Convolutiona neural network (CNN) is one of the best neural networks for classification, segmentation, natural language processing (NLP), and video processing. The CNN consists of multiple layers or structural parameters. The architecture of CNN can be divided into three sections: convolution layers, pooling layers, and fully connected layers. The application of CNN became most demanding due to its ability to learn features from images automatically, involving massive amount of training data and high computational resources like GPUs. Due to the availability of the above-stated resources, multiple CNN architectures have been reported. This study focuses on the working of convolution, pooling, and the fully connected layers of CNN architecture, origin of architectures, limitation, benefits of reported architectures, and comparative analysis of contemporary architecture concerning the number of parameters, architectural depth, and significant contribution.

Cloud datacenters have become a backbone for today’s business and economy, which are the fastest-growing electricity consumers, globally. Numerous studies suggest that $\sim$ 30% of the US datacenters are comatose and the others are grossly less-utilized, which make it possible to save energy through resource consolidation techniques. However, consolidation comprises migrations that are expensive in terms of energy consumption and performance degradation, which is mostly not accounted for in many existing models, and, possibly, it could be more energy and performance efficient not to consolidate. In this paper, we investigate how migration decisions should be taken so that the migration cost is recovered, as only when migration cost has been recovered and performance is guaranteed, will energy start to be saved. We demonstrate through several experiments, using the Google workload data for 12,583 hosts and approximately one million tasks that belong to three different kinds of workload, how different allocation policies, combined with various migration approaches, will impact on datacenter’s energy and performance efficiencies. Using several plausible assumptions for containerised datacenter set-up, we suggest, that a combination of the proposed energy-performance-aware allocation ( Epc-Fu ) and migration ( Cper ) techniques, and migrating relatively long-running containers only, offers for ideal energy and performance efficiencies.

With recent advancement in computational biology, high throughput next generation sequencing technology has become a de facto standard technology for genes expression studies including DNAs, RNAs and proteins. As a promising technology, it has significant impact on medical sciences and genomic research. However, it generates several millions of short DNA and RNA sequences with several petabytes size in single run. In addition, the raw sequencing datasets such as RNAs are increasing exponentially leading to a big data analytics issue in computational biology. Due to the explosive growth of RNA sequences, the timely classification of RNAs sequence into piRNAs and non-piRNAs have become a challenging issue for traditional technology and conventional machine learning algorithms. Parallel and distributed computing models along with deep neural network have become a major computing platform for big data analytics now required in the field of computational biology. This paper presents a computational model based on parallel deep neural network for timely classification of large number of RNAs sequence into piRNAs and non-piRNAs, taking advantages of parallel and distributed computing platform. The performance of the proposed model was extensively evaluated using two-fold performance metrics. In the first fold, the performance of the proposed model was assessed using accuracy-based metrics such as accuracy, specificity, sensitivity and Matthew’s correlation coefficient. In the second fold, computational-based metrics such as computation times, speedup and scalability were observed. Moreover, initially the performance of the proposed model was assessed using real benchmark dataset and subsequently the performance was assessed using replicated benchmark dataset. The evaluation results in both cases showed that the proposed model improved computation speedup in order of magnitude in comparison with sequential approach without affected accuracy level.

Enhancers are short DNA regulatory elements which play a vital role in gene expression. Due to their important roles in genomics, several computational models have been proposed in the literature for identification of enhancers and their strengths using traditional machine learning algorithms, however, the proposed models are unable to identify enhancers and their strength with reasonable accuracy because of high non-linearity in DNA sequences. This article proposes a two-level intelligent model based on Deep Neural Network (DNN) along with multiple feature extraction methods. Firstly, the proposed model represents the given DNA sequences into feature vectors using Pseudo K-tuple Nucleotide Composition (PseKNC) and FastText methods. Secondly, the features vectors are fused to make a heterogeneous features vector that considered the local and global correlation amongst the given sequences along with internal structure information. Finally, the heterogeneous feature vector is given to a DNN model to make final predictions. The proposed iEnhancer-DHF is developed using two-layer approach. The first layer predicts whether the given DNA samples are enhancers or non-enhancers whereas the second layer identifies either the enhancers are strong enhancers or weak enhancers. The outcome of the proposed model was rigorously assessed using both training and independent datasets via 10-fold cross validation method. The validation outcome demonstrated that the iEnhancer-DHF model yielded accuracies 86.07% and 69.60% at first layer and second layer respectively utilizing the training dataset. Similarly, the model yielded accuracies 83.21% and 67.54% at first layer and at second layer respectively by using the independent dataset. Additionally, the outcomes of the proposed model was initially compared with widely applied classifiers such as Support Vector Machine, Random Forest and K-nearest Neighbor and subsequently the performance is compared with the existing models using both the training and independent datasets. The comparison results exhibited that the iEnhancer-DHF model performed superior than the recently published models.

With recent advancements in computational biology, high throughput Next-Generation Sequencing (NGS) has become a de facto standard technology for gene expression studies, including DNAs, RNAs, and proteins; however, it generates several millions of sequences in a single run. Moreover, the raw sequencing datasets are increasing exponentially, doubling in size every 18 months, leading to a big data issue in computational biology. Moreover, inflammatory illnesses and boosting immune function have recently attracted a lot of attention, yet accurate recognition of Anti-Inflammatory Peptides (AIPs) through a biological process is time-consuming as therapeutic agents for inflammatory-related diseases. Similarly, precise classification of these AIPs is challenging for traditional technology and conventional machine learning algorithms. Parallel and distributed computing models and deep neural networks have become major computing platforms for big data analytics now required in computational biology. This study proposes an efficient high-throughput anti-inflammatory peptide predictor based on a parallel deep neural network model. The model performance is extensively evaluated regarding performance measurement parameters such as accuracy, efficiency, scalability, and speedup in sequential and distributed environments. The encoding sequence data were balanced using the SMOTETomek approach, resulting in a high-accuracy performance. The parallel deep neural network demonstrated high speed up and scalability compared to other traditional classification algorithms study’s outcome could promote a parallel-based model for predicting anti-Inflammatory Peptides.