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Dr. Angela Tartaglia
University "G. d'Annunzio" of Chieti-Pescara; Dept. of Pharmacy, Via dei Vestini 31 - 66100 Chieti, Italy

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0 Method Development
0 HPLC
0 method validation
0 Analytical and bioanalytical chemistry
0 Hyphenated assay

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method validation

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Review
Published: 29 June 2021 in Pharmaceuticals
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Therapeutic drug monitoring (TDM) of antiseizure medications (ASMs) represents a valuable tool to establish an appropriate patient therapy, to collect important information about drugs’ interactions and to evaluate patient’s metabolic capabilities. In recent years, a new volumetric absorptive microsampling technique using VAMS® technology and Mitra® devices, consisting of a sampling technique for the collection of fixed-volume capillary blood, was developed. These new devices provide a new home-sampling technique for whole blood that has been spread out to simplify sample collection from finger-pricks. This review is aimed to compare published articles concerning the application of VAMS® in epilepsy and to identify the strengths and improvement points for the TDM of antiseizure medications. VAMS® allowed a minimally invasive blood sampling even in the absence of trained personnel. Good stability data have indicated that storage and delivery can be facilitated only for specific ASMs. Trueness and precision parameters have been evaluated, and the hematocrit (HCT) effect was minimized.

ACS Style

AnnaChiara D’Urso; Marcello Locatelli; Angela Tartaglia; Linda Molteni; Cristian D’Ovidio; Fabio Savini; James Rudge; Ugo de Grazia. Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We? Pharmaceuticals 2021, 14, 627 .

AMA Style

AnnaChiara D’Urso, Marcello Locatelli, Angela Tartaglia, Linda Molteni, Cristian D’Ovidio, Fabio Savini, James Rudge, Ugo de Grazia. Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We? Pharmaceuticals. 2021; 14 (7):627.

Chicago/Turabian Style

AnnaChiara D’Urso; Marcello Locatelli; Angela Tartaglia; Linda Molteni; Cristian D’Ovidio; Fabio Savini; James Rudge; Ugo de Grazia. 2021. "Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We?" Pharmaceuticals 14, no. 7: 627.

Review
Published: 28 May 2021 in Molecules
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Currently, forensic research is multidisciplinary with new methods and parameters useful to define the cause and time of death as well as survival/agony times. The identification of biochemical markers able to estimate agonal period has been studied by many forensic researchers. It is known that the estimation of agonal time in different types of death is not always easy, hence our interest in literature’s data. The studies analyzed in this review confirm the important role of thanatobiochemistry for the estimation of survival times. Regardless of the death cause, the survival/agony time between the primary event and death influences markers concentrations in biological samples (e.g., blood, urine, cerebrospinal fluid). Different biomarkers can be used for qualitative evaluations in deaths with short and long agony (e.g., C-reactive protein, ferritin, GFAP, etc.). Instead, the quantitative interpretation showed limits due to the lack of reference cut-offs. Thanatobiochemistry is a useful tool to confirm what emerged from autopsies findings (macroscopic and histological analysis), but further studies are desirable to confirm the evidence emerging from our review of the literature.

ACS Style

Enrica Rosato; Martina Bonelli; Marcello Locatelli; Ugo de Grazia; Angela Tartaglia; Fabio Savini; Cristian D'Ovidio. Forensic Biochemical Markers to Evaluate the Agonal Period: A Literature Review. Molecules 2021, 26, 3259 .

AMA Style

Enrica Rosato, Martina Bonelli, Marcello Locatelli, Ugo de Grazia, Angela Tartaglia, Fabio Savini, Cristian D'Ovidio. Forensic Biochemical Markers to Evaluate the Agonal Period: A Literature Review. Molecules. 2021; 26 (11):3259.

Chicago/Turabian Style

Enrica Rosato; Martina Bonelli; Marcello Locatelli; Ugo de Grazia; Angela Tartaglia; Fabio Savini; Cristian D'Ovidio. 2021. "Forensic Biochemical Markers to Evaluate the Agonal Period: A Literature Review." Molecules 26, no. 11: 3259.

