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Prof. Dr. Fawzi Mahomoodally
University of Mauritius

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Journal article
Published: 30 August 2021 in South African Journal of Botany
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Essential oils (EOs) extracted from botanical resources have greatly been appraised as antimicrobials against a broad spectrum of microorganisms. A panoply of experimental studies have pointed out the immense potency of EOs as natural antimicrobial agents at relatively low doses; largely attributed to the synergistic interaction of various bioactive components. In the present study, 10 EOs prepared from two endemic (Pittosporum senacia Putterl. subsp. Senacia and Syzygium coriaceum J. Bosser & J. Guého) and seven exotic (Cinnamomum camphora (L.) Nees & Eberm, Citrus aurantium L., Curcuma longa L, Morinda citrifolia L., Petroselinum crispum (Mill.) Fuss, Plectranthus amboinicus (Lour.) Sprengel and Syzygium samarangense (Blume) Merr. & L. M. Perry) aromatic medicinal plants from Mauritius, were screened for their growth inhibitory activities against eight bacteria (ATCC strains and clinical isolates) using broth microdilution techniques. The EOs were found to possess varying degree of antibacterial potency. The most active EOs were found to have minimum inhibitory concentration (MIC) of 0.25-4 mg/mL and minimum bactericidal concentration (MBC) of 0.25-16 mg/mL. In particular, at its MIC values, P. amboinicus EO showed bactericidal effects against four strains. However, all tested bacteria were insensitive to P. senecia and C. aurantium fruit peel EOs. Bacillus spizizenii was found to be the most susceptible strain to the active EOs. Additionally, P. amboinicus and the two Syzygium spp. EOs showed antibiotic potentiating activities. Mostly synergistic and partial synergistic actions of the EOs, in combination with the conventional antibiotics (streptomycin, chloramphenicol and ciprofloxacin) at a ratio of 1:1 were obtained against the tested bacteria. Thus, results from this study highlighted the antibacterial potential and the efficacy of the most active EOs as antibiotic potentiating agents that could potentially be used in combinational therapy along with conventional antibiotics for a synergistic approach in the treatment/management of clinically relevant bacterial infections.

ACS Style

Bibi Sharmeen Jugreet; Mohamad Fawzi Mahomoodally. Reprint of: Essential oils from 9 exotic and endemic medicinal plants from Mauritius shows in vitro antibacterial and antibiotic potentiating activities. South African Journal of Botany 2021, 140, 478 -485.

AMA Style

Bibi Sharmeen Jugreet, Mohamad Fawzi Mahomoodally. Reprint of: Essential oils from 9 exotic and endemic medicinal plants from Mauritius shows in vitro antibacterial and antibiotic potentiating activities. South African Journal of Botany. 2021; 140 ():478-485.

Chicago/Turabian Style

Bibi Sharmeen Jugreet; Mohamad Fawzi Mahomoodally. 2021. "Reprint of: Essential oils from 9 exotic and endemic medicinal plants from Mauritius shows in vitro antibacterial and antibiotic potentiating activities." South African Journal of Botany 140, no. : 478-485.

Journal article
Published: 30 August 2021 in Antioxidants
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Epilobium hirsutum is extensively used as a traditional remedy in folk medicine, especially against prostate inflammation. Therefore, we evaluated the chemical profiles and biopharmaceutical potentials of different extracts of E. hirsutum aerial parts and roots. Metabolomic, antioxidant, and enzyme inhibitory profiles were investigated. Human prostate cancer PC3 cells were exposed to the extracts to evaluate antiproliferative effects. Gene expression and bioinformatics analyses were performed to investigate anti-inflammatory mechanisms. Oenothein B and myricetin were prominent compounds in the extracts. In scavenging/reducing assays, the methanol, infusion, and methanol/water extracts exhibited similar activities. We also observed the reduction of PC3 viability occurring following exposure to methanol and methanol/water extracts. According to bioinformatics analysis, myricetin was predicted to interact with COX-2 and TNFα. The interaction between TNFα and oxo-dihydroxy-octadecenoic acid was predicted as well. Intriguingly, the gene expression of COX-2 and TNFα was reduced in PC3 cells after exposure to methanol and methanol/water extracts. These effects were paralleled by the decreased gene expression of IL-8 and NFkB and the inhibition of PGE2 release. Therefore, the present findings suggest the potential use of E. hirsutum for the management of the burden of inflammation and oxidative stress occurring in lower urinary tract diseases, including prostatitis.

ACS Style

Gunes Ak; Gokhan Zengin; Mohamad Fawzi Mahomoodally; Eulogio Llorent-Martínez; Giustino Orlando; Annalisa Chiavaroli; Luigi Brunetti; Lucia Recinella; Sheila Leone; Simonetta Cristina Di Simone; Luigi Menghini; Claudio Ferrante. Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure? Antioxidants 2021, 10, 1389 .

AMA Style

Gunes Ak, Gokhan Zengin, Mohamad Fawzi Mahomoodally, Eulogio Llorent-Martínez, Giustino Orlando, Annalisa Chiavaroli, Luigi Brunetti, Lucia Recinella, Sheila Leone, Simonetta Cristina Di Simone, Luigi Menghini, Claudio Ferrante. Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure? Antioxidants. 2021; 10 (9):1389.

Chicago/Turabian Style

Gunes Ak; Gokhan Zengin; Mohamad Fawzi Mahomoodally; Eulogio Llorent-Martínez; Giustino Orlando; Annalisa Chiavaroli; Luigi Brunetti; Lucia Recinella; Sheila Leone; Simonetta Cristina Di Simone; Luigi Menghini; Claudio Ferrante. 2021. "Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure?" Antioxidants 10, no. 9: 1389.

Original research article
Published: 17 August 2021 in Frontiers in Pharmacology
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Traditionally, plants of the genus Calotropis have been used to cure various common diseases. The present research work explores the chemical and biological characterization of one of the most common species of this genus, i.e., Calotropis gigantea (L.) Dryand (syn. Calotropis gigantea (L.) Dryand.), having multiple folklore applications. The ethanolic extract of leaves of Calotropis gigantea (L.) Dryand was analyzed for the phytochemical composition by determining the total bioactive (total phenolic and total flavonoid) contents and UHPLC-MS secondary metabolites analysis. For phytopharmacological evaluation, in vitro antioxidant (including DPPH, ABTS, FRAP, CUPRAC, phosphomolybdenum, and metal chelation antioxidant assays) activities, enzyme inhibition potential (against AChE, BChE, α-amylase, and tyrosinase enzymes), and in vivo wound healing potential were determined. The tested extract has been shown to contain considerable flavonoid (46.75 mg RE/g extract) and phenolic (33.71 mg GAE/g extract) contents. The plant extract presented considerable antioxidant potential, being the most active for CUPRAC assays. Secondary metabolite UHPLC-MS characterization, in both the positive and negative ionization modes, indicated the tentative presence of 17 different phytocompounds, mostly derivatives of sesquiterpene, alkaloids, and flavonoids. Similarly, the tested extract exhibited considerable inhibitory effects on tyrosinase (81.72 mg KAE/g extract), whereas it showed weak inhibition ability against other tested enzymes. Moreover, in the case of in vivo wound healing assays, significant improvement in wound healing was observed in both the tested models at the doses of 0.5 percent w/w (p < 0.001) and 2.0 percent w/w (p < 0.01) on the 16th day. The outcomes of the present research work suggested that C. gigantea (L.) Dryand plant extract could be appraised as a potential origin of bioactive molecules having multifunctional medicinal uses.

