The present review provides an up-to-date overview of chairside CAD/CAM materials used in restorative dentistry, focusing on their classification, properties, and clinical applications. If CAD/CAM technology was only an aspiration in the past, a higher proportion of clinics are employing it nowadays. The market is overflowing with biomaterials, and these materials are constantly evolving, making it challenging for practitioners to choose the most appropriate one, especially in correlation with patients’ medical diseases. The evolution of CAD/CAM technology has revolutionized dental practice, enabling the efficient fabrication of high-quality restorations in a single appointment. The main categories of chairside CAD/CAM materials include feldspathic ceramics, leucite-reinforced ceramics, lithium disilicate, zirconia, hybrid ceramics, and acrylic resins. The mechanical, physical, and aesthetic properties of these materials are discussed, along with their advantages and limitations for different clinical scenarios. Factors influencing material selection, such as strength, aesthetics, and ease of use, are also assessed. Ultimately, the guiding principle of dentistry is minimally invasive treatment following the particularity of the clinical case to obtain the envisioned result. Correlating all these factors, a simple, up-to-date classification is required to begin an individualized treatment. By synthesizing current evidence, this comprehensive review aims to guide clinicians in selecting appropriate chairside CAD/CAM materials to achieve optimal functional and aesthetic outcomes in restorative procedures. The integration of digital workflows and continued development of novel materials promise to further enhance the capabilities of chairside CAD/CAM systems in modern dental practice.

Background/Objectives: Dental anxiety in children is a common issue that can hinder the delivery of effective dental care. Traditional approaches to managing this are often insufficient or involve pharmacological interventions. This study shows the potential of virtual reality (VR) to aid in reducing anxiety in children undergoing simple dental procedures. By immersing children in relaxing VR environments (such as beaches, forests, mountains, or underwater scenes with calm music), the objective is to assess VR’s effectiveness in calming pediatrics patients during these procedures. Methods: Children scheduled for minor dental treatments wore a wearable device that monitored pulse, perspiration, and stress levels. Each child’s baseline data was collected without the VR headset, followed by data collection during VR exposure before and during dental procedures. VR scenarios ranged from soothing nature scenes to animated cartoons, designed to foster relaxation. Results: The data collected showed a reduction in physiological indicators of stress, such as lower heart rate and reduced perspiration, when the VR headset was used. Children appeared more relaxed, with a calmer response during the procedure itself, compared to baseline levels without VR. Conclusions: This study provides preliminary evidence supporting VR as an effective tool for reducing anxiety and stress in pediatric dental patients. By offering an engaging, immersive experience, VR can serve as an alternative or complementary approach to traditional anxiety management strategies in pediatric dentistry, potentially improving patient comfort and cooperation during dental procedures. Further research could determine if VR may serve as an alternative to local anesthesia for non-intrusive pediatric dental procedures.

Background/Objectives: Thymol (THY) is widely used in oral care products for its antimicrobial and anti-inflammatory activity, but data on its cytocompatibility, potential differential effects on oropharyngeal-derived cells, and mucosal irritation under prolonged exposure remain limited. This study evaluated THY’s effects on healthy human gingival fibroblasts (HGF-1) and pharyngeal carcinoma (Detroit-562) cells after 24 h exposure, together with its irritation potential in ovo. Methods: Cells were treated with THY (100–300 µM) for 24 h. Cellular viability (MTT), morphology, mitochondrial alterations (MitoTracker™/Hoechst 33342), mitochondrial membrane potential (JC-1), and apoptosis/necrosis (AO/PI) were assessed. Clonogenic assays evaluated long-term proliferative capacity. Lastly, irritation score was examined using the HET-CAM assay at 300 µM. Results: THY produced a dose-dependent viability decrease in both lines, with HGF-1 viability remaining ≥75% and Detroit-562 reduced to ~68% at 300 µM. Morphology, mitochondrial staining, JC-1 ratios, and AO/PI imaging showed progressive apoptotic features, more evident in Detroit-562 cells. Clonogenic capacity increased slightly in HGF-1 at 100 µM and declined to ~75% at 300 µM, whereas Detroit-562 colonies decreased from ~68% to ~40% across the dose range. Additionally, THY (300 µM) showed no irritation in the HET-CAM assay. Conclusions: THY demonstrated acceptable cytocompatibility in gingival fibroblasts, stronger inhibitory effects on carcinoma cells at higher concentrations, and no acute irritation in ovo. These findings support THY’s safe use within defined concentration limits and justify further evaluation in advanced oral tissue models.

