In search of prospective agents against infectious diseases, 1,1′-bis(diphenylphosphino)ferrocene pyridine-2-thiolato-1-oxide M(II) hexafluorophosphate compounds [M(mpo)(dppf)](PF₆), where M = palladium or platinum, were synthesized and fully characterized in the solid state and in solution using experimental and DFT computational techniques. The compounds are isomorphous and the M(II) transition metal ions are in a nearly planar trapezoidal cis-coordination bound to the pyridine-2-thiolato-1-oxide (mpo) and to the 1,1′-bis(diphenylphosphino)ferrocene molecules, both acting as bidentate ligands. Both compounds showed high cytotoxic activity on Trypanosoma cruzi and Mycobacterium tuberculosis (MTB) and acceptable selectivities towards MTB, but good to excellent selectivity index values as anti-T. cruzi compounds. The inclusion of the ferrocene moiety (dppf ligand) improved the selectivity towards the parasite when compared to the previously reported [M(mpo)₂] complexes. Related to the probable mechanism of action of the complexes, molecular docking studies on modelled T. cruzi NADH-fumarate reductase (TcFR) predicted that both be very good inhibitors of the enzyme. The effect of the compounds on the enzyme activity was experimentally confirmed using T. cruzi protein extracts. According to all obtained results, both [M(mpo)(dppf)](PF₆) compounds could be considered prospective anti-trypanosomal agents that deserve further research.

Multifunctional Re(i) tricarbonyls including phenanthroline derivatives and Clotrimazole showed high activity against Trypanosoma cruzi and inhibited parasite lanosterol 14-α-demethylase (CYP51).

[V^IVO(L-H)₂] and [V^VO(OCH₃)(L-H)₂] compounds of 8-hydroxyquinoline derivatives L showed activity againstTrypanosoma cruziandLeishmania infantumand high selectivities. Metallomics and interaction with BSA, apo-HTF and DNA were studied.

Threads of dental implants with healing chamber configurations have become a target to improve osseointegration. This biomechanical and histometric study aimed to evaluate the influence of implant healing chamber configurations on the torque removal value (RTv), percentage of bone-to-implant contact (BIC%), bone fraction occupancy inside the thread area (BAFO%), and bone and osteocyte density (Ost) in the rabbit tibia after two months of healing. Titanium implants with three different thread configurations were evaluated: Group 1 (G1), with a conventional “v” thread-shaped implant design; Group 2 (G2), with square threads; and Group 3 (G3), the experimental group with longer threads (healing chamber). Ten rabbits (4.5 ± 0.5 kg) received three implants in each tibia (one per group), distributed in a randomized manner. After a period of two months, the tibia blocks (implants and the surrounding tissue) were removed and processed for ground sectioning to evaluate BIC%, BAFO%, and osteocyte density. The ANOVA one-way statistical test was used followed by the Bonferoni’s multiple comparison test to determine individual difference among groups, considering a statistical difference when p < 0.05. Histometric evaluation showed a higher BAFO% values and Ost density for G3 in comparison with the other two groups (G1 and G2), with p < 0.05. However, the RTv and BIC% parameters were not significantly different between groups (p > 0.05). The histological data suggest that the healing chambers in the implant macrogeometry can improve the bone reaction in comparison with the conventional thread design.

Five heteroleptic compounds, [V^VO(IN-2H)(L-H)], where L are 8-hydroxyquinoline derivatives and IN is a Schiff base ligand, were synthesized and characterized in both the solid and solution state. The compounds were evaluated on epimastigotes and trypomastigotes of Trypanosoma cruzi as well as on VERO cells, as a mammalian cell model. Compounds showed activity against trypomastigotes with IC₅₀ values of 0.29–3.02 μM. IN ligand and the new [V^VO₂(IN-H)] complex showed negligible activity. The most active compound [V^VO(IN-2H)(L2-H)], with L2 = 5-chloro-7-iodo-8-hydroxyquinoline, showed good selectivity towards the parasite and was selected to carry out further biological studies. Stability studies suggested a partial decomposition in solution. [V^VO(IN-2H)(L2-H)] affects the infection potential of cell-derived trypomastigotes. Low total vanadium uptake by parasites and preferential accumulation in the soluble proteins fraction were determined. A trypanocide effect was observed when incubating epimastigotes with 10 × IC₅₀ values of [V^VO(IN-2H)(L2-H)] and the generation of ROS after treatments was suggested. Fluorescence competition measurements with DNA:ethidium bromide adduct showed a moderate DNA interaction of the complexes. In vivo toxicity study on C. elegans model showed no toxicity up to a 100 μM concentration of [V^VO(IN-2H)(L2-H)]. This compound could be considered a prospective anti-T. cruzi agent that deserves further research.