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Dr. Andrei-Marius Mocan
Department of Pharmaceutical Botany, Iuliu Hațieganu University of Medicine and Pharmacy, 23 Ghe. Marinescu Street, Cluj-Napoca 400337, Romania

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Research Keywords & Expertise

0 Pharmaceutical biology (botany)
0 Valorization of traditional medicinal and edible plants and fungi
0 Extraction optimization of bioactive compounds from plant materials
0 Experimental design applied to extraction and process optimization
0 Bioactivity and chemical characterization of natural products, development of new nutraceuticals based on medicinal plants and fungi, natural products as enzyme inhibitors

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Extraction optimization of bioactive compounds from plant materials

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Journal article
Published: 22 July 2021 in Molecules
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Prunus mahaleb L. fruit has long been used in the production of traditional liqueurs. The fruit also displayed scavenging and reducing activity, in vitro. The present study focused on unravelling peripheral and central protective effects, antimicrobial but also anti-COVID-19 properties exerted by the water extract of P. mahaleb. Anti-inflammatory effects were studied in isolated mouse colons exposed to lipopolysaccharide. Neuroprotection, measured as a blunting effect on hydrogen-peroxide-induced dopamine turnover, was investigated in hypothalamic HypoE22 cells. Antimicrobial effects were tested against different Gram+ and Gram- bacterial strains. Whereas anti-COVID-19 activity was studied in lung adenocarcinoma H1299 cells, where the gene expression of ACE2 and TMPRSS2 was measured after extract treatment. The bacteriostatic effects induced on Gram+ and Gram- strains, together with the inhibition of COX-2, TNFα, HIF1α, and VEGFA in the colon, suggest the potential of P. mahaleb water extract in contrasting the clinical symptoms related to ulcerative colitis. The inhibition of the hydrogen peroxide-induced DOPAC/DA ratio indicates promising neuroprotective effects. Finally, the downregulation of the gene expression of ACE2 and TMPRSS2 in H1299 cells, suggests the potential to inhibit SARS-CoV-2 virus entry in the human host. Overall, the results support the valorization of the local cultivation of P. mahaleb.

ACS Style

Giustino Orlando; Annalisa Chiavaroli; Sabrina Adorisio; Domenico Delfino; Luigi Brunetti; Lucia Recinella; Sheila Leone; Gokhan Zengin; Alessandra Acquaviva; Paola Angelini; Giancarlo Flores; Roberto Venanzoni; Simonetta Di Simone; Francesca Di Corpo; Andrei Mocan; Luigi Menghini; Claudio Ferrante. Unravelling the Phytochemical Composition and the Pharmacological Properties of an Optimized Extract from the Fruit from Prunus mahaleb L.: From Traditional Liqueur Market to the Pharmacy Shelf. Molecules 2021, 26, 4422 .

AMA Style

Giustino Orlando, Annalisa Chiavaroli, Sabrina Adorisio, Domenico Delfino, Luigi Brunetti, Lucia Recinella, Sheila Leone, Gokhan Zengin, Alessandra Acquaviva, Paola Angelini, Giancarlo Flores, Roberto Venanzoni, Simonetta Di Simone, Francesca Di Corpo, Andrei Mocan, Luigi Menghini, Claudio Ferrante. Unravelling the Phytochemical Composition and the Pharmacological Properties of an Optimized Extract from the Fruit from Prunus mahaleb L.: From Traditional Liqueur Market to the Pharmacy Shelf. Molecules. 2021; 26 (15):4422.

Chicago/Turabian Style

Giustino Orlando; Annalisa Chiavaroli; Sabrina Adorisio; Domenico Delfino; Luigi Brunetti; Lucia Recinella; Sheila Leone; Gokhan Zengin; Alessandra Acquaviva; Paola Angelini; Giancarlo Flores; Roberto Venanzoni; Simonetta Di Simone; Francesca Di Corpo; Andrei Mocan; Luigi Menghini; Claudio Ferrante. 2021. "Unravelling the Phytochemical Composition and the Pharmacological Properties of an Optimized Extract from the Fruit from Prunus mahaleb L.: From Traditional Liqueur Market to the Pharmacy Shelf." Molecules 26, no. 15: 4422.

Pharmacology
Published: 11 May 2021 in Frontiers in Pharmacology
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Cherry stems (CS) represent a by-product intensively used in Eastern European countries as a traditional remedy for urinary tract disorders. Ethnopharmacological evidences sustain the use of CS as aqueous preparations (infusion and decoction), but few data were previously reported about phytochemical profile and pharmacological potential of CS hydroalcoholic extracts. In this regard, we aimed to evaluate the phenolic profile, in vitro antioxidant and tyrosinase inhibitory potential, and in vivo diuretic activity of 70% hydroethanolic cherry stems extract and cherry stems decoction (CSD). LC-DAD-ESI/MSn analysis revealed the presence of flavonoid-type compounds as main constituents for both preparations, especially flavanones (naringenin glycosides). Antioxidant activity evaluated through DPPH, ABTS, and FRAP methods was superior for cherry stems extract, probably due to the presence of phenolic-derived compounds in higher amounts than CSD. On the other hand, tyrosinase inhibitory potential and diuretic effect exerted by CSD were stronger, highlighting that other types of hydrophilic secondary metabolites are responsible for this bioactivity. Overall, our findings indicate that CS preparations could be used as promising mild diuretic agents and encourage further investigations regarding the correlation between their chemical composition and bioactive potential.

ACS Style

Mihai Babotă; Oliviu Voştinaru; Ramona Păltinean; Cosmin Mihali; Maria Inês Dias; Lillian Barros; Isabel C. F. R. Ferreira; Andrei Mocan; Ovidiu Crişan; Cristina Nicula; Gianina Crişan. Chemical Composition, Diuretic, and Antityrosinase Activity of Traditionally Used Romanian Cerasorum stipites. Frontiers in Pharmacology 2021, 12, 1 .

AMA Style

Mihai Babotă, Oliviu Voştinaru, Ramona Păltinean, Cosmin Mihali, Maria Inês Dias, Lillian Barros, Isabel C. F. R. Ferreira, Andrei Mocan, Ovidiu Crişan, Cristina Nicula, Gianina Crişan. Chemical Composition, Diuretic, and Antityrosinase Activity of Traditionally Used Romanian Cerasorum stipites. Frontiers in Pharmacology. 2021; 12 ():1.

Chicago/Turabian Style

Mihai Babotă; Oliviu Voştinaru; Ramona Păltinean; Cosmin Mihali; Maria Inês Dias; Lillian Barros; Isabel C. F. R. Ferreira; Andrei Mocan; Ovidiu Crişan; Cristina Nicula; Gianina Crişan. 2021. "Chemical Composition, Diuretic, and Antityrosinase Activity of Traditionally Used Romanian Cerasorum stipites." Frontiers in Pharmacology 12, no. : 1.

Paper
Published: 09 March 2021 in Food & Function
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The main goal of our work was to establish the optimal parameters for the drying process of rosehip and sea buckthorn fruits, in order to enhance the recovery of bioactive compounds from these vegetal matrices.