Journal article
Published: 07 December 2020 in Molecules
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The increased risk of illness and disability is related to the age inevitable biological changes. Oxidative stress is a proposed mechanism for many age-related diseases. The crucial importance of polyphenol pharmacophore for aging process is largely described thanks to its effects on concentrations of reactive oxygen species. Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV) plays a critical role in slowing the aging process but has a poor bioavailabity after oral intake. In this present work, a series of RSV derivatives was designed, synthesized, and evaluated as potential antioxidant agents. These derivatives contain substituents with different electronic and steric properties in different positions of aromatic rings. This kind of substituents affects the activity and the bioavailability of these compounds compared with RSV used as reference compound. Studies of Log P values demonstrated that the introduction of halogens gives the optimum lipophilicity to be considered promising active agents. Among them, compound 6 showed the higher antioxidant activity than RSV. The presence of trifluoromethyl group together with a chlorine atom increased the antioxidant activity compared to RSV.

ACS Style

Ester Sara Di Filippo; Letizia Giampietro; Barbara De Filippis; Marwa Balaha; Vincenzo Ferrone; Marcello Locatelli; Tiziana Pietrangelo; Angela Tartaglia; Rosa Amoroso; Stefania Fulle. Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents. Molecules 2020, 25, 5770 .

AMA Style

Ester Sara Di Filippo, Letizia Giampietro, Barbara De Filippis, Marwa Balaha, Vincenzo Ferrone, Marcello Locatelli, Tiziana Pietrangelo, Angela Tartaglia, Rosa Amoroso, Stefania Fulle. Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents. Molecules. 2020; 25 (23):5770.

Chicago/Turabian Style

Ester Sara Di Filippo; Letizia Giampietro; Barbara De Filippis; Marwa Balaha; Vincenzo Ferrone; Marcello Locatelli; Tiziana Pietrangelo; Angela Tartaglia; Rosa Amoroso; Stefania Fulle. 2020. "Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents." Molecules 25, no. 23: 5770.

Review
Published: 30 October 2020 in Analytica
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Nowadays, the challenges in analytical chemistry, and mostly in quantitative analysis, include the development and validation of new materials, strategies and procedures to meet the growing need for rapid, sensitive, selective and green methods. In this context, considering the constantly updated International Guidelines, constant innovation is mandatory both in the pre-treatment procedures and in the instrumental configurations to obtain reliable, true, and reproducible information. In this context, additionally to the classic plasma (or serum) matrices, biopsies, whole blood, and urine have seen an increase in the works that also consider non-conventional matrices. Obviously, all these studies have shown that there is a correlation between the blood levels and those found in the new matrix, in order to be able to correlate and compare the results in a robust way and reduce any bias problems. This review provides an update of the most recent developments currently in use in the sample pre-treatment and instrument configurations in the biological/clinical fields. Furthermore, the review concludes with a series of considerations regarding the role and future developments of Analytical Chemistry in light of the forthcoming challenges and new goals to be achieved.

ACS Style

Giuseppe Merone; Angela Tartaglia; Marcello Locatelli; Cristian D’Ovidio; Enrica Rosato; Ugo De Grazia; Francesco Santavenere; Sandra Rossi; Fabio Savini. Analytical Chemistry in the 21st Century: Challenges, Solutions, and Future Perspectives of Complex Matrices Quantitative Analyses in Biological/Clinical Field. Analytica 2020, 1, 44 -59.

AMA Style

Giuseppe Merone, Angela Tartaglia, Marcello Locatelli, Cristian D’Ovidio, Enrica Rosato, Ugo De Grazia, Francesco Santavenere, Sandra Rossi, Fabio Savini. Analytical Chemistry in the 21st Century: Challenges, Solutions, and Future Perspectives of Complex Matrices Quantitative Analyses in Biological/Clinical Field. Analytica. 2020; 1 (1):44-59.

Chicago/Turabian Style

Giuseppe Merone; Angela Tartaglia; Marcello Locatelli; Cristian D’Ovidio; Enrica Rosato; Ugo De Grazia; Francesco Santavenere; Sandra Rossi; Fabio Savini. 2020. "Analytical Chemistry in the 21st Century: Challenges, Solutions, and Future Perspectives of Complex Matrices Quantitative Analyses in Biological/Clinical Field." Analytica 1, no. 1: 44-59.

