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From all types of cancer, cervical cancer manages to be in top four most frequent types, with a 6.5% rate of occurrence. The infectious vector that induces the disease, the high-risk Human papillomavirus (HPV), which is a sexually transmitted virus, is capable of transforming the host cell by modulating some of the principal signaling pathways responsible for cell cycle arrest, proliferation, and survival. Fortunately, like other cancer types, cervical cancer can be treated by chirurgical interventions or chemoradiotherapy, but these methods are not exactly the lucky clover of modern medicine because of the adverse effects they have. That is the reason why in the last years the emphasis has been on alternative medicine, more specifically on phytochemicals, as a substantial number of studies showed that diet contributes to cancer prevention and treatment. All these studies are trying to find new chemopreventive agents with less toxicity but high effectiveness both in vitro and in vivo. The aim of this review is to evaluate the literature in order to underline the advantages and disadvantages of polyphenols, a class of dietary compounds, as chemopreventive and chemotherapeutic agents. This review also aims to present polyphenols from different perspectives, starting with mechanisms of action and ending with their toxicity. The bigger picture illustrates that polyphenols have great potential in cervical cancer prevention, with strong effects on gene modulation.
Georgiana Drețcanu; Cristian I. Iuhas; Zorița Diaconeasa. The Involvement of Natural Polyphenols in the Chemoprevention of Cervical Cancer. International Journal of Molecular Sciences 2021, 22, 8812 .
AMA StyleGeorgiana Drețcanu, Cristian I. Iuhas, Zorița Diaconeasa. The Involvement of Natural Polyphenols in the Chemoprevention of Cervical Cancer. International Journal of Molecular Sciences. 2021; 22 (16):8812.
Chicago/Turabian StyleGeorgiana Drețcanu; Cristian I. Iuhas; Zorița Diaconeasa. 2021. "The Involvement of Natural Polyphenols in the Chemoprevention of Cervical Cancer." International Journal of Molecular Sciences 22, no. 16: 8812.
Being delicious and containing strong disease-fighting agents, berries represent an increasing proportion of fruits consumed nowadays in our diet. However, berries are highly perishable as fresh and, therefore, they are usually processed into various products to extend their shelf-life and availability throughout the year. Among the fruit-containing products, jam is one of the most common due to its nourishing properties, its low production costs, and its accessibility for a lengthy period. Rather than home preparation, consumers nowadays increasingly prefer to purchase commercial jams from markets due to its convenience. Although fresh berries have been extensively studied for their phenolic compounds, a limited number of studies investigating commercially manufactured jams have been conducted so far. Considering this, the objective of this study was to assess the total phenolic, flavonoid, and anthocyanin content and the antioxidant activity of five commonly consumed commercial berry jams (blueberry (Vaccinium myrtillus), blackberry (Rubus fruticosus) and blackcurrant (Ribes nigrun) mixture, blackcurrant (Ribes nigrun), cranberry (Vaccinium macrocarpon) and raspberry (Rubus idaeus)) collected from the market. Even though a possible loss of phenolics, anthocyanins, and a decrease of radical scavenging activity may occur during jam processing and subsequent storage, our data indicated that the selected commercial jams remained good sources of nutritive molecules with antioxidant properties based on the high levels of total phenolics, flavonoids, anthocyanins, and elevated antioxidant activities determined in this study. Additionally, the samples were characterized by GC-MS for their volatile profiles, and terpenes were found to be the dominating class covering more than 74% of volatile compounds in the jams.
Zoriţa Diaconeasa; Cristian I. Iuhas; Huseyin Ayvaz; Dumitriţa Rugină; Andreea Stanilă; Francisc Dulf; Andrea Bunea; Sonia Ancuța Socaci; Carmen Socaciu; Adela Pintea. Phytochemical Characterization of Commercial Processed Blueberry, Blackberry, Blackcurrant, Cranberry, and Raspberry and Their Antioxidant Activity. Antioxidants 2019, 8, 540 .
AMA StyleZoriţa Diaconeasa, Cristian I. Iuhas, Huseyin Ayvaz, Dumitriţa Rugină, Andreea Stanilă, Francisc Dulf, Andrea Bunea, Sonia Ancuța Socaci, Carmen Socaciu, Adela Pintea. Phytochemical Characterization of Commercial Processed Blueberry, Blackberry, Blackcurrant, Cranberry, and Raspberry and Their Antioxidant Activity. Antioxidants. 2019; 8 (11):540.
Chicago/Turabian StyleZoriţa Diaconeasa; Cristian I. Iuhas; Huseyin Ayvaz; Dumitriţa Rugină; Andreea Stanilă; Francisc Dulf; Andrea Bunea; Sonia Ancuța Socaci; Carmen Socaciu; Adela Pintea. 2019. "Phytochemical Characterization of Commercial Processed Blueberry, Blackberry, Blackcurrant, Cranberry, and Raspberry and Their Antioxidant Activity." Antioxidants 8, no. 11: 540.
