been directly and/or indirectly linked to DM and DM complications. For instance, hypericin, pseudohypericin and I3,II8-biapigenin isolated from Hypericum perforatum L., and palmatine and columbamine isolated from Dichocarpum auriculatum (Franch.) W. T. Wang & P. K have been found to be powerful lipase and cholinesterase inhibitors, respectively. Moreover, a number of plant-derived compounds such as feruloylated oligosaccharides from maize bran, baicalein and berberine are reported to mediate anti-diabetic property via modulation of gut microbiota. Conclusion: The information amassed in this review is anticipated to provide useful scientific baseline information to support advanced research in natural antidiabetic drug development.

ACS Style

Mohamad Fawzi Mahomoodally; Devina Lobine; Marie Carene Nancy Picot-Allain; Nabeelah Sadeer; Sharmeen Jugreet; Gokhan Zengin. Conventional and non-conventional targets of natural products in the management of diabetes mellitus and associated complications. Current Medicinal Chemistry 2020, 27, 1 -28.

AMA Style

Mohamad Fawzi Mahomoodally, Devina Lobine, Marie Carene Nancy Picot-Allain, Nabeelah Sadeer, Sharmeen Jugreet, Gokhan Zengin. Conventional and non-conventional targets of natural products in the management of diabetes mellitus and associated complications. Current Medicinal Chemistry. 2020; 27 ():1-28.

Chicago/Turabian Style

Mohamad Fawzi Mahomoodally; Devina Lobine; Marie Carene Nancy Picot-Allain; Nabeelah Sadeer; Sharmeen Jugreet; Gokhan Zengin. 2020. "Conventional and non-conventional targets of natural products in the management of diabetes mellitus and associated complications." Current Medicinal Chemistry 27, no. : 1-28.

Review
Published: 01 November 2020 in South African Journal of Botany
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Seagrasses, one of the most threatened yet overlooked ecosystems on Earth, are the only flowering plants to recolonising the seabed. Apart from their critical ecological prominence on the life of many marine organisms, seagrasses are also used as an alternative or complementary medicine to manage an array of pathological disorders such as muscle aches, wounds, abdominal pain, indigestion, hangover, and mental disorders. However, a compilation of existing work on their ethnopharmacological uses, nutritional values, pharmacological propensities and bioactive compounds is lacking. Thus, this review aims at elaborating on the biochemical composition, phytochemical analysis, and biological properties including antioxidant, antimicrobial activities of various species of seagrasses. Seagrasses harbour several metabolites with multiple bioactivities. The phytochemical compounds isolated from Zostera marina L., Thalassia testudinum K. D. Koenig. and Thalassodendron ciliatum (Forssk.) exhibit a plethora of biological activities, including cytotoxicity against cancer cell lines, anti-human immunodeficiency virus (HIV), antimicrobial, and skin regenerating properties. This review also identifies vital lacuna in seagrass research. For instance, the mechanism and site of action of compounds displaying potent biological activities has not been adequately addressed together with optimisation of extraction methods to isolate minor metabolites and applying technological advancements in biological assays. In conclusion, this review provides a synthesis of current knowledge and highlights future work that needs to be undertaken for the biomedical application of such natural resources.

ACS Style

Doo Hwan Kim; Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Park Gyun Seok; Gokhan Zengin; Kishneth Palaniveloo; Anees Ahmed Khalil; Abdur Rauf; Kannan Rr Rengasamy. Nutritional and bioactive potential of seagrasses: A review. South African Journal of Botany 2020, 137, 216 -227.

AMA Style

Doo Hwan Kim, Mohamad Fawzi Mahomoodally, Nabeelah Bibi Sadeer, Park Gyun Seok, Gokhan Zengin, Kishneth Palaniveloo, Anees Ahmed Khalil, Abdur Rauf, Kannan Rr Rengasamy. Nutritional and bioactive potential of seagrasses: A review. South African Journal of Botany. 2020; 137 ():216-227.

Chicago/Turabian Style

Doo Hwan Kim; Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Park Gyun Seok; Gokhan Zengin; Kishneth Palaniveloo; Anees Ahmed Khalil; Abdur Rauf; Kannan Rr Rengasamy. 2020. "Nutritional and bioactive potential of seagrasses: A review." South African Journal of Botany 137, no. : 216-227.