ACS Style

Ahmed Alafnan; Swathi Sridharagatta; Hammad Saleem; Umair Khurshid; Abdulwahab Alamri; Shabana Yasmeen Ansari; Syafiq Asnawi Zainal Abidin; Siddique Akber Ansari; Abdulhakeem S. Alamri; Nafees Ahemad; Sirajudheen Anwar. Evaluation of the Phytochemical, Antioxidant, Enzyme Inhibition, and Wound Healing Potential of Calotropis gigantea (L.) Dryand: A Source of a Bioactive Medicinal Product. Frontiers in Pharmacology 2021, 12, 1 .

AMA Style

Ahmed Alafnan, Swathi Sridharagatta, Hammad Saleem, Umair Khurshid, Abdulwahab Alamri, Shabana Yasmeen Ansari, Syafiq Asnawi Zainal Abidin, Siddique Akber Ansari, Abdulhakeem S. Alamri, Nafees Ahemad, Sirajudheen Anwar. Evaluation of the Phytochemical, Antioxidant, Enzyme Inhibition, and Wound Healing Potential of Calotropis gigantea (L.) Dryand: A Source of a Bioactive Medicinal Product. Frontiers in Pharmacology. 2021; 12 ():1.

Chicago/Turabian Style

Ahmed Alafnan; Swathi Sridharagatta; Hammad Saleem; Umair Khurshid; Abdulwahab Alamri; Shabana Yasmeen Ansari; Syafiq Asnawi Zainal Abidin; Siddique Akber Ansari; Abdulhakeem S. Alamri; Nafees Ahemad; Sirajudheen Anwar. 2021. "Evaluation of the Phytochemical, Antioxidant, Enzyme Inhibition, and Wound Healing Potential of Calotropis gigantea (L.) Dryand: A Source of a Bioactive Medicinal Product." Frontiers in Pharmacology 12, no. : 1.

Full paper
Published: 13 August 2021 in Chemistry & Biodiversity
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Spermacoce verticillata (L.) G. Mey. is commonly used in the folk medicine by various cultures to manage common diseases. Herein, the chemical and biological profiles of S. verticillata were studied in order to provide a comprehensive characterization of bioactive compounds and also to highlight the therapeutic properties. The in vitro antioxidant activity using free-radical scavenging, phosphomolybdenum, ferrous-ion chelating and reducing power assays, and the inhibitory activity against key enzymes such as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), tyrosinase, α-amylase and α-glucosidase of S. verticillata extracts (dichloromethane, ethyl acetate, methanol and water) were investigated. The highest total phenolic and flavonoid content were observed in the methanolic and aqueous extracts. Exhaustive 2DNMR investigation has revealed the presence of rutin, ursolic and oleanoic acids. The methanolic extract, followed by aqueous extract have showed remarkable free radical quenching and reducing ability, while the dichloromethane extract was the best source of metal chelators. The tested extracts showed notable inhibitory activity against cholinesterases (AChE: 1.63 - 4.99 mg GALAE/g extract and BChE: 12.40 - 15.48 mg GALAE/g extract) and tyrosinase (60.85 - 159.64 mg KAE/g extract). No inhibitory activity was displayed by ethyl acetate and aqueous extracts against BChE and tyrosinase, respectively. All the tested extracts showed modest α-amylase inhibitory activity, while only the ethyl acetate and aqueous extracts were potent against α-glycosidase. This study further validates the use of S. verticillata in the traditional medicine, while advocating for further investigation for phytomedicine development.

ACS Style

Kouadio Ibrahime Sinan; Gökhan Zengin; Antonio Fiorentino; Brigida D’Abrosca; Gunes Ak; Devina Lobine; Ouattara Katinan Etienne; Anwar Hussein Subratty; Fawzi Mahomoodally. Biological insights and NMR metabolic profiling of different extracts of Spermacoce verticillata (L.) G. Mey. Chemistry & Biodiversity 2021, 1 .

AMA Style

Kouadio Ibrahime Sinan, Gökhan Zengin, Antonio Fiorentino, Brigida D’Abrosca, Gunes Ak, Devina Lobine, Ouattara Katinan Etienne, Anwar Hussein Subratty, Fawzi Mahomoodally. Biological insights and NMR metabolic profiling of different extracts of Spermacoce verticillata (L.) G. Mey. Chemistry & Biodiversity. 2021; ():1.

Chicago/Turabian Style

Kouadio Ibrahime Sinan; Gökhan Zengin; Antonio Fiorentino; Brigida D’Abrosca; Gunes Ak; Devina Lobine; Ouattara Katinan Etienne; Anwar Hussein Subratty; Fawzi Mahomoodally. 2021. "Biological insights and NMR metabolic profiling of different extracts of Spermacoce verticillata (L.) G. Mey." Chemistry & Biodiversity , no. : 1.

Book chapter
Published: 10 August 2021 in Handbook of Dietary Phytochemicals
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Ellagitannins (ETs) are widely distributed secondary metabolites classified as hydrolyzable tannins found mainly in berries such as raspberries, blueberries (BBs), black raspberries (BRBs), strawberries, and pomegranates. A plethora of reports tend to show that ETs can impact positively on human health by promoting therapeutic activities such as being an antioxidant, antimicrobial, anti-inflammatory, and anticancer. Studies showed that ETs found in the seeds of black raspberries (BRBs) increase the functional activity of juices or wines which used BRBs as ingredients. It has been reported that berries have the potential to reduce the systolic and diastolic blood pressure and increase superoxide dismutase activity after the consumption of BBs. Numerous studies showed that ETs isolated from pomegranates possess good antimicrobial activities against a panel of microbes including human pathogens such as Escherichia coli, Salmonella enteritidis, Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Yersinia enterocolitica, Listeria monocytogenes, and Candida albicans. Interestingly, it was shown that these therapeutic values are attributed to the presence of ETs. Furthermore, ETs are also distributed in various nuts, namely, pecans, cashews, walnuts, pistachios, or hazelnuts. It is known clinically that frequent nut intake is associated with protective effects against cardiovascular diseases. Although it is mentioned that ETs can also be found in vegetables, however as far as our literature search could establish, there are no scientific validation of ETs in vegetables. Thus, it is proposed that more scientific investigations be geared to shed light on the potential of ETs found in vegetables. Overall, foods containing ETs are recommended to be consumed on a regular basis since a panoply of scientific investigations showed that they are associated with promising health benefits.

ACS Style

Nabeelah Bibi Sadeer; Mohamad Fawzi Mahomoodally; Kannan R. R. Rengasamy. Dietary Ellagitannins. Handbook of Dietary Phytochemicals 2021, 1145 -1171.

AMA Style

Nabeelah Bibi Sadeer, Mohamad Fawzi Mahomoodally, Kannan R. R. Rengasamy. Dietary Ellagitannins. Handbook of Dietary Phytochemicals. 2021; ():1145-1171.

Chicago/Turabian Style

Nabeelah Bibi Sadeer; Mohamad Fawzi Mahomoodally; Kannan R. R. Rengasamy. 2021. "Dietary Ellagitannins." Handbook of Dietary Phytochemicals , no. : 1145-1171.