ACS Style

Cadmiel Moldovan; Mihai Babotă; Andrei Mocan; Luigi Menghini; Stefania Cesa; Alexandru Gavan; Cristian Sisea; Dan C. Vodnar; Maria Inês Dias; Carla Pereira; Isabel C. F. R. Ferreira; Gianina Crişan; Lillian Barros. Optimization of the drying process of autumn fruits rich in antioxidants: a study focusing on rosehip (Rosa canina L.) and sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) and their bioactive properties. Food & Function 2021, 12, 3939 -3953.

AMA Style

Cadmiel Moldovan, Mihai Babotă, Andrei Mocan, Luigi Menghini, Stefania Cesa, Alexandru Gavan, Cristian Sisea, Dan C. Vodnar, Maria Inês Dias, Carla Pereira, Isabel C. F. R. Ferreira, Gianina Crişan, Lillian Barros. Optimization of the drying process of autumn fruits rich in antioxidants: a study focusing on rosehip (Rosa canina L.) and sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) and their bioactive properties. Food & Function. 2021; 12 (9):3939-3953.

Chicago/Turabian Style

Cadmiel Moldovan; Mihai Babotă; Andrei Mocan; Luigi Menghini; Stefania Cesa; Alexandru Gavan; Cristian Sisea; Dan C. Vodnar; Maria Inês Dias; Carla Pereira; Isabel C. F. R. Ferreira; Gianina Crişan; Lillian Barros. 2021. "Optimization of the drying process of autumn fruits rich in antioxidants: a study focusing on rosehip (Rosa canina L.) and sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) and their bioactive properties." Food & Function 12, no. 9: 3939-3953.

Journal article
Published: 22 February 2021 in Foods
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The chemical composition and biological properties correlation in several medicinal and aromatic plants is still underexplored, especially in its most common form of consumption as tisane. The present study aims to characterize the organic acids and vitamin E composition of five tisanes and their extracts by High-Performance Liquid Chromatography coupled to a diode-array detector (HPLC-DAD) and HPLC coupled to a fluorescence detector techniques, respectively, and the phenolic composition by HPLC-DAD-ESI/MS (mass spectrometry by electrospray ionization). It also focuses on their bioactive properties, namely antioxidant, antimicrobial, anti-inflammatory, cytotoxic, anti-tyrosinase, and anti-diabetic activities. A Principal Component Analysis (PCA) was performed in order to understand the correlation between the chemical composition and bioactive properties of the tisanes. The tisane 5 (T5) composed by lemon thyme, tutsan, cloves, and cinnamon, was the most promising mixture, presenting the lowest values for the lipid peroxidation inhibition, anti-inflammatory, and anti-diabetic activity. It also presented the highest concentration of phenolic acids (caffeoylquinic acids derivatives), and flavan-3-ols (catechin derivatives). Only the dry plants presented tocopherols. For the antihemolytic, antimicrobial, and cytotoxic activity, T2 and T4 (with lemon thyme) were highlighted as the best herbal mixtures. The PCA proved to be a valid tool to select the most promising tisane according to the bioactivity. These results suggest that the studied tisanes can be source of high added-value bioactive compounds with health-promoting effects and potential for application in the food and nutraceutical industries, among others.

ACS Style

Beatriz Paschoalinotto; Maria Dias; José Pinela; Tânia Pires; Maria Alves; Andrei Mocan; Ricardo Calhelha; Lillian Barros; Rafael Ineu; Isabel Ferreira. Phytochemical Characterization and Evaluation of Bioactive Properties of Tisanes Prepared from Promising Medicinal and Aromatic Plants. Foods 2021, 10, 475 .

AMA Style

Beatriz Paschoalinotto, Maria Dias, José Pinela, Tânia Pires, Maria Alves, Andrei Mocan, Ricardo Calhelha, Lillian Barros, Rafael Ineu, Isabel Ferreira. Phytochemical Characterization and Evaluation of Bioactive Properties of Tisanes Prepared from Promising Medicinal and Aromatic Plants. Foods. 2021; 10 (2):475.

Chicago/Turabian Style

Beatriz Paschoalinotto; Maria Dias; José Pinela; Tânia Pires; Maria Alves; Andrei Mocan; Ricardo Calhelha; Lillian Barros; Rafael Ineu; Isabel Ferreira. 2021. "Phytochemical Characterization and Evaluation of Bioactive Properties of Tisanes Prepared from Promising Medicinal and Aromatic Plants." Foods 10, no. 2: 475.

Journal article
Published: 11 January 2021 in Molecules
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The concern for implementing bioactive nutraceuticals in antioxidant-related therapies is of great importance for skin homeostasis in benign or malignant diseases. In order to elucidate some novel insights of Lycium barbarum (Goji berry) activity on skin cells, the present study focused on its active compound zeaxanthin. By targeting the stemness markers CD44 and CD105, with deep implications in skin oxidative stress mechanisms, we revealed, for the first time, selectivity in zeaxanthin activity. When applied in vitro on BJ human fibroblast cell line versus the A375 malignant melanoma cells, despite the moderate cytotoxicity, the zeaxanthin-rich extracts 1 and 2 were able to downregulate significantly the CD44 and CD105 membrane expression and extracellular secretion in A375, and to upregulate them in BJ cells. At mechanistic level, the present study is the first to demonstrate that the zeaxanthin-rich Goji extracts are able to influence selectively the mitogen-activated protein kinases (MAPK): ERK, JNK and p38 in normal BJ versus tumor-derived A375 skin cells. These results point out towards the applications of zeaxanthin from L. barbarum as a cytoprotective agent in normal skin and raises questions about its use as an antitumor prodrug alone or in combination with standard therapy.

ACS Style

Diana Cenariu; Eva Fischer-Fodor; Adrian Bogdan Țigu; Andrea Bunea; Piroska Virág; Maria Perde-Schrepler; Vlad-Alexandru Toma; Andrei Mocan; Ioana Berindan-Neagoe; Adela Pintea; Gianina Crișan; Mihai Cenariu; Alma Maniu. Zeaxanthin-Rich Extract from Superfood Lycium barbarum Selectively Modulates the Cellular Adhesion and MAPK Signaling in Melanoma versus Normal Skin Cells In Vitro. Molecules 2021, 26, 333 .

AMA Style

Diana Cenariu, Eva Fischer-Fodor, Adrian Bogdan Țigu, Andrea Bunea, Piroska Virág, Maria Perde-Schrepler, Vlad-Alexandru Toma, Andrei Mocan, Ioana Berindan-Neagoe, Adela Pintea, Gianina Crișan, Mihai Cenariu, Alma Maniu. Zeaxanthin-Rich Extract from Superfood Lycium barbarum Selectively Modulates the Cellular Adhesion and MAPK Signaling in Melanoma versus Normal Skin Cells In Vitro. Molecules. 2021; 26 (2):333.