Journal article
Published: 17 August 2020 in South African Journal of Botany
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The genus Scorzonera contains important plants as traditional drugs and foods. In this sense, the aim of the present study was to determine the chemical composition, antioxidant activity and enzyme inhibitory effects of the root and aerial part of Scorzonera hispanica L. (S. hispanica) extracts. The antioxidant activities were evaluated using ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), metal chelating and phosphomolybdenum assays and the enzyme inhibitory properties were assessed against acetyl- (AChE) and butyryl-cholinesterase (BChE), tyrosinase, α-amylase and α-glucosidase. The results showed that the methanolic and ethyl acetate extracts possessed the highest phenol and flavonoid contents. The methanolic aerial part extract represented the highest antioxidant properties (FRAP: 58.41±1.55; CUPRAC: 126.18±0.94; DPPH: 47.92±0.07; ABTS: 71.69±0.03 mg Trolox equivalent (TE)/g) compared to the root extracts. The root extract significantly depressed AChE (2.64±0.02 mg galantamine equivalent (GALAE)/g), BChE (5.36±0.45 mg galantamine equivalent (GALAE)/g), tyrosinase (60.36±0.23 mg kojic acid equivalent (KAE)/g), α-amylase (0.61±0.01 mmol acarbose equivalent (ACAE)/g) and α-glucosidase (0.82±0.01 mmol acarbose equivalent (ACAE)/g) enzymes. Liquid chromatography hyphenated with photodiode-array detection and tandem electrospray ionization mass spectrometry (LC-DAD-MSn) analysis revealed phytochemical fingerprint of the two part of the plant and the most abundant constituents were rutin and orientin for aerial parts, 3,5 and 4,5-dicaffeoyl quinic acids for roots respectively. This is the first report gathering scientific data on antioxidant, enzyme inhibitory activities and phytochemical composition of S. hispanica. Thus, this research can be used as one methodological starting point for further investigation on this plant.

ACS Style

Gunes Ak; Stefano Dall'Acqua; Stefania Sut; Irene Ferrarese; Evren Yıldıztugay; Mohamad Fawzi Mahomoodally; Kouadio Ibrahime Sinan; Nabeelah Bibi Sadeer; Kannan R.R. Rengasamy; Gokhan Zengin. Chemical characterization and bio-pharmaceutical abilities of five different solvent extracts from aerial parts and roots of Scorzonera hispanica L. South African Journal of Botany 2020, 133, 212 -221.

AMA Style

Gunes Ak, Stefano Dall'Acqua, Stefania Sut, Irene Ferrarese, Evren Yıldıztugay, Mohamad Fawzi Mahomoodally, Kouadio Ibrahime Sinan, Nabeelah Bibi Sadeer, Kannan R.R. Rengasamy, Gokhan Zengin. Chemical characterization and bio-pharmaceutical abilities of five different solvent extracts from aerial parts and roots of Scorzonera hispanica L. South African Journal of Botany. 2020; 133 ():212-221.

Chicago/Turabian Style

Gunes Ak; Stefano Dall'Acqua; Stefania Sut; Irene Ferrarese; Evren Yıldıztugay; Mohamad Fawzi Mahomoodally; Kouadio Ibrahime Sinan; Nabeelah Bibi Sadeer; Kannan R.R. Rengasamy; Gokhan Zengin. 2020. "Chemical characterization and bio-pharmaceutical abilities of five different solvent extracts from aerial parts and roots of Scorzonera hispanica L." South African Journal of Botany 133, no. : 212-221.

Review
Published: 05 August 2020 in Antioxidants
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Currently, there is a growing interest in screening and quantifying antioxidants from biological samples in the quest for natural and effective antioxidants to combat free radical-related pathological complications. Antioxidant assays play a crucial role in high-throughput and cost-effective assessment of antioxidant capacities of natural products such as medicinal plants and food samples. However, several investigators have expressed concerns about the reliability of existing in vitro assays. Such concerns arise mainly from the poor correlation between in vitro and in vivo results. In addition, in vitro assays have the problem of reproducibility. To date, antioxidant capacities are measured using a panel of assays whereby each assay has its own advantages and limitations. This unparalleled review hotly disputes on in vitro antioxidant assays and elaborates on the chemistry behind each assay with the aim to point out respective principles/concepts. The following critical questions are also addressed: (1) What make antioxidant assays coloured? (2) What is the reason for working at a particular wavelength? (3) What are the advantages and limitations of each assay? and (4) Why is a particular colour observed in antioxidant–oxidant chemical reactions? Furthermore, this review details the chemical mechanism of reactions that occur in each assay together with a colour ribbon to illustrate changes in colour. The review ends with a critical conclusion on existing assays and suggests constructive improvements on how to develop an adequate and universal antioxidant assay.