Journal article
Published: 07 August 2021 in South African Journal of Botany
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Strobilanthes glutinosus (family: Acanthaceae) is one of the important medicinal plants and the current research work was carried out to assess the phytochemical, biological, and in-silico evaluations of different solvent extracts of S. glutinosus. The phytochemical composition was assessed by determining qualitative phytochemical testing, total bioactive contents, and GC-MS analysis. For biological evaluation, antioxidant (DPPH and FRAP), antibacterial, and enzyme inhibition (urease) potential were determined. The methanol extract was found to contain the highest total phenolic (247.85 mg GAE/g extract), and flavonoid content (71.91 mg QAE/g extract), which can be correlated to the observed higher antioxidant potential of this extract. On the contrary, the n-hexane extract presented maximum anti-urease activity with IC50 value of 0.244 mg/ml, whereas, in the case of antibacterial assays, a dose-dependent activity was observed. Similarly, the GC-MS investigation of methanol extract and n-hexane fraction revealed the tentative identification of several important classes of secondary metabolites. Furthermore, the main compounds as identified by GC-MS were further studied for in-silico molecular docking studies in order to highlight any interactions between the compounds identified and the urease enzyme. Overall, the present investigation highlighted the studied plant extracts to be considered further for the isolation of bioactive compounds for the pharmaceutical and food industry.

ACS Style

Marya Aziz; Saeed Ahmad; Muhammad Nouman Iqbal; Umair Khurshid; Hammad Saleem; Kashif- Ur- Rehman; Abdulwahab Alamri; Sirajudheen Anwar; Abdulhakeem S. Alamri; Tahir Ali Chohan. Phytochemical, pharmacological, and In-silico molecular docking studies of Strobilanthes glutinosus Nees: An unexplored source of bioactive compounds. South African Journal of Botany 2021, 1 .

AMA Style

Marya Aziz, Saeed Ahmad, Muhammad Nouman Iqbal, Umair Khurshid, Hammad Saleem, Kashif- Ur- Rehman, Abdulwahab Alamri, Sirajudheen Anwar, Abdulhakeem S. Alamri, Tahir Ali Chohan. Phytochemical, pharmacological, and In-silico molecular docking studies of Strobilanthes glutinosus Nees: An unexplored source of bioactive compounds. South African Journal of Botany. 2021; ():1.

Chicago/Turabian Style

Marya Aziz; Saeed Ahmad; Muhammad Nouman Iqbal; Umair Khurshid; Hammad Saleem; Kashif- Ur- Rehman; Abdulwahab Alamri; Sirajudheen Anwar; Abdulhakeem S. Alamri; Tahir Ali Chohan. 2021. "Phytochemical, pharmacological, and In-silico molecular docking studies of Strobilanthes glutinosus Nees: An unexplored source of bioactive compounds." South African Journal of Botany , no. : 1.

Journal article
Published: 06 August 2021 in Food Chemistry
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In this study, the aerial parts and bulbs of nine Allium species were investigated for their functional phytochemical profile, in vitro antioxidant activities, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-amylase, α-glucosidase, and tyrosinase inhibitory properties. Phenolics, alkaloids, glucosinolates and other sulfur-containing compounds were distinctively profiled in the different species. Maceration in methanol allowed recovering the highest cumulative phenolic content in A. scabrifolium (42.31 mg/g), followed by A. goekyigiti (33.15 mg/g) and A. atroviolaceum (28.35 mg/g). The aerial parts of all Allium species showed high in vitro antioxidant activity whereas methanolic extract of A. cappadocicum bulb showed the highest inhibition against AChE (2.44 mg galantamine equivalent/g) and the water extracts of A. isauricum aerial part were the best BChE inhibitors (4.31 mg galantamine equivalent/g). Bulbs were the richer source of oligosaccharides, and in vitro digestion determined an increase of oligosaccharides bioaccessibility. A promising nutraceutical potential could be highlighted in our understudied Allium species.

ACS Style

Gabriele Rocchetti; Leilei Zhang; Serena Bocchi; Gianluca Giuberti; Gunes Ak; Fevzi Elbasan; Evren Yıldıztugay; Ramazan Ceylan; Marie Carene Nancy Picot-Allain; Mohamad Fawzi Mahomoodally; Luigi Lucini; Gokhan Zengin. The functional potential of nine Allium species related to their untargeted phytochemical characterization, antioxidant capacity and enzyme inhibitory ability. Food Chemistry 2021, 368, 130782 .

AMA Style

Gabriele Rocchetti, Leilei Zhang, Serena Bocchi, Gianluca Giuberti, Gunes Ak, Fevzi Elbasan, Evren Yıldıztugay, Ramazan Ceylan, Marie Carene Nancy Picot-Allain, Mohamad Fawzi Mahomoodally, Luigi Lucini, Gokhan Zengin. The functional potential of nine Allium species related to their untargeted phytochemical characterization, antioxidant capacity and enzyme inhibitory ability. Food Chemistry. 2021; 368 ():130782.

Chicago/Turabian Style

Gabriele Rocchetti; Leilei Zhang; Serena Bocchi; Gianluca Giuberti; Gunes Ak; Fevzi Elbasan; Evren Yıldıztugay; Ramazan Ceylan; Marie Carene Nancy Picot-Allain; Mohamad Fawzi Mahomoodally; Luigi Lucini; Gokhan Zengin. 2021. "The functional potential of nine Allium species related to their untargeted phytochemical characterization, antioxidant capacity and enzyme inhibitory ability." Food Chemistry 368, no. : 130782.

Journal article
Published: 30 July 2021 in Food and Chemical Toxicology
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The genus Acacia (Family Leguminosae) is composed of several medicinal plants used for treating miscellaneous diseases. Amid the important members of this genus, A. nilotica and A. ataxacantha are widely employed for their tremendous healing properties. Hence, this present work aimed to determine the total phenolic and flavonoid contents and investigate the antioxidant, antiproliferative, anti-enzyme and antimicrobial potentials of methanolic and water extracts of leaves and stem bark of A. nilotica and A. ataxacantha obtained by maceration and ultrasonication. The total phenolic and flavonoid contents were obtained in the range of 33.35–116.60 mg GAE/g and 0.26–49.90 mg RE/g, respectively, with the methanolic leaf extracts of both species showing the highest contents. Moreover, the methanolic extracts were observed to display higher antioxidant potentials in almost all antioxidant assays performed compared to the water extracts (ABTS: 52.66–943.81 mg TE/g, DPPH: 8.51–493.90 mg TE/g, CUPRAC: 106.39–1193.75 mg TE/g; FRAP: 31.38–416.21 mg TE/g, and phosphomolybdenum: 0.90–4.17 mM TE/g). However, the water extracts were seen to be better metal chelators than the methanolic extracts (8.47–36.85 mg EDTAE/g). Additionally, all extracts were found to exhibit anti-tyrosinase (30.79–74.80 mg KAE/g) and anti-amylase (0.10–1.10 mM ACAE/g) properties. With the exception of a few extracts, glucosidase and acetylcholinesterase inhibitions (1.69–2.12 mg ACAE/g and 0.42–2.61 mg GALAE/g, respectively) were also demonstrated. While the methanolic extracts of both species showed antimicrobial potency against all the 18 tested microorganisms (gram positive, gram negative, and fungi), the water extracts were effective only against the gram positive bacteria. The extracts were also found to exhibit antiproliferative effects on SH-SY5Y human neuroblastoma cells, with the methanolic extracts showing higher cytotoxic potential than the water extracts. Therefore, this study showed these species to be good sources of antioxidants, enzyme inhibitors, antimicrobials and antiproliferative agents, which could be of great interest for their applications as natural bioactive ingredients in the development of pharmaceuticals and nutraceuticals.

