Agata Kolkowska

Ms. Agata Kolkowska

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 January 2025 in Journal of Clinical Medicine
Verified
Journal Article
Open access
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RZRafal Zielinski
Rafal Zielinski
JOJakub Okulski
Jakub Okulski
MPMartyna Piechaczek
Martyna Piechaczek
JŁJan Andrzej Łoś
Jan Andrzej Łoś
JSJerzy Sowinski
Jerzy Sowinski
Marcin KozakiewiczMarcin Kozakiewicz
Marcin Kozakiewicz
Background/Objectives: Severe maxillary atrophy presents challenges in maxillofacial rehabilitation. This study compares the clinical outcomes of zygomatic and subperiosteal implants, focusing on implant survival, soft tissue management, and postoperative complications over a five-year follow-up. Methods: A retrospective cohort study analyzed 150 patients divided into two groups based on the type of implant. Zygomatic implants were assessed for immediate functional loading, procedural efficiency, and complications such as sinus-related issues and orbital damage. Subperiosteal implants were evaluated for their customized design, keratinized mucosa integration, and adaptation to severe anatomical limitations. Statistical analyses, including Chi-square tests, were used to determine significant differences (p < 0.05). Results: This study demonstrated differences in complication rates (sinus-related complications: 12.4% for zygomatic implants; peri-implantitis: 5.6% for subperiosteal implants). Implant survival rates were comparable (zygomatic: 96.3%, subperiosteal: 97.1%, p = 0.278). Zygomatic implants demonstrated higher incidences of sinus-related complications (12.4%) and risks of orbital damage. Subperiosteal implants exhibited superior soft tissue stability with fewer cases of peri-implantitis (5.6%, p < 0.05). Procedural duration was shorter for zygomatic implants (177 min vs. 123 min); however, subperiosteal implants allowed for re-implantation after failure, providing flexibility that was unavailable with zygomatic implants. Conclusions: Zygomatic implants excel in immediate functional loading and reduced procedural time but require advanced surgical expertise to mitigate anatomical risks. Subperiosteal implants offer a safer, customizable solution, particularly in anatomically complex cases. These findings emphasize the importance of individualized treatment planning and technological advancements in implant design to optimize clinical outcomes for patients with severe maxillary atrophy.

6 March 2024 in Materials
Verified
Journal Article
Open access
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RZRafal Zielinski
Rafal Zielinski
SLSebastian Lipa
Sebastian Lipa
MPMartyna Piechaczek
Martyna Piechaczek
JSJerzy Sowinski
Jerzy Sowinski
AKAgata Kolkowska
Agata Kolkowska
Wojciech SimkaWojciech Simka
Wojciech Simka
The study involved numerical FEA (finite element analysis) of dental implants. Based on this, fatigue tests were conducted according to the PN-EN 14801 standard required for the certification of dental products. Thanks to the research methodology developed by the authors, it was possible to conduct a thorough analysis of the impact of external and internal factors such as material, geometry, loading, and assembly of the dental system on the achieved value of fatigue strength limit in the examined object. For this purpose, FEM studies were based on identifying potential sites of fatigue crack initiation in reference to the results of the test conducted on a real model. The actions described in the study helped in the final evaluation of the dental system design process named by the manufacturer as INTEGRA OPTIMA 3.35. The objective of the research was to identify potential sites for fatigue crack initiation in a selected dental system built on the INTEGRA OPTIMA 3.35 set. The material used in the research was titanium grade 4. A map of reduced von Mises stresses was used to search for potential fatigue crack areas. The research [loading] was conducted on two mutually perpendicular planes positioned in such a way that the edge intersecting the planes coincided with the axis of the system. The research indicated that the connecting screw showed the least sensitivity (stress change) to the change in the loading plane, while the value of preload has a significant impact on the achieved fatigue strength of the system. In contrast, the endosteal implant (root) and the prosthetic connector showed the greatest sensitivity to the change in the loading plane. The method of mounting [securing] the endosteal implant using a holder, despite meeting the standards, may contribute to generating excessive stress concentration in the threaded part. Observation of the prosthetic connector in the Optima 3.35 system, cyclically loaded with a force of F ≈ 300 N in the area of the upper hexagonal peg, revealed a fatigue fracture. The observed change in stress peak in the dental connector for two different force application surfaces shows that the positioning of the dental system (setting of the socket in relation to the force action plane) is significantly decisive in estimating the limited fatigue strength.

10 June 2024 in Materials
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Journal Article
Open access
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AKAgata Kolkowska
Agata Kolkowska
JMJoanna Michalska
Joanna Michalska
RZRafal Zielinski
Rafal Zielinski
Wojciech SimkaWojciech Simka
Wojciech Simka
This paper reports the results of our study on electrochemical polishing of titanium and a Ti-based alloy using non-aqueous electrolyte. It was shown that electropolishing ensured the removal of surface defects, thereby providing surface smoothing and decreasing surface roughness. The research was conducted using samples made of titanium and Ti6Al4V alloy, as well as implant system elements: implant analog, multiunit, and healing screw. Electropolishing was carried out under a constant voltage (10–15 V) with a specified current density. The electrolyte used contained methanol and sulfuric acid. The modified surface was subjected to a thorough analysis regarding its surface morphology, chemical composition, and physicochemical properties. Scanning electron microscope images and profilometer tests of roughness confirmed significantly smoother surfaces after electropolishing. The surface profile analysis of processed samples also yielded satisfactory results, showing less imperfections than before modification. The EDX spectra showed that electropolishing does not have significant influence on the chemical composition of the samples.