ACS Style

Nabeelah Bibi Sadeer; Domenico Montesano; Stefania Albrizio; Gokhan Zengin; Mohamad Fawzi Mahomoodally. The Versatility of Antioxidant Assays in Food Science and Safety—Chemistry, Applications, Strengths, and Limitations. Antioxidants 2020, 9, 709 .

AMA Style

Nabeelah Bibi Sadeer, Domenico Montesano, Stefania Albrizio, Gokhan Zengin, Mohamad Fawzi Mahomoodally. The Versatility of Antioxidant Assays in Food Science and Safety—Chemistry, Applications, Strengths, and Limitations. Antioxidants. 2020; 9 (8):709.

Chicago/Turabian Style

Nabeelah Bibi Sadeer; Domenico Montesano; Stefania Albrizio; Gokhan Zengin; Mohamad Fawzi Mahomoodally. 2020. "The Versatility of Antioxidant Assays in Food Science and Safety—Chemistry, Applications, Strengths, and Limitations." Antioxidants 9, no. 8: 709.

Journal article
Published: 23 June 2020 in South African Journal of Botany
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Crinum asiaticum L. (Amaryllidaceae), also known as poison bulb or spider lily, is a perennial bulbous herb bearing feathery green leaves, employed to induce emesis during poisoning. In Ayurveda, it is called ‘naagadami’, in Malaysia, the natives refer to it as ‘bakong’, ‘morabau’ is its name in Papua New Guinea, and it is known as ‘lys’ or ‘lis sauvage’ in Mauritius. In ethnomedicine, it is employed to relieve anguish from a plethora of ailment conditions such as boils, contusions, earache, edema, fever, fractures, gastrointestinal complaints, hernia, mumps, rheumatism, tonsillitis, urinary difficulties and vomiting, amongst others. It is economically valuable due to its medicinal and ornamental attributes. Given the lack of an updated comprehensive one stop documentation on this species, this review aims to compile its morphological characteristics, geographical distribution, as well as its traditional uses, phytochemistry, pharmacological properties and toxicity potential. While the extracts of C. asiaticum were found to be particularly rich in alkaloids, chemical analysis of essential oils obtained from C. asiaticum revealed the presence of miscellaneous components including alcohols, phenolics, fatty acids, esters, aldehydes, terpenoids and terpenes. Extracts and compounds from C. asiaticum have been evaluated for their antioxidant, analgesic, anti-inflammatory, anti-plasmodial, cytotoxicity, anti-cancer and antimicrobial properties. Only one clinical study has showed that repeated and single cutaneous applications of the extract under the occlusive patch did not provoke any cumulative irritation and sensitization reactions. In conclusion, this plant holds promising pharmacological properties that deserves renewed attention, especially with regard to its toxicity that could be significant in the development of phytopharmaceuticals.

ACS Style

M.F. Mahomoodally; N.B. Sadeer; S. Suroowan; S. Jugreet; D. Lobine; K.R.R. Rengasamy. Ethnomedicinal, phytochemistry, toxicity and pharmacological benefits of poison bulb – Crinum asiaticum L. South African Journal of Botany 2020, 136, 16 -29.

AMA Style

M.F. Mahomoodally, N.B. Sadeer, S. Suroowan, S. Jugreet, D. Lobine, K.R.R. Rengasamy. Ethnomedicinal, phytochemistry, toxicity and pharmacological benefits of poison bulb – Crinum asiaticum L. South African Journal of Botany. 2020; 136 ():16-29.

Chicago/Turabian Style

M.F. Mahomoodally; N.B. Sadeer; S. Suroowan; S. Jugreet; D. Lobine; K.R.R. Rengasamy. 2020. "Ethnomedicinal, phytochemistry, toxicity and pharmacological benefits of poison bulb – Crinum asiaticum L." South African Journal of Botany 136, no. : 16-29.