ACS Style

Dimitrina Zheleva-Dimitrova; Kouadio Ibrahime Sinan; Ouattara Katinan Etienne; Gunes Ak; Jugreet B. Sharmeen; Gokhan Dervisoglu; Fethi Ahmet Ozdemir; Mohamad Fawzi Mahomoodally; Gokhan Zengin. Comprehensive chemical characterization and biological evaluation of two Acacia species: A. nilotica and A. ataxacantha. Food and Chemical Toxicology 2021, 156, 112446 .

AMA Style

Dimitrina Zheleva-Dimitrova, Kouadio Ibrahime Sinan, Ouattara Katinan Etienne, Gunes Ak, Jugreet B. Sharmeen, Gokhan Dervisoglu, Fethi Ahmet Ozdemir, Mohamad Fawzi Mahomoodally, Gokhan Zengin. Comprehensive chemical characterization and biological evaluation of two Acacia species: A. nilotica and A. ataxacantha. Food and Chemical Toxicology. 2021; 156 ():112446.

Chicago/Turabian Style

Dimitrina Zheleva-Dimitrova; Kouadio Ibrahime Sinan; Ouattara Katinan Etienne; Gunes Ak; Jugreet B. Sharmeen; Gokhan Dervisoglu; Fethi Ahmet Ozdemir; Mohamad Fawzi Mahomoodally; Gokhan Zengin. 2021. "Comprehensive chemical characterization and biological evaluation of two Acacia species: A. nilotica and A. ataxacantha." Food and Chemical Toxicology 156, no. : 112446.

Journal article
Published: 24 July 2021 in Antioxidants
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In the current study, Achillea santolinoides and Achillea aleppica aeral parts and root were extracted with ethyl acetate, methanol, and water. Detailed phytochemical profiles were obtained using UHPLC-MS, yielding the identification of hydroxybenzoic and hydroxycinnamic acids, phenolic acid glycosides and sugar esters, acylquinic acids, O-glycosyl flavones and flavonols, and flavonoid aglycons, among others. The antioxidant properties and enzyme inhibitory activities of the extracts were assayed with in vitro tests. The phenolic content of the water extracts was significantly higher as compared to the ethyl acetate and methanol ones. A. aleppica aerial parts methanol extract possessed highest flavonoid content (49.18 mg rutin equivalent/g). Antioxidant properties assessment revealed that the methanol extract of A. santolinoides roots actively scavenged DPPH (54.11 mg TE/g) and ABTS radicals (112.53 mg TE/g) and possessed highest reducing potential (183.55 and 129.92 mg TE/g, for CUPRAC and FRAP, respectively). The ethyl acetate extracts of aerial parts and roots of both species showed highest inhibition against BuCHE (6.07–6.76 mg GALAE/g). The ethyl acetate extract of A.santolinoides aerial part showed highest inhibition against tyrosinase (73.00 mg KAE/g). These results showed that the tested Achillea species might represent novel phytotherapeutic avenues for the management of Alzheimer’s disease and epidermal hyperpigmentation conditions, which are both associated with oxidative stress. This paper could shed light into future potential industrial applications using the tested Achillea species.

ACS Style

Reneta Gevrenova; Gokhan Zengin; Kouadio Ibrahime Sinan; Evren Yıldıztugay; Dimitrina Zheleva-Dimitrova; Carene Picot-Allain; Mohamad Fawzi Mahomoodally; Muhammad Imran; Stefano Dall’Acqua. UHPLC-MS Characterization and Biological Insights of Different Solvent Extracts of Two Achillea Species (A. aleppica and A. santolinoides) from Turkey. Antioxidants 2021, 10, 1180 .

AMA Style

Reneta Gevrenova, Gokhan Zengin, Kouadio Ibrahime Sinan, Evren Yıldıztugay, Dimitrina Zheleva-Dimitrova, Carene Picot-Allain, Mohamad Fawzi Mahomoodally, Muhammad Imran, Stefano Dall’Acqua. UHPLC-MS Characterization and Biological Insights of Different Solvent Extracts of Two Achillea Species (A. aleppica and A. santolinoides) from Turkey. Antioxidants. 2021; 10 (8):1180.

Chicago/Turabian Style

Reneta Gevrenova; Gokhan Zengin; Kouadio Ibrahime Sinan; Evren Yıldıztugay; Dimitrina Zheleva-Dimitrova; Carene Picot-Allain; Mohamad Fawzi Mahomoodally; Muhammad Imran; Stefano Dall’Acqua. 2021. "UHPLC-MS Characterization and Biological Insights of Different Solvent Extracts of Two Achillea Species (A. aleppica and A. santolinoides) from Turkey." Antioxidants 10, no. 8: 1180.

Journal article
Published: 19 July 2021 in Food and Chemical Toxicology
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Herbals in the form of medicine are employed extensively around the world. Herbal and conventional medicine combination is a potentially dangerous practice mainly in comorbid, hepato insufficient and frail patients leading to perilous herb-drug interactions (HDI) and toxicity. This study features potential HDI of 15 globally famous plant species through data mining and computational methods. Several plant species were found to mimic warfarin. Phytochemicals from M. charantia induced hypoglycemica. M. chamomila and G. biloba possessed anticoagulant activities. S. hispanica reduces postprandial glycemia. R. officinalis has been reported to inhibit the efflux of anticancer substrates while A. sativum can boost the clearance of anticancer agents. P. ginseng can alter blood coagulation. A cross link of the biological and in silico data revealed that a plethora of herbal metabolites such as ursolic and rosmarinic acid among others are possible/probable inhibitors of specific CYP450 enzymes. Consequently, plant species/metabolites with a given pharmacological property/metabolizing enzyme should not be mixed with drugs having the same pharmacological property/metabolizing enzyme. Even if combined with drugs, herbal medicines must be used at low doses for a short period of time and under the supervision of a healthcare professional to avoid potential adverse and toxic effects.

ACS Style

Shanoo Suroowan; Hassan Hadi Abdallah; Mohamad Fawzi Mahomoodally. Herb-drug interactions and toxicity: Underscoring potential mechanisms and forecasting clinically relevant interactions induced by common phytoconstituents via data mining and computational approaches. Food and Chemical Toxicology 2021, 112432 .

AMA Style

Shanoo Suroowan, Hassan Hadi Abdallah, Mohamad Fawzi Mahomoodally. Herb-drug interactions and toxicity: Underscoring potential mechanisms and forecasting clinically relevant interactions induced by common phytoconstituents via data mining and computational approaches. Food and Chemical Toxicology. 2021; ():112432.

Chicago/Turabian Style

Shanoo Suroowan; Hassan Hadi Abdallah; Mohamad Fawzi Mahomoodally. 2021. "Herb-drug interactions and toxicity: Underscoring potential mechanisms and forecasting clinically relevant interactions induced by common phytoconstituents via data mining and computational approaches." Food and Chemical Toxicology , no. : 112432.

