Haydarpa?a Numune Medical Journal

Objective:We aimed to evaluate the effects of probiotic drops containing the microbial strains Bifidobacterium breve BR03 and Bifidobacterium breve B632 on symptoms and quality-of-life indicators in infants aged 0–12 months under real-life conditions, particularly in subgroups such as colic, cesarean delivery, prematurity, hospitalization, and antibiotic exposure.Materials and Methods:This four-center, multicenter study was conducted in the pediatric clinics of Prof. Dr. Cemil Taşcıoğlu City Hospital, Yalova Training and Research Hospital, Esenyurt State Hospital, and Sancaktepe Prof. Dr. İlhan Varank Training and Research Hospital. Symptoms of a total of 150 infants aged 0–12 months were compared before and after probiotic use using a parental questionnaire. The Wilcoxon signed-rank test was used for continuous/ordinal variables, and the McNemar test was used for binary variables (statistical significance set at p<0.05).Results:The median age of the infants was 4.5 months (25th–75th percentile: 2–8), and 56% of the cases were male. The reasons for initiating probiotic use were irritability (42.7%), colic (26.7%), gas (22.7%), and recommendation (8.0%). The median duration of use was 90 days, and the median daily dose was 5 drops. After probiotic use, a marked improvement was observed in crying-related parameters: median crying duration decreased from 1 hour/day (25th–75th percentile: 1–3) to 0 hours/day (25th–75th percentile: 0–1), median crying frequency decreased from 2 (25th–75th percentile: 2–3) to 1 (25th–75th percentile: 1–1), and the median number of daily crying episodes decreased from 10 (25th–75th percentile: 8–10) to 2 (25th–75th percentile: 2–4). In parallel, significant reductions were observed in the severity scores of gasses, abdominal distension, and irritability, along with increases in maternal and paternal sleep duration and a decrease in maternal depressive mood score (all comparisons p<0.001). In binary symptom assessment, the presence of gas decreased from 63.3% to 7.3%, irritability from 47.3% to 11.3%, and abdominal distension from 63.3% to 22.7%, while the proportion of infants reported to have nighttime sleep increased from 32.0% to 68.0% (all p<0.001).Conclusion:The use of probiotic drops containing the microbial strains Bifidobacterium breve BR03 and Bifidobacterium breve B632 was found to be associated with clinically meaningful improvement in gastrointestinal complaints and parent-related sleep and mood parameters, as well as good tolerability, in infants aged 0–12 months.

Amaç: Bu çalışmada, rotavirüs antijen testi pozitif akut gastroenteritli 2–14 yaş çocuklarda ayaktan standart tedaviye Kolloidal Silisyum Dioksit eklenmesinin klinik seyir üzerine etkisini değerlendirmek amaçlandı. Kolloidal Silisyum DioksitGereç ve Yöntem: Rotavirüs pozitif ayaktan izlenen çocuklarda iki gruplu karşılaştırmalı analiz yapıldı (Standart tedavi: sıvı + çinko + probiyotik; Standart+ Kolloidal Silisyum Dioksit. Çalışma toplam 5 ayrı hastanede standart tedavi verilen 150 ve standart tedaviye ek olarak Kolloidal Silisyum Dioksit kullanan 150 Rotavirüs tanılı çocuk dahil edilidi. Çalışmamız çok merkezli, multisentrik ve iki grup karşılaştırmalı olarak planlandı. Çalışma Takip penceresi Gün 0–7 idi. Primer sonlanım ishalin düzelmesine kadar geçen süre olarak tanımlandı (ilk kez dışkı sayısı ≤3/gün ve Bristol ≤5 sağlanması). İkincil sonlanımlar toplam dışkı sayısı, dışkı tipi, dışkı kıvamı, ateş seyri, hastaneye başvuru, okul ve işgücü kaybı ve ürün güvenliği idi. Sürekli değişkenlerde uygun parametrik/parametrik olmayan testler; ikili değişkenlerde Fisher kesin testi; ishal düzelme için Kaplan-Meier ve log-rank testi kullanıldı (p

En tr Objective: The aim of our study is to present the association between respiratory system disorders and gastrointestinal system involvement through showing that pediatric COVİD 19 patients can only display gastrointestinal symptoms. Materials and Methods: Three hundered COVID-19 patients between 1-18 years of age were included into the study. The patients were divided into 3 groups according to symptoms which are classified gastrointestinal, respiratory and gastrointestinal and respiratory groups. Diagnosis of COVID-19 were made by PCR testing. In patients with negative PCR testing, diagnosis was made according to clinical symptoms and contact history. Patients were analyzed in terms of demographic features, laboratory and imaging findings. Results: There were 300 patients diagnosed with COVID-19. PCR testing was positive in 129 of 300 children. All patients with only gastrointestinal symptoms had close contact history, 24 of 58 patients had PCR positivity (41.3%) and in 7 patients (12%), chest X- Ray findings were compatible with COVID-19. Two of 7 patients had negative PCR testing. Median NRL and CRP was higher in gastrointestinal group than respiratory group (p=0.034, p=0.028 respectively). Conclusions: Patients with gastrointestinal symptom and negative PCR testing should be evaluated carefully for early respiratory involvement without symptoms. Amaç: Çalışmanın amacı pediyatrik COVİD-19 hastalarının klinik olarak sadece gastrointestinal semptomlar sergileyebileceğine dikkat çekerek, gastrointestinal sistem ile solunum sistemi tutulumu arasındaki ilişkiyi ortaya koymaktır. Materyal ve Metot: Çalışmaya 1-18 yaş arasında 300 hasta dahil edildi. Hastalar semptomlarına göre; gastrointestinal semptomları, solunum semptomları ve gastrointestinal semptomları ile solunumsal semptomları olanlar şeklinde 3 gruba ayrıldı. PCR testi pozitif hastalar COVID-19 tanısı aldı. PCR negatif saptanan hastaların tanısı klinik semptomlara ve temas öyküsüne göre konuldu. Hastalar demografik özellikler, laboratuvar ve görüntüleme bulguları açısından analiz edildi. Bulgular: COVID-19 tanısı alan 300 hastanın 29' unda PCR pozitif saptandı. Sadece gastrointestinal semptomları olan 58 hastanın tümünde yakın temas öyküsü vardı, ellisekiz hastanın 24'ünde PCR pozitifliği (%41.3) saptandı. Yedi hastanın ikisinde (%12) görüntüleme bulguları COVID ile uyumluydu, 7 hastanın ikisinde PCR negatifti. Medyan nötrofil lökosit oranı ve CRP gastrointestinal semptomları olan grupta solunum semptomları olan gruba göre daha yüksek bulundu (sırasıyla p = 0.034, p = 0.028). Sonuç: Solunumsal şikayetler içermeyen, sadece gastrointestinal semptom bulguları olan ve PCR testi negatif saptanan hastalar, olası COVİD-19’un erken solunum tutulumu açısından dikkatle değerlendirilmelidir.