Communication
Published: 29 June 2020 in Processes
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The current research work is an endeavor to study the chemical profiling and enzyme-inhibition potential of different polarity solvent (n-hexane, dichloromethane—DCM and methanol—MeOH) extracts from the aerial and stem parts of Buxus papillosa C.K. Schneid. All the extracts were analyzed for HPLC-PDA phenolic quantification, while both (aerial and stem) DCM extracts were studied for UHPLC-MS phytochemical composition. The inhibitory activity against the clinically important enzymes having crucial role in different pathologies like skin diseases (tyrosinase), inflammatory problems (lipoxygenase—LOX) and diabetes mellitus (α-amylase) were studied using standard in vitro bioassays. The DCM extracts upon UHPLC-MS analysis conducted in both negative and positive ionization modes has led to the tentative identification of 52 important secondary metabolites. Most of these belonged to the alkaloid, flavonoid, phenolic and triterpenoid classes. The HPLC-PDA polyphenolic quantification identified the presence of 10 phenolic compounds. Catechin was present in significant amounts in aerial-MeOH (7.62 ± 0.45 μg/g extract) and aerial-DCM (2.39 ± 0.51-μg/g extract) extracts. Similarly, higher amounts of epicatechin (2.76 ± 0.32-μg/g extract) and p-hydroxybenzoic acid (1.06 ± 0.21 μg/g extract) were quantified in aerial-DCM and stem-MeOH extracts, respectively. Likewise, all the extracts exhibited moderate inhibition against all the tested enzymes. These findings explain the wide usage of this plant in folklore medicine and suggest that it could be further studied as an origin of novel bioactive phytocompounds and for the designing of new pharmaceuticals.

ACS Style

Hammad Saleem; Thet Thet Htar; Rakesh Naidu; Gokhan Zengin; Marcello Locatelli; Angela Tartaglia; Syafiq Asnawi Zainal Abidin; Nafees Ahemad. Phytochemical Composition and Enzyme Inhibition Studies of Buxus papillosa C.K. Schneid. Processes 2020, 8, 757 .

AMA Style

Hammad Saleem, Thet Thet Htar, Rakesh Naidu, Gokhan Zengin, Marcello Locatelli, Angela Tartaglia, Syafiq Asnawi Zainal Abidin, Nafees Ahemad. Phytochemical Composition and Enzyme Inhibition Studies of Buxus papillosa C.K. Schneid. Processes. 2020; 8 (7):757.

Chicago/Turabian Style

Hammad Saleem; Thet Thet Htar; Rakesh Naidu; Gokhan Zengin; Marcello Locatelli; Angela Tartaglia; Syafiq Asnawi Zainal Abidin; Nafees Ahemad. 2020. "Phytochemical Composition and Enzyme Inhibition Studies of Buxus papillosa C.K. Schneid." Processes 8, no. 7: 757.

Journal article
Published: 12 June 2020 in Molecules
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Ethanol (ethylic alcohol) represents the most commonly used drug worldwide and is often involved in clinical and forensic toxicology. Based on several reports, excessive alcohol consumption is the main contributing factor in traffic accidents, drownings, suicides, and other crimes. For these reasons, it becomes essential to analyze the alcohol concentration during autopsy. Although blood is usually used for alcohol analysis in post-mortem cases, it could suffer alterations, putrefaction, and microbial contaminations. As an alternative to whole blood, vitreous humor has been successfully used in medico-legal studies. In this work, post-mortem specimens were analyzed for ethanol determination. The analysis of blood and vitreous humor were carried-out using gas chromatography-flame ionized detector (GC-FID) with a total run time of 6 min. The method was validated in terms of limit of detection, limit of quantification, dynamic range, sensibility, recovery, precision and trueness. A linear regression analysis indicated a coefficient of determination (R2) of 0.9981. The study confirmed no statistically differences between alcohol concentration in blood and vitreous humor, leading vitreous humor as an excellent matrix that could be used as an alternative to whole blood in toxicological analysis in cases where blood is not available.

