The problem of tumour therapy has attracted the attention of many researchers for many decades. One of the promising strategies for the development of new dosage forms to improve oncology treatment efficacy and minimise side effects is the development of nanoparticle-based targeted transport systems for anticancer drugs. Among inorganic nanoparticles, mesoporous silica deserves special attention due to its outstanding surface properties and drug-loading capability. This review analyses the various factors affecting the cytotoxicity, cellular uptake, and biocompatibility of mesoporous silica nanoparticles (MSNs), constituting a key aspect in the development of safe and effective drug delivery systems. Special attention is paid to technological approaches to chemically modifying MSNs to alter their surface properties. The stimuli that regulate drug release from nanoparticles are also discussed, contributing to the effective control of the delivery process in the body. The findings emphasise the importance of modifying MSNs with different surface functional groups, bio-recognisable molecules, and polymers for their potential use in anticancer drug delivery systems.

This article presents a critical review of chemical and technological approaches to the production of composites based on recycled polyolefins using thermoplastic processing. The aim of the review is to identify the relationships between feedstock condition, changes during processing, interactions between components, and material propertie. The main focus is on recycled polyethylene and polypropylene, including mixed and multi-component waste. The influence of the origin, contaminants and thermomechanical history of the raw materials on processability is analysed. Chain scission, branching and cross-linking are examined, together with their effects on molecular-weight characteristics, crystallinity and rheological behaviour. Methods for stabilising polymers and modifying composites using fillers and compatibilisers are summarised. The roles of extrusion, co-extrusion, injection moulding, calendering and compression moulding are analysed. It is shown that the content of recycled polymer and the melt flow index, taken separately, are insufficient for predicting properties. Environmental, economic and regulatory aspects are considered. The need for an integrated ‘chemical changes – structure – technology – properties’ approach is justified; this approach enables the targeted formation of the structure and regulation of the performance characteristics of composites through the selection of composition, modifiers and processing conditions.

The article deals with the issue of course design management for university students of technical majors. The issue is related to the frequent notion that students do not come to the defense of their course projects on time. Similarly, to other types of independent student work, working on a course project develops creative thinking, teaches students how to solve professional problems, prepares them to preplan work and be responsible for the quality of its implementation. A violation of the work schedule and/or inability to independently complete a task accordingly is regularly observed in courses for various reasons. However, this problem indicates the under development of students' skills, such as responsibility, adaptability, independence, the ability to learn new things and find solutions in non-standard circumstances, precisely those skills that employers often find the most important. The article identifies several reasons for the mentioned problem, but the main attention is paid to planning students work, both from the instructor’s and students’ perspectives. In order to plan and control students’ time, it is proposed to apply principles of the critical chain method, which has proven its effectiveness in industry and can be useful in planning the independent work of students. Using the example of a hypothetical course project, the average distribution of curriculum time needed for solving the tasks related to the course project is shown. The time set in the curriculum is determined by the critical chain method as sufficient for working on a project. Careful planning of students' own work can allow them to complete a course project in a much shorter period of time, which eliminates the disruption of project defense deadlines.

В работе исследовано влияние различных УФ-стабилизаторов на физико-механические свойства полипропиленовых нитей, полотна и клапанно-коробчатых мешков, полученных методом экструзии с последующей ориентацией. Рассмотрены механизмы фотоокислительной деградации полимеров и принципы действия светостабилизаторов на основе стерически затруднённых аминов (HALS) и УФ-абсорберов. В качестве объектов исследования использованы три промышленных светостабилизатора, введённые в полипропиленовую композицию. Проведены испытания образцов до и после ускоренного УФ-старения (168 и 336 часов) с оценкой прочности, удлинения, линейной плотности и остаточной усадки. Установлено, что эффективность стабилизаторов существенно различается: наилучшую стойкость к фотодеструкции показал стабилизатор UV 5010 PE, тогда как POL PE 920052-UV обеспечил наибольшую технологическую стабильность переработки. Исследование влияния концентрации POL PE 920052-UV в диапазоне 1–2 % показало, что увеличение его содержания сопровождалось ростом линейной плотности и массы изделий, при этом относительное удлинение нити снижалось, а прочность сварного дна мешков уменьшалась. В исследованном диапазоне концентраций наилучшее сочетание показателей получено при содержании стабилизатора POL PE 920052-UV 1 %. Полученные результаты могут быть использованы при разработке и промышленном производстве полипропиленовой упаковочной продукции.