Chicago/Turabian Style

Diana Cenariu; Eva Fischer-Fodor; Adrian Bogdan Țigu; Andrea Bunea; Piroska Virág; Maria Perde-Schrepler; Vlad-Alexandru Toma; Andrei Mocan; Ioana Berindan-Neagoe; Adela Pintea; Gianina Crișan; Mihai Cenariu; Alma Maniu. 2021. "Zeaxanthin-Rich Extract from Superfood Lycium barbarum Selectively Modulates the Cellular Adhesion and MAPK Signaling in Melanoma versus Normal Skin Cells In Vitro." Molecules 26, no. 2: 333.

Journal article
Published: 14 December 2020 in Current Molecular Pharmacology
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Background: Substances present in nature have been a continuous source for the development of drugs for cardiovascular and infectious diseases, cancer, and many other diseases. As the literature concerning these natural products grows, it becomes more difficult for a reader to quickly grasp the essential facts and develop a well-informed impression of this field of research. Until now, it has also been difficult to determine which natural products and research objectives were receiving the most attention as measured by number of citations. Objective: The current study of all published articles concerned with natural products sought to identify which natural products and which research objectives are connected with the major contributors to scientific journals based on the number of relevant publications and the number of times each publication was cited elsewhere. Methods: Bibliometric data, including citation data, were extracted from the Web of Science database using the search string TS=(“natural product*)” and analyzed by the VOSviewer software. Results: The search yielded 63,194 articles, with more than half of the manuscripts published since 2012. The ratio of original articles to reviews was 5.8:1. The major contributing countries were the United States, China, Germany, Japan, and India. Articles were published mainly in journals focused on chemistry, pharmacology or biochemistry. Curcumin, resveratrol, and terpenoids were the most frequently cited natural products. Conclusion: The results of the current study provide researchers from different backgrounds and healthcare professionals with a brief overview of the major trends in natural-product research in the form of a citation-based summary of the relevant literature.

ACS Style

Andy Wai Kan Yeung; Andrei Mocan; Nikolay T. Tzvetkov; Karel Šmejkal; Elke H. Heiss; Atanas G. Atanasov. Natural products, the continuous source of therapeutic molecules for various diseases: literature landscape analysis. Current Molecular Pharmacology 2020, 13, 1 -11.

AMA Style

Andy Wai Kan Yeung, Andrei Mocan, Nikolay T. Tzvetkov, Karel Šmejkal, Elke H. Heiss, Atanas G. Atanasov. Natural products, the continuous source of therapeutic molecules for various diseases: literature landscape analysis. Current Molecular Pharmacology. 2020; 13 ():1-11.

Chicago/Turabian Style

Andy Wai Kan Yeung; Andrei Mocan; Nikolay T. Tzvetkov; Karel Šmejkal; Elke H. Heiss; Atanas G. Atanasov. 2020. "Natural products, the continuous source of therapeutic molecules for various diseases: literature landscape analysis." Current Molecular Pharmacology 13, no. : 1-11.

Journal article
Published: 12 September 2020 in Plants
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Blueberries have seen an ascending production line boosted by World Health Organization (WHO) approvals for their contributions to a healthy diet and the evidence that they act against different diseases. This increase resulted in significant amounts of discarded leaves, which could be a valuable source of bioactive compounds. In the present study, ultrasound-assisted extraction technology was used to determine and compare the chemical and biological profiles of leaves from six commercial blueberry (Vaccinium corymbosum L.) varieties. Feruloylquinic acid was the major compound identified, ranging from 19.23 ± 0.18 mg/g (at the lowest level, registered in the Spartan variety) to 49.62 ± 0.41 mg/g (at the highest level, registered in the Nelson variety). Rutin was the second major compound identified, for which Toro, Nelson, and Elliot leaves registered the highest values, with 35.77 ± 0.19 mg/g, 32.50 ± 0.20 mg/g, and 31.53 ± 0.1 mg/g, respectively. Even though analogous polyphenols were detected in the six cultivars, their concentrations and amounts were different. The leaf extracts of the cultivars Toro, Elliot, and Nelson appear to be good sources of antioxidants, registering high percentage inhibitions of DPPH radicals, of 70.41%, 68.42%, and 58.69%, respectively. The blueberry leaf extracts had a strong antibacterial activity and a low antifungal capacity, and a low-to-moderate antimutagenic capacity towards Salmonella typhimurium TA98 and TA100 strains, with Toro leaf being the best candidate. All of these biological activities indicate health-related benefits, recommending them as suitable candidates for medical and pharmaceutical applications. The present paper adds significant knowledge to the field of blueberry leaves via chemical and biological profiles, supporting the ultrasound-assisted extraction technique as a useful and green method to provide alternative sources of bioactive compounds.

ACS Style

Bianca-Eugenia Ștefănescu; Lavinia Florina Călinoiu; Floricuța Ranga; Florinela Fetea; Andrei Mocan; Dan Cristian Vodnar; Gianina Crișan. The Chemical and Biological Profiles of Leaves from Commercial Blueberry Varieties. Plants 2020, 9, 1193 .

AMA Style

Bianca-Eugenia Ștefănescu, Lavinia Florina Călinoiu, Floricuța Ranga, Florinela Fetea, Andrei Mocan, Dan Cristian Vodnar, Gianina Crișan. The Chemical and Biological Profiles of Leaves from Commercial Blueberry Varieties. Plants. 2020; 9 (9):1193.

Chicago/Turabian Style

Bianca-Eugenia Ștefănescu; Lavinia Florina Călinoiu; Floricuța Ranga; Florinela Fetea; Andrei Mocan; Dan Cristian Vodnar; Gianina Crișan. 2020. "The Chemical and Biological Profiles of Leaves from Commercial Blueberry Varieties." Plants 9, no. 9: 1193.

Journal article
Published: 17 July 2020 in Antioxidants
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Strawberries belonging to cultivar Clery (Fragaria x ananassa (Duchesne ex Weston)), cultivated in central Italy were subjected to a multi-methodological experimental study. Fresh and defrosted strawberries were exposed to different processing methods, such as homogenization, thermal and microwave treatments. The homogenate samples were submitted to CIEL*a*b* color analysis and Head-Space GC/MS analysis to determine the impact of these procedures on phytochemical composition. Furthermore, the corresponding strawberry hydroalcoholic extracts were further analyzed by HPLC-DAD for secondary metabolites quantification and by means of spectrophotometric in vitro assays to evaluate their total phenolic and total flavonoid contents and antioxidant activity. These chemical investigations confirmed the richness in bioactive metabolites supporting the extraordinary healthy potential of this fruit as a food ingredient, as well as functional food, highlighting the strong influence of the processing steps which could negatively impact on the polyphenol composition. Despite a more brilliant red color and aroma preservation, non-pasteurized samples were characterized by a lower content of polyphenols and antioxidant activity with respect to pasteurized samples, as also suggested by the PCA analysis of the collected data.