Journal article
Published: 16 July 2021 in International Journal of Molecular Sciences
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This study focused on the biological evaluation and chemical characterization of Geranium pyrenaicum Burm. f. Different solvent extracts (hexane, ethyl acetate, methanol, and water extracts) were prepared. The phytochemical profile, antioxidant, and enzyme inhibitory activity were investigated. Cytotoxicity was assessed using VERO, FaDu, HeLa and RKO cells. The antiviral activity was carried out against HSV-1 (Herpes simplex virus 1) propagated in VERO cell line. The aqueous extract, possessing high phenolic content (170.50 mg gallic acid equivalent/g extract), showed the highest reducing capacity (613.27 and 364.10 mg Trolox equivalent/g extract, for cupric reducing antioxidant capacity and ferric reducing antioxidant power, respectively), radical scavenging potential (469.82 mg Trolox equivalent/g extract, against 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)), metal chelating ability (52.39 mg ethylenediaminetetraacetic acid equivalent/g extract) and total antioxidant capacity (3.15 mmol Trolox equivalent/g extract). Liquid chromatography-electrospray ionization-quadrupole time-of-flight-mass spectrometry (LC-ESI-QTOF-MS/MS) alloved to tentatively identify a total of 56 compounds in the extracts, including ellagitannins, gallic acid and galloyl derivatives amongst others. The ethyl acetate extracts substantially depressed cholinesterase enzymes (4.49 and 12.26 mg galantamine equivalent/g extract against AChE and BChE, respectively) and α-amylase enzyme (1.04 mmol acarbose equivalent/g extract). On the other hand, the methanolic extract inhibited tyrosinase (121.42 mg kojic acid equivalent/g extract) and α-glucosidase (2.39 mmol acarbose equivalent/g extract) activities. The highest selectivity towards all cancer cell lines (SI 4.5–10.8) was observed with aqueous extract with the FaDu cells being the most sensitive (CC50 40.22 µg/mL). It can be concluded that the presence of certain bioactive antiviral molecules may be related to the high anti HSV-1 activity of the methanolic extract. This work has generated vital scientific data on this medicinal plant, which is a prospective candidate for the creation of innovative phyto-pharmaceuticals.

ACS Style

Łukasz Świątek; Elwira Sieniawska; Kouadio Sinan; Magdalena Maciejewska-Turska; Anastazja Boguszewska; Małgorzata Polz-Dacewicz; Ismail Senkardes; Gokalp Guler; Nabeelah Bibi Sadeer; Mohamad Mahomoodally; Gokhan Zengin. LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure. International Journal of Molecular Sciences 2021, 22, 7621 .

AMA Style

Łukasz Świątek, Elwira Sieniawska, Kouadio Sinan, Magdalena Maciejewska-Turska, Anastazja Boguszewska, Małgorzata Polz-Dacewicz, Ismail Senkardes, Gokalp Guler, Nabeelah Bibi Sadeer, Mohamad Mahomoodally, Gokhan Zengin. LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure. International Journal of Molecular Sciences. 2021; 22 (14):7621.

Chicago/Turabian Style

Łukasz Świątek; Elwira Sieniawska; Kouadio Sinan; Magdalena Maciejewska-Turska; Anastazja Boguszewska; Małgorzata Polz-Dacewicz; Ismail Senkardes; Gokalp Guler; Nabeelah Bibi Sadeer; Mohamad Mahomoodally; Gokhan Zengin. 2021. "LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure." International Journal of Molecular Sciences 22, no. 14: 7621.

Journal article
Published: 08 July 2021 in Food and Chemical Toxicology
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Capparis spinose L. also known as Caper is of great significance as a traditional medicinal food plant. The present work was targeted on the determination of chemical composition, pharmacological properties, and in-vitro toxicity of methanol and dichloromethane (DCM) extracts of different parts of C. spinosa. Chemical composition was established by determining total bioactive contents and via UHPLC-MS secondary metabolites profiling. For determination of biological activities, antioxidant capacity was determined through DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating assays while enzyme inhibition against cholinesterase, tyrosinase, α-amylase and α-glucosidase were also tested. All the extracts were also tested for toxicity against two breast cell lines. The methanolic extracts were found to contain highest total phenolic and flavonoids which is correlated with their significant radical scavenging, cholinesterase, tyrosinase and glucosidase inhibition potential. Whereas DCM extracts showed significant activity for reducing power, phosphomolybdenum, metal chelation, tyrosinase, and α-amylase inhibition activities. The secondary metabolites profiling of both methanolic extracts exposed the presence of 21 different secondary metabolites belonging to glucosinolate, alkaloid, flavonoid, phenol, triterpene, and alkaloid derivatives. The present results tend to validate folklore uses of C. spinose and indicate this plant to be used as a potent source of designing novel bioactive compounds.

ACS Style

Hammad Saleem; Umair Khurshid; Muhammad Sarfraz; Irshad Ahmad; Abdulwahab Alamri; Sirajudheen Anwar; Abdulhakeem S. Alamri; Marcello Locatelli; Angela Tartaglia; Mohamad Fawzi Mahomoodally; Syafiq Asnawi Zainal Abidin; Nafees Ahemad. Investigation into the biological properties, secondary metabolites composition, and toxicity of aerial and root parts of Capparis spinosa L.: An important medicinal food plant. Food and Chemical Toxicology 2021, 155, 112404 .

AMA Style

Hammad Saleem, Umair Khurshid, Muhammad Sarfraz, Irshad Ahmad, Abdulwahab Alamri, Sirajudheen Anwar, Abdulhakeem S. Alamri, Marcello Locatelli, Angela Tartaglia, Mohamad Fawzi Mahomoodally, Syafiq Asnawi Zainal Abidin, Nafees Ahemad. Investigation into the biological properties, secondary metabolites composition, and toxicity of aerial and root parts of Capparis spinosa L.: An important medicinal food plant. Food and Chemical Toxicology. 2021; 155 ():112404.

Chicago/Turabian Style

Hammad Saleem; Umair Khurshid; Muhammad Sarfraz; Irshad Ahmad; Abdulwahab Alamri; Sirajudheen Anwar; Abdulhakeem S. Alamri; Marcello Locatelli; Angela Tartaglia; Mohamad Fawzi Mahomoodally; Syafiq Asnawi Zainal Abidin; Nafees Ahemad. 2021. "Investigation into the biological properties, secondary metabolites composition, and toxicity of aerial and root parts of Capparis spinosa L.: An important medicinal food plant." Food and Chemical Toxicology 155, no. : 112404.

Journal article
Published: 16 June 2021 in Food and Chemical Toxicology
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Suaeda fruticosa is an edible medicinal halophyte known for its traditional uses. In this study, methanol and dichloromethane extracts of S. fruticosa were explored for phytochemical, biological and toxicological parameters. Total phenolic and flavonoid constituents were determined by using standard aluminum chloride and Folin-Ciocalteu methods, and UHPLC-MS analysis of methanol extract was performed for tentative identification of secondary metabolites. Different standard methods like DPPH, ABTS, FRAP, CUPRAC, total antioxidant capacity (TAC), and metal chelation assays were utilized to find out the antioxidant potential of extracts. Enzyme inhibition studies of extracts against acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-amylase and, α-glucosidase enzymes were also studied. Likewise, the cytotoxicity was also assessed against MCF-7, MDA-MB-231, and DU-145 cell lines. The higher phenolic and flavonoids contents were observed in methanol extracts which can be correlated to its higher radical scavenging potential. Similarly, 11 different secondary metabolites were tentatively identified by UHPLC profiling. Both the extract showed significant inhibition against all the enzymes except for α-glucosidase. Moreover, docking studies were also performed against the tested enzymes. In the case of cytotoxicity, both the samples were found moderately toxic against the tested cell lines. This plant can be explored further for its potential therapeutic and edible uses.