Journal article
Published: 18 June 2020 in Antioxidants
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Mangrove forests exemplify a multifaceted ecosystem since they do not only play a crucial ecological role but also possess medicinal properties. Methanolic, ethyl acetate and aqueous leaf and bark extracts were prepared using homogenizer-assisted extraction (HAE), infusion and maceration (with and without stirring). The different extracts were screened for phytochemical profiling and antioxidant capacities in terms of radical scavenging (DPPH, ABTS), reducing potential (CUPRAC, FRAP), total antioxidant capacity and chelating power. Additionally, R. racemosa was evaluated for its anti-diabetic (α-amylase, α-glucosidase), anti-tyrosinase and anti-cholinesterase (AChE, BChE) activities. Additionally, antimycotic and antibacterial effects were investigated against Eescherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Listeria monocytogenes, Enterobacter cloacae, Bacillus cereus, Micrococcus luteus, Staphylococcus aureus, Aspergillus fumigatus, Aspergillus niger, Trichoderma viride, Penicillium funiculosum, Penicillium ochrochloron and Penicillium verrucosum. Finally, based on phytochemical fingerprint, in silico studies, including bioinformatics, network pharmacology and docking approaches were conducted to predict the putative targets, namely tyrosinase, lanosterol-14-α-demethylase and E. coli DNA gyrase, underlying the observed bio-pharmacological and microbiological effects. The methanolic leave and bark extracts (prepared by both HAE and maceration) abounded with phenolics, flavonoids, phenolic acids and flavonols. Results displayed that both methanolic leaf and bark extracts (prepared by HAE) exhibited the highest radical scavenging, reducing potential and total antioxidant capacity. Furthermore, our findings showed that the highest enzymatic inhibitory activity recorded was with the tyrosinase enzyme. In this context, bioinformatics analysis predicted putative interactions between tyrosinase and multiple secondary metabolites including apigenin, luteolin, vitexin, isovitexin, procyanidin B, quercetin and methoxy-trihydroxyflavone. The same compounds were also docked against lanosterol-14α-demethylase and E. Coli DNA gyrase, yielding affinities in the submicromolar–micromolar range that further support the observed anti-microbial effects exerted by the extracts. In conclusion, extracts of R. racemosa may be considered as novel sources of phytoanti-oxidants and enzyme inhibitors that can be exploited as future first-line pharmacophores.

ACS Style

Annalisa Chiavaroli; Koaudio Ibrahime Sinan; Gokhan Zengin; Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Ouattara Katinan Etienne; Zoltán Cziáky; József Jekő; Jasmina Glamočlija; Marina Soković; Lucia Recinella; Luigi Brunetti; Sheila Leone; Hassan H. Abdallah; Paola Angelini; Giancarlo Angeles Flores; Roberto Venanzoni; Luigi Menghini; Giustino Orlando; Claudio Ferrante. Identification of Chemical Profiles and Biological Properties of Rhizophora racemosa G. Mey. Extracts Obtained by Different Methods and Solvents. Antioxidants 2020, 9, 533 .

AMA Style

Annalisa Chiavaroli, Koaudio Ibrahime Sinan, Gokhan Zengin, Mohamad Fawzi Mahomoodally, Nabeelah Bibi Sadeer, Ouattara Katinan Etienne, Zoltán Cziáky, József Jekő, Jasmina Glamočlija, Marina Soković, Lucia Recinella, Luigi Brunetti, Sheila Leone, Hassan H. Abdallah, Paola Angelini, Giancarlo Angeles Flores, Roberto Venanzoni, Luigi Menghini, Giustino Orlando, Claudio Ferrante. Identification of Chemical Profiles and Biological Properties of Rhizophora racemosa G. Mey. Extracts Obtained by Different Methods and Solvents. Antioxidants. 2020; 9 (6):533.