ACS Style

Stefania Garzoli; Francesco Cairone; Simone Carradori; Andrei Mocan; Luigi Menghini; Patrizia Paolicelli; Gunes Ak; Gokhan Zengin; Stefania Cesa. Effects of Processing on Polyphenolic and Volatile Composition and Fruit Quality of Clery Strawberries. Antioxidants 2020, 9, 632 .

AMA Style

Stefania Garzoli, Francesco Cairone, Simone Carradori, Andrei Mocan, Luigi Menghini, Patrizia Paolicelli, Gunes Ak, Gokhan Zengin, Stefania Cesa. Effects of Processing on Polyphenolic and Volatile Composition and Fruit Quality of Clery Strawberries. Antioxidants. 2020; 9 (7):632.

Chicago/Turabian Style

Stefania Garzoli; Francesco Cairone; Simone Carradori; Andrei Mocan; Luigi Menghini; Patrizia Paolicelli; Gunes Ak; Gokhan Zengin; Stefania Cesa. 2020. "Effects of Processing on Polyphenolic and Volatile Composition and Fruit Quality of Clery Strawberries." Antioxidants 9, no. 7: 632.

Journal article
Published: 05 June 2020 in Antioxidants
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This study was performed to evaluate and compare the in vitro antioxidant, antimicrobial, and antimutagenic activities, and the polyphenolic content of the Nord-West Romanian wild bilberry (Vaccinium myrtillus L.) and lingonberry (Vaccinium vitis-idaea L.) leaves from three different natural habitats (Smida, Turda, Borsa). In the case of both species, the flavanols level was higher in Smida habitat (altitude 1100 m), whereas quercetin derivates were more abundant in Borsa habitat (altitude 850 m). The bilberry leaf extracts contained in the highest amounts the feruloylquinic acid (59.65 ± 0.44 mg/g for Borsa habitat) and rutin (49.83 ± 0.63 mg/g for Borsa habitat), and showed relevant 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant activity (271.65 mM Trolox/100 g plant material for Borsa habitat, 262.77 mM Trolox/100 g plant material for Smida habitat, and 320.83 mM Trolox/100 g plant material for Turda habitat), for all the three extracts. Gallocatechin was the dominant flavanol in lingonberry species, with the highest amount being registered for Smida habitat (46.81 ± 0.3 mg/g), revealing a DPPH antioxidant activity of 251.49 mM Trolox/100 g plant material. The results obtained in the antimicrobial tests showed that the best inhibitory effect among bilberry species was attributed to the Turda (altitude 436 m) and Smida locations, against both Gram-positive and Gram-negative bacterial strains. For lingonberry, the differences in habitat did not influence the antibacterial effect, but the antifungal effect, only in the case of Candida zeylanoides. A strong antimutagenic effect was registered by the bilberry leaves toward Salmonella typhimurium TA100. Our study may be able to provide a better understanding of the correlation between natural habitat conditions and the accumulation of secondary metabolites and their related bioactivities in studied leaves.

ACS Style

Bianca-Eugenia Ștefănescu; Lavinia Florina Călinoiu; Floricuța Ranga; Florinela Fetea; Andrei Mocan; Dan Cristian Vodnar; Gianina Crișan. Chemical Composition and Biological Activities of the Nord-West Romanian Wild Bilberry (Vaccinium myrtillus L.) and Lingonberry (Vaccinium vitis-idaea L.) Leaves. Antioxidants 2020, 9, 495 .

AMA Style

Bianca-Eugenia Ștefănescu, Lavinia Florina Călinoiu, Floricuța Ranga, Florinela Fetea, Andrei Mocan, Dan Cristian Vodnar, Gianina Crișan. Chemical Composition and Biological Activities of the Nord-West Romanian Wild Bilberry (Vaccinium myrtillus L.) and Lingonberry (Vaccinium vitis-idaea L.) Leaves. Antioxidants. 2020; 9 (6):495.

Chicago/Turabian Style

Bianca-Eugenia Ștefănescu; Lavinia Florina Călinoiu; Floricuța Ranga; Florinela Fetea; Andrei Mocan; Dan Cristian Vodnar; Gianina Crișan. 2020. "Chemical Composition and Biological Activities of the Nord-West Romanian Wild Bilberry (Vaccinium myrtillus L.) and Lingonberry (Vaccinium vitis-idaea L.) Leaves." Antioxidants 9, no. 6: 495.

Journal article
Published: 02 June 2020 in Antioxidants
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Even though Salvia genus is one of the most known and studied taxa of Lamiaceae family, the knowledge regarding the chemical composition and health-related benefits of some locally used Salvia species (mostly endemic) is still scarce. In this regard, the present work aims to evaluate the chemical profile and potential bioactivities of 70% (v/v) ethanolic extracts obtained from the less-studied S. transsylvanica and S. glutinosa in comparison with S. officinalis. HPLC-PDA analysis revealed the presence of rutin and catechin as the main compounds in the extracts of the three studied species (using the employed HPLC method), whereas the presence of naringenin was highlighted only in S. glutinosa extract. Chlorogenic acid, rutin and quercetin were identified and quantified for the first time in S. transsylvanica extracts. The in vitro antioxidant capacity of each extract was tested through complementary methods (phosphomolybdenum assay, DPPH, ABTS, CUPRAC and FRAP assays), and correlated with the presence of phenolics (especially flavonoids) in high amounts. The neuroprotective and antidiabetic abilities of S. officinalis (the most active as AChE, BChE and α-glucosidase inhibitor), S. glutinosa (the most active as α-amylase inhibitor) and S. transsylvanica were also studied. For each extract it was determined the antimicrobial, antifungal and cytotoxic effects using in vitro assays. The obtained results confirm the potential of S. transsylvanica and S. glutinosa as promising sources of bioactive compounds and as a starting point for further analyses.

ACS Style

Andrei Mocan; Mihai Babota; Anca Pop; Ionel Fizeșan; Alina Diuzheva; Marcello Locatelli; Simone Carradori; Cristina Campestre; Luigi Menghini; Cristian R. Sisea; Marina Soković; Gokhan Zengin; Ramona Păltinean; Sabin Badarau; Dan C. C. Vodnar; Gianina Crișan. Chemical Constituents and Biologic Activities of Sage Species: A Comparison between Salvia officinalis L., S. glutinosa L. and S. transsylvanica (Schur ex Griseb. & Schenk) Schur. Antioxidants 2020, 9, 1 .

AMA Style

Andrei Mocan, Mihai Babota, Anca Pop, Ionel Fizeșan, Alina Diuzheva, Marcello Locatelli, Simone Carradori, Cristina Campestre, Luigi Menghini, Cristian R. Sisea, Marina Soković, Gokhan Zengin, Ramona Păltinean, Sabin Badarau, Dan C. C. Vodnar, Gianina Crișan. Chemical Constituents and Biologic Activities of Sage Species: A Comparison between Salvia officinalis L., S. glutinosa L. and S. transsylvanica (Schur ex Griseb. & Schenk) Schur. Antioxidants. 2020; 9 (6):1.