ACS Style

Hammad Saleem; Umair Khurshid; Muhammad Sarfraz; Muhammad Imran Tousif; Abdulwahab Alamri; Sirajudheen Anwar; Abdulhakeem Alamri; Irshad Ahmad; Hassan H. Abdallah; Fawzi M. Mahomoodally; Nafees Ahemad. A comprehensive phytochemical, biological, toxicological and molecular docking evaluation of Suaeda fruticosa (L.) Forssk.: An edible halophyte medicinal plant. Food and Chemical Toxicology 2021, 154, 112348 .

AMA Style

Hammad Saleem, Umair Khurshid, Muhammad Sarfraz, Muhammad Imran Tousif, Abdulwahab Alamri, Sirajudheen Anwar, Abdulhakeem Alamri, Irshad Ahmad, Hassan H. Abdallah, Fawzi M. Mahomoodally, Nafees Ahemad. A comprehensive phytochemical, biological, toxicological and molecular docking evaluation of Suaeda fruticosa (L.) Forssk.: An edible halophyte medicinal plant. Food and Chemical Toxicology. 2021; 154 ():112348.

Chicago/Turabian Style

Hammad Saleem; Umair Khurshid; Muhammad Sarfraz; Muhammad Imran Tousif; Abdulwahab Alamri; Sirajudheen Anwar; Abdulhakeem Alamri; Irshad Ahmad; Hassan H. Abdallah; Fawzi M. Mahomoodally; Nafees Ahemad. 2021. "A comprehensive phytochemical, biological, toxicological and molecular docking evaluation of Suaeda fruticosa (L.) Forssk.: An edible halophyte medicinal plant." Food and Chemical Toxicology 154, no. : 112348.

Review
Published: 12 June 2021 in Neurochemical Research
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Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria. Natural compounds/herbs with scientifically proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that flavonoids, alkaloids and terpenoids may have anticonvulsant mechanisms similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant effect, pharmacological models, seizure-inducing factors and response, effective dose were also analyzed and discussed. The results of in vitro and in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural anticonvulsant drugs.

ACS Style

Javad Sharifi-Rad; Cristina Quispe; Jesús Herrera-Bravo; Miquel Martorell; Farukh Sharopov; Tugba Boyunegmez Tumer; Begum Kurt; Chintha Lankatillake; Anca Oana Docea; Ana Catarina Moreira; Daniel A. Dias; Mohamad Fawzi Mahomoodally; Devina Lobine; Natália Cruz-Martins; Manoj Kumar; Daniela Calina. A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy. Neurochemical Research 2021, 1 -21.

AMA Style

Javad Sharifi-Rad, Cristina Quispe, Jesús Herrera-Bravo, Miquel Martorell, Farukh Sharopov, Tugba Boyunegmez Tumer, Begum Kurt, Chintha Lankatillake, Anca Oana Docea, Ana Catarina Moreira, Daniel A. Dias, Mohamad Fawzi Mahomoodally, Devina Lobine, Natália Cruz-Martins, Manoj Kumar, Daniela Calina. A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy. Neurochemical Research. 2021; ():1-21.

Chicago/Turabian Style

Javad Sharifi-Rad; Cristina Quispe; Jesús Herrera-Bravo; Miquel Martorell; Farukh Sharopov; Tugba Boyunegmez Tumer; Begum Kurt; Chintha Lankatillake; Anca Oana Docea; Ana Catarina Moreira; Daniel A. Dias; Mohamad Fawzi Mahomoodally; Devina Lobine; Natália Cruz-Martins; Manoj Kumar; Daniela Calina. 2021. "A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy." Neurochemical Research , no. : 1-21.

Journal article
Published: 11 June 2021 in South African Journal of Botany
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The plants of the Erythrina genus possess tremendous pharmacological properties and thus are utilized in traditional medicines owing to their bioactivities. In the present study, methanolic extract (EsM) of flowers of Erythrina suberosa Roxb. and its fractions (n-hexane (EsH), chloroform (EsC) and aqueous (EsW) parts) were tested for preliminary phytochemical analysis, antioxidant and urease inhibition activities. The EsM extract was found to be most active for antioxidant activity, whereas the EsH extract showed the highest anti-urease potential with an inhibition value of 62.9 % (at a concentration of 100 µg/ml), while the other extracts were least active. The EsH extract being most active against urease enzyme, was further subjected to gas chromatography-mass spectrometry (GC-MS) analysis, which revealed the tentative presence of 18 secondary metabolites of various classes. Furthermore, the in-silico studies of the major compounds as detected in EsH extract by GC-MS analysis were performed to correlate the potential interaction of compounds with the active site of the enzyme. The selected compounds were docked against the urease enzyme, and their affinities were compared. Binding affinity data and interaction patterns of all the studied phytochemicals indicated that these compounds could inhibit urease enzyme synergistically and can be further studied to prevent ulcer and related problems. It is, therefore concluded that E. suberosa flowers possess interesting antioxidant and anti-urease potential and thus could further be adopted for industrial and biopharmaceutical applications.

ACS Style

Shehla Parveen; Hammad Saleem; Muhammad Sarfraz; Umair Khurshid; Maroof Habib; Mamona Nazir; Naseem Akhtar; Faiz-Ul-Hassan Nasim; Umer Rashid; Ghayoor Abbas Chotana. Phytochemical profiling, In vitro antioxidant and identification of urease inhibitory metabolites from Erythrina suberosa flowers by GC-MS analysis and docking studies. South African Journal of Botany 2021, 1 .

AMA Style

Shehla Parveen, Hammad Saleem, Muhammad Sarfraz, Umair Khurshid, Maroof Habib, Mamona Nazir, Naseem Akhtar, Faiz-Ul-Hassan Nasim, Umer Rashid, Ghayoor Abbas Chotana. Phytochemical profiling, In vitro antioxidant and identification of urease inhibitory metabolites from Erythrina suberosa flowers by GC-MS analysis and docking studies. South African Journal of Botany. 2021; ():1.

Chicago/Turabian Style

Shehla Parveen; Hammad Saleem; Muhammad Sarfraz; Umair Khurshid; Maroof Habib; Mamona Nazir; Naseem Akhtar; Faiz-Ul-Hassan Nasim; Umer Rashid; Ghayoor Abbas Chotana. 2021. "Phytochemical profiling, In vitro antioxidant and identification of urease inhibitory metabolites from Erythrina suberosa flowers by GC-MS analysis and docking studies." South African Journal of Botany , no. : 1.

