Background: To identify prognostic factors related to survival in patients with early-stage cervical cancer treated with radical surgery in six high-volume gynecologic oncology centers in Turkey. Methods: This retrospective analysis examined a cohort of 612 patients diagnosed with cervical cancer who underwent type II/III radical hysterectomy and pelvic lymphadenectomy, with or without para-aortic lymphadenectomy at six gynecologic oncology centers. A total of 537 patients between 1993 and 2023 were included. According to the 2009 FIGO staging system, 411 patients (76.5%) were stage IB1, 76 (14.2%) were stage IB2, 40 (4.7%) were stage IIA1, and 10 (1.9%) were stage IIA2. Patients underwent either type II or type III radical hysterectomy with pelvic lymphadenectomy, with para-aortic lymphadenectomy performed in 93.1% of cases. Among the 537 patients, 258 (48%) underwent type II radical hysterectomy and 279 (52%) underwent type III. Univariate and multivariate analyses of 5-year overall survival (OS) and 5-year disease-free survival (DFS) were performed. Results: In the entire cohort, 258 (48%) patients underwent radical surgery alone, while 279 (52%) patients underwent radical surgery followed by adjuvant therapy. The 5-year DFS and 5-year OS rates were 85.3% and 98.4%, respectively. In the multivariate logistic analysis, lymph node metastasis was identified as an independent prognostic factor for DFS and OS. Conclusions: Lymph node metastasis was the most important prognostic factor for survival in this large multicenter Turkish cohort. These findings highlight the prognostic value of nodal status, stromal invasion, margin status, and LVSI, while underscoring the importance of tailored adjuvant treatment strategies.

Background: This study aimed to determine the effect of neoadjuvant chemotherapy (NACT) on the complex surgical procedures required in addition to staging surgery for the need to achieve a residual tumor 1 cm or less in a population of stage IIIC–IV epithelial ovarian cancer patients. Methods: Patients were referred for NACT if preoperative imaging and/or intraoperative evaluation confirmed that it was not possible to achieve a residual tumor size of 1 cm or less with cytoreductive surgery or if the patient had a poor performance status and a high American Society of Anesthesiologists (ASA) score. Surgical complexity was defined as complex or non-complex. Results: One hundred and twenty-six patients with stage IIIC–IV ovarian cancer were included in the study. Primary cytoreductive surgery was performed in 67 patients, and interval cytoreductive surgery was performed in 59 patients after NACT. At least one complex surgery was performed in 74.6% of the patients in the primary cytoreductive surgery group and in 61% of the patients in the NACT group, with no statistically significant difference between the groups. However, the NACT group showed significantly decreased rates of low-rectal resection, diaphragmatic peritoneal stripping, and peritonectomy. Conclusions: The analyses showed no reduction in the requirement for at least one complex surgical procedure in the group of patients who underwent NACT. Nevertheless, this group exhibited a significant decrease in low-rectal resection, diaphragmatic peritoneal stripping, and peritonectomy due to their effectiveness in reducing peritoneal disease.

Aim: We aimed to analyses the high-risk HPV type distribution and pathology results in high-risk HPV positive patients. Materials and Methods: The research was retrospectively conducted and data was obtained from a tertiary gynecologic oncology colposcopy outpatient clinic. From September 2019 to December 2022, data from 3546 patients who tested positive for HPV and underwent colposcopic examination were analyzed. All patients granted the institution explicit permission to utilize their clinical data. Results: A total of 3546 patients with a median age of 40 years (range, 18–77 years) were analysed. Patient’s HPV status was; 1169 (33%) patients were HPV 16, 343 (9.7%) patients were HPV 18, and 2318 (65.4%) patients were HPV others. The detailed HPV positive results of patients were that 888 (25.4%) patients were only HPV 16, 197 (5.6%) patients were only HPV 18, and 2097 (59.9%) patients were only HPV others. In the study cohort, 529 (14.9%) patients had CIN 2+ lesions. HPV 16 and/or HPV 18 were detected in 331 (62.5%) of 529 patients with CIN 2+ lesions. The final pathology result of 507 (14.3%) patients was CIN 2/3 and of 22 (0.6%) patients was cancer. Conclusion: In conclusion, we found that while HPV other types were positive in two-thirds of the patients, HPV 16 and/or 18 were positive in more than four-fifths of the cancer cases. In the high-risk HPV positive patient group, HPV type can be used as a criterion when referring the patient to colposcopy