Chicago/Turabian Style

Andrei Mocan; Mihai Babota; Anca Pop; Ionel Fizeșan; Alina Diuzheva; Marcello Locatelli; Simone Carradori; Cristina Campestre; Luigi Menghini; Cristian R. Sisea; Marina Soković; Gokhan Zengin; Ramona Păltinean; Sabin Badarau; Dan C. C. Vodnar; Gianina Crișan. 2020. "Chemical Constituents and Biologic Activities of Sage Species: A Comparison between Salvia officinalis L., S. glutinosa L. and S. transsylvanica (Schur ex Griseb. & Schenk) Schur." Antioxidants 9, no. 6: 1.

Journal article
Published: 22 May 2020 in Molecules
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Averrhoa carambola L. is a tropical tree with edible fruit that grows at different climatic conditions. Despite its nutritive value and reported health benefits, it is a controversial fruit owing to its rich oxalate content. The present study aimed at investigating aroma and nutrient primary metabolites distribution in A. carambola fruits grown in Indonesia, Malaysia (its endemic origin) versus Egypt, and at different ripening stages. Two techniques were employed to assess volatile and non-volatile metabolites including headspace solid-phase micro-extraction (HS-SPME) joined with gas chromatography coupled with mass-spectrometry (GC-MS) and GC-MS post silylation, respectively. Twenty-four volatiles were detected, with esters amounting for the major class of volatiles in Egyptian fruit at ca. 66%, with methyl caproate as the major component, distinguishing it from other origins. In contrast, aldehydes predominated tropically grown fruits with the ether myristicin found exclusively in these. Primary metabolites profiling led to the identification of 117 metabolites viz. sugars, polyols and organic acids. Fructose (38–48%) and glucose (21–25%) predominated sugar compositions in ripe fruits, whereas sorbitol was the major sugar alcohol (2.4–10.5%) in ripe fruits as well. Oxalic acid, an anti-nutrient with potential health risks, was the major organic acid detected in all the studied fruits (1.7–2.7%), except the Malaysian one (0.07%). It increases upon fruit ripening, including considerable amounts of volatile oxalate esters detected via SPME, and which must not be omitted in total oxalate determinations for safety assessments.

ACS Style

Nehal S. Ramadan; Ludger A. Wessjohann; Andrei Mocan; Dan C Vodnar; Nabil H. El-Sayed; Sayed A. El-Toumy; Doha Abdou Mohamed; Zeinab Abdel Aziz; Anja Ehrlich; Mohamed A. Farag. Nutrient and Sensory Metabolites Profiling of Averrhoa Carambola L. (Starfruit) in the Context of Its Origin and Ripening Stage by GC/MS and Chemometric Analysis. Molecules 2020, 25, 2423 .

AMA Style

Nehal S. Ramadan, Ludger A. Wessjohann, Andrei Mocan, Dan C Vodnar, Nabil H. El-Sayed, Sayed A. El-Toumy, Doha Abdou Mohamed, Zeinab Abdel Aziz, Anja Ehrlich, Mohamed A. Farag. Nutrient and Sensory Metabolites Profiling of Averrhoa Carambola L. (Starfruit) in the Context of Its Origin and Ripening Stage by GC/MS and Chemometric Analysis. Molecules. 2020; 25 (10):2423.

Chicago/Turabian Style

Nehal S. Ramadan; Ludger A. Wessjohann; Andrei Mocan; Dan C Vodnar; Nabil H. El-Sayed; Sayed A. El-Toumy; Doha Abdou Mohamed; Zeinab Abdel Aziz; Anja Ehrlich; Mohamed A. Farag. 2020. "Nutrient and Sensory Metabolites Profiling of Averrhoa Carambola L. (Starfruit) in the Context of Its Origin and Ripening Stage by GC/MS and Chemometric Analysis." Molecules 25, no. 10: 2423.

Journal article
Published: 14 May 2020 in Antioxidants
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Antioxidant dietary intervention is considered a potential strategy in delaying age-related dysfunctions. In this study of 56 days, we assessed the antioxidant effects of walnut kernel (WK) and walnut septum extract (WSE) in a D-galactose (D-gal)-induced aging model and in a naturally aged rat model. Young Wistar rats, treated with D-gal (1200 mg/week), and old rats received daily WK or WSE added to the feed. After 8 weeks, blood, liver, and brain samples were collected and hematological, biochemical, oxidative stress biomarkers, histological, and immunohistochemical analyses were performed. Moreover, acetylcholinesterase activity was investigated in brain homogenates. The outcomes demonstrated significant improvement in cellular antioxidant activity and/or decrease of reactive oxygen species, advanced glycation end products, nitric oxide, malondialdehyde, or increase of glutathione after WK or WSE intake in both models. Additionally, WSE showed hypoglycemic effect, and both WK and WSE lowered acetylcholinesterase activity. Both diets could protect neurons against the induced senescence and could reverse the pathological conditions in the physiological aged brain. Thus, dietary supplementation with WK or WSE can maintain the liver and brain health and reduce the risk of age-related diseases, as well as delaying the onset of aging processes.

ACS Style

Marius Emil Rusu; Carmen Georgiu; Anca Pop; Andrei Mocan; Bela Kiss; Oliviu Vostinaru; Ionel Fizesan; Maria-Georgia Stefan; Ana-Maria Gheldiu; Letitia Mates; Rebeca Moldovan; Dana Maria Muntean; Felicia Loghin; Laurian Vlase; Daniela-Saveta Popa. Antioxidant Effects of Walnut (Juglans regia L.) Kernel and Walnut Septum Extract in a D-Galactose-Induced Aging Model and in Naturally Aged Rats. Antioxidants 2020, 9, 424 .

AMA Style

Marius Emil Rusu, Carmen Georgiu, Anca Pop, Andrei Mocan, Bela Kiss, Oliviu Vostinaru, Ionel Fizesan, Maria-Georgia Stefan, Ana-Maria Gheldiu, Letitia Mates, Rebeca Moldovan, Dana Maria Muntean, Felicia Loghin, Laurian Vlase, Daniela-Saveta Popa. Antioxidant Effects of Walnut (Juglans regia L.) Kernel and Walnut Septum Extract in a D-Galactose-Induced Aging Model and in Naturally Aged Rats. Antioxidants. 2020; 9 (5):424.

Chicago/Turabian Style

Marius Emil Rusu; Carmen Georgiu; Anca Pop; Andrei Mocan; Bela Kiss; Oliviu Vostinaru; Ionel Fizesan; Maria-Georgia Stefan; Ana-Maria Gheldiu; Letitia Mates; Rebeca Moldovan; Dana Maria Muntean; Felicia Loghin; Laurian Vlase; Daniela-Saveta Popa. 2020. "Antioxidant Effects of Walnut (Juglans regia L.) Kernel and Walnut Septum Extract in a D-Galactose-Induced Aging Model and in Naturally Aged Rats." Antioxidants 9, no. 5: 424.