Journal article
Published: 10 June 2021 in Molecules
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The cyclooxygenase-2 (COX-2) enzyme is an important target for drug discovery and development of novel anti-inflammatory agents. Selective COX-2 inhibitors have the advantage of reduced side-effects, which result from COX-1 inhibition that is usually observed with nonselective COX inhibitors. In this study, the design and synthesis of a new series of 7-methoxy indolizines as bioisostere indomethacin analogues (5a–e) were carried out and evaluated for COX-2 enzyme inhibition. All the compounds showed activity in micromolar ranges, and the compound diethyl 3-(4-cyanobenzoyl)-7-methoxyindolizine-1,2-dicarboxylate (5a) emerged as a promising COX-2 inhibitor with an IC50 of 5.84 µM, as compared to indomethacin (IC50 = 6.84 µM). The molecular modeling study of indolizines indicated that hydrophobic interactions were the major contribution to COX-2 inhibition. The title compound diethyl 3-(4-bromobenzoyl)-7-methoxyindolizine-1,2-dicarboxylate (5c) was subjected for single-crystal X-ray studies, Hirshfeld surface analysis, and energy framework calculations. The X-ray diffraction analysis showed that the molecule (5c) crystallizes in the monoclinic crystal system with space group P 21/n with a = 12.0497(6)Å, b = 17.8324(10)Å, c = 19.6052(11)Å, α = 90.000°, β = 100.372(1)°, γ = 90.000°, and V = 4143.8(4)Å3. In addition, with the help of Crystal Explorer software program using the B3LYP/6-31G(d, p) basis set, the theoretical calculation of the interaction and graphical representation of energy value was measured in the form of the energy framework in terms of coulombic, dispersion, and total energy.

ACS Style

Katharigatta Venugopala; Sandeep Chandrashekharappa; Christophe Tratrat; Pran Deb; Rahul Nagdeve; Susanta Nayak; Mohamed Morsy; Pobitra Borah; Fawzi Mahomoodally; Raghu Mailavaram; Mahesh Attimarad; Bandar Aldhubiab; Nagaraja Sreeharsha; Anroop Nair; Osama Alwassil; Michelyne Haroun; Viresh Mohanlall; Pottathil Shinu; Rashmi Venugopala; Mahmoud Kandeel; Belakatte Nandeshwarappa; Yasmine Ibrahim. Crystallography, Molecular Modeling, and COX-2 Inhibition Studies on Indolizine Derivatives. Molecules 2021, 26, 3550 .

AMA Style

Katharigatta Venugopala, Sandeep Chandrashekharappa, Christophe Tratrat, Pran Deb, Rahul Nagdeve, Susanta Nayak, Mohamed Morsy, Pobitra Borah, Fawzi Mahomoodally, Raghu Mailavaram, Mahesh Attimarad, Bandar Aldhubiab, Nagaraja Sreeharsha, Anroop Nair, Osama Alwassil, Michelyne Haroun, Viresh Mohanlall, Pottathil Shinu, Rashmi Venugopala, Mahmoud Kandeel, Belakatte Nandeshwarappa, Yasmine Ibrahim. Crystallography, Molecular Modeling, and COX-2 Inhibition Studies on Indolizine Derivatives. Molecules. 2021; 26 (12):3550.

Chicago/Turabian Style

Katharigatta Venugopala; Sandeep Chandrashekharappa; Christophe Tratrat; Pran Deb; Rahul Nagdeve; Susanta Nayak; Mohamed Morsy; Pobitra Borah; Fawzi Mahomoodally; Raghu Mailavaram; Mahesh Attimarad; Bandar Aldhubiab; Nagaraja Sreeharsha; Anroop Nair; Osama Alwassil; Michelyne Haroun; Viresh Mohanlall; Pottathil Shinu; Rashmi Venugopala; Mahmoud Kandeel; Belakatte Nandeshwarappa; Yasmine Ibrahim. 2021. "Crystallography, Molecular Modeling, and COX-2 Inhibition Studies on Indolizine Derivatives." Molecules 26, no. 12: 3550.

Journal article
Published: 09 June 2021 in Plants
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Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further.

ACS Style

Gokhan Zengin; Mohamad Mahomoodally; Abdurrahman Aktumsek; József Jekő; Zoltán Cziáky; Maria Rodrigues; Luisa Custodio; Rıdvan Polat; Ugur Cakilcioglu; Adnan Ayna; Monica Gallo; Domenico Montesano; Carene Picot-Allain. Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey. Plants 2021, 10, 1176 .

AMA Style

Gokhan Zengin, Mohamad Mahomoodally, Abdurrahman Aktumsek, József Jekő, Zoltán Cziáky, Maria Rodrigues, Luisa Custodio, Rıdvan Polat, Ugur Cakilcioglu, Adnan Ayna, Monica Gallo, Domenico Montesano, Carene Picot-Allain. Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey. Plants. 2021; 10 (6):1176.

Chicago/Turabian Style

Gokhan Zengin; Mohamad Mahomoodally; Abdurrahman Aktumsek; József Jekő; Zoltán Cziáky; Maria Rodrigues; Luisa Custodio; Rıdvan Polat; Ugur Cakilcioglu; Adnan Ayna; Monica Gallo; Domenico Montesano; Carene Picot-Allain. 2021. "Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey." Plants 10, no. 6: 1176.

Journal article
Published: 07 June 2021 in Molecules
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Lupin seeds can represent a valuable source of phenolics and other antioxidant compounds. In this work, a comprehensive analysis of the phytochemical profile was performed on seeds from three Lupinus species, including one cultivar (Lupinus albus) and two wild accessions (Lupinus cossentinii and Lupinus luteus), collected from the northern region of Tunisia. Untargeted metabolomic profiling allowed to identify 249 compounds, with a great abundance of phenolics and alkaloids. In this regard, the species L. cossentinii showed the highest phenolic content, being 6.54 mg/g DW, followed by L. luteus (1.60 mg/g DW) and L. albus (1.14 mg/g DW). The in vitro antioxidant capacity measured by the ABTS assay on seed extracts ranged from 4.67 to 17.58 mg trolox equivalents (TE)/g, recording the highest values for L. albus and the lowest for L. luteus. The DPPH radical scavenging activity ranged from 0.39 to 3.50 mg TE/g. FRAP values varied between 4.11 and 5.75 mg TE/g. CUPRAC values for lupin seeds ranged from 7.20 to 8.95 mg TE/g, recording the highest for L. cossentinii. The results of phosphomolybdenum assay and metal chelation showed similarity between the three species of Lupinus. The acetylcholinesterase (AChE) inhibition activity was detected in each methanolic extract analyzed with similar results. Regarding the butyrylcholinesterase (BChE) enzyme, it was weakly inhibited by the Lupinus extracts; in particular, the highest activity values were recorded for L. albus (1.74 mg GALAE/g). Overall, our results showed that L. cossentinii was the most abundant source of polyphenols, consisting mainly in tyrosol equivalents (5.82 mg/g DW). Finally, significant correlations were outlined between the phenolic compounds and the in vitro biological activity measured, particularly when considering flavones, phenolic acids and lower-molecular-weight phenolics.

ACS Style

Amna Ben Hassine; Gabriele Rocchetti; Leilei Zhang; Biancamaria Senizza; Gökhan Zengin; Mohamad Mahomoodally; Mossadok Ben-Attia; Youssef Rouphael; Luigi Lucini; Safia El-Bok. Untargeted Phytochemical Profile, Antioxidant Capacity and Enzyme Inhibitory Activity of Cultivated and Wild Lupin Seeds from Tunisia. Molecules 2021, 26, 3452 .