Chicago/Turabian Style

Annalisa Chiavaroli; Koaudio Ibrahime Sinan; Gokhan Zengin; Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Ouattara Katinan Etienne; Zoltán Cziáky; József Jekő; Jasmina Glamočlija; Marina Soković; Lucia Recinella; Luigi Brunetti; Sheila Leone; Hassan H. Abdallah; Paola Angelini; Giancarlo Angeles Flores; Roberto Venanzoni; Luigi Menghini; Giustino Orlando; Claudio Ferrante. 2020. "Identification of Chemical Profiles and Biological Properties of Rhizophora racemosa G. Mey. Extracts Obtained by Different Methods and Solvents." Antioxidants 9, no. 6: 533.

Journal article
Published: 07 May 2020 in Biomolecules
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Bruguiera gymnorhiza (L.) Lam. is claimed to effectively manage a number of ailments including diabetes and associated complications. Nonetheless, no attempt has been made to delineate its pharmacological propensities and phytochemical profile. This study was designed to appraise the antioxidant and enzymatic inhibitory properties relevant to the management of diabetes mellitus, obesity, and neurodegenerative and skin disorders. A combination of colorimetric assays and ultra-high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS) were applied for the phytochemical screening of leaf, root, twig, and fruit extracts (methanol and ethyl acetate). In vitro antioxidant evaluations were via radical scavenging abilities (DPPH, ABTS), reducing potential (FRAP, CUPRAC), chelating power, and total antioxidant capacity (phosphomolybdenum). Seven key metabolic enzymes (α-amylase, α-glucosidase, tyrosinase, elastase, lipase, AChE, and BChE) were targeted to determine the inhibitory effects. Multivariate and in silico docking analysis were performed on collected data. Methanolic fruit extract yielded the highest total phenolic, tannin, and triterpenoid contents (174.18 ± 4.27 mg GAE/g, 176.24 ± 3.10 mg CE/g, 63.11 ± 3.27 mg OAE/g, respectively); significantly depressed tyrosinase, elastase, and α-amylase activities (155.35 ± 0.29 mg KAE/g, 4.56 ± 0.10 mg CAE/g, 1.00 ± 0.05 mmol ACAE/g, accordingly); and harboured the most potent antioxidant capacities with DPPH, CUPRAC, FRAP (492.62 ± 5.31, 961.46 ± 11.18, 552.49 ± 8.71 mg TE/g, respectively), and phosphomolybdenum (4.17 ± 0.31 mmol TE/g) assays. Multivariate analysis suggested that the type of solvents used influenced the biological activities more compared to plant parts. Docking analysis showed that azelaic acid binds with tyrosinase by Van der Waals and conventional hydrogen bonds. We anticipate that the present study may establish baseline data on this halophyte that could open new avenues for the development of biomedicine.

ACS Style

Nabeelah Bibi Sadeer; Kouadio Ibrahime Sinan; Zoltán Cziáky; József Jekő; Gokhan Zengin; Rajesh Jeewon; Hassan H. Abdallah; Kannan R. R. Rengasamy; Mohamad Fawzi Mahomoodally. Assessment of the Pharmacological Properties and Phytochemical Profile of Bruguiera gymnorhiza (L.) Lam Using In Vitro Studies, In Silico Docking, and Multivariate Analysis. Biomolecules 2020, 10, 731 .

AMA Style

Nabeelah Bibi Sadeer, Kouadio Ibrahime Sinan, Zoltán Cziáky, József Jekő, Gokhan Zengin, Rajesh Jeewon, Hassan H. Abdallah, Kannan R. R. Rengasamy, Mohamad Fawzi Mahomoodally. Assessment of the Pharmacological Properties and Phytochemical Profile of Bruguiera gymnorhiza (L.) Lam Using In Vitro Studies, In Silico Docking, and Multivariate Analysis. Biomolecules. 2020; 10 (5):731.

Chicago/Turabian Style

Nabeelah Bibi Sadeer; Kouadio Ibrahime Sinan; Zoltán Cziáky; József Jekő; Gokhan Zengin; Rajesh Jeewon; Hassan H. Abdallah; Kannan R. R. Rengasamy; Mohamad Fawzi Mahomoodally. 2020. "Assessment of the Pharmacological Properties and Phytochemical Profile of Bruguiera gymnorhiza (L.) Lam Using In Vitro Studies, In Silico Docking, and Multivariate Analysis." Biomolecules 10, no. 5: 731.