Background and objectives: As pelvic floor disorders are often difficult to assess thoroughly based on clinical examination alone, the use of imaging as a complementary technique is helpful. This study’s aim was to investigate by transperineal ultrasound (US) if there was any significant difference in the mobility of the bladder neck in women with stress urinary incontinence (SUI) without a cystocele and in those with SUI and an associated cystocele. The study also investigated whether the number of vaginal births and/or the heaviest newborn’s birth weight was correlated with the bladder neck mobility. Materials and Methods: A total of 71 women suffering from SUI were included in the study and divided into two groups based on the presence of a cystocele. Their bladder neck mobility was evaluated by transperineal US, calculating the distance from the inferior margin of the symphysis pubis to the bladder neck (SPBN), and the dorsocaudal linear movement (DLM), term used to illustrate the displacement of the bladder neck by subtracting rest and Valsalva values. GraphPad Prism 8 was used for statistical analysis. Results: Within both study groups, the SPBN values were significantly higher and the DLM values were significantly lower at rest as compared to Valsalva maneuver (p < 0.05). No significant difference between the groups regarding SPBN and DLM values at rest, Valsalva, or subtraction was demonstrated. A significant positive correlation was found between the bladder neck mobility and the heaviest newborn’s birth weight, regardless of the presence of a cystocele (p = 0.042). Conclusions: The presence of a cystocele had no significant impact on the bladder neck mobility measurements in patients with SUI. The heaviest newborn’s birth weight positively correlated with bladder neck hypermobility, as quantified by SPBN.
Maria-Patricia Rada; Răzvan Ciortea; Andrei Mihai Măluțan; Doru Diculescu; Costin Berceanu; Mihaela Oancea; Cristian Ioan Iuhas; Carmen Elena Bucuri; Andrei Roman; Dan Mihu. Transperineal Ultrasound Assessment of a Cystocele’s Impact on the Bladder Neck Mobility in Women with Stress Urinary Incontinence. Medicina 2019, 55, 562 .
AMA StyleMaria-Patricia Rada, Răzvan Ciortea, Andrei Mihai Măluțan, Doru Diculescu, Costin Berceanu, Mihaela Oancea, Cristian Ioan Iuhas, Carmen Elena Bucuri, Andrei Roman, Dan Mihu. Transperineal Ultrasound Assessment of a Cystocele’s Impact on the Bladder Neck Mobility in Women with Stress Urinary Incontinence. Medicina. 2019; 55 (9):562.
Chicago/Turabian StyleMaria-Patricia Rada; Răzvan Ciortea; Andrei Mihai Măluțan; Doru Diculescu; Costin Berceanu; Mihaela Oancea; Cristian Ioan Iuhas; Carmen Elena Bucuri; Andrei Roman; Dan Mihu. 2019. "Transperineal Ultrasound Assessment of a Cystocele’s Impact on the Bladder Neck Mobility in Women with Stress Urinary Incontinence." Medicina 55, no. 9: 562.
Vegetables comprise a significant portion of our daily diet with their high content in nutrients including fiber, vitamins, minerals, as well as phenolic compounds. Vegetable consumption has been shown to be positively associated with the prevention of several degenerative diseases thanks to their bioactive compounds. Accordingly, five selected vegetables, namely, red chicory, red onion, eggplant, purple sweet potato, and black carrot were thoroughly assessed for their phenolic content in this study. For this purpose, the total phenolic and flavonoid content of these five vegetables and their antioxidant activities that are based on three common methods ABTS radical cation decolorization assay (ABTS), Cupric Ion Reducing Antioxidant Capacity (CUPRAC), and DPPH scavenging activity assay were determined. Additionally, HPLC-PDA/Electrospray ionization coupled with mass spectrometry (HPLC-PDA/-ESI+-MS)-based identification and quantification of the members belonging to polyphenols present in each vegetable were determined. Statistical correlations between antioxidant activities and the specific type of phenolic compounds, such as anthocyanins, flavonoids, anthocyanins, and phenolic acids were further elucidated. Phenolic acids (chlorogenic and syringic acids) were found to be the most abundant compounds that are present in all samples. Among the anthocyanins, cyaniding derivatives were present in all vegetables. In terms of their antioxidant activities, the analyzed vegetables were ranked as red chicory > purple sweet potato > black carrot > eggplant > red onion, in descending order. Superior antioxidant activities exhibited by red chicory and purple sweet potato were attributed to the high content of phenolic compounds, especially flavonols (quercetin-3,4-O-diglucoside) in red chicory and anthocyanins (peonidin-3-caffeoyl p-hydroxybenzoylsophoroside-5-glucoside) in purple sweet potato.
Alexandra D. Frond; Cristian I. Iuhas; Ioana Stirbu; Loredana Leopold; Sonia Socaci; Stǎnilǎ Andreea; Huseyin Ayvaz; Socaciu Andreea; Socaciu Mihai; Zorița Diaconeasa; Socaciu Carmen. Phytochemical Characterization of Five Edible Purple-Reddish Vegetables: Anthocyanins, Flavonoids, and Phenolic Acid Derivatives. Molecules 2019, 24, 1536 .
AMA StyleAlexandra D. Frond, Cristian I. Iuhas, Ioana Stirbu, Loredana Leopold, Sonia Socaci, Stǎnilǎ Andreea, Huseyin Ayvaz, Socaciu Andreea, Socaciu Mihai, Zorița Diaconeasa, Socaciu Carmen. Phytochemical Characterization of Five Edible Purple-Reddish Vegetables: Anthocyanins, Flavonoids, and Phenolic Acid Derivatives. Molecules. 2019; 24 (8):1536.
Chicago/Turabian StyleAlexandra D. Frond; Cristian I. Iuhas; Ioana Stirbu; Loredana Leopold; Sonia Socaci; Stǎnilǎ Andreea; Huseyin Ayvaz; Socaciu Andreea; Socaciu Mihai; Zorița Diaconeasa; Socaciu Carmen. 2019. "Phytochemical Characterization of Five Edible Purple-Reddish Vegetables: Anthocyanins, Flavonoids, and Phenolic Acid Derivatives." Molecules 24, no. 8: 1536.