20 September 2023 in Nanomaterials
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Journal Article
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KGKarlis Grundsteins
Karlis Grundsteins
KDKateryna Diedkova
Kateryna Diedkova
VKViktoriia Korniienko
Viktoriia Korniienko
ASAnita Stoppel
Anita Stoppel
SBSascha Balakin
Sascha Balakin
MPMaksym Pogorielov
Maksym Pogorielov
Cardiovascular diseases (CVDs) remain a leading cause of death in the European population, primarily attributed to atherosclerosis and subsequent complications. Although statin drugs effectively prevent atherosclerosis, they fail to reduce plaque size and vascular stenosis. Bare metal stents (BMS) have shown promise in acute coronary disease treatment but are associated with restenosis in the stent. Drug-eluting stents (DES) have improved restenosis rates but present long-term complications. To overcome these limitations, nanomaterial-based modifications of the stent surfaces have been explored. This study focuses on the incorporation of detonation nanodiamonds (NDs) into a plasma electrolytic oxidation (PEO) coating on nitinol stents to enhance their performance. The functionalized ND showed a high surface-to-volume ratio and was incorporated into the oxide layer to mimic high-density lipoproteins (HDL) for reverse cholesterol transport (RCT). We provide substantial characterization of DND, including stability in two media (acetone and water), Fourier transmission infrared spectroscopy, and nanoparticle tracking analysis. The characterization of the modified ND revealed successful functionalization and adequate suspension stability. Scanning electron microscopy with EDX demonstrated successful incorporation of DND into the ceramic layer, but the formation of a porous surface is possible only in the high-voltage PEO. The biological assessment demonstrated the biocompatibility of the decorated nitinol surface with enhanced cell adhesion and proliferation. This study presents a novel approach to improving the performance of nitinol stents using ND-based surface modifications, providing a promising avenue for cardiovascular disease.

5 November 2024 in Materials
Verified
Journal Article
Open access
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RZRafal Zielinski
Rafal Zielinski
Adam PuszkarzAdam Puszkarz
Adam Puszkarz
TPTomasz Piętka
Tomasz Piętka
JSJerzy Sowinski
Jerzy Sowinski
MSMonika Sadowska-Sowińska
Monika Sadowska-Sowińska
Wojciech SimkaWojciech Simka
Wojciech Simka
This study evaluated the bone-to-implant contact (BIC) of various surface-treated dental implants using high-resolution micro-CT in rabbit bone, focusing on the effects of different treatments on osseointegration and implant stability before and after bone demineralization. Six male New Zealand White rabbits were used. Four implant types were tested: machined surface with anodizing, only etching, sandblasting with Al2O3 + etching, and sandblasting with TiO2 + etching. Implants were scanned with high-resolution micro-CT before and after demineralization. Parameters like implant volume, surface area, and BIC were determined using specific software tools. During demineralization, the BIC changed about 6% for machined surface with anodizing, 5% for only etching, 4% for sandblasting with Al2O3 + etching, and 10% for sandblasting with TiO2 + etching. Demineralization reduced BIC percentages, notably in the machined surface with anodizing and sandblasting with TiO2 + etching groups. Etching and sandblasting combined with etching showed higher initial BIC compared to anodizing alone. Demineralization negatively impacted the BIC across all treatments. This study underscores the importance of surface modification in implant integration, especially in compromised bone. Further research with larger sample sizes and advanced techniques is recommended.

6 August 2024 in Biomedicines
Verified
Journal Article
Open access
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RZRafal Zielinski
Rafal Zielinski
AKAgata Kolkowska
Agata Kolkowska
JSJerzy Sowinski
Jerzy Sowinski
BKBartlomiej Konieczny
Bartlomiej Konieczny
Marcin KozakiewiczMarcin Kozakiewicz
Marcin Kozakiewicz
Wojciech SimkaWojciech Simka
Wojciech Simka
The newest technology allows the medical industry to manufacture innovative products such as milled titanium prosthodontic parts in an implant for a screw-retained suprastructure. In the literature, there are some articles on the clinical usage of subperiosteal implants, but none of these publications, either in PubMed or Google Scholar, thoroughly describe the workflow for the design and manufacture of individual implants for maxillofacial surgery with milled threads for a screw-retained prosthodontic bridge. The aim of the article is to present a step-by-step method of producing personalized implants, from the first steps of production to the implantation of the final product. The article includes information on patient qualification for surgery, computational preparation and skull printing, planning of Mai Implants®, meshing, 3D printing and milling, cleaning, rinsing, anodizing, and laser marking, as well as the cleaning and sterilization process in a hospital or dental clinic. A detailed description of implant production allows for the analysis of each step and the development of technology. The production of implants is an expensive procedure, but considering all the advantages of the Mai Implants® treatment and the disadvantages of alternatives, the product is worth the price.