Background/Objectives: Healthcare workers in chronic care hospitals are vulnerable to psychosocial risks such as burnout and moral injury due to prolonged patient exposure and limited institutional support. This study assessed the prevalence of burnout and moral injury among staff at the Chronic Diseases Hospital of Sebiș, Romania, and examined their associations with perceived stress and managerial support. Methods: A cross-sectional study was conducted between October 2022 and October 2024, including 62 healthcare workers (physicians, nurses, and auxiliary staff). Participants completed a sociodemographic survey, the Maslach Burnout Inventory (MBI), the Moral Injury Symptom Scale-Health Professional (MISS-HP), and additional items on perceived stress and institutional support. Statistical analysis included descriptive statistics, group comparisons, correlation matrices, and logistic regression. Results: High emotional exhaustion (MBI-EE ≥ 27) was reported by 45.2% of participants, with the highest rates among nurses (50%) and auxiliary staff (45.5%). Mean moral injury scores were moderate (mean = 5.3), with elevated levels observed in nurses and auxiliary staff. Pearson correlation analysis revealed no strong linear associations between burnout dimensions and moral injury. Logistic regression did not identify emotional exhaustion, perceived stress, or support as significant predictors of high moral injury. Conclusions: Burnout and moral injury are prevalent but appear to be partially dissociated in this Romanian chronic care setting. Moral injury may arise from contextual ethical pressures beyond general occupational strain. Interventions should focus on ethical climate, institutional responsiveness, and peer-based moral support to enhance staff resilience.

Background/Objectives: The prevalence of dental caries in Romania is significantly high, especially among children and adolescents. We aimed to assess the prevalence of dental caries and their associated factors among schoolchildren aged 6–11 years learning at urban and rural schools from Mureş County, Romania. Methods: This cross-sectional study included a sample of 1124 children, aged 6–8 years (n = 524), as well as aged 9–11 years (n = 600). Nine schools in Mureş County, Romania, were selected for screening, based on their location (4 schools from urban areas and 5 schools from rural areas). Data were collected based on children’s visual dental screenings and a self-administered questionnaire addressed to their parents to collect information about oral health behaviors, sugar consumption, and dental care history. Dental clinical examination was performed by specialists, and DMFT/dmft values were recorded. Binary logistic and negative binomial regression analyses were used to assess the factors associated with dental caries. Results: Among 6–8-year-olds, the prevalence of untreated decay was 76.5% and the prevalence of caries experience was 77.7% (mean dmft = 3.9). Among 9–11-year-olds, the prevalence of untreated decay was 43.5% and the prevalence of caries experience was 48.2% (mean DMFT = 1.9). Among the most significant factors associated with caries prevalence were school location (p = 0.04 for children aged 6–8 years, and p < 0.001 for 9–11 years); the employment status of mothers (p = 0.04 for 9–11 years); eating sweets ≥4 times/day (p = 0.04 for 6–8 years); brushing time ≥3 min (p = 0.03 for 9–11 years); as well as past dental restorative treatments or emergency (p < 0.001 for all the children examined). Conclusions: Preventive measures and innovative educational interventions are needed to mitigate the impact of dental caries prevalence on the health and education of schoolchildren.

Ultraviolet radiation (UVR) is generally considered a primary tumorigenic agent. While UVR exposure has been studied, especially at the skin level, the impact of UV exposure on internal tissues and its effect on the appearance and the development of tumors has not yet been fully examined. Although there are maximum limits for UVR exposure on external tissues, other internal tissues, such as oral tissue, can be exposed to UVR as well. Over the course of diagnosis and treatment, oral cells may be exposed to ultraviolet radiation; however, there has not been an established limit for UV radiation exposure. Therefore, the aim of the current study was to examine the effects of ultraviolet-B (UVB) radiation at two doses (2.5 and 5 J/cm²) on tumor cells (pharyngeal carcinoma and tongue carcinoma) and healthy cells (gingival fibroblasts). The viability of the cells and their morphology, actin filaments, and nuclei structures; the expression of anti-apoptotic (Bcl-2) and pro-apoptotic (Bax) genes; and the roles of caspases-3/7, 8, and 9 were determined after the cells had been exposed to UVB. The experiments revealed that both types of cell lines showed reductions in viability, especially at a dose of 5 J/cm². Additionally, apoptotic-like changes (rounding of the cells, the condensation of the nuclei, the re-organization of the actin filaments) were observed in all analyzed cells. The expression of anti-apoptotic (Bcl-2) and pro-apoptotic (Bax) genes revealed that UVB (5 J/cm²) may induce apoptosis in both oral tumor and healthy cells. Moreover, an analysis of caspases-3/7, 8, and 9 showed that UVB exposure enhanced their activity, suggesting that cell death could be caused by both intrinsic and extrinsic apoptosis. Accordingly, UVB exposure at the maximum doses used in dental practices (5 J/cm²) induced nonselective apoptotic changes, thereby reducing both tumor and healthy cell viability.