Journal article
Published: 08 April 2020 in Marine Drugs
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Seaweeds have been exploited as both food products and therapeutics to manage human ailments for centuries. This study investigated the metabolite profile of five seaweeds (Halimeda spp., Spyridia hypnoides (Bory de Saint-Vincent) Papenfuss, Valoniopsis pachynema (G. Martens) Børgesen, Gracilaria fergusonii J. Agardh and Amphiroa anceps (Lamarck) Decaisne using ultra-high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (UHPLC-ESI-MS/MS). Furthermore, these seaweeds were assessed for antioxidant and inhibitory effects against α-amylase, α-glucosidase, acetyl-cholinesterase (AChE), butyryl-cholinesterase (BChE) and tyrosinase. Valoniopsis pachynema and A. anceps yielded the highest flavonoid (4.30 ± 0.29 mg RE/g) and phenolic content (7.83 ± 0.08 mg RE/g), respectively. Additionally, A. anceps exhibited significant antioxidant properties with all assays and significantly depressed BChE (IC50 = 6.68 ± 0.83 mg/mL) and α-amylase activities (IC50 = 5.34 ± 0.14 mg/mL). Interestingly, the five seaweeds revealed potent inhibitory effects against tyrosinase activity. In conclusion, A. anceps might be considered as a key source of phytoantioxidants and a potential candidate to develop nutritional supplements. Besides, the five tested seaweeds warrant further study and may be exploited as promising natural sources for managing hyperpigmentation.

ACS Style

Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Gokhan Zengin; Zoltán Cziáky; József Jekő; Alina Diuzheva; Kouadio Ibrahime Sinan; Kishneth Palaniveloo; Doo Hwan Kim; Kannan R. R. Rengasamy. In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds. Marine Drugs 2020, 18, 198 .

AMA Style

Mohamad Fawzi Mahomoodally, Nabeelah Bibi Sadeer, Gokhan Zengin, Zoltán Cziáky, József Jekő, Alina Diuzheva, Kouadio Ibrahime Sinan, Kishneth Palaniveloo, Doo Hwan Kim, Kannan R. R. Rengasamy. In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds. Marine Drugs. 2020; 18 (4):198.

Chicago/Turabian Style

Mohamad Fawzi Mahomoodally; Nabeelah Bibi Sadeer; Gokhan Zengin; Zoltán Cziáky; József Jekő; Alina Diuzheva; Kouadio Ibrahime Sinan; Kishneth Palaniveloo; Doo Hwan Kim; Kannan R. R. Rengasamy. 2020. "In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds." Marine Drugs 18, no. 4: 198.

Journal article
Published: 16 October 2019 in Antioxidants
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Currently, there is a renewed interest towards the development of plant-based pharmacophores. In this work, 16 extracts prepared from the leaves, twigs, roots and fruits of a hydro-halophyte, Rhizophora mucronata Lam. (Family: Rhizophoraceae), were studied for possible antioxidant activity and the phenolic profiles established. Thereafter, enzymatic inhibitory activities (α-amylase, α-glucosidase, tyrosinase, acetyl- (AChE), butyrylcholinesterase (BChE), lipase, and elastase) were assessed. The total phenolic, flavonoid, phenolic acid, tannin, flavanol and triterpenoid content were estimated using standard assays. An untargeted metabolomics-based approach, based on ultra-high-pressure liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UHPLC-QTOF-MS) followed by multivariate statistics, was then used to comprehensively profile and describe the phenolics present. UHPLC-QTOF-MS allowed for putatively annotating 104 phenolic acids, 103 flavonols, 94 flavones, 71 anthocyanins, 66 tyrosols, 29 lignans, 15 alkylphenols and 10 stilbenes in the extracts. Nine strains (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Methicillin-resistant Staphylococcus aureus (MRSA), Salmonella enteritidis, Sarcina lutea, Proteus mirabilis, Bacillus cereus and Candida albicans) were then used to investigate the antimicrobial properties. The methanolic twig extract exhibited significant reducing potential towards Cu (II)/Cu (I) and Fe (III)/Fe (II) (1336.88 ± 15.70 and 710.18 ± 21.04 mg TE/g, respectively) and was the most potent DPPH radical scavenger (807.07 ± 6.83 mg TE/g). Additionally, the methanolic twig extract showed significant inhibition against most targeted enzymes. Anti-microbial results showed that all extracts were active against MRSA. Multivariate analysis demonstrated that the phenolic profile of ethyl acetate extracts and leaves were the two most discriminative parameters in terms of solvents and organs, respectively. The present findings indicated that R. mucronata may be further explored for the management/prevention of oxidative stress, neurodegenerative complications and hyperpigmentation.

