Resveratrol (RSV) is a natural flavonoid polyphenol compound extracted from the plants which shows various biological activities. However, the clinical application of RSV is limited by its poor aqueous solubility, rapid metabolism and poor bioavailability. In this study, resveratrol-loaded solid lipid nanoparticles (RSV- SLNs) was design as a nano-antioxidant against the physical fatigue. The resultant RSV-SLNs were characterized by photon correlation spectroscopy (PCS), transmission electron micrographs (TEM), zeta potential, differential scanning calorimetry (DSC) and Raman spectroscopy pattern. Furthermore, the in vivo anti-fatigue effect assays showed that RSV-SLNs prolonged the mice exhausted time and running distance. The biochemical parameters of blood related to fatigue suggested that RSV-SLNs have potential applications to improve the antioxidant defense of the mice after extensive exercise and confer anti-fatigue capability. Furthermore, the molecular mechanisms of antioxidant by RSV-SLNs supplementation was investigated through the analysis of silent information regulator 2 homolog 1 (SIRT1) protein expression, which demonstrated that it could downregulate the expression of SIRT1 and increase autophagy markers, microtubule-associated protein 1 light chain 3-II (LC3-II) and sequestosome-1 (SQSTM1/p62). These results reveal that the RSV-SLNs may have great potential used as a novel anti-fatigue sports nutritional supplement.

Purpose: Footwork speed is closely linked to explosive strength, and both percentage- (PBRT) and velocity-based resistance training (VBRT) are popular methods for developing muscle strength. This study aimed to compare the effects of PBRT and VBRT on lower limb explosive power and footwork movement speed in elite university badminton players over a 6-week training period. Methods: A total of 20 elite badminton players (12 males, 8 females) from Tongji University were randomly divided into VBRT (n = 10) and PBRT groups (n = 10). The VBRT group trained with loads determined by target speed and velocity loss, while the PBRT participants used fixed loads based on a percentage of their one-repetition maximum (1RM). Both the groups performed free-weight back squats with relative loads ranging from 65% to 95% of 1RM over 6 weeks. The pre- and post-training measurements included back squat 1RM; countermovement (CMJ), squat (SJ), and standing long jumps (SLJs); self-weighted squat jump speed (SJS); left and right touch line (LRF), full-field four-point (FF), and front and back touch net footwork (FBF). Results: (1) The baseline measurements showed no significant differences between the groups (p > 0.05). (2) Post-training, both VBRT and PBRT improved the participants’ lower limb explosive power and footwork movement (p < 0.05). (3) The VBRT group demonstrated significantly greater improvements than the PBRT group in all the measures (p < 0.05). Conclusions: VBRT was superior to PBRT in boosting lower limb explosive power and footwork speed in badminton players over 6 weeks, leading to more significant strength–related and neural adaptations.

In an era characterized by rapid economic growth and evolving lifestyles, college students encounter numerous challenges, encompassing academic pressures and professional competition. The respiratory muscle endurance capability is important for college students during prolonged aerobic exercise. Therefore, it is of great significance to explore an effective intervention to enhance the endurance level of college students. This study explores the transformative potential of inspiratory muscle training (IMT) to improve the physical functions of college students. This research comprised a group of 20 participants who underwent IMT integrated into their daily physical education classes or regular training sessions over an 8-week period, with 18 participants forming the control group. The IMT group adhered to the manufacturer’s instructions for utilizing the PowerBreathe device. The findings indicated a significant positive effect on inspiratory muscle strength (p < 0.001), showing improvements in pulmonary function, exercise tolerance, cardiac function, and overall athletic performance. These results revealed the substantial benefits of IMT in enhancing physical fitness and promoting health maintenance among college students.

