The increasing demand for customized medical devices has driven the need for highly integrated, data-driven, and adaptable production and logistics systems. Traditional approaches no longer suffice for patient-specific implants, which require rapid design cycles, strict regulatory compliance, and precise coordination among clinical teams, engineering departments, manufacturing operations, sterilization units, and hospital logistics. Smart Information Systems (SIS) that incorporate IIoT, digital twins, AI analytics, and enterprise platforms have become essential for managing these complex workflows. When combined with Industrial Metaverse technologies such as immersive XR interfaces, multi-user collaboration environments, and persistent digital twins, a new paradigm emerges that connects physical and virtual operations across the entire medical device lifecycle. This paper presents a conceptual, integrated framework that illustrates how immersive collaboration, structured knowledge exchange, and real-time simulation improve design precision, manufacturing dependability, sterilization safety, and logistics efficiency, while supporting Industry 5.0 in healthcare manufacturing. These technologies enable a high level of accuracy, transparency, and human–machine interaction through virtual simulations.