Journal article
Published: 07 May 2020 in Molecules
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Walnut (Juglans regia L.) septum represents an interesting bioactive compound source by-product. In our study, a rich phenolic walnut septum extract, previously selected, was further examined. The tocopherol content determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) revealed higher amounts of α-tocopherol compared to γ- and δ-tocopherols. Moreover, several biological activities were investigated. The in vitro inhibiting assessment against acetylcholinesterase, α-glucosidase, or lipase attested a real management potential in diabetes or obesity. The extract demonstrated very strong antimicrobial potential against Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella enteritidis. It also revealed moderate (36.08%) and strong (43.27%) antimutagenic inhibitory effects against TA 98 and TA 100 strains. The cytotoxicity of the extract was assessed on cancerous (A549, T47D-KBluc, MCF-7) and normal (human gingival fibroblasts (HGF)) cell lines. Flow cytometry measurements confirmed the cytotoxicity of the extract in the cancerous cell lines. Additionally, the extract demonstrated antioxidant activity on all four cell types, as well as anti-inflammatory activity by lowering the inflammatory cytokines (interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-1 β (IL-1β)) evaluated in HGF cells. To the best of our knowledge, most of the cellular model analyses were performed for the first time in this matrix. The results prove that walnut septum may be a potential phytochemical source for pharmaceutical and food industry.

ACS Style

Marius Emil Rusu; Ionel Fizesan; Anca Pop; Andrei Mocan; Ana-Maria Gheldiu; Mihai Babota; Dan Cristian Vodnar; Ancuta Jurj; Ioana Berindan-Neagoe; Laurian Vlase; Daniela-Saveta Popa. Walnut (Juglans regia L.) Septum: Assessment of Bioactive Molecules and In Vitro Biological Effects. Molecules 2020, 25, 2187 .

AMA Style

Marius Emil Rusu, Ionel Fizesan, Anca Pop, Andrei Mocan, Ana-Maria Gheldiu, Mihai Babota, Dan Cristian Vodnar, Ancuta Jurj, Ioana Berindan-Neagoe, Laurian Vlase, Daniela-Saveta Popa. Walnut (Juglans regia L.) Septum: Assessment of Bioactive Molecules and In Vitro Biological Effects. Molecules. 2020; 25 (9):2187.

Chicago/Turabian Style

Marius Emil Rusu; Ionel Fizesan; Anca Pop; Andrei Mocan; Ana-Maria Gheldiu; Mihai Babota; Dan Cristian Vodnar; Ancuta Jurj; Ioana Berindan-Neagoe; Laurian Vlase; Daniela-Saveta Popa. 2020. "Walnut (Juglans regia L.) Septum: Assessment of Bioactive Molecules and In Vitro Biological Effects." Molecules 25, no. 9: 2187.

Journal article
Published: 22 January 2020 in Molecules
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Despite recent advances in disease management and prevention, heart failure (HF) prevalence is still high. Hypertension, inflammation and oxidative stress are being investigated as important causative processes in HF. L. barbarum L. polysaccharides (LBPs) are widely used for their anti-inflammatory and antioxidant properties. Thus, the aim of the present study was to evaluate the effects of LBPs on inflammation and oxidative stress markers in a pressure overload-induced HF rat model, surgically induced by abdominal aorta banding in Wistar rats (AAB) (n = 28). Also, control rats (n = 10) were subjected to a sham operation. After echocardiographic confirmation of HF (week 24), AAB rats were divided into three groups: rats treated with LBPs for 12 weeks: 100 mg/kg body weight /day (AAB_100, n = 9), 200 mg/kg body weight /day (AAB_200, n = 7) and no-treatment group (control AAB, n = 12). After 12 weeks of treatment with LBPs, the decline of cardiac function was prevented compared to the control AAB rats. Treatment with 200 mg/kg body weight /day LBPs significantly reduced the inflammation as seen by cytokine levels (IL-6 and TNF-α) and the plasma lipid peroxidation, as seen by malondialdehyde levels. These results suggest that LBPs present anti-inflammatory and antioxidant effects with utility in a HF animal model and encourage further investigation of the cardioprotective effects of these polysaccharides.

ACS Style

Cristina Pop; Cristian Berce; Steliana Ghibu; Iuliu Scurtu; Olga Sorițău; Cezar Login; Béla Kiss; Maria Georgia Stefan; Ionel Fizeșan; Horațiu Silaghi; Andrei Mocan; Gianina Crișan; Felicia Loghin; Cristina Mogoșan. Effects of Lycium barbarum L. Polysaccharides on Inflammation and Oxidative Stress Markers in a Pressure Overload-Induced Heart Failure Rat Model. Molecules 2020, 25, 466 .

AMA Style

Cristina Pop, Cristian Berce, Steliana Ghibu, Iuliu Scurtu, Olga Sorițău, Cezar Login, Béla Kiss, Maria Georgia Stefan, Ionel Fizeșan, Horațiu Silaghi, Andrei Mocan, Gianina Crișan, Felicia Loghin, Cristina Mogoșan. Effects of Lycium barbarum L. Polysaccharides on Inflammation and Oxidative Stress Markers in a Pressure Overload-Induced Heart Failure Rat Model. Molecules. 2020; 25 (3):466.

Chicago/Turabian Style

Cristina Pop; Cristian Berce; Steliana Ghibu; Iuliu Scurtu; Olga Sorițău; Cezar Login; Béla Kiss; Maria Georgia Stefan; Ionel Fizeșan; Horațiu Silaghi; Andrei Mocan; Gianina Crișan; Felicia Loghin; Cristina Mogoșan. 2020. "Effects of Lycium barbarum L. Polysaccharides on Inflammation and Oxidative Stress Markers in a Pressure Overload-Induced Heart Failure Rat Model." Molecules 25, no. 3: 466.

Journal article
Published: 16 November 2019 in Antioxidants
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Goji berries are undoubtedly a source of potentially bioactive compounds but their phytochemical profile can vary depending on their geographical origin, cultivar, and/or industrial processing. A rapid and cheap extraction of the polyphenolic fraction from Lycium barbarum cultivars, applied after homogenization treatments, was combined with high-performance liquid chromatography (HPLC) analyses based on two different methods. The obtained hydroalcoholic extracts, containing interesting secondary metabolites (gallic acid, chlorogenic acid, catechin, sinapinic acid, rutin, and carvacrol), were also submitted to a wide biological screening. The total phenolic and flavonoid contents, the antioxidant capacity using three antioxidant assays, tyrosinase inhibition, and anti-Candida activity were evaluated in order to correlate the impact of the homogenization treatment, geographical origin, and cultivar type on the polyphenolic and flavonoid amount, and consequently the bioactivity. The rutin amount, considered as a quality marker for goji berries according to European Pharmacopeia, varied from ≈200 to ≈400 µg/g among the tested samples, showing important differences observed in relation to the influence of the evaluated parameters.

ACS Style

Andrei Mocan; Francesco Cairone; Marcello Locatelli; Francesco Cacciagrano; Simone Carradori; Dan C. Vodnar; Gianina Crișan; Giovanna Simonetti; Stefania Cesa. Polyphenols from Lycium barbarum (Goji) Fruit European Cultivars at Different Maturation Steps: Extraction, HPLC-DAD Analyses, and Biological Evaluation. Antioxidants 2019, 8, 562 .