Silica aerogel has garnered significant attention in the biomedical field, primarily due to its unique combination of a three-dimensional structure, low density, tunable nanoscale pores, and an extensive surface area. These intrinsic properties render it as an exceptional candidate for advanced drug delivery systems (DDSs). In the realm of medical applications, silica aerogels have demonstrated remarkable potential, especially in nanoscale DDSs. Traditional drug delivery methods, such as capsules and tablets, are often plagued by several drawbacks, including poor bioavailability, lack of target specificity, and multidrug resistance. These limitations necessitate the development of more efficient and targeted drug delivery systems. Recent advancements in the synthesis and modification of silica aerogels have significantly enhanced their biocompatibility and functionalization capabilities. These improvements have further bolstered their potential for controlled release and targeted delivery of therapeutic agents. This study is based on silica aerogel-based nanocarrier systems, providing an in-depth exploration of its fundamental principles, preparation processes, and recent advancements. Based on this, we summarize the drug delivery methods, drug release characteristics, and diverse medical applications of silica aerogels. Additionally, we discuss the challenges and future prospects of applying silica aerogels in drug delivery systems, aiming to provide a comprehensive overview of this field.

Recent studies have identified the hip joint as a central component of the human kinetic chain, playing a pivotal role in optimizing force transmission during movement. Enhancing its functional capacity represents an effective strategy for enhancing overall physical well-being and preventing injuries. This study investigates the effects of an eight-week hip joint functional training program on the health-related physical fitness, hip joint function, and factors associated with injury risk in university students from a track and field elective class. A total of 56 participants were randomly assigned to an experimental group (n = 28) or a control group (n = 28). The experimental group incorporated hip joint functional training, which comprising dynamic stretching and activation exercises, into their standard physical education (PE) class activities, while the control group continued with the regular physical education curriculum. Pre-intervention and post-intervention assessments included hip joint range of motion (ROM), functional movement screening (FMS), a 50 m sprint, standing long jump, sit-and-reach test, and spinal health evaluations. Results indicated that the experimental group demonstrated significant improvements in multi-directional hip range of motion (ROM), with examples including flexion increasing by 10° and external rotation by 9°. These improvements were accompanied by significant gains in functional movement screen (FMS) scores, with significant improvements in the Hurdle Step, whose median score increased to 3.0, Active Straight Leg Raise, and Rotary Stability components (all p < 0.05) compared to the control group. Furthermore, the training significantly reduced spinal asymmetry (axial trunk rotation reduced from 3.86° to 3.43°) and enhanced performance in the 50 m sprint (−0.26 s) and standing long jump (+0.08 m) (all p < 0.05). These objective improvements in functional movement patterns, postural alignment, and physical performance are associated with key biomechanical factors known to influence injury risk, such as the demonstrated gains in joint mobility and movement efficiency. Therefore, incorporating hip joint functional training into college physical education programs may effectively enhance students’ fundamental movement quality, improve joint stability, and promote postural health, thereby mitigating key biomechanical risk factors. This approach offers a practical strategy for educators to improve student physical health in general PE settings.

Children’s outdoor physical activity (PA) serves as a crucial mechanism for health development, but its safety is affected by urban space design and management. However, most existing studies focus on isolated risk factors or singular spatial typologies, which lack a comprehensive safety assessment framework. This study aims to construct a safety assessment system for children’s outdoor public activity spaces and explore safety optimization strategies. This study employs a mixed methods approach to systematically analyze 13 outdoor public activity spaces across Shanghai, utilizing NVivo 12 Plus for qualitative coding of the data. Based on the coding results, a questionnaire survey targeting parents of children under 12 years old (with a balanced gender ratio) was designed and administered, yielding 509 valid responses. A 32-indicator assessment system was finally constructed via principal component analysis (PCA). The assessment system encompasses seven dimensions: site facilities (24.0%), spatial conditions (16.1%), site management (13.5%), material conditions (13.0%), service facilities (12.8%), traffic and landscape (10.3%), and ground conditions (10.3%). This study provides a quantitative safety assessment instrument for designing child-friendly urban public activity spaces, which has important implications for improving the public health service system and promoting the construction of healthy cities in the Sustainable Development Goals.