ACS Style

Nabeelah Bibi Sadeer; Gabriele Rocchetti; Biancamaria Senizza; Domenico Montesano; Gokhan Zengin; Ahmet Uysal; Rajesh Jeewon; Luigi Lucini; Mohamad Fawzi Mahomoodally. Untargeted Metabolomic Profiling, Multivariate Analysis and Biological Evaluation of the True Mangrove (Rhizophora mucronata Lam.). Antioxidants 2019, 8, 489 .

AMA Style

Nabeelah Bibi Sadeer, Gabriele Rocchetti, Biancamaria Senizza, Domenico Montesano, Gokhan Zengin, Ahmet Uysal, Rajesh Jeewon, Luigi Lucini, Mohamad Fawzi Mahomoodally. Untargeted Metabolomic Profiling, Multivariate Analysis and Biological Evaluation of the True Mangrove (Rhizophora mucronata Lam.). Antioxidants. 2019; 8 (10):489.

Chicago/Turabian Style

Nabeelah Bibi Sadeer; Gabriele Rocchetti; Biancamaria Senizza; Domenico Montesano; Gokhan Zengin; Ahmet Uysal; Rajesh Jeewon; Luigi Lucini; Mohamad Fawzi Mahomoodally. 2019. "Untargeted Metabolomic Profiling, Multivariate Analysis and Biological Evaluation of the True Mangrove (Rhizophora mucronata Lam.)." Antioxidants 8, no. 10: 489.

Review
Published: 18 April 2019 in Marine Drugs
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Mangroves are ecologically important plants in marine habitats that occupy the coastlines of many countries. In addition to their key ecological importance, various parts of mangroves are widely used in folklore medicine and claimed to effectively manage a panoply of human pathologies. To date, no comprehensive attempt has been made to compile and critically analyze the published literature in light of its ethnopharmacological uses. This review aims to provide a comprehensive account of the morphological characteristics, ethnobotany, global distribution, taxonomy, ethnopharmacology, phytochemical profiles, and pharmacological activities of traditionally used mangroves. Out of 84 mangrove species, only 27 species were found to be traditionally used, however not all of them are pharmacologically validated. The most common pharmacological activities reported were antioxidant, antimicrobial, and antidiabetic properties. Mangroves traditionally reported against ulcers have not been extensively validated for possible pharmacological properties. Terpenoids, tannins, steroids, alkaloids, flavonoids, and saponins were the main classes of phytochemicals isolated from mangroves. Given that mangroves have huge potential for a wide array of medicinal products and drug discovery to prevent and treat many diseases, there is a dire need for careful investigations substantiated with accurate scientific and clinical evidence to ensure safety and efficient use of these plants and validate their pharmacological properties and toxicity.

ACS Style

Sadeer Nabeelah Bibi; Mahomoodally Mohamad Fawzi; Zengin Gokhan; Jeewon Rajesh; Nazurally Nadeem; Rengasamy Kannan R.R.; Albuquerque R.D.D.G.; Shunmugiah Karutha Pandian. Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves―A Comprehensive Review. Marine Drugs 2019, 17, 231 .

AMA Style

Sadeer Nabeelah Bibi, Mahomoodally Mohamad Fawzi, Zengin Gokhan, Jeewon Rajesh, Nazurally Nadeem, Rengasamy Kannan R.R., Albuquerque R.D.D.G., Shunmugiah Karutha Pandian. Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves―A Comprehensive Review. Marine Drugs. 2019; 17 (4):231.

Chicago/Turabian Style

Sadeer Nabeelah Bibi; Mahomoodally Mohamad Fawzi; Zengin Gokhan; Jeewon Rajesh; Nazurally Nadeem; Rengasamy Kannan R.R.; Albuquerque R.D.D.G.; Shunmugiah Karutha Pandian. 2019. "Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves―A Comprehensive Review." Marine Drugs 17, no. 4: 231.