AMA Style

Andrei Mocan, Francesco Cairone, Marcello Locatelli, Francesco Cacciagrano, Simone Carradori, Dan C. Vodnar, Gianina Crișan, Giovanna Simonetti, Stefania Cesa. Polyphenols from Lycium barbarum (Goji) Fruit European Cultivars at Different Maturation Steps: Extraction, HPLC-DAD Analyses, and Biological Evaluation. Antioxidants. 2019; 8 (11):562.

Chicago/Turabian Style

Andrei Mocan; Francesco Cairone; Marcello Locatelli; Francesco Cacciagrano; Simone Carradori; Dan C. Vodnar; Gianina Crișan; Giovanna Simonetti; Stefania Cesa. 2019. "Polyphenols from Lycium barbarum (Goji) Fruit European Cultivars at Different Maturation Steps: Extraction, HPLC-DAD Analyses, and Biological Evaluation." Antioxidants 8, no. 11: 562.

Journal article
Published: 30 October 2019 in Nanomaterials
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Biosynthesized silver nanoparticles (AgNPs) are widely used in Pharmacy and Medicine. In particular, AgNPs synthesized and mediated by plant extracts have shown topossess several biological activities. In the present study, AgNPs were synthesized using Picea abies L. stem bark extract as reducing agent. Factors, such as metal ion solution, pH, and time, which play a role in the AgNPs synthesis, were assessed. The synthesized AgNPs were characterized by Ultraviolet-Visible Spectrometry, Fourier transform infrared spectroscopy, and Transmission Electron Microscopy (TEM). Further, the study has been extended to evaluate the antimicrobial and antioxidant activity of AgNPs. The broad peak obtained at 411–475 nm (UV-Vis spectroscopy), and the color change pattern, confirmed the synthesis of AgNPs. TEM results showed spherical or rarely polygonal AgNPs with an average size of 44 nm at pH = 9. The AgNPs showed antioxidant activity and antibacterial effect against human pathogenic Gram-positive and Gram-negative bacteria. The results show that spruce bark extract is suitable for obtaining AgNPs, with antibacterial and antioxidant activity.

ACS Style

Corneliu Tanase; Lavinia Berta; Năstaca Alina Coman; Ioana Roșca; Adrian Man; Felicia Toma; Andrei Mocan; Alexandru Nicolescu; László Jakab-Farkas; Domokos Biró; Anca Mare. Antibacterial and Antioxidant Potential of Silver Nanoparticles Biosynthesized Using the Spruce Bark Extract. Nanomaterials 2019, 9, 1541 .

AMA Style

Corneliu Tanase, Lavinia Berta, Năstaca Alina Coman, Ioana Roșca, Adrian Man, Felicia Toma, Andrei Mocan, Alexandru Nicolescu, László Jakab-Farkas, Domokos Biró, Anca Mare. Antibacterial and Antioxidant Potential of Silver Nanoparticles Biosynthesized Using the Spruce Bark Extract. Nanomaterials. 2019; 9 (11):1541.

Chicago/Turabian Style

Corneliu Tanase; Lavinia Berta; Năstaca Alina Coman; Ioana Roșca; Adrian Man; Felicia Toma; Andrei Mocan; Alexandru Nicolescu; László Jakab-Farkas; Domokos Biró; Anca Mare. 2019. "Antibacterial and Antioxidant Potential of Silver Nanoparticles Biosynthesized Using the Spruce Bark Extract." Nanomaterials 9, no. 11: 1541.

Journal article
Published: 08 October 2019 in Antioxidants
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Green synthesis is one of the rapid and best ways for silver nanoparticles (AgNP) synthesis. In the present study, synthesis and bioactivity of AgNPs has been demonstrated using water beech (Fagus sylvatica L.) bark extract. The physical and chemical factors such as time, metal ion solution, and pH, which play a vital role in the AgNPs synthesis, were assessed. The AgNPs were characterized by ultraviolet-visible (UV-Vis) spectrometry, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM). Antioxidant and antimicrobial activity of the obtained AgNPs was evaluated. AgNPs were characterized by color change pattern, and the broad peak obtained at 420–475 nm with UV-Vis confirmed the synthesis of AgNPs. FT-IR results confirmed that phenols and proteins of beech bark extract are mainly responsible for capping and stabilization of synthesized AgNPs. TEM micrographs showed spherical or rarely polygonal and triangular particles with an average size of 32 nm at pH = 9, and 62 nm at pH = 4. Furthermore, synthesized AgNPs were found to exhibit antioxidant activity and have antibacterial effect against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Pseudomonas aeruginosa. These results indicate that bark extract of F. sylvatica L. is suitable for synthesizing stable AgNPs, which act as an excellent antimicrobial agent.

ACS Style

Corneliu Tanase; Lavinia Berta; Năstaca Alina Coman; Ioana Roșca; Adrian Man; Felicia Toma; Andrei Mocan; László Jakab-Farkas; Domokos Biró; Anca Mare; Man; Toma; Jakab- Farkas; Biró; Mare. Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract. Antioxidants 2019, 8, 459 .

AMA Style

Corneliu Tanase, Lavinia Berta, Năstaca Alina Coman, Ioana Roșca, Adrian Man, Felicia Toma, Andrei Mocan, László Jakab-Farkas, Domokos Biró, Anca Mare, Man, Toma, Jakab- Farkas, Biró, Mare. Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract. Antioxidants. 2019; 8 (10):459.

Chicago/Turabian Style

Corneliu Tanase; Lavinia Berta; Năstaca Alina Coman; Ioana Roșca; Adrian Man; Felicia Toma; Andrei Mocan; László Jakab-Farkas; Domokos Biró; Anca Mare; Man; Toma; Jakab- Farkas; Biró; Mare. 2019. "Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract." Antioxidants 8, no. 10: 459.

Journal article
Published: 08 October 2019 in Antioxidants
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Tree nut by-products could contain a wide range of phytochemicals, natural antioxidants, which might be used as a natural source for dietary supplements. The aim of the present study was to evaluate the phenolic and sterolic composition, as well as the antioxidant and other biological activities, of hazelnut involucre (HI) extracts. Experimental designs were developed in order to select the optimum extraction conditions (solvent, temperature, time) using turbo-extraction by Ultra-Turrax for obtaining extracts rich in bioactive compounds. Qualitative and quantitative analyses were performed by LC-MS and LC-MS/MS and they revealed important amounts of individual polyphenols and phytosterols, molecules with antioxidant potential. The richest polyphenolic HI extract with the highest antioxidant activity by TEAC assay was further evaluated by other in vitro antioxidant tests (DPPH, FRAP) and enzyme inhibitory assays. Additionally, the cytotoxic and antioxidant effects of this extract on two cancerous cell lines and on normal cells were tested. This is the first study to analyze the composition of both hydrophilic and lipophilic bioactive compounds in HI extracts. Our findings reveal that this plant by-product presents strong biological activities, justifying further research, and it could be considered an inexpensive source of natural antioxidants for food, pharmaceutical, or cosmetic industry.