ACS Style

Fabio Savini; Angela Tartaglia; Ludovica Coccia; Danilo Palestini; Cristian D’Ovidio; Ugo De Grazia; Giuseppe Maria Merone; Elisa Bassotti; Marcello Locatelli. Ethanol Determination in Post-Mortem Samples: Correlation between Blood and Vitreous Humor Concentration. Molecules 2020, 25, 1 .

AMA Style

Fabio Savini, Angela Tartaglia, Ludovica Coccia, Danilo Palestini, Cristian D’Ovidio, Ugo De Grazia, Giuseppe Maria Merone, Elisa Bassotti, Marcello Locatelli. Ethanol Determination in Post-Mortem Samples: Correlation between Blood and Vitreous Humor Concentration. Molecules. 2020; 25 (12):1.

Chicago/Turabian Style

Fabio Savini; Angela Tartaglia; Ludovica Coccia; Danilo Palestini; Cristian D’Ovidio; Ugo De Grazia; Giuseppe Maria Merone; Elisa Bassotti; Marcello Locatelli. 2020. "Ethanol Determination in Post-Mortem Samples: Correlation between Blood and Vitreous Humor Concentration." Molecules 25, no. 12: 1.

Journal article
Published: 28 May 2020 in Separations
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Recently, high demand of high-throughput analyses with high sensitivity and selectivity to molecules and drugs in different classes with different physical-chemical properties—and a reduction in analysis time—is a principal milestone for novel methodologies that researchers are trying to achieve—especially when analytical procedures are applied to clinical purposes. In addition, to avoid high doses of a single drug that could cause serious side effects, multi-drug therapies are often used to treat numerous diseases. For these reasons, the demand for methods that allow the rapid analysis of mixed compounds has increased in recent years. In order to respond to these needs, new methods and instruments have been developed. However, often the complexity of a matrix can require a long time for the preparation and processing of the samples. Different problems in terms of components, types of matrices, compounds and physical-chemical complexity are encountered when considering drugs association profiles for quantitative analyses. This review addresses not only recently optimized procedures such as chromatographic separation, but also methods that have allowed us to obtain accuracy (precision and trueness), sensitivity and selectivity in quantitative analyses for cases of drug associations.

ACS Style

Christian Celia; Luisa Di Marzio; Marcello Locatelli; Piera Ramundo; Francesca D’Ambrosio; Angela Tartaglia. Current Trends in Simultaneous Determination of Co-Administered Drugs. Separations 2020, 7, 1 .

AMA Style

Christian Celia, Luisa Di Marzio, Marcello Locatelli, Piera Ramundo, Francesca D’Ambrosio, Angela Tartaglia. Current Trends in Simultaneous Determination of Co-Administered Drugs. Separations. 2020; 7 (2):1.

Chicago/Turabian Style

Christian Celia; Luisa Di Marzio; Marcello Locatelli; Piera Ramundo; Francesca D’Ambrosio; Angela Tartaglia. 2020. "Current Trends in Simultaneous Determination of Co-Administered Drugs." Separations 7, no. 2: 1.

Journal article
Published: 06 March 2020 in Molecules
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Phenolic compounds are secondary metabolites that are found ubiquitously in plants, fruits, and vegetables. Many studies have shown that regular consumption of these compounds could have a positive effect on our health. The aim of this study was to compare the phytochemical contents of the water extracts from three different plants used as folk remedies in Turkey: Aesculus hippocastanum, Olea europaea, and Hypericum perforatum. A liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS) analysis was performed to explore the phenolic profiles. The biological activities of these extracts were also evaluated in terms of their antioxidant activities (2,2-diphenyl-1-picrylhydrazyl DPPH, 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid ABTS, Ferric Reducing Antioxidant Power Assay FRAP, cupric ion reducing antioxidant capacity CUPRAC, β-carotene, phosphomolybdenum, and metal chelating) and enzyme inhibitory properties (against acetylcholinesterase, butyrylcholinesterase, and tyrosinase). The aqueous extract of H. perforatum showed the highest levels of total phenolic, flavonoid, and saponin contents. Protocatechuic acid, vanillic acid, verbascoside, hesperidin, hyperoside, apigenin 7-hexosides, and quercetin were the most common compounds found in this species. The results confirm that A. hippocastanum, O. europaea, and H. perforatum represent a potential source of natural-derived molecules with positive properties that could be used as valid starting point for new food supplements, and drugs in the pharmaceutical, cosmetic, and food industries.