AMA Style

Amna Ben Hassine, Gabriele Rocchetti, Leilei Zhang, Biancamaria Senizza, Gökhan Zengin, Mohamad Mahomoodally, Mossadok Ben-Attia, Youssef Rouphael, Luigi Lucini, Safia El-Bok. Untargeted Phytochemical Profile, Antioxidant Capacity and Enzyme Inhibitory Activity of Cultivated and Wild Lupin Seeds from Tunisia. Molecules. 2021; 26 (11):3452.

Chicago/Turabian Style

Amna Ben Hassine; Gabriele Rocchetti; Leilei Zhang; Biancamaria Senizza; Gökhan Zengin; Mohamad Mahomoodally; Mossadok Ben-Attia; Youssef Rouphael; Luigi Lucini; Safia El-Bok. 2021. "Untargeted Phytochemical Profile, Antioxidant Capacity and Enzyme Inhibitory Activity of Cultivated and Wild Lupin Seeds from Tunisia." Molecules 26, no. 11: 3452.

Review
Published: 01 June 2021 in Food Reviews International
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The faunatic world represents an untapped potential reservoir for both food and medicine. A plethora of uses that humans have exploited since time immemorial to counter sufferings and deficiency diseases. This study aims to systematically review the scientific literature for the last 10 years and highlight the therapeutic uses of marine animal and animal products used globally. A total of 159 marine animals were documented comprising of 305 traditional uses. Marine animals of the Actinopterygii class were the most used against ailments. From the study, it was observed that a single aquatic animal could be used for treating and/or managing multiple ailments and at the same an ailment could be addressed by several marine animals and animal-derived products. The latter were mostly consumed cooked and the mode of administration varies depending on their origin. Although a panoply of traditional uses of marine animal and animal products exists, a dearth of validated pharmacological studies was observed to support the functional and medical uses of such products. This calls out researchers to address this gap as the exploration of marine faunatic resources, which could provide sustainable solution to many current health and wellness challenges. Graphical abstract

ACS Style

Mohamad Fawzi Mahomoodally; Dilmar Aniisah Sanaa; Gokhan Zengin; Monica Gallo; Domenico Montesano. Traditional Therapeutic Uses of Marine Animal Parts and Derived Products as Functional Foods – A Systematic Review. Food Reviews International 2021, 1 -31.

AMA Style

Mohamad Fawzi Mahomoodally, Dilmar Aniisah Sanaa, Gokhan Zengin, Monica Gallo, Domenico Montesano. Traditional Therapeutic Uses of Marine Animal Parts and Derived Products as Functional Foods – A Systematic Review. Food Reviews International. 2021; ():1-31.

Chicago/Turabian Style

Mohamad Fawzi Mahomoodally; Dilmar Aniisah Sanaa; Gokhan Zengin; Monica Gallo; Domenico Montesano. 2021. "Traditional Therapeutic Uses of Marine Animal Parts and Derived Products as Functional Foods – A Systematic Review." Food Reviews International , no. : 1-31.

Journal article
Published: 17 May 2021 in Antioxidants
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Jatropha L. species, in particular, J. curcas and J. gossypiifolia, are well known medicinal plants used for treating various diseases. In the present study, leaf and stem bark extracts of J. curcas and J. gossypiifolia obtained by maceration or homogenizer assisted extraction, were investigated for their phytochemical contents and biological potential as antioxidants, enzyme inhibitors and neuromodulators. In this regard, the gene expression of tumor necrosis factor α (TNFα) and brain-derived neurotrophic factor (BDNF) was investigated in hypothalamic HypoE22 cells. Finally, a bioinformatics analysis was carried out with the aim to unravel the putative mechanisms consistent with both metabolomic fingerprints and pharmacological effects. The leaf extracts of J. curcas showed higher total phenolic content (TPC) and total flavonoid content (TFC) than the stem bark extracts (range: 5.79–48.95 mg GAE/g and 1.64–13.99 mg RE/g, respectively), while J. gossypiifolia possessed TPC and TFC in the range of 42.62–62.83 mg GAE/g and 6.97–17.63 mg RE/g, respectively. HPLC-MS/MS analysis revealed that the leaf extracts of both species obtained by homogenizer assisted extraction are richer in phytochemical compounds compared to the stem bark extracts obtained by the same extraction method. In vitro antioxidant potentials were also demonstrated in different assays (DPPH: 6.89–193.93 mg TE/g, ABTS: 20.20–255.39 mg TE/g, CUPRAC: 21.07–333.30 mg TE/g, FRAP: 14.02–168.93 mg TE/g, metal chelating activity: 3.21–17.51 mg EDTAE/g and phosphomolybdenum assay: 1.76–3.55 mmol TE/g). In particular, the leaf extract of J. curcas and the stem bark extract of J. gossypiifolia, both obtained by homogenizer assisted extraction, showed the most potent antioxidant capacity in terms of free radical scavenging and reducing activity, which could be related to their higher TPC and TFC. Furthermore, anti-neurodegenerative (acetylcholinesterase inhibition: 1.12–2.36 mg GALAE/g; butyrylcholinetserase inhibition: 0.50–3.68 mg GALAE/g), anti-hyperpigmentation (tyrosinase inhibition: 38.14–57.59 mg KAE/g) and antidiabetic (amylase inhibition: 0.28–0.62 mmol ACAE/g; glucosidase inhibition: 0.65–0.81 mmol ACAE/g) properties were displayed differentially by the different extracts. Additionally, the extracts were effective in reducing the gene expression of both TNFα and BDNF, which could be partially mediated by phenolic compounds such as naringenin, apigenin and quercetin. Indeed, the scientific data obtained from the present study complement the several other reports highlighting the pharmacological potentials of these two species, thus supporting their uses as therapeutically active plants.

ACS Style

Gokhan Zengin; Mohamad Mahomoodally; Kouadio Sinan; Gunes Ak; Ouattara Etienne; Jugreet Sharmeen; Luigi Brunetti; Sheila Leone; Simonetta Di Simone; Lucia Recinella; Annalisa Chiavaroli; Luigi Menghini; Giustino Orlando; József Jekő; Zoltán Cziáky; Claudio Ferrante. Chemical Composition and Biological Properties of Two Jatropha Species: Different Parts and Different Extraction Methods. Antioxidants 2021, 10, 792 .

AMA Style

Gokhan Zengin, Mohamad Mahomoodally, Kouadio Sinan, Gunes Ak, Ouattara Etienne, Jugreet Sharmeen, Luigi Brunetti, Sheila Leone, Simonetta Di Simone, Lucia Recinella, Annalisa Chiavaroli, Luigi Menghini, Giustino Orlando, József Jekő, Zoltán Cziáky, Claudio Ferrante. Chemical Composition and Biological Properties of Two Jatropha Species: Different Parts and Different Extraction Methods. Antioxidants. 2021; 10 (5):792.

Chicago/Turabian Style

Gokhan Zengin; Mohamad Mahomoodally; Kouadio Sinan; Gunes Ak; Ouattara Etienne; Jugreet Sharmeen; Luigi Brunetti; Sheila Leone; Simonetta Di Simone; Lucia Recinella; Annalisa Chiavaroli; Luigi Menghini; Giustino Orlando; József Jekő; Zoltán Cziáky; Claudio Ferrante. 2021. "Chemical Composition and Biological Properties of Two Jatropha Species: Different Parts and Different Extraction Methods." Antioxidants 10, no. 5: 792.