Photodynamic therapy (PDT) is currently regarded as a promising method for the treatment of oncological diseases. However, it involves a number of limitations related to the specific features of the method and the specific characteristics of photosensitizer molecules, including tumor hypoxia, small depth of light penetration into the tumor tissue, and low accumulation sensitivity. These drawbacks can be overcome by combining PDT with other treatment methods, for example, chemotherapy. In this work, we were the first to obtain agents that contain bacteriopurpurinimide as a photodynamic subunit and complexes of gold(I) that implement the chemotherapy effect. To bind the latter agents, N-heterocyclic carbenes (NHC) based on histidine and histamine were obtained. We considered alternative techniques for synthesizing the target conjugates and selected an optimal one that enabled the production of preparative amounts for biological assays. In vitro studies showed that all the compounds obtained exhibited high photoinduced activity. The C-donor Au(I) complexes exhibited the maximum specific activity at longer incubation times compared to the other derivatives, both under exposure to light and without irradiation. In in vivo studies, the presence of histamine in the NHC-derivative of dipropoxy-BPI (7b) had no significant effect on its antitumor action, whereas the Au(I) metal complex of histamine NHC-derivative with BPI (8b) resulted in enhanced antitumor activity and in an increased number of remissions after photodynamic treatment.

Background: Vitamin D3 is an important factor for bone metabolism, and its deficiency may affect dental implantation results. Materials and methods: 384 patients with a diagnosis of tooth loss and vitamin D deficiency were examined and treated with dental implants. Vitamin D3 supplements were prescribed by the endocrinologist for all patients in the individual dose. The patients were divided into two equal study groups (n = 192) depending on the dental implantation period: Group 1—operation after blood serum vitamin D3 level normalization; group 2—before reaching the reference level of vitamin D3. Follow-up examinations were performed on the day of dental implantation, 7 days later, 1, 3, 6, and 12 months later, and every 1 year after treatment (up to 10 years). Implant stability and peri-implant tissue condition were assessed with clinical and X-ray diagnostics. Patients also visited an endocrinologist 2 months after the start of the treatment, then every 6 months. Results: The target vitamin D3 level (30–60 ng/mL) (p < 0.001) was achieved in all patients after treatment. At the control examinations, peri-implantitis was diagnosed in 10 patients (2.6%). It was detected in the group of patients with severe vitamin D deficiency and vitamin D deficiency—2 (25%) and 8 (3.4%) patients; respectively (p < 0.05). There was no significant difference between groups for risk of complications or bone quality after treatment. Conclusions: Timely screening of vitamin D3 levels and the appropriate treatment by an endocrinologist in young and middle-aged patients allow for achieving 97.4% dental implantation success for a ten-year period.

Background/Objectives: Alveolitis, or “dry socket,” is a common complication after tooth extraction, associated with pain, inflammation and delayed healing. Standard surgical treatments are often invasive and insufficient. Laser therapy offers antimicrobial, anti-inflammatory and regenerative effects. This study aimed to compare the efficacy of 980 nm monolaser therapy and 980 nm and 1550 nm dual-wavelength therapy on alveolar socket healing in a rabbit model. Methods: In vitro tests evaluated bactericidal effects of 980 nm laser exposure. Eighteen adult male chinchilla rabbits underwent the extraction of the first incisors with the prevention of clot formation to model alveolar socket healing. On day 3, animals were randomized to three groups: mechanical curettage and antiseptic irrigation, 980 nm diode laser therapy, or combined 980 nm + 1550 nm therapy. Clinical parameters (hyperemia, edema, pain, socket closure) were assessed up to day 7. Histological and microbiological analyses were performed on days 7 and 12. Results: Laser therapy showed superior outcomes compared to mechanical treatment. In vitro, 980 nm exposure eradicated microorganisms after 3 s. By day 7, hyperemia decreased to 0.7 ± 0.6 points in the dual-laser group, versus 2.0 ± 0.0 (980 nm) and 3.0 ± 0.0 (mechanical). Complete socket closure occurred in 33% with mechanical treatment and in 67% of sites in the dual-laser group. Pain was fully resolved only after dual-laser therapy. Histology confirmed more organized granulation tissue and angiogenesis in the dual-laser group. Conclusions: Dual-wavelength laser therapy demonstrated superior anti-inflammatory, antimicrobial and regenerative effects compared with diode monotherapy and mechanical treatment. These findings highlight its promise as a minimally invasive approach for managing alveolitis, warranting further clinical evaluation.