ACS Style

Cengiz Sarikurkcu; Marcello Locatelli; Angela Tartaglia; Vincenzo Ferrone; Aleksandra M. Juszczak; Mehmet Sabih Ozer; Bektas Tepe; Michał Tomczyk. Enzyme and Biological Activities of the Water Extracts from the Plants Aesculus hippocastanum, Olea europaea and Hypericum perforatum That Are Used as Folk Remedies in Turkey. Molecules 2020, 25, 1202 .

AMA Style

Cengiz Sarikurkcu, Marcello Locatelli, Angela Tartaglia, Vincenzo Ferrone, Aleksandra M. Juszczak, Mehmet Sabih Ozer, Bektas Tepe, Michał Tomczyk. Enzyme and Biological Activities of the Water Extracts from the Plants Aesculus hippocastanum, Olea europaea and Hypericum perforatum That Are Used as Folk Remedies in Turkey. Molecules. 2020; 25 (5):1202.

Chicago/Turabian Style

Cengiz Sarikurkcu; Marcello Locatelli; Angela Tartaglia; Vincenzo Ferrone; Aleksandra M. Juszczak; Mehmet Sabih Ozer; Bektas Tepe; Michał Tomczyk. 2020. "Enzyme and Biological Activities of the Water Extracts from the Plants Aesculus hippocastanum, Olea europaea and Hypericum perforatum That Are Used as Folk Remedies in Turkey." Molecules 25, no. 5: 1202.

Journal article
Published: 13 September 2019 in Molecules
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In this work, the synthesis, characterization, and application of novel parabens imprinted polymers as highly selective solid-phase extraction (SPE) sorbents have been reported. The imprinted polymers were created using sol–gel molecular imprinting process. All the seven parabens were considered herein in order to check the phase selectivity. By means of a validated HPLC-photodiode array detector (PDA) method all seven parabens were resolved in a single chromatographic run of 25 min. These SPE sorbents, in-house packed in SPE empty cartridges, were first characterized in terms of extraction capability, breakthrough volume, retention volume, hold-up volume, number of theoretical plates, and retention factor. Finally, the device was applied to a real urine sample to check the method feasibility on a very complex matrix. The new paraben imprinted SPE sorbents, not yet present in the literature, potentially encourage the development of novel molecularly imprinted polymers (MIPs) to enhance the extraction efficiency, and consequently the overall analytical performances, when the trace quantification is required.

ACS Style

Angela Tartaglia; Abuzar Kabir; Songul Ulusoy; Halil Ibrahim Ulusoy; Giuseppe Maria Merone; Fabio Savini; Cristian D’Ovidio; Ugo De Grazia; Serena Gabrielli; Fabio Maroni; Pantaleone Bruni; Fausto Croce; Dora Melucci; Kenneth G. Furton; Marcello Locatelli. Novel MIPs-Parabens based SPE Stationary Phases Characterization and Application. Molecules 2019, 24, 3334 .

AMA Style

Angela Tartaglia, Abuzar Kabir, Songul Ulusoy, Halil Ibrahim Ulusoy, Giuseppe Maria Merone, Fabio Savini, Cristian D’Ovidio, Ugo De Grazia, Serena Gabrielli, Fabio Maroni, Pantaleone Bruni, Fausto Croce, Dora Melucci, Kenneth G. Furton, Marcello Locatelli. Novel MIPs-Parabens based SPE Stationary Phases Characterization and Application. Molecules. 2019; 24 (18):3334.

Chicago/Turabian Style

Angela Tartaglia; Abuzar Kabir; Songul Ulusoy; Halil Ibrahim Ulusoy; Giuseppe Maria Merone; Fabio Savini; Cristian D’Ovidio; Ugo De Grazia; Serena Gabrielli; Fabio Maroni; Pantaleone Bruni; Fausto Croce; Dora Melucci; Kenneth G. Furton; Marcello Locatelli. 2019. "Novel MIPs-Parabens based SPE Stationary Phases Characterization and Application." Molecules 24, no. 18: 3334.

Journal article
Published: 14 August 2019 in Biomolecules
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The Lamiaceae family comprises many flowering plants classified into about 236 genera. The genus Ziziphora is one of the well-known genera of this family and its species are important in different fields of pharmaceutical, chemical, traditional, and folk medicines. The phytochemicals present in Ziziphora include monoterpenic essential oils, triterpenes, and phenolic substances. The aim of this paper was to study the phytochemical profile of Ziziphora taurica subsp. taurica and compare and evaluate the biological activities of its ethyl acetate (ZTT-EtOAc), methanolic (ZTT-MeOH), and aqueous (ZTT-W) extracts based on their enzyme inhibition and antioxidant capacities. Determination of total phenolic (TPC) and total flavonoid (TFC) contents as well as biological activities were determined using spectrophotometric procedures. Subsequently, the individual phenolic compounds were detected by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). In total, twenty-two different phenolic compounds were identified, including apigenin, ferulic acid, and luteolin which were the most common. ZTT-MeOH extract showed the best antioxidant activity, whereas ZTT-EtOAc extract was the most effective against tyrosinase and α-amylase. Ziziphora taurica subsp. taurica represents a potential source of natural compounds with positive effects on human health.

ACS Style

Michał Tomczyk; Olcay Ceylan; Marcello Locatelli; Angela Tartaglia; Vincenzo Ferrone; Cengiz Sarikurkcu. Ziziphora taurica subsp. taurica: Analytical Characterization and Biological Activities. Biomolecules 2019, 9, 367 .

AMA Style

Michał Tomczyk, Olcay Ceylan, Marcello Locatelli, Angela Tartaglia, Vincenzo Ferrone, Cengiz Sarikurkcu. Ziziphora taurica subsp. taurica: Analytical Characterization and Biological Activities. Biomolecules. 2019; 9 (8):367.

Chicago/Turabian Style

Michał Tomczyk; Olcay Ceylan; Marcello Locatelli; Angela Tartaglia; Vincenzo Ferrone; Cengiz Sarikurkcu. 2019. "Ziziphora taurica subsp. taurica: Analytical Characterization and Biological Activities." Biomolecules 9, no. 8: 367.

Journal article
Published: 28 March 2019 in Molecules
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Background: Galium is a plant rich in iridoid glycosides, flavonoids, anthraquinones, and small amounts of essential oils and vitamin C. Recent works showed the antibacterial, antifungal, antiparasitic, and antioxidant activity of this plant genus. Methods: For the determination of the multicomponent phenolic pattern, liquid phase microextraction procedures were applied, combined with HPLC-PDA instrument configuration in five Galium species aerial parts (G.verum, G. album, G.rivale, G.pseudoaristatum, and G. purpureum). Dispersive Liquid⁻Liquid MicroExtraction (DLLME) with NaCl and NAtural Deep Eutectic Solvent (NADES) medium and Ultrasound-Assisted (UA)-DLLME with β-cyclodextrin medium were optimized. Results: The optimal DLLME conditions were found to be: 10 mg of the sample, 10% NaCl, 15% NADES or 1% β-cyclodextrin as extraction solvent-400 μL of ethyl acetate as dispersive solvent-300 μL of ethanol, vortex time-30 s, extraction time-1 min, centrifugation at 12000× g for 5 min. Conclusions: These results were compared with microwave-assisted extraction procedures. G. purpureum and G.verum extracts showed the highest total phenolic and flavonoid content, respectively. The most potent extract in terms of antioxidant capacity was obtained from G. purpureum, whereas the extract obtained from G. album exhibited the strongest inhibitory effect against tyrosinase.

ACS Style

Andrei Mocan; Alina Diuzheva; Sabin Bădărău; Cadmiel Moldovan; Vasil Andruch; Simone Carradori; Cristina Campestre; Angela Tartaglia; Marta De Simone; Dan Vodnar; Matteo Tiecco; Raimondo Germani; Gianina Crișan; Marcello Locatelli. Liquid Phase and Microwave-Assisted Extractions for Multicomponent Phenolic Pattern Determination of Five Romanian Galium Species Coupled with Bioassays. Molecules 2019, 24, 1226 .