ACS Style

Marius Emil Rusu; Ionel Fizeșan; Anca Pop; Ana-Maria Gheldiu; Andrei Mocan; Gianina Crișan; Laurian Vlase; Felicia Loghin; Daniela-Saveta Popa; Ioan Tomuta; Rusu; Pop; Popa. Enhanced Recovery of Antioxidant Compounds from Hazelnut (Corylus avellana L.) Involucre Based on Extraction Optimization: Phytochemical Profile and Biological Activities. Antioxidants 2019, 8, 460 .

AMA Style

Marius Emil Rusu, Ionel Fizeșan, Anca Pop, Ana-Maria Gheldiu, Andrei Mocan, Gianina Crișan, Laurian Vlase, Felicia Loghin, Daniela-Saveta Popa, Ioan Tomuta, Rusu, Pop, Popa. Enhanced Recovery of Antioxidant Compounds from Hazelnut (Corylus avellana L.) Involucre Based on Extraction Optimization: Phytochemical Profile and Biological Activities. Antioxidants. 2019; 8 (10):460.

Chicago/Turabian Style

Marius Emil Rusu; Ionel Fizeșan; Anca Pop; Ana-Maria Gheldiu; Andrei Mocan; Gianina Crișan; Laurian Vlase; Felicia Loghin; Daniela-Saveta Popa; Ioan Tomuta; Rusu; Pop; Popa. 2019. "Enhanced Recovery of Antioxidant Compounds from Hazelnut (Corylus avellana L.) Involucre Based on Extraction Optimization: Phytochemical Profile and Biological Activities." Antioxidants 8, no. 10: 460.

Journal article
Published: 01 October 2019 in Antioxidants
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This work aimed to characterize compositional and bioactive features of Aloe vera leaf (fillet, mucilage, and rind) and flower. The edible fillet was analysed for its nutritional value, and all samples were studied for phenolic composition and antioxidant, anti-inflammatory, antimicrobial, tyrosinase inhibition, and cytotoxic activities. Dietary fibre (mainly mannan) and available carbohydrates (mainly free glucose and fructose) were abundant macronutrients in fillet, which also contained high amounts of malic acid (5.75 g/100 g dw) and α-tocopherol (4.8 mg/100 g dw). The leaf samples presented similar phenolic profiles, with predominance of chromones and anthrones, and the highest contents were found in mucilage (131 mg/g) and rind (105 mg/g) extracts, which also revealed interesting antioxidant properties. On the other hand, the flower extract was rich in apigenin glycoside derivatives (4.48 mg/g), effective against Pseudomonas aeruginosa (MIC = 0.025 mg/mL and MBC = 0.05 mg/mL) and capable of inhibiting the tyrosinase activity (IC50 = 4.85 mg/mL). The fillet, rind, and flower extracts also showed a powerful antifungal activity against Aspergillus flavus, A. niger, Penicillium funiculosum, and Candida albicans, higher than that of ketoconazole. Thus, the studied Aloe vera samples displayed high potential to be exploited by the food or cosmetic industries, among others.

ACS Style

Mikel Añibarro-Ortega; José Pinela; Lillian Barros; Ana Ćirić; Soraia P. Silva; Elisabete Coelho; Andrei Mocan; Ricardo C. Calhelha; Marina Soković; Manuel A. Coimbra; Isabel C. F. R. Ferreira; Añibarro- Ortega. Compositional Features and Bioactive Properties of Aloe vera Leaf (Fillet, Mucilage, and Rind) and Flower. Antioxidants 2019, 8, 444 .

AMA Style

Mikel Añibarro-Ortega, José Pinela, Lillian Barros, Ana Ćirić, Soraia P. Silva, Elisabete Coelho, Andrei Mocan, Ricardo C. Calhelha, Marina Soković, Manuel A. Coimbra, Isabel C. F. R. Ferreira, Añibarro- Ortega. Compositional Features and Bioactive Properties of Aloe vera Leaf (Fillet, Mucilage, and Rind) and Flower. Antioxidants. 2019; 8 (10):444.

Chicago/Turabian Style

Mikel Añibarro-Ortega; José Pinela; Lillian Barros; Ana Ćirić; Soraia P. Silva; Elisabete Coelho; Andrei Mocan; Ricardo C. Calhelha; Marina Soković; Manuel A. Coimbra; Isabel C. F. R. Ferreira; Añibarro- Ortega. 2019. "Compositional Features and Bioactive Properties of Aloe vera Leaf (Fillet, Mucilage, and Rind) and Flower." Antioxidants 8, no. 10: 444.

Journal article
Published: 19 September 2019 in Antioxidants
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The present study aimed, on the one hand, to improve the yield of microwave assisted extraction (MAE) of polyphenols from beech bark by using a design of experiments (DoE) approach. On the other hand, beech bark extracts (BBE) were characterized in terms of their phytochemical profile and evaluated for biological potential (antioxidant, antibacterial, antifungal, antimutagen, anti-α-glucosidase, and anti-tyrosinase). The extraction time varies with the amount of extracted total phenolic content (TPC). The microwave power favors TPC extraction but in different proportions. The optimum conditions which gave the highest TPC (76.57 mg GAE/g dry plant material) were reached when the microwave power was 300 W, extraction time was 4 min, and the solvent was an ethanol-water (50:50) mixture. The practical value of TPC after a controlled experiment was 76.49 mg GAE/g plant material. The identified compounds were vanillic acid, gallic acid, epicatechin, catechin, protocatechuic acid, chlorogenic acid, ferulic acid, and isoquercitrin. The antioxidant potential of BBEs was demonstrated by in vitro experiments. The BBEs were active against Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli, and Candida species. All extracts were antimutagenic and expressed an inhibition on α-glucosidase and tyrosinase activity. Regarding antimutagen activity, the assayed extracts may be considered to have low or no antimutagen effects.

ACS Style

Corneliu Tanase; Andrei Mocan; Sanda Coșarcă; Alexandru Gavan; Alexandru Nicolescu; Ana-Maria Gheldiu; Dan C. Vodnar; Daniela-Lucia Muntean; Ovidiu Crișan. Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties. Antioxidants 2019, 8, 417 .

AMA Style

Corneliu Tanase, Andrei Mocan, Sanda Coșarcă, Alexandru Gavan, Alexandru Nicolescu, Ana-Maria Gheldiu, Dan C. Vodnar, Daniela-Lucia Muntean, Ovidiu Crișan. Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties. Antioxidants. 2019; 8 (9):417.

Chicago/Turabian Style

Corneliu Tanase; Andrei Mocan; Sanda Coșarcă; Alexandru Gavan; Alexandru Nicolescu; Ana-Maria Gheldiu; Dan C. Vodnar; Daniela-Lucia Muntean; Ovidiu Crișan. 2019. "Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties." Antioxidants 8, no. 9: 417.