AMA Style

Andrei Mocan, Alina Diuzheva, Sabin Bădărău, Cadmiel Moldovan, Vasil Andruch, Simone Carradori, Cristina Campestre, Angela Tartaglia, Marta De Simone, Dan Vodnar, Matteo Tiecco, Raimondo Germani, Gianina Crișan, Marcello Locatelli. Liquid Phase and Microwave-Assisted Extractions for Multicomponent Phenolic Pattern Determination of Five Romanian Galium Species Coupled with Bioassays. Molecules. 2019; 24 (7):1226.

Chicago/Turabian Style

Andrei Mocan; Alina Diuzheva; Sabin Bădărău; Cadmiel Moldovan; Vasil Andruch; Simone Carradori; Cristina Campestre; Angela Tartaglia; Marta De Simone; Dan Vodnar; Matteo Tiecco; Raimondo Germani; Gianina Crișan; Marcello Locatelli. 2019. "Liquid Phase and Microwave-Assisted Extractions for Multicomponent Phenolic Pattern Determination of Five Romanian Galium Species Coupled with Bioassays." Molecules 24, no. 7: 1226.

Journal article
Published: 22 January 2019 in Molecules
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This paper reports the performance comparison between the exhaustive and equilibrium extraction using classical Avantor C18 solid phase extraction (SPE) sorbent, hydrophilic-lipophilic balance (HLB) SPE sorbent, Sep-Pak C18 SPE sorbent, novel sol-gel Carbowax 20M (sol-gel CW 20M) SPE sorbent, and sol-gel CW 20M coated fabric phase sorptive extraction (FPSE) media for the simultaneous extraction and analysis of three inflammatory bowel disease (IBD) drugs that possess logP values (polarity) ranging from 1.66 for cortisone, 2.30 for ciprofloxacin, and 2.92 for sulfasalazine. Both the commercial SPE phases and in-house synthesized sol-gel CW 20M SPE phases were loaded in SPE cartridges and the extractions were carried out under an exhaustive extraction mode. FPSE was carried out under an equilibrium extraction mode. The drug compounds were resolved using a Luna C18 column (250 mm × 4.6 mm; 5 m particle size) in gradient elution mode within 20 min and the method was validated in compliance with international guidelines for the bioanalytical method validation. Novel in-house synthesized and loaded sol-gel CW 20M SPE sorbent cartridges were characterized in terms of their extraction capability, breakthrough volume, retention volume, hold-up volume, number of the theoretical plate, and the retention factor.

ACS Style

Angela Tartaglia; Marcello Locatelli; Abuzar Kabir; Kenneth G. Furton; Daniela Macerola; Elena Sperandio; Silvia Piccolantonio; Halil I. Ulusoy; Fabio Maroni; Pantaleone Bruni; Fausto Croce; Victoria F. Samanidou. Comparison between Exhaustive and Equilibrium Extraction Using Different SPE Sorbents and Sol-Gel Carbowax 20M Coated FPSE Media. Molecules 2019, 24, 382 .

AMA Style

Angela Tartaglia, Marcello Locatelli, Abuzar Kabir, Kenneth G. Furton, Daniela Macerola, Elena Sperandio, Silvia Piccolantonio, Halil I. Ulusoy, Fabio Maroni, Pantaleone Bruni, Fausto Croce, Victoria F. Samanidou. Comparison between Exhaustive and Equilibrium Extraction Using Different SPE Sorbents and Sol-Gel Carbowax 20M Coated FPSE Media. Molecules. 2019; 24 (3):382.

Chicago/Turabian Style

Angela Tartaglia; Marcello Locatelli; Abuzar Kabir; Kenneth G. Furton; Daniela Macerola; Elena Sperandio; Silvia Piccolantonio; Halil I. Ulusoy; Fabio Maroni; Pantaleone Bruni; Fausto Croce; Victoria F. Samanidou. 2019. "Comparison between Exhaustive and Equilibrium Extraction Using Different SPE Sorbents and Sol-Gel Carbowax 20M Coated FPSE Media." Molecules